Amino acid dipepetide frequency for Metallosphaera rod-shaped virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.317AlaCys: 0.317 ± 0.208
3.958AlaAsp: 3.958 ± 0.727
3.958AlaGlu: 3.958 ± 1.399
2.692AlaPhe: 2.692 ± 0.745
2.217AlaGly: 2.217 ± 0.728
0.317AlaHis: 0.317 ± 0.199
6.966AlaIle: 6.966 ± 1.128
5.858AlaLys: 5.858 ± 0.676
7.125AlaLeu: 7.125 ± 0.925
1.108AlaMet: 1.108 ± 0.465
3.483AlaAsn: 3.483 ± 0.545
1.9AlaPro: 1.9 ± 0.393
3.167AlaGln: 3.167 ± 0.677
3.008AlaArg: 3.008 ± 0.485
3.325AlaSer: 3.325 ± 0.631
4.275AlaThr: 4.275 ± 0.733
4.117AlaVal: 4.117 ± 0.624
1.108AlaTrp: 1.108 ± 0.267
3.958AlaTyr: 3.958 ± 1.187
0.0AlaXaa: 0.0 ± 0.0
Cys
0.158CysAla: 0.158 ± 0.141
0.0CysCys: 0.0 ± 0.0
0.633CysAsp: 0.633 ± 0.428
0.95CysGlu: 0.95 ± 0.485
0.0CysPhe: 0.0 ± 0.0
1.425CysGly: 1.425 ± 0.441
0.158CysHis: 0.158 ± 0.156
0.475CysIle: 0.475 ± 0.256
0.792CysLys: 0.792 ± 0.385
0.475CysLeu: 0.475 ± 0.266
0.0CysMet: 0.0 ± 0.0
0.317CysAsn: 0.317 ± 0.176
0.0CysPro: 0.0 ± 0.0
0.633CysGln: 0.633 ± 0.278
0.0CysArg: 0.0 ± 0.0
0.475CysSer: 0.475 ± 0.251
0.633CysThr: 0.633 ± 0.349
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.317CysTyr: 0.317 ± 0.218
0.0CysXaa: 0.0 ± 0.0
Asp
3.167AspAla: 3.167 ± 0.479
0.475AspCys: 0.475 ± 0.365
2.85AspAsp: 2.85 ± 0.882
4.592AspGlu: 4.592 ± 0.809
2.217AspPhe: 2.217 ± 0.519
1.425AspGly: 1.425 ± 0.505
0.95AspHis: 0.95 ± 0.303
5.541AspIle: 5.541 ± 1.06
3.8AspLys: 3.8 ± 1.021
6.333AspLeu: 6.333 ± 1.269
0.317AspMet: 0.317 ± 0.241
3.8AspAsn: 3.8 ± 0.751
1.583AspPro: 1.583 ± 0.493
1.742AspGln: 1.742 ± 0.407
2.217AspArg: 2.217 ± 0.466
2.692AspSer: 2.692 ± 0.475
1.108AspThr: 1.108 ± 0.391
4.592AspVal: 4.592 ± 0.618
0.792AspTrp: 0.792 ± 0.361
2.058AspTyr: 2.058 ± 0.476
0.0AspXaa: 0.0 ± 0.0
Glu
2.375GluAla: 2.375 ± 0.535
0.633GluCys: 0.633 ± 0.407
2.533GluAsp: 2.533 ± 0.717
4.117GluGlu: 4.117 ± 0.766
1.9GluPhe: 1.9 ± 0.496
1.742GluGly: 1.742 ± 0.467
0.792GluHis: 0.792 ± 0.245
9.341GluIle: 9.341 ± 2.598
8.233GluLys: 8.233 ± 1.302
6.333GluLeu: 6.333 ± 1.664
2.058GluMet: 2.058 ± 0.697
3.8GluAsn: 3.8 ± 0.555
1.583GluPro: 1.583 ± 0.583
3.642GluGln: 3.642 ± 0.698
1.425GluArg: 1.425 ± 0.43
2.375GluSer: 2.375 ± 0.501
2.533GluThr: 2.533 ± 0.591
4.908GluVal: 4.908 ± 1.002
0.158GluTrp: 0.158 ± 0.163
3.642GluTyr: 3.642 ± 0.792
0.0GluXaa: 0.0 ± 0.0
Phe
3.008PheAla: 3.008 ± 0.526
1.108PheCys: 1.108 ± 0.532
2.85PheAsp: 2.85 ± 0.845
3.642PheGlu: 3.642 ± 0.778
1.9PhePhe: 1.9 ± 0.703
3.167PheGly: 3.167 ± 0.559
0.633PheHis: 0.633 ± 0.28
3.325PheIle: 3.325 ± 0.719
3.8PheLys: 3.8 ± 0.831
4.75PheLeu: 4.75 ± 0.694
0.633PheMet: 0.633 ± 0.285
3.008PheAsn: 3.008 ± 0.685
1.108PhePro: 1.108 ± 0.349
2.375PheGln: 2.375 ± 0.48
1.108PheArg: 1.108 ± 0.368
4.592PheSer: 4.592 ± 0.616
3.167PheThr: 3.167 ± 0.55
4.592PheVal: 4.592 ± 0.716
0.0PheTrp: 0.0 ± 0.0
1.9PheTyr: 1.9 ± 0.56
0.0PheXaa: 0.0 ± 0.0
Gly
2.533GlyAla: 2.533 ± 0.64
0.633GlyCys: 0.633 ± 0.304
1.742GlyAsp: 1.742 ± 0.505
2.533GlyGlu: 2.533 ± 0.677
2.692GlyPhe: 2.692 ± 0.733
3.642GlyGly: 3.642 ± 1.061
0.317GlyHis: 0.317 ± 0.234
4.433GlyIle: 4.433 ± 1.002
2.533GlyLys: 2.533 ± 0.703
4.275GlyLeu: 4.275 ± 0.587
2.058GlyMet: 2.058 ± 0.497
3.167GlyAsn: 3.167 ± 0.681
1.742GlyPro: 1.742 ± 0.586
1.108GlyGln: 1.108 ± 0.309
0.95GlyArg: 0.95 ± 0.351
3.642GlySer: 3.642 ± 0.933
1.425GlyThr: 1.425 ± 0.537
3.167GlyVal: 3.167 ± 0.808
0.317GlyTrp: 0.317 ± 0.312
3.325GlyTyr: 3.325 ± 0.724
0.0GlyXaa: 0.0 ± 0.0
His
0.633HisAla: 0.633 ± 0.258
0.158HisCys: 0.158 ± 0.156
0.792HisAsp: 0.792 ± 0.414
0.633HisGlu: 0.633 ± 0.216
1.267HisPhe: 1.267 ± 0.372
0.633HisGly: 0.633 ± 0.354
0.633HisHis: 0.633 ± 0.284
1.742HisIle: 1.742 ± 0.64
0.95HisLys: 0.95 ± 0.447
1.583HisLeu: 1.583 ± 0.446
0.317HisMet: 0.317 ± 0.187
0.475HisAsn: 0.475 ± 0.253
0.317HisPro: 0.317 ± 0.282
0.158HisGln: 0.158 ± 0.174
0.792HisArg: 0.792 ± 0.304
0.633HisSer: 0.633 ± 0.431
0.317HisThr: 0.317 ± 0.214
0.475HisVal: 0.475 ± 0.403
0.158HisTrp: 0.158 ± 0.166
0.633HisTyr: 0.633 ± 0.237
0.0HisXaa: 0.0 ± 0.0
Ile
6.65IleAla: 6.65 ± 0.976
0.633IleCys: 0.633 ± 0.367
4.117IleAsp: 4.117 ± 0.865
7.125IleGlu: 7.125 ± 1.014
5.225IlePhe: 5.225 ± 0.667
2.85IleGly: 2.85 ± 1.05
1.425IleHis: 1.425 ± 0.577
6.491IleIle: 6.491 ± 1.246
5.066IleLys: 5.066 ± 1.149
8.233IleLeu: 8.233 ± 1.01
0.633IleMet: 0.633 ± 0.319
5.225IleAsn: 5.225 ± 0.785
4.908IlePro: 4.908 ± 0.867
5.541IleGln: 5.541 ± 1.01
2.533IleArg: 2.533 ± 0.686
7.6IleSer: 7.6 ± 1.181
3.958IleThr: 3.958 ± 0.942
6.491IleVal: 6.491 ± 1.331
0.95IleTrp: 0.95 ± 0.301
3.8IleTyr: 3.8 ± 0.841
0.0IleXaa: 0.0 ± 0.0
Lys
5.541LysAla: 5.541 ± 1.06
0.158LysCys: 0.158 ± 0.141
3.642LysAsp: 3.642 ± 0.84
5.066LysGlu: 5.066 ± 1.135
3.642LysPhe: 3.642 ± 0.725
2.217LysGly: 2.217 ± 0.439
1.108LysHis: 1.108 ± 0.341
8.55LysIle: 8.55 ± 1.606
6.333LysLys: 6.333 ± 1.224
8.075LysLeu: 8.075 ± 0.755
1.742LysMet: 1.742 ± 0.441
4.75LysAsn: 4.75 ± 0.893
1.9LysPro: 1.9 ± 0.567
3.325LysGln: 3.325 ± 0.948
1.9LysArg: 1.9 ± 0.548
1.742LysSer: 1.742 ± 0.398
3.8LysThr: 3.8 ± 0.691
4.275LysVal: 4.275 ± 0.9
0.792LysTrp: 0.792 ± 0.359
6.491LysTyr: 6.491 ± 0.869
0.0LysXaa: 0.0 ± 0.0
Leu
5.541LeuAla: 5.541 ± 0.918
0.792LeuCys: 0.792 ± 0.411
5.383LeuAsp: 5.383 ± 1.019
6.016LeuGlu: 6.016 ± 0.814
3.8LeuPhe: 3.8 ± 0.852
4.275LeuGly: 4.275 ± 0.761
0.95LeuHis: 0.95 ± 0.442
7.441LeuIle: 7.441 ± 1.91
9.183LeuLys: 9.183 ± 1.271
9.975LeuLeu: 9.975 ± 1.911
2.375LeuMet: 2.375 ± 0.448
4.592LeuAsn: 4.592 ± 0.737
4.75LeuPro: 4.75 ± 0.688
6.175LeuGln: 6.175 ± 1.389
3.958LeuArg: 3.958 ± 1.07
6.333LeuSer: 6.333 ± 1.16
6.016LeuThr: 6.016 ± 1.268
3.958LeuVal: 3.958 ± 0.761
0.475LeuTrp: 0.475 ± 0.272
6.808LeuTyr: 6.808 ± 1.194
0.0LeuXaa: 0.0 ± 0.0
Met
1.425MetAla: 1.425 ± 0.468
0.0MetCys: 0.0 ± 0.0
1.108MetAsp: 1.108 ± 0.531
0.633MetGlu: 0.633 ± 0.272
0.95MetPhe: 0.95 ± 0.361
0.633MetGly: 0.633 ± 0.341
0.317MetHis: 0.317 ± 0.174
0.633MetIle: 0.633 ± 0.41
0.792MetLys: 0.792 ± 0.269
1.267MetLeu: 1.267 ± 0.4
0.317MetMet: 0.317 ± 0.206
0.95MetAsn: 0.95 ± 0.332
1.742MetPro: 1.742 ± 0.539
0.792MetGln: 0.792 ± 0.236
0.95MetArg: 0.95 ± 0.508
1.583MetSer: 1.583 ± 0.469
1.583MetThr: 1.583 ± 0.375
0.792MetVal: 0.792 ± 0.284
0.158MetTrp: 0.158 ± 0.153
0.792MetTyr: 0.792 ± 0.27
0.0MetXaa: 0.0 ± 0.0
Asn
5.066AsnAla: 5.066 ± 0.784
0.792AsnCys: 0.792 ± 0.33
2.533AsnAsp: 2.533 ± 0.611
2.375AsnGlu: 2.375 ± 0.452
4.908AsnPhe: 4.908 ± 1.053
2.375AsnGly: 2.375 ± 0.79
0.633AsnHis: 0.633 ± 0.297
5.858AsnIle: 5.858 ± 1.017
3.167AsnLys: 3.167 ± 0.961
6.966AsnLeu: 6.966 ± 0.983
0.633AsnMet: 0.633 ± 0.309
3.642AsnAsn: 3.642 ± 0.97
2.692AsnPro: 2.692 ± 0.59
1.742AsnGln: 1.742 ± 0.438
1.425AsnArg: 1.425 ± 0.492
4.75AsnSer: 4.75 ± 0.718
2.058AsnThr: 2.058 ± 0.465
6.016AsnVal: 6.016 ± 0.858
0.317AsnTrp: 0.317 ± 0.196
3.008AsnTyr: 3.008 ± 0.755
0.0AsnXaa: 0.0 ± 0.0
Pro
4.275ProAla: 4.275 ± 0.844
0.0ProCys: 0.0 ± 0.0
2.217ProAsp: 2.217 ± 0.479
2.375ProGlu: 2.375 ± 0.458
1.583ProPhe: 1.583 ± 0.408
1.583ProGly: 1.583 ± 0.404
0.95ProHis: 0.95 ± 0.456
3.642ProIle: 3.642 ± 0.594
1.9ProLys: 1.9 ± 0.726
2.692ProLeu: 2.692 ± 0.561
0.0ProMet: 0.0 ± 0.0
2.217ProAsn: 2.217 ± 0.483
2.217ProPro: 2.217 ± 0.52
1.267ProGln: 1.267 ± 0.38
1.742ProArg: 1.742 ± 0.629
3.167ProSer: 3.167 ± 0.774
3.325ProThr: 3.325 ± 0.801
2.692ProVal: 2.692 ± 0.575
0.158ProTrp: 0.158 ± 0.141
2.058ProTyr: 2.058 ± 0.448
0.0ProXaa: 0.0 ± 0.0
Gln
1.108GlnAla: 1.108 ± 0.274
0.317GlnCys: 0.317 ± 0.23
2.217GlnAsp: 2.217 ± 0.5
3.483GlnGlu: 3.483 ± 0.888
2.375GlnPhe: 2.375 ± 0.538
2.217GlnGly: 2.217 ± 0.414
0.633GlnHis: 0.633 ± 0.323
4.908GlnIle: 4.908 ± 0.812
4.433GlnLys: 4.433 ± 0.776
6.175GlnLeu: 6.175 ± 1.13
0.792GlnMet: 0.792 ± 0.396
4.592GlnAsn: 4.592 ± 0.95
1.108GlnPro: 1.108 ± 0.38
3.008GlnGln: 3.008 ± 0.663
1.108GlnArg: 1.108 ± 0.351
1.425GlnSer: 1.425 ± 0.329
1.583GlnThr: 1.583 ± 0.445
2.692GlnVal: 2.692 ± 0.741
0.317GlnTrp: 0.317 ± 0.187
3.325GlnTyr: 3.325 ± 0.747
0.0GlnXaa: 0.0 ± 0.0
Arg
2.058ArgAla: 2.058 ± 0.679
0.317ArgCys: 0.317 ± 0.186
1.108ArgAsp: 1.108 ± 0.386
2.058ArgGlu: 2.058 ± 0.731
2.217ArgPhe: 2.217 ± 0.685
1.425ArgGly: 1.425 ± 0.362
0.792ArgHis: 0.792 ± 0.257
3.008ArgIle: 3.008 ± 0.577
2.533ArgLys: 2.533 ± 0.511
2.692ArgLeu: 2.692 ± 0.605
0.633ArgMet: 0.633 ± 0.287
1.267ArgAsn: 1.267 ± 0.404
0.633ArgPro: 0.633 ± 0.235
2.217ArgGln: 2.217 ± 0.535
1.583ArgArg: 1.583 ± 0.551
2.85ArgSer: 2.85 ± 0.554
0.633ArgThr: 0.633 ± 0.288
1.9ArgVal: 1.9 ± 0.543
0.0ArgTrp: 0.0 ± 0.0
1.9ArgTyr: 1.9 ± 0.523
0.0ArgXaa: 0.0 ± 0.0
Ser
5.225SerAla: 5.225 ± 1.049
0.158SerCys: 0.158 ± 0.141
5.066SerAsp: 5.066 ± 0.936
3.167SerGlu: 3.167 ± 0.489
3.325SerPhe: 3.325 ± 0.697
5.7SerGly: 5.7 ± 1.277
0.633SerHis: 0.633 ± 0.291
3.167SerIle: 3.167 ± 0.636
3.8SerLys: 3.8 ± 0.875
5.066SerLeu: 5.066 ± 1.213
0.95SerMet: 0.95 ± 0.368
2.533SerAsn: 2.533 ± 0.591
2.533SerPro: 2.533 ± 0.493
3.483SerGln: 3.483 ± 0.859
2.375SerArg: 2.375 ± 0.446
2.85SerSer: 2.85 ± 0.697
3.642SerThr: 3.642 ± 0.812
4.117SerVal: 4.117 ± 0.622
0.633SerTrp: 0.633 ± 0.239
3.008SerTyr: 3.008 ± 0.534
0.0SerXaa: 0.0 ± 0.0
Thr
4.908ThrAla: 4.908 ± 1.148
0.0ThrCys: 0.0 ± 0.0
2.058ThrAsp: 2.058 ± 0.589
3.008ThrGlu: 3.008 ± 0.737
2.85ThrPhe: 2.85 ± 0.606
2.375ThrGly: 2.375 ± 0.435
0.158ThrHis: 0.158 ± 0.163
5.7ThrIle: 5.7 ± 0.831
2.85ThrLys: 2.85 ± 0.521
4.275ThrLeu: 4.275 ± 0.951
0.792ThrMet: 0.792 ± 0.261
3.642ThrAsn: 3.642 ± 0.932
3.8ThrPro: 3.8 ± 0.936
2.058ThrGln: 2.058 ± 0.453
0.95ThrArg: 0.95 ± 0.305
2.692ThrSer: 2.692 ± 0.481
2.375ThrThr: 2.375 ± 0.756
3.483ThrVal: 3.483 ± 0.541
0.475ThrTrp: 0.475 ± 0.324
1.742ThrTyr: 1.742 ± 0.543
0.0ThrXaa: 0.0 ± 0.0
Val
5.066ValAla: 5.066 ± 1.108
0.633ValCys: 0.633 ± 0.345
4.433ValAsp: 4.433 ± 0.707
5.541ValGlu: 5.541 ± 0.945
2.85ValPhe: 2.85 ± 0.603
2.533ValGly: 2.533 ± 0.534
0.792ValHis: 0.792 ± 0.35
3.958ValIle: 3.958 ± 0.79
4.75ValLys: 4.75 ± 1.085
5.7ValLeu: 5.7 ± 0.754
0.633ValMet: 0.633 ± 0.331
3.325ValAsn: 3.325 ± 0.848
3.008ValPro: 3.008 ± 0.6
1.9ValGln: 1.9 ± 0.439
1.742ValArg: 1.742 ± 0.542
5.858ValSer: 5.858 ± 1.341
4.275ValThr: 4.275 ± 1.05
3.642ValVal: 3.642 ± 0.713
0.317ValTrp: 0.317 ± 0.207
4.275ValTyr: 4.275 ± 1.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.633TrpAla: 0.633 ± 0.257
0.0TrpCys: 0.0 ± 0.0
0.158TrpAsp: 0.158 ± 0.156
0.317TrpGlu: 0.317 ± 0.212
0.317TrpPhe: 0.317 ± 0.156
0.158TrpGly: 0.158 ± 0.141
0.317TrpHis: 0.317 ± 0.186
0.317TrpIle: 0.317 ± 0.24
1.108TrpLys: 1.108 ± 0.282
0.158TrpLeu: 0.158 ± 0.134
0.0TrpMet: 0.0 ± 0.0
1.425TrpAsn: 1.425 ± 0.447
0.0TrpPro: 0.0 ± 0.0
0.475TrpGln: 0.475 ± 0.235
0.475TrpArg: 0.475 ± 0.251
0.475TrpSer: 0.475 ± 0.305
0.792TrpThr: 0.792 ± 0.382
0.158TrpVal: 0.158 ± 0.156
0.0TrpTrp: 0.0 ± 0.0
0.317TrpTyr: 0.317 ± 0.221
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.483TyrAla: 3.483 ± 0.88
0.317TyrCys: 0.317 ± 0.223
2.85TyrAsp: 2.85 ± 0.694
2.533TyrGlu: 2.533 ± 0.721
3.958TyrPhe: 3.958 ± 0.8
3.642TyrGly: 3.642 ± 0.652
0.792TyrHis: 0.792 ± 0.264
3.958TyrIle: 3.958 ± 0.696
3.325TyrLys: 3.325 ± 0.861
6.65TyrLeu: 6.65 ± 0.967
1.267TyrMet: 1.267 ± 0.347
4.75TyrAsn: 4.75 ± 0.802
2.533TyrPro: 2.533 ± 0.741
3.008TyrGln: 3.008 ± 0.525
1.583TyrArg: 1.583 ± 0.541
2.375TyrSer: 2.375 ± 0.428
2.692TyrThr: 2.692 ± 0.668
3.167TyrVal: 3.167 ± 0.597
0.475TyrTrp: 0.475 ± 0.273
3.958TyrTyr: 3.958 ± 0.854
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 27 proteins (6317 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski