Amino acid dipepetide frequency for Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.505AlaAla: 12.505 ± 0.164	1.343AlaCys: 1.343 ± 0.037	4.802AlaAsp: 4.802 ± 0.066	6.605AlaGlu: 6.605 ± 0.078	3.615AlaPhe: 3.615 ± 0.054	8.979AlaGly: 8.979 ± 0.107	1.7AlaHis: 1.7 ± 0.04	5.091AlaIle: 5.091 ± 0.068	4.937AlaLys: 4.937 ± 0.069	11.031AlaLeu: 11.031 ± 0.118	2.556AlaMet: 2.556 ± 0.052	2.628AlaAsn: 2.628 ± 0.049	4.506AlaPro: 4.506 ± 0.095	3.461AlaGln: 3.461 ± 0.057	5.643AlaArg: 5.643 ± 0.078	5.605AlaSer: 5.605 ± 0.079	5.073AlaThr: 5.073 ± 0.09	7.544AlaVal: 7.544 ± 0.074	0.906AlaTrp: 0.906 ± 0.029	2.263AlaTyr: 2.263 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.196CysAla: 1.196 ± 0.032	0.277CysCys: 0.277 ± 0.017	0.712CysAsp: 0.712 ± 0.024	0.654CysGlu: 0.654 ± 0.024	0.49CysPhe: 0.49 ± 0.019	1.359CysGly: 1.359 ± 0.038	0.813CysHis: 0.813 ± 0.074	0.627CysIle: 0.627 ± 0.027	0.432CysLys: 0.432 ± 0.017	1.125CysLeu: 1.125 ± 0.032	0.266CysMet: 0.266 ± 0.015	0.414CysAsn: 0.414 ± 0.017	0.663CysPro: 0.663 ± 0.032	0.377CysGln: 0.377 ± 0.018	0.887CysArg: 0.887 ± 0.027	0.925CysSer: 0.925 ± 0.031	0.598CysThr: 0.598 ± 0.023	0.768CysVal: 0.768 ± 0.027	0.13CysTrp: 0.13 ± 0.01	0.409CysTyr: 0.409 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.765AspAla: 4.765 ± 0.058	0.674AspCys: 0.674 ± 0.027	2.318AspAsp: 2.318 ± 0.047	3.234AspGlu: 3.234 ± 0.063	2.213AspPhe: 2.213 ± 0.048	3.971AspGly: 3.971 ± 0.08	0.934AspHis: 0.934 ± 0.026	2.928AspIle: 2.928 ± 0.051	2.204AspLys: 2.204 ± 0.048	5.779AspLeu: 5.779 ± 0.076	1.175AspMet: 1.175 ± 0.031	1.494AspAsn: 1.494 ± 0.038	2.895AspPro: 2.895 ± 0.052	1.63AspGln: 1.63 ± 0.033	3.268AspArg: 3.268 ± 0.056	2.598AspSer: 2.598 ± 0.044	2.293AspThr: 2.293 ± 0.051	3.241AspVal: 3.241 ± 0.061	0.582AspTrp: 0.582 ± 0.02	1.654AspTyr: 1.654 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.513GluAla: 6.513 ± 0.089	0.605GluCys: 0.605 ± 0.022	2.533GluAsp: 2.533 ± 0.046	5.207GluGlu: 5.207 ± 0.078	2.181GluPhe: 2.181 ± 0.043	4.737GluGly: 4.737 ± 0.058	1.247GluHis: 1.247 ± 0.029	4.126GluIle: 4.126 ± 0.066	4.252GluLys: 4.252 ± 0.088	7.61GluLeu: 7.61 ± 0.097	1.992GluMet: 1.992 ± 0.043	2.012GluAsn: 2.012 ± 0.037	2.5GluPro: 2.5 ± 0.057	2.819GluGln: 2.819 ± 0.054	4.804GluArg: 4.804 ± 0.081	3.249GluSer: 3.249 ± 0.055	3.023GluThr: 3.023 ± 0.047	4.972GluVal: 4.972 ± 0.068	0.578GluTrp: 0.578 ± 0.024	1.608GluTyr: 1.608 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.702PheAla: 3.702 ± 0.056	0.601PheCys: 0.601 ± 0.022	2.342PheAsp: 2.342 ± 0.047	2.152PheGlu: 2.152 ± 0.045	1.828PhePhe: 1.828 ± 0.041	3.24PheGly: 3.24 ± 0.042	0.794PheHis: 0.794 ± 0.025	2.021PheIle: 2.021 ± 0.047	1.707PheLys: 1.707 ± 0.035	4.05PheLeu: 4.05 ± 0.067	0.918PheMet: 0.918 ± 0.024	1.443PheAsn: 1.443 ± 0.034	1.814PhePro: 1.814 ± 0.042	1.224PheGln: 1.224 ± 0.028	2.231PheArg: 2.231 ± 0.043	2.875PheSer: 2.875 ± 0.052	2.361PheThr: 2.361 ± 0.043	2.637PheVal: 2.637 ± 0.048	0.463PheTrp: 0.463 ± 0.019	1.171PheTyr: 1.171 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.704GlyAla: 7.704 ± 0.088	1.386GlyCys: 1.386 ± 0.038	3.93GlyAsp: 3.93 ± 0.063	5.665GlyGlu: 5.665 ± 0.068	3.356GlyPhe: 3.356 ± 0.051	6.714GlyGly: 6.714 ± 0.106	1.547GlyHis: 1.547 ± 0.034	5.178GlyIle: 5.178 ± 0.075	4.969GlyLys: 4.969 ± 0.071	7.145GlyLeu: 7.145 ± 0.1	2.405GlyMet: 2.405 ± 0.039	2.736GlyAsn: 2.736 ± 0.049	2.207GlyPro: 2.207 ± 0.045	2.145GlyGln: 2.145 ± 0.045	4.733GlyArg: 4.733 ± 0.058	5.041GlySer: 5.041 ± 0.076	4.658GlyThr: 4.658 ± 0.09	6.427GlyVal: 6.427 ± 0.08	0.944GlyTrp: 0.944 ± 0.027	2.679GlyTyr: 2.679 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.752HisAla: 1.752 ± 0.04	0.29HisCys: 0.29 ± 0.017	1.1HisAsp: 1.1 ± 0.031	1.141HisGlu: 1.141 ± 0.033	0.872HisPhe: 0.872 ± 0.023	1.726HisGly: 1.726 ± 0.042	0.506HisHis: 0.506 ± 0.022	0.906HisIle: 0.906 ± 0.026	0.813HisLys: 0.813 ± 0.028	2.202HisLeu: 2.202 ± 0.04	0.45HisMet: 0.45 ± 0.019	0.634HisAsn: 0.634 ± 0.026	1.329HisPro: 1.329 ± 0.032	0.689HisGln: 0.689 ± 0.022	1.239HisArg: 1.239 ± 0.032	1.146HisSer: 1.146 ± 0.033	0.901HisThr: 0.901 ± 0.03	1.152HisVal: 1.152 ± 0.028	0.214HisTrp: 0.214 ± 0.012	0.647HisTyr: 0.647 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.697IleAla: 5.697 ± 0.07	0.803IleCys: 0.803 ± 0.024	3.15IleAsp: 3.15 ± 0.05	3.576IleGlu: 3.576 ± 0.06	2.165IlePhe: 2.165 ± 0.041	4.462IleGly: 4.462 ± 0.065	0.986IleHis: 0.986 ± 0.024	2.766IleIle: 2.766 ± 0.058	2.514IleLys: 2.514 ± 0.046	4.981IleLeu: 4.981 ± 0.069	1.229IleMet: 1.229 ± 0.034	1.858IleAsn: 1.858 ± 0.046	2.847IlePro: 2.847 ± 0.052	1.441IleGln: 1.441 ± 0.033	2.97IleArg: 2.97 ± 0.054	3.555IleSer: 3.555 ± 0.06	3.072IleThr: 3.072 ± 0.051	3.937IleVal: 3.937 ± 0.067	0.467IleTrp: 0.467 ± 0.021	1.495IleTyr: 1.495 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.696LysAla: 4.696 ± 0.075	0.463LysCys: 0.463 ± 0.024	2.425LysAsp: 2.425 ± 0.041	4.213LysGlu: 4.213 ± 0.074	1.364LysPhe: 1.364 ± 0.032	4.433LysGly: 4.433 ± 0.066	0.858LysHis: 0.858 ± 0.029	2.708LysIle: 2.708 ± 0.05	3.438LysLys: 3.438 ± 0.074	4.659LysLeu: 4.659 ± 0.064	1.462LysMet: 1.462 ± 0.033	1.678LysAsn: 1.678 ± 0.037	2.252LysPro: 2.252 ± 0.046	1.616LysGln: 1.616 ± 0.041	2.961LysArg: 2.961 ± 0.051	2.796LysSer: 2.796 ± 0.051	2.521LysThr: 2.521 ± 0.047	3.927LysVal: 3.927 ± 0.067	0.447LysTrp: 0.447 ± 0.019	1.202LysTyr: 1.202 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	11.487LeuAla: 11.487 ± 0.127	1.316LeuCys: 1.316 ± 0.04	5.363LeuAsp: 5.363 ± 0.073	6.869LeuGlu: 6.869 ± 0.094	4.227LeuPhe: 4.227 ± 0.069	7.551LeuGly: 7.551 ± 0.086	1.956LeuHis: 1.956 ± 0.044	4.975LeuIle: 4.975 ± 0.072	5.744LeuLys: 5.744 ± 0.078	11.52LeuLeu: 11.52 ± 0.147	2.439LeuMet: 2.439 ± 0.05	3.281LeuAsn: 3.281 ± 0.044	5.301LeuPro: 5.301 ± 0.067	3.613LeuGln: 3.613 ± 0.057	5.964LeuArg: 5.964 ± 0.083	7.245LeuSer: 7.245 ± 0.077	5.425LeuThr: 5.425 ± 0.07	7.562LeuVal: 7.562 ± 0.081	0.939LeuTrp: 0.939 ± 0.028	2.638LeuTyr: 2.638 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.617MetAla: 2.617 ± 0.047	0.188MetCys: 0.188 ± 0.012	1.28MetAsp: 1.28 ± 0.035	1.819MetGlu: 1.819 ± 0.041	0.74MetPhe: 0.74 ± 0.027	1.886MetGly: 1.886 ± 0.042	0.486MetHis: 0.486 ± 0.02	1.256MetIle: 1.256 ± 0.033	1.626MetLys: 1.626 ± 0.034	2.594MetLeu: 2.594 ± 0.054	0.624MetMet: 0.624 ± 0.023	0.959MetAsn: 0.959 ± 0.027	1.18MetPro: 1.18 ± 0.026	0.965MetGln: 0.965 ± 0.025	1.441MetArg: 1.441 ± 0.027	1.471MetSer: 1.471 ± 0.031	1.465MetThr: 1.465 ± 0.033	1.945MetVal: 1.945 ± 0.043	0.143MetTrp: 0.143 ± 0.011	0.438MetTyr: 0.438 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.845AsnAla: 2.845 ± 0.058	0.53AsnCys: 0.53 ± 0.025	1.455AsnAsp: 1.455 ± 0.03	1.602AsnGlu: 1.602 ± 0.035	1.243AsnPhe: 1.243 ± 0.032	2.618AsnGly: 2.618 ± 0.058	0.598AsnHis: 0.598 ± 0.022	1.846AsnIle: 1.846 ± 0.039	1.288AsnLys: 1.288 ± 0.031	3.525AsnLeu: 3.525 ± 0.053	0.749AsnMet: 0.749 ± 0.025	1.051AsnAsn: 1.051 ± 0.038	2.018AsnPro: 2.018 ± 0.04	0.982AsnGln: 0.982 ± 0.027	2.005AsnArg: 2.005 ± 0.038	1.817AsnSer: 1.817 ± 0.048	1.468AsnThr: 1.468 ± 0.038	2.309AsnVal: 2.309 ± 0.053	0.402AsnTrp: 0.402 ± 0.016	1.023AsnTyr: 1.023 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	5.168ProAla: 5.168 ± 0.088	0.462ProCys: 0.462 ± 0.021	2.674ProAsp: 2.674 ± 0.046	3.829ProGlu: 3.829 ± 0.061	2.015ProPhe: 2.015 ± 0.042	4.011ProGly: 4.011 ± 0.062	0.888ProHis: 0.888 ± 0.027	2.006ProIle: 2.006 ± 0.043	1.966ProLys: 1.966 ± 0.051	4.758ProLeu: 4.758 ± 0.067	1.047ProMet: 1.047 ± 0.025	1.181ProAsn: 1.181 ± 0.03	2.202ProPro: 2.202 ± 0.058	1.742ProGln: 1.742 ± 0.039	2.122ProArg: 2.122 ± 0.042	2.399ProSer: 2.399 ± 0.044	2.032ProThr: 2.032 ± 0.042	3.965ProVal: 3.965 ± 0.068	0.508ProTrp: 0.508 ± 0.019	1.316ProTyr: 1.316 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.616GlnAla: 3.616 ± 0.053	0.324GlnCys: 0.324 ± 0.019	1.373GlnAsp: 1.373 ± 0.035	2.419GlnGlu: 2.419 ± 0.046	1.106GlnPhe: 1.106 ± 0.031	2.763GlnGly: 2.763 ± 0.055	0.671GlnHis: 0.671 ± 0.022	1.868GlnIle: 1.868 ± 0.042	1.864GlnLys: 1.864 ± 0.044	3.528GlnLeu: 3.528 ± 0.059	0.993GlnMet: 0.993 ± 0.025	1.02GlnAsn: 1.02 ± 0.03	1.374GlnPro: 1.374 ± 0.038	1.567GlnGln: 1.567 ± 0.044	2.191GlnArg: 2.191 ± 0.044	1.785GlnSer: 1.785 ± 0.04	1.564GlnThr: 1.564 ± 0.04	2.815GlnVal: 2.815 ± 0.045	0.371GlnTrp: 0.371 ± 0.016	0.82GlnTyr: 0.82 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	4.705ArgAla: 4.705 ± 0.069	0.764ArgCys: 0.764 ± 0.027	3.067ArgAsp: 3.067 ± 0.045	4.759ArgGlu: 4.759 ± 0.068	2.784ArgPhe: 2.784 ± 0.047	4.107ArgGly: 4.107 ± 0.057	1.408ArgHis: 1.408 ± 0.033	3.738ArgIle: 3.738 ± 0.061	2.847ArgLys: 2.847 ± 0.051	6.833ArgLeu: 6.833 ± 0.086	1.685ArgMet: 1.685 ± 0.038	1.922ArgAsn: 1.922 ± 0.038	2.338ArgPro: 2.338 ± 0.045	2.265ArgGln: 2.265 ± 0.044	3.945ArgArg: 3.945 ± 0.063	3.269ArgSer: 3.269 ± 0.053	2.499ArgThr: 2.499 ± 0.046	4.359ArgVal: 4.359 ± 0.046	0.653ArgTrp: 0.653 ± 0.024	1.968ArgTyr: 1.968 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.813SerAla: 5.813 ± 0.086	0.931SerCys: 0.931 ± 0.04	2.963SerAsp: 2.963 ± 0.053	3.271SerGlu: 3.271 ± 0.054	2.947SerPhe: 2.947 ± 0.057	5.585SerGly: 5.585 ± 0.076	1.252SerHis: 1.252 ± 0.033	3.322SerIle: 3.322 ± 0.064	2.332SerLys: 2.332 ± 0.046	6.179SerLeu: 6.179 ± 0.075	1.427SerMet: 1.427 ± 0.033	1.706SerAsn: 1.706 ± 0.038	2.675SerPro: 2.675 ± 0.046	1.911SerGln: 1.911 ± 0.043	3.675SerArg: 3.675 ± 0.06	3.658SerSer: 3.658 ± 0.066	2.909SerThr: 2.909 ± 0.059	4.221SerVal: 4.221 ± 0.059	0.686SerTrp: 0.686 ± 0.026	2.009SerTyr: 2.009 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.161ThrAla: 5.161 ± 0.083	0.652ThrCys: 0.652 ± 0.028	2.486ThrAsp: 2.486 ± 0.054	2.78ThrGlu: 2.78 ± 0.052	2.058ThrPhe: 2.058 ± 0.045	5.12ThrGly: 5.12 ± 0.09	0.854ThrHis: 0.854 ± 0.029	2.806ThrIle: 2.806 ± 0.049	1.94ThrLys: 1.94 ± 0.04	5.732ThrLeu: 5.732 ± 0.077	1.113ThrMet: 1.113 ± 0.032	1.449ThrAsn: 1.449 ± 0.045	3.022ThrPro: 3.022 ± 0.054	1.362ThrGln: 1.362 ± 0.029	2.594ThrArg: 2.594 ± 0.047	2.959ThrSer: 2.959 ± 0.062	2.652ThrThr: 2.652 ± 0.07	4.446ThrVal: 4.446 ± 0.096	0.472ThrTrp: 0.472 ± 0.02	1.192ThrTyr: 1.192 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	7.885ValAla: 7.885 ± 0.116	0.97ValCys: 0.97 ± 0.029	3.809ValAsp: 3.809 ± 0.054	4.835ValGlu: 4.835 ± 0.063	2.659ValPhe: 2.659 ± 0.042	5.153ValGly: 5.153 ± 0.071	1.316ValHis: 1.316 ± 0.033	4.188ValIle: 4.188 ± 0.059	3.788ValLys: 3.788 ± 0.06	7.497ValLeu: 7.497 ± 0.08	1.872ValMet: 1.872 ± 0.039	2.565ValAsn: 2.565 ± 0.051	3.381ValPro: 3.381 ± 0.052	2.513ValGln: 2.513 ± 0.044	4.295ValArg: 4.295 ± 0.057	4.758ValSer: 4.758 ± 0.084	4.568ValThr: 4.568 ± 0.111	6.185ValVal: 6.185 ± 0.091	0.668ValTrp: 0.668 ± 0.027	1.778ValTyr: 1.778 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.692TrpAla: 0.692 ± 0.024	0.135TrpCys: 0.135 ± 0.01	0.522TrpAsp: 0.522 ± 0.023	0.641TrpGlu: 0.641 ± 0.021	0.445TrpPhe: 0.445 ± 0.018	0.843TrpGly: 0.843 ± 0.031	0.269TrpHis: 0.269 ± 0.013	0.519TrpIle: 0.519 ± 0.022	0.457TrpLys: 0.457 ± 0.02	1.12TrpLeu: 1.12 ± 0.031	0.244TrpMet: 0.244 ± 0.013	0.371TrpAsn: 0.371 ± 0.02	0.386TrpPro: 0.386 ± 0.018	0.453TrpGln: 0.453 ± 0.02	0.678TrpArg: 0.678 ± 0.024	0.696TrpSer: 0.696 ± 0.03	0.436TrpThr: 0.436 ± 0.017	0.669TrpVal: 0.669 ± 0.021	0.147TrpTrp: 0.147 ± 0.011	0.331TrpTyr: 0.331 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.274TyrAla: 2.274 ± 0.041	0.412TyrCys: 0.412 ± 0.021	1.548TyrAsp: 1.548 ± 0.038	1.296TyrGlu: 1.296 ± 0.03	1.267TyrPhe: 1.267 ± 0.034	2.306TyrGly: 2.306 ± 0.046	0.627TyrHis: 0.627 ± 0.021	1.096TyrIle: 1.096 ± 0.029	1.0TyrLys: 1.0 ± 0.027	3.545TyrLeu: 3.545 ± 0.062	0.476TyrMet: 0.476 ± 0.021	0.973TyrAsn: 0.973 ± 0.029	1.402TyrPro: 1.402 ± 0.034	1.258TyrGln: 1.258 ± 0.032	2.271TyrArg: 2.271 ± 0.046	1.627TyrSer: 1.627 ± 0.046	1.331TyrThr: 1.331 ± 0.034	1.602TyrVal: 1.602 ± 0.038	0.334TyrTrp: 0.334 ± 0.016	0.877TyrTyr: 0.877 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4042 proteins (1343640 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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