Amino acid dipepetide frequency for Salmonella phage vB_SosS_Oslo

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.697AlaAla: 8.697 ± 1.339
0.674AlaCys: 0.674 ± 0.184
5.731AlaAsp: 5.731 ± 0.694
6.338AlaGlu: 6.338 ± 0.679
3.371AlaPhe: 3.371 ± 0.486
6.54AlaGly: 6.54 ± 0.698
1.011AlaHis: 1.011 ± 0.261
4.72AlaIle: 4.72 ± 0.554
5.529AlaLys: 5.529 ± 0.645
6.001AlaLeu: 6.001 ± 0.692
3.034AlaMet: 3.034 ± 0.421
4.382AlaAsn: 4.382 ± 0.964
2.427AlaPro: 2.427 ± 0.479
2.899AlaGln: 2.899 ± 0.449
5.731AlaArg: 5.731 ± 0.688
5.596AlaSer: 5.596 ± 0.806
4.652AlaThr: 4.652 ± 0.771
5.663AlaVal: 5.663 ± 0.62
1.82AlaTrp: 1.82 ± 0.391
2.427AlaTyr: 2.427 ± 0.424
0.0AlaXaa: 0.0 ± 0.0
Cys
0.809CysAla: 0.809 ± 0.231
0.202CysCys: 0.202 ± 0.12
0.944CysAsp: 0.944 ± 0.234
1.079CysGlu: 1.079 ± 0.286
0.337CysPhe: 0.337 ± 0.16
1.079CysGly: 1.079 ± 0.315
0.202CysHis: 0.202 ± 0.117
0.674CysIle: 0.674 ± 0.221
1.011CysLys: 1.011 ± 0.279
0.944CysLeu: 0.944 ± 0.269
0.405CysMet: 0.405 ± 0.152
0.472CysAsn: 0.472 ± 0.151
0.337CysPro: 0.337 ± 0.156
0.405CysGln: 0.405 ± 0.163
1.348CysArg: 1.348 ± 0.301
0.809CysSer: 0.809 ± 0.231
0.742CysThr: 0.742 ± 0.224
0.472CysVal: 0.472 ± 0.173
0.27CysTrp: 0.27 ± 0.162
0.539CysTyr: 0.539 ± 0.166
0.0CysXaa: 0.0 ± 0.0
Asp
5.461AspAla: 5.461 ± 0.637
0.742AspCys: 0.742 ± 0.273
3.708AspAsp: 3.708 ± 0.553
4.45AspGlu: 4.45 ± 0.504
2.427AspPhe: 2.427 ± 0.4
5.798AspGly: 5.798 ± 0.657
0.674AspHis: 0.674 ± 0.203
3.978AspIle: 3.978 ± 0.505
3.034AspLys: 3.034 ± 0.403
4.315AspLeu: 4.315 ± 0.618
1.82AspMet: 1.82 ± 0.28
2.495AspAsn: 2.495 ± 0.517
2.225AspPro: 2.225 ± 0.473
2.09AspGln: 2.09 ± 0.37
2.629AspArg: 2.629 ± 0.43
3.371AspSer: 3.371 ± 0.386
2.629AspThr: 2.629 ± 0.381
3.91AspVal: 3.91 ± 0.537
0.944AspTrp: 0.944 ± 0.296
1.416AspTyr: 1.416 ± 0.309
0.0AspXaa: 0.0 ± 0.0
Glu
5.663GluAla: 5.663 ± 0.536
1.011GluCys: 1.011 ± 0.289
2.292GluAsp: 2.292 ± 0.513
5.731GluGlu: 5.731 ± 0.832
3.101GluPhe: 3.101 ± 0.429
3.843GluGly: 3.843 ± 0.531
1.82GluHis: 1.82 ± 0.357
4.854GluIle: 4.854 ± 0.642
4.787GluLys: 4.787 ± 0.624
6.405GluLeu: 6.405 ± 0.762
1.955GluMet: 1.955 ± 0.386
2.023GluAsn: 2.023 ± 0.306
2.292GluPro: 2.292 ± 0.328
3.708GluGln: 3.708 ± 0.524
4.787GluArg: 4.787 ± 0.646
3.101GluSer: 3.101 ± 0.435
3.236GluThr: 3.236 ± 0.512
4.585GluVal: 4.585 ± 0.556
1.955GluTrp: 1.955 ± 0.346
2.495GluTyr: 2.495 ± 0.34
0.0GluXaa: 0.0 ± 0.0
Phe
2.832PheAla: 2.832 ± 0.42
0.809PheCys: 0.809 ± 0.259
2.292PheAsp: 2.292 ± 0.406
2.427PheGlu: 2.427 ± 0.391
0.876PhePhe: 0.876 ± 0.222
3.169PheGly: 3.169 ± 0.423
0.27PheHis: 0.27 ± 0.117
2.225PheIle: 2.225 ± 0.35
1.955PheLys: 1.955 ± 0.35
1.955PheLeu: 1.955 ± 0.378
0.809PheMet: 0.809 ± 0.241
2.023PheAsn: 2.023 ± 0.323
1.146PhePro: 1.146 ± 0.303
1.011PheGln: 1.011 ± 0.22
2.09PheArg: 2.09 ± 0.504
2.225PheSer: 2.225 ± 0.377
2.225PheThr: 2.225 ± 0.425
1.686PheVal: 1.686 ± 0.327
0.876PheTrp: 0.876 ± 0.214
1.011PheTyr: 1.011 ± 0.278
0.0PheXaa: 0.0 ± 0.0
Gly
5.866GlyAla: 5.866 ± 0.965
0.944GlyCys: 0.944 ± 0.232
4.854GlyAsp: 4.854 ± 0.66
5.124GlyGlu: 5.124 ± 0.639
1.753GlyPhe: 1.753 ± 0.367
4.585GlyGly: 4.585 ± 0.685
1.551GlyHis: 1.551 ± 0.336
4.585GlyIle: 4.585 ± 0.633
4.652GlyLys: 4.652 ± 0.701
4.787GlyLeu: 4.787 ± 0.425
2.495GlyMet: 2.495 ± 0.386
3.506GlyAsn: 3.506 ± 0.458
1.146GlyPro: 1.146 ± 0.257
2.832GlyGln: 2.832 ± 0.42
3.978GlyArg: 3.978 ± 0.485
5.057GlySer: 5.057 ± 0.728
3.371GlyThr: 3.371 ± 0.455
5.124GlyVal: 5.124 ± 0.544
1.618GlyTrp: 1.618 ± 0.326
2.157GlyTyr: 2.157 ± 0.407
0.0GlyXaa: 0.0 ± 0.0
His
1.214HisAla: 1.214 ± 0.311
0.202HisCys: 0.202 ± 0.106
1.079HisAsp: 1.079 ± 0.235
1.214HisGlu: 1.214 ± 0.301
0.674HisPhe: 0.674 ± 0.203
1.551HisGly: 1.551 ± 0.285
0.337HisHis: 0.337 ± 0.183
0.674HisIle: 0.674 ± 0.201
0.742HisLys: 0.742 ± 0.242
1.618HisLeu: 1.618 ± 0.299
0.539HisMet: 0.539 ± 0.188
0.539HisAsn: 0.539 ± 0.207
0.876HisPro: 0.876 ± 0.235
0.674HisGln: 0.674 ± 0.209
1.348HisArg: 1.348 ± 0.309
0.876HisSer: 0.876 ± 0.256
0.809HisThr: 0.809 ± 0.25
1.079HisVal: 1.079 ± 0.294
0.405HisTrp: 0.405 ± 0.183
0.809HisTyr: 0.809 ± 0.212
0.0HisXaa: 0.0 ± 0.0
Ile
5.596IleAla: 5.596 ± 0.591
0.337IleCys: 0.337 ± 0.147
4.113IleAsp: 4.113 ± 0.418
2.899IleGlu: 2.899 ± 0.441
1.281IlePhe: 1.281 ± 0.322
3.573IleGly: 3.573 ± 0.348
0.876IleHis: 0.876 ± 0.216
3.236IleIle: 3.236 ± 0.507
2.562IleLys: 2.562 ± 0.412
4.18IleLeu: 4.18 ± 0.54
1.483IleMet: 1.483 ± 0.303
3.439IleAsn: 3.439 ± 0.523
3.439IlePro: 3.439 ± 0.436
2.023IleGln: 2.023 ± 0.351
3.708IleArg: 3.708 ± 0.498
4.652IleSer: 4.652 ± 0.499
4.585IleThr: 4.585 ± 0.523
2.764IleVal: 2.764 ± 0.487
1.348IleTrp: 1.348 ± 0.267
0.809IleTyr: 0.809 ± 0.257
0.0IleXaa: 0.0 ± 0.0
Lys
4.922LysAla: 4.922 ± 0.596
0.472LysCys: 0.472 ± 0.161
2.292LysAsp: 2.292 ± 0.451
4.382LysGlu: 4.382 ± 0.495
1.955LysPhe: 1.955 ± 0.317
3.843LysGly: 3.843 ± 0.484
1.011LysHis: 1.011 ± 0.302
2.629LysIle: 2.629 ± 0.411
4.517LysLys: 4.517 ± 0.669
4.517LysLeu: 4.517 ± 0.795
1.888LysMet: 1.888 ± 0.335
2.292LysAsn: 2.292 ± 0.44
2.764LysPro: 2.764 ± 0.498
3.641LysGln: 3.641 ± 0.503
4.315LysArg: 4.315 ± 0.504
3.506LysSer: 3.506 ± 0.504
3.169LysThr: 3.169 ± 0.423
3.101LysVal: 3.101 ± 0.419
1.079LysTrp: 1.079 ± 0.238
2.292LysTyr: 2.292 ± 0.352
0.0LysXaa: 0.0 ± 0.0
Leu
6.675LeuAla: 6.675 ± 0.672
1.281LeuCys: 1.281 ± 0.289
4.18LeuAsp: 4.18 ± 0.459
4.922LeuGlu: 4.922 ± 0.572
2.697LeuPhe: 2.697 ± 0.515
3.573LeuGly: 3.573 ± 0.494
1.281LeuHis: 1.281 ± 0.246
4.45LeuIle: 4.45 ± 0.635
4.113LeuLys: 4.113 ± 0.588
6.001LeuLeu: 6.001 ± 0.576
1.753LeuMet: 1.753 ± 0.31
4.585LeuAsn: 4.585 ± 0.637
3.708LeuPro: 3.708 ± 0.56
2.562LeuGln: 2.562 ± 0.578
4.72LeuArg: 4.72 ± 0.925
5.663LeuSer: 5.663 ± 0.603
4.652LeuThr: 4.652 ± 0.533
5.124LeuVal: 5.124 ± 0.596
1.618LeuTrp: 1.618 ± 0.32
3.236LeuTyr: 3.236 ± 0.568
0.0LeuXaa: 0.0 ± 0.0
Met
2.967MetAla: 2.967 ± 0.504
0.27MetCys: 0.27 ± 0.139
1.618MetAsp: 1.618 ± 0.349
1.551MetGlu: 1.551 ± 0.338
1.011MetPhe: 1.011 ± 0.267
1.618MetGly: 1.618 ± 0.435
0.337MetHis: 0.337 ± 0.122
1.214MetIle: 1.214 ± 0.273
1.618MetLys: 1.618 ± 0.295
2.764MetLeu: 2.764 ± 0.511
0.607MetMet: 0.607 ± 0.201
1.416MetAsn: 1.416 ± 0.328
1.618MetPro: 1.618 ± 0.326
1.079MetGln: 1.079 ± 0.253
1.753MetArg: 1.753 ± 0.331
2.832MetSer: 2.832 ± 0.343
2.562MetThr: 2.562 ± 0.372
1.348MetVal: 1.348 ± 0.334
0.607MetTrp: 0.607 ± 0.203
0.876MetTyr: 0.876 ± 0.226
0.0MetXaa: 0.0 ± 0.0
Asn
4.18AsnAla: 4.18 ± 0.573
0.337AsnCys: 0.337 ± 0.134
2.967AsnAsp: 2.967 ± 0.436
3.573AsnGlu: 3.573 ± 0.467
1.011AsnPhe: 1.011 ± 0.198
5.124AsnGly: 5.124 ± 0.734
1.416AsnHis: 1.416 ± 0.239
2.09AsnIle: 2.09 ± 0.431
2.36AsnLys: 2.36 ± 0.313
3.843AsnLeu: 3.843 ± 0.918
1.281AsnMet: 1.281 ± 0.292
2.36AsnAsn: 2.36 ± 0.471
2.09AsnPro: 2.09 ± 0.376
2.157AsnGln: 2.157 ± 0.535
2.157AsnArg: 2.157 ± 0.359
3.91AsnSer: 3.91 ± 0.415
2.292AsnThr: 2.292 ± 0.501
2.764AsnVal: 2.764 ± 0.465
0.472AsnTrp: 0.472 ± 0.19
1.955AsnTyr: 1.955 ± 0.393
0.0AsnXaa: 0.0 ± 0.0
Pro
3.708ProAla: 3.708 ± 0.506
0.337ProCys: 0.337 ± 0.155
2.899ProAsp: 2.899 ± 0.398
3.708ProGlu: 3.708 ± 0.407
1.82ProPhe: 1.82 ± 0.381
2.292ProGly: 2.292 ± 0.496
0.742ProHis: 0.742 ± 0.258
2.225ProIle: 2.225 ± 0.401
1.888ProLys: 1.888 ± 0.39
2.629ProLeu: 2.629 ± 0.509
0.876ProMet: 0.876 ± 0.26
1.416ProAsn: 1.416 ± 0.262
1.551ProPro: 1.551 ± 0.275
1.483ProGln: 1.483 ± 0.318
1.618ProArg: 1.618 ± 0.304
2.292ProSer: 2.292 ± 0.382
2.36ProThr: 2.36 ± 0.396
3.843ProVal: 3.843 ± 0.636
0.405ProTrp: 0.405 ± 0.184
1.551ProTyr: 1.551 ± 0.318
0.0ProXaa: 0.0 ± 0.0
Gln
4.45GlnAla: 4.45 ± 0.723
0.539GlnCys: 0.539 ± 0.172
1.416GlnAsp: 1.416 ± 0.276
2.764GlnGlu: 2.764 ± 0.309
1.348GlnPhe: 1.348 ± 0.352
2.157GlnGly: 2.157 ± 0.328
0.607GlnHis: 0.607 ± 0.17
2.427GlnIle: 2.427 ± 0.346
2.629GlnLys: 2.629 ± 0.381
2.629GlnLeu: 2.629 ± 0.371
1.281GlnMet: 1.281 ± 0.238
1.551GlnAsn: 1.551 ± 0.31
1.888GlnPro: 1.888 ± 0.458
3.236GlnGln: 3.236 ± 0.627
2.697GlnArg: 2.697 ± 0.505
2.225GlnSer: 2.225 ± 0.442
2.157GlnThr: 2.157 ± 0.45
2.967GlnVal: 2.967 ± 0.448
0.674GlnTrp: 0.674 ± 0.198
1.955GlnTyr: 1.955 ± 0.331
0.0GlnXaa: 0.0 ± 0.0
Arg
3.506ArgAla: 3.506 ± 0.453
0.876ArgCys: 0.876 ± 0.282
3.843ArgAsp: 3.843 ± 0.485
4.922ArgGlu: 4.922 ± 0.74
2.157ArgPhe: 2.157 ± 0.404
3.439ArgGly: 3.439 ± 0.54
1.416ArgHis: 1.416 ± 0.349
3.506ArgIle: 3.506 ± 0.527
3.708ArgLys: 3.708 ± 0.57
5.596ArgLeu: 5.596 ± 0.553
2.697ArgMet: 2.697 ± 0.478
2.967ArgAsn: 2.967 ± 0.472
2.967ArgPro: 2.967 ± 0.448
2.764ArgGln: 2.764 ± 0.428
3.776ArgArg: 3.776 ± 0.638
2.832ArgSer: 2.832 ± 0.467
2.562ArgThr: 2.562 ± 0.331
3.573ArgVal: 3.573 ± 0.412
0.876ArgTrp: 0.876 ± 0.218
2.292ArgTyr: 2.292 ± 0.436
0.0ArgXaa: 0.0 ± 0.0
Ser
6.001SerAla: 6.001 ± 0.697
1.214SerCys: 1.214 ± 0.302
3.371SerAsp: 3.371 ± 0.515
3.843SerGlu: 3.843 ± 0.485
2.697SerPhe: 2.697 ± 0.415
5.191SerGly: 5.191 ± 0.758
1.281SerHis: 1.281 ± 0.302
4.045SerIle: 4.045 ± 0.551
3.101SerLys: 3.101 ± 0.593
5.529SerLeu: 5.529 ± 0.847
2.495SerMet: 2.495 ± 0.356
2.832SerAsn: 2.832 ± 0.52
2.899SerPro: 2.899 ± 0.455
2.562SerGln: 2.562 ± 0.409
3.506SerArg: 3.506 ± 0.44
4.18SerSer: 4.18 ± 0.798
2.427SerThr: 2.427 ± 0.545
4.652SerVal: 4.652 ± 0.479
0.944SerTrp: 0.944 ± 0.212
2.157SerTyr: 2.157 ± 0.433
0.0SerXaa: 0.0 ± 0.0
Thr
5.866ThrAla: 5.866 ± 0.793
0.607ThrCys: 0.607 ± 0.221
3.304ThrAsp: 3.304 ± 0.394
3.371ThrGlu: 3.371 ± 0.468
1.483ThrPhe: 1.483 ± 0.425
4.854ThrGly: 4.854 ± 0.631
0.472ThrHis: 0.472 ± 0.169
3.169ThrIle: 3.169 ± 0.503
3.371ThrLys: 3.371 ± 0.45
3.573ThrLeu: 3.573 ± 0.529
1.483ThrMet: 1.483 ± 0.361
3.169ThrAsn: 3.169 ± 0.527
2.832ThrPro: 2.832 ± 0.503
1.348ThrGln: 1.348 ± 0.314
2.629ThrArg: 2.629 ± 0.349
3.371ThrSer: 3.371 ± 0.507
2.967ThrThr: 2.967 ± 0.503
4.248ThrVal: 4.248 ± 0.728
0.944ThrTrp: 0.944 ± 0.249
2.09ThrTyr: 2.09 ± 0.435
0.0ThrXaa: 0.0 ± 0.0
Val
4.45ValAla: 4.45 ± 0.618
1.146ValCys: 1.146 ± 0.253
3.776ValAsp: 3.776 ± 0.377
4.517ValGlu: 4.517 ± 0.654
2.36ValPhe: 2.36 ± 0.469
4.045ValGly: 4.045 ± 0.566
1.011ValHis: 1.011 ± 0.254
3.439ValIle: 3.439 ± 0.402
4.315ValLys: 4.315 ± 0.493
4.989ValLeu: 4.989 ± 0.535
1.618ValMet: 1.618 ± 0.331
3.91ValAsn: 3.91 ± 0.672
1.82ValPro: 1.82 ± 0.354
1.82ValGln: 1.82 ± 0.269
3.978ValArg: 3.978 ± 0.477
4.787ValSer: 4.787 ± 0.696
4.787ValThr: 4.787 ± 0.633
5.529ValVal: 5.529 ± 0.765
1.011ValTrp: 1.011 ± 0.256
2.697ValTyr: 2.697 ± 0.487
0.0ValXaa: 0.0 ± 0.0
Trp
1.416TrpAla: 1.416 ± 0.282
0.539TrpCys: 0.539 ± 0.172
1.348TrpAsp: 1.348 ± 0.254
1.079TrpGlu: 1.079 ± 0.254
0.876TrpPhe: 0.876 ± 0.249
0.674TrpGly: 0.674 ± 0.223
0.202TrpHis: 0.202 ± 0.114
0.944TrpIle: 0.944 ± 0.233
0.944TrpLys: 0.944 ± 0.244
2.225TrpLeu: 2.225 ± 0.477
0.472TrpMet: 0.472 ± 0.175
1.214TrpAsn: 1.214 ± 0.298
0.337TrpPro: 0.337 ± 0.144
1.214TrpGln: 1.214 ± 0.317
1.079TrpArg: 1.079 ± 0.239
0.876TrpSer: 0.876 ± 0.214
0.876TrpThr: 0.876 ± 0.296
1.551TrpVal: 1.551 ± 0.364
0.337TrpTrp: 0.337 ± 0.161
0.472TrpTyr: 0.472 ± 0.182
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.034TyrAla: 3.034 ± 0.437
0.539TyrCys: 0.539 ± 0.159
2.09TyrAsp: 2.09 ± 0.348
1.753TyrGlu: 1.753 ± 0.279
0.674TyrPhe: 0.674 ± 0.21
3.034TyrGly: 3.034 ± 0.535
0.742TyrHis: 0.742 ± 0.189
1.82TyrIle: 1.82 ± 0.321
1.753TyrLys: 1.753 ± 0.37
2.292TyrLeu: 2.292 ± 0.405
0.607TyrMet: 0.607 ± 0.204
1.753TyrAsn: 1.753 ± 0.432
1.281TyrPro: 1.281 ± 0.267
2.09TyrGln: 2.09 ± 0.38
2.427TyrArg: 2.427 ± 0.374
2.764TyrSer: 2.764 ± 0.41
2.09TyrThr: 2.09 ± 0.355
2.023TyrVal: 2.023 ± 0.349
0.472TyrTrp: 0.472 ± 0.17
0.944TyrTyr: 0.944 ± 0.267
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (14833 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski