Amino acid dipepetide frequency for Haematobacter massiliensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.572AlaAla: 18.572 ± 0.183	1.006AlaCys: 1.006 ± 0.033	6.778AlaAsp: 6.778 ± 0.086	9.374AlaGlu: 9.374 ± 0.114	4.436AlaPhe: 4.436 ± 0.067	11.475AlaGly: 11.475 ± 0.118	2.144AlaHis: 2.144 ± 0.048	5.877AlaIle: 5.877 ± 0.083	3.202AlaLys: 3.202 ± 0.069	14.587AlaLeu: 14.587 ± 0.154	3.811AlaMet: 3.811 ± 0.066	2.446AlaAsn: 2.446 ± 0.044	6.12AlaPro: 6.12 ± 0.081	3.915AlaGln: 3.915 ± 0.059	10.054AlaArg: 10.054 ± 0.108	5.767AlaSer: 5.767 ± 0.061	6.382AlaThr: 6.382 ± 0.076	9.09AlaVal: 9.09 ± 0.104	1.516AlaTrp: 1.516 ± 0.038	2.328AlaTyr: 2.328 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.954CysAla: 0.954 ± 0.027	0.105CysCys: 0.105 ± 0.009	0.497CysAsp: 0.497 ± 0.019	0.344CysGlu: 0.344 ± 0.016	0.302CysPhe: 0.302 ± 0.017	0.833CysGly: 0.833 ± 0.031	0.229CysHis: 0.229 ± 0.016	0.386CysIle: 0.386 ± 0.017	0.156CysLys: 0.156 ± 0.011	0.811CysLeu: 0.811 ± 0.027	0.135CysMet: 0.135 ± 0.01	0.165CysAsn: 0.165 ± 0.012	0.47CysPro: 0.47 ± 0.023	0.177CysGln: 0.177 ± 0.014	0.583CysArg: 0.583 ± 0.024	0.366CysSer: 0.366 ± 0.018	0.398CysThr: 0.398 ± 0.018	0.502CysVal: 0.502 ± 0.022	0.118CysTrp: 0.118 ± 0.011	0.155CysTyr: 0.155 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.601AspAla: 6.601 ± 0.076	0.419AspCys: 0.419 ± 0.017	2.763AspAsp: 2.763 ± 0.052	3.11AspGlu: 3.11 ± 0.06	2.21AspPhe: 2.21 ± 0.04	4.999AspGly: 4.999 ± 0.068	1.253AspHis: 1.253 ± 0.034	2.893AspIle: 2.893 ± 0.052	1.276AspLys: 1.276 ± 0.034	6.155AspLeu: 6.155 ± 0.081	1.507AspMet: 1.507 ± 0.038	1.058AspAsn: 1.058 ± 0.031	3.758AspPro: 3.758 ± 0.065	1.539AspGln: 1.539 ± 0.034	4.69AspArg: 4.69 ± 0.071	2.0AspSer: 2.0 ± 0.04	2.542AspThr: 2.542 ± 0.048	3.873AspVal: 3.873 ± 0.061	1.128AspTrp: 1.128 ± 0.033	1.459AspTyr: 1.459 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.833GluAla: 8.833 ± 0.102	0.282GluCys: 0.282 ± 0.017	3.124GluAsp: 3.124 ± 0.057	4.08GluGlu: 4.08 ± 0.069	1.666GluPhe: 1.666 ± 0.034	5.403GluGly: 5.403 ± 0.065	1.056GluHis: 1.056 ± 0.037	3.482GluIle: 3.482 ± 0.051	1.968GluLys: 1.968 ± 0.053	5.01GluLeu: 5.01 ± 0.069	1.744GluMet: 1.744 ± 0.043	1.439GluAsn: 1.439 ± 0.04	2.793GluPro: 2.793 ± 0.055	1.948GluGln: 1.948 ± 0.045	5.175GluArg: 5.175 ± 0.073	2.287GluSer: 2.287 ± 0.051	3.781GluThr: 3.781 ± 0.063	4.588GluVal: 4.588 ± 0.065	0.735GluTrp: 0.735 ± 0.025	0.958GluTyr: 0.958 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.379PheAla: 4.379 ± 0.071	0.396PheCys: 0.396 ± 0.017	2.475PheAsp: 2.475 ± 0.046	1.825PheGlu: 1.825 ± 0.043	1.433PhePhe: 1.433 ± 0.04	3.759PheGly: 3.759 ± 0.065	0.75PheHis: 0.75 ± 0.027	1.511PheIle: 1.511 ± 0.037	0.695PheLys: 0.695 ± 0.025	3.585PheLeu: 3.585 ± 0.057	0.793PheMet: 0.793 ± 0.025	0.921PheAsn: 0.921 ± 0.03	1.638PhePro: 1.638 ± 0.038	0.987PheGln: 0.987 ± 0.027	2.498PheArg: 2.498 ± 0.04	2.104PheSer: 2.104 ± 0.048	2.046PheThr: 2.046 ± 0.041	2.609PheVal: 2.609 ± 0.049	0.574PheTrp: 0.574 ± 0.022	0.833PheTyr: 0.833 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.072GlyAla: 10.072 ± 0.103	0.791GlyCys: 0.791 ± 0.031	4.391GlyAsp: 4.391 ± 0.068	5.307GlyGlu: 5.307 ± 0.072	3.639GlyPhe: 3.639 ± 0.052	7.559GlyGly: 7.559 ± 0.107	1.841GlyHis: 1.841 ± 0.037	4.556GlyIle: 4.556 ± 0.069	2.899GlyLys: 2.899 ± 0.059	9.588GlyLeu: 9.588 ± 0.105	2.609GlyMet: 2.609 ± 0.046	2.038GlyAsn: 2.038 ± 0.042	3.924GlyPro: 3.924 ± 0.059	3.028GlyGln: 3.028 ± 0.058	6.998GlyArg: 6.998 ± 0.092	4.265GlySer: 4.265 ± 0.064	4.686GlyThr: 4.686 ± 0.064	6.618GlyVal: 6.618 ± 0.081	1.603GlyTrp: 1.603 ± 0.043	2.279GlyTyr: 2.279 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.339HisAla: 2.339 ± 0.052	0.208HisCys: 0.208 ± 0.013	1.245HisAsp: 1.245 ± 0.036	0.972HisGlu: 0.972 ± 0.033	0.714HisPhe: 0.714 ± 0.026	1.933HisGly: 1.933 ± 0.046	0.489HisHis: 0.489 ± 0.023	0.874HisIle: 0.874 ± 0.029	0.381HisLys: 0.381 ± 0.018	2.0HisLeu: 2.0 ± 0.044	0.482HisMet: 0.482 ± 0.022	0.384HisAsn: 0.384 ± 0.018	1.447HisPro: 1.447 ± 0.034	0.504HisGln: 0.504 ± 0.021	1.494HisArg: 1.494 ± 0.036	0.846HisSer: 0.846 ± 0.026	0.747HisThr: 0.747 ± 0.026	1.56HisVal: 1.56 ± 0.039	0.33HisTrp: 0.33 ± 0.016	0.506HisTyr: 0.506 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.291IleAla: 7.291 ± 0.089	0.519IleCys: 0.519 ± 0.023	3.195IleAsp: 3.195 ± 0.058	2.914IleGlu: 2.914 ± 0.05	1.69IlePhe: 1.69 ± 0.039	5.011IleGly: 5.011 ± 0.063	0.93IleHis: 0.93 ± 0.029	1.989IleIle: 1.989 ± 0.045	0.94IleLys: 0.94 ± 0.029	4.749IleLeu: 4.749 ± 0.083	1.009IleMet: 1.009 ± 0.031	1.13IleAsn: 1.13 ± 0.033	2.393IlePro: 2.393 ± 0.044	1.034IleGln: 1.034 ± 0.027	3.686IleArg: 3.686 ± 0.061	2.729IleSer: 2.729 ± 0.049	2.713IleThr: 2.713 ± 0.051	3.941IleVal: 3.941 ± 0.059	0.669IleTrp: 0.669 ± 0.024	1.061IleTyr: 1.061 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.467LysAla: 3.467 ± 0.065	0.134LysCys: 0.134 ± 0.011	1.374LysAsp: 1.374 ± 0.04	1.426LysGlu: 1.426 ± 0.042	0.72LysPhe: 0.72 ± 0.025	2.416LysGly: 2.416 ± 0.047	0.436LysHis: 0.436 ± 0.019	1.28LysIle: 1.28 ± 0.03	0.864LysLys: 0.864 ± 0.041	2.566LysLeu: 2.566 ± 0.052	0.703LysMet: 0.703 ± 0.028	0.595LysAsn: 0.595 ± 0.023	1.591LysPro: 1.591 ± 0.041	0.747LysGln: 0.747 ± 0.029	1.911LysArg: 1.911 ± 0.048	1.449LysSer: 1.449 ± 0.035	1.573LysThr: 1.573 ± 0.044	2.115LysVal: 2.115 ± 0.048	0.316LysTrp: 0.316 ± 0.016	0.526LysTyr: 0.526 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.466LeuAla: 14.466 ± 0.16	0.849LeuCys: 0.849 ± 0.025	5.878LeuAsp: 5.878 ± 0.085	5.246LeuGlu: 5.246 ± 0.067	3.366LeuPhe: 3.366 ± 0.061	8.622LeuGly: 8.622 ± 0.097	2.033LeuHis: 2.033 ± 0.042	5.369LeuIle: 5.369 ± 0.093	2.828LeuLys: 2.828 ± 0.055	10.344LeuLeu: 10.344 ± 0.139	2.574LeuMet: 2.574 ± 0.055	2.438LeuAsn: 2.438 ± 0.045	6.473LeuPro: 6.473 ± 0.085	2.593LeuGln: 2.593 ± 0.043	8.046LeuArg: 8.046 ± 0.097	6.952LeuSer: 6.952 ± 0.078	6.227LeuThr: 6.227 ± 0.081	7.247LeuVal: 7.247 ± 0.108	1.386LeuTrp: 1.386 ± 0.036	1.966LeuTyr: 1.966 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.481MetAla: 3.481 ± 0.055	0.139MetCys: 0.139 ± 0.011	1.285MetAsp: 1.285 ± 0.037	1.518MetGlu: 1.518 ± 0.044	0.778MetPhe: 0.778 ± 0.028	2.076MetGly: 2.076 ± 0.05	0.413MetHis: 0.413 ± 0.019	1.434MetIle: 1.434 ± 0.035	0.871MetLys: 0.871 ± 0.027	2.575MetLeu: 2.575 ± 0.051	0.689MetMet: 0.689 ± 0.026	0.742MetAsn: 0.742 ± 0.029	1.487MetPro: 1.487 ± 0.036	0.927MetGln: 0.927 ± 0.029	1.99MetArg: 1.99 ± 0.04	1.603MetSer: 1.603 ± 0.041	2.183MetThr: 2.183 ± 0.048	1.828MetVal: 1.828 ± 0.042	0.219MetTrp: 0.219 ± 0.013	0.303MetTyr: 0.303 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.85AsnAla: 2.85 ± 0.051	0.219AsnCys: 0.219 ± 0.015	1.141AsnAsp: 1.141 ± 0.034	1.061AsnGlu: 1.061 ± 0.031	0.807AsnPhe: 0.807 ± 0.024	2.143AsnGly: 2.143 ± 0.05	0.428AsnHis: 0.428 ± 0.02	1.181AsnIle: 1.181 ± 0.034	0.464AsnLys: 0.464 ± 0.02	2.325AsnLeu: 2.325 ± 0.051	0.574AsnMet: 0.574 ± 0.023	0.524AsnAsn: 0.524 ± 0.023	1.788AsnPro: 1.788 ± 0.039	0.612AsnGln: 0.612 ± 0.022	1.774AsnArg: 1.774 ± 0.045	1.01AsnSer: 1.01 ± 0.034	1.184AsnThr: 1.184 ± 0.031	1.7AsnVal: 1.7 ± 0.035	0.379AsnTrp: 0.379 ± 0.018	0.547AsnTyr: 0.547 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.867ProAla: 6.867 ± 0.095	0.299ProCys: 0.299 ± 0.017	3.707ProAsp: 3.707 ± 0.062	4.47ProGlu: 4.47 ± 0.063	2.038ProPhe: 2.038 ± 0.044	5.028ProGly: 5.028 ± 0.074	1.03ProHis: 1.03 ± 0.028	2.134ProIle: 2.134 ± 0.046	1.448ProLys: 1.448 ± 0.041	5.474ProLeu: 5.474 ± 0.075	1.329ProMet: 1.329 ± 0.031	1.173ProAsn: 1.173 ± 0.034	2.897ProPro: 2.897 ± 0.071	1.585ProGln: 1.585 ± 0.039	3.303ProArg: 3.303 ± 0.061	2.667ProSer: 2.667 ± 0.047	2.41ProThr: 2.41 ± 0.047	4.766ProVal: 4.766 ± 0.068	0.689ProTrp: 0.689 ± 0.025	1.146ProTyr: 1.146 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.726GlnAla: 3.726 ± 0.058	0.163GlnCys: 0.163 ± 0.012	1.411GlnAsp: 1.411 ± 0.036	1.628GlnGlu: 1.628 ± 0.039	0.936GlnPhe: 0.936 ± 0.029	2.632GlnGly: 2.632 ± 0.056	0.541GlnHis: 0.541 ± 0.024	1.72GlnIle: 1.72 ± 0.036	0.982GlnLys: 0.982 ± 0.032	2.619GlnLeu: 2.619 ± 0.052	0.944GlnMet: 0.944 ± 0.028	0.807GlnAsn: 0.807 ± 0.026	1.706GlnPro: 1.706 ± 0.044	1.084GlnGln: 1.084 ± 0.038	2.442GlnArg: 2.442 ± 0.05	1.603GlnSer: 1.603 ± 0.043	1.616GlnThr: 1.616 ± 0.038	2.181GlnVal: 2.181 ± 0.042	0.342GlnTrp: 0.342 ± 0.017	0.518GlnTyr: 0.518 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.115ArgAla: 9.115 ± 0.097	0.461ArgCys: 0.461 ± 0.023	4.326ArgAsp: 4.326 ± 0.066	4.658ArgGlu: 4.658 ± 0.069	2.958ArgPhe: 2.958 ± 0.059	5.358ArgGly: 5.358 ± 0.066	1.703ArgHis: 1.703 ± 0.042	4.38ArgIle: 4.38 ± 0.065	2.214ArgLys: 2.214 ± 0.043	8.956ArgLeu: 8.956 ± 0.104	2.161ArgMet: 2.161 ± 0.043	1.83ArgAsn: 1.83 ± 0.042	4.021ArgPro: 4.021 ± 0.059	2.662ArgGln: 2.662 ± 0.052	6.404ArgArg: 6.404 ± 0.083	3.727ArgSer: 3.727 ± 0.057	3.356ArgThr: 3.356 ± 0.056	5.278ArgVal: 5.278 ± 0.07	1.113ArgTrp: 1.113 ± 0.033	1.695ArgTyr: 1.695 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.977SerAla: 5.977 ± 0.073	0.405SerCys: 0.405 ± 0.022	3.004SerAsp: 3.004 ± 0.048	2.601SerGlu: 2.601 ± 0.052	2.086SerPhe: 2.086 ± 0.045	5.546SerGly: 5.546 ± 0.06	1.103SerHis: 1.103 ± 0.03	2.287SerIle: 2.287 ± 0.046	1.113SerLys: 1.113 ± 0.03	5.284SerLeu: 5.284 ± 0.064	1.217SerMet: 1.217 ± 0.031	1.167SerAsn: 1.167 ± 0.035	2.782SerPro: 2.782 ± 0.053	1.474SerGln: 1.474 ± 0.031	3.919SerArg: 3.919 ± 0.059	2.539SerSer: 2.539 ± 0.054	2.45SerThr: 2.45 ± 0.049	3.654SerVal: 3.654 ± 0.056	0.72SerTrp: 0.72 ± 0.024	1.249SerTyr: 1.249 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.598ThrAla: 6.598 ± 0.084	0.425ThrCys: 0.425 ± 0.02	2.747ThrAsp: 2.747 ± 0.051	3.015ThrGlu: 3.015 ± 0.052	1.991ThrPhe: 1.991 ± 0.045	5.617ThrGly: 5.617 ± 0.071	1.019ThrHis: 1.019 ± 0.032	2.577ThrIle: 2.577 ± 0.051	1.131ThrLys: 1.131 ± 0.031	6.259ThrLeu: 6.259 ± 0.076	1.242ThrMet: 1.242 ± 0.034	1.11ThrAsn: 1.11 ± 0.033	3.527ThrPro: 3.527 ± 0.058	1.437ThrGln: 1.437 ± 0.038	3.683ThrArg: 3.683 ± 0.051	2.651ThrSer: 2.651 ± 0.054	2.779ThrThr: 2.779 ± 0.054	4.333ThrVal: 4.333 ± 0.063	0.644ThrTrp: 0.644 ± 0.024	1.156ThrTyr: 1.156 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.535ValAla: 9.535 ± 0.106	0.549ValCys: 0.549 ± 0.027	3.714ValAsp: 3.714 ± 0.052	4.946ValGlu: 4.946 ± 0.06	2.722ValPhe: 2.722 ± 0.045	5.262ValGly: 5.262 ± 0.079	1.293ValHis: 1.293 ± 0.036	4.12ValIle: 4.12 ± 0.063	1.939ValLys: 1.939 ± 0.047	7.917ValLeu: 7.917 ± 0.099	2.159ValMet: 2.159 ± 0.042	1.83ValAsn: 1.83 ± 0.039	3.853ValPro: 3.853 ± 0.057	2.09ValGln: 2.09 ± 0.045	4.744ValArg: 4.744 ± 0.067	4.145ValSer: 4.145 ± 0.059	5.031ValThr: 5.031 ± 0.062	5.881ValVal: 5.881 ± 0.084	0.991ValTrp: 0.991 ± 0.03	1.357ValTyr: 1.357 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.323TrpAla: 1.323 ± 0.036	0.122TrpCys: 0.122 ± 0.01	0.681TrpAsp: 0.681 ± 0.028	0.681TrpGlu: 0.681 ± 0.027	0.541TrpPhe: 0.541 ± 0.025	1.023TrpGly: 1.023 ± 0.03	0.309TrpHis: 0.309 ± 0.018	0.689TrpIle: 0.689 ± 0.022	0.421TrpLys: 0.421 ± 0.018	1.847TrpLeu: 1.847 ± 0.05	0.398TrpMet: 0.398 ± 0.016	0.396TrpAsn: 0.396 ± 0.019	0.743TrpPro: 0.743 ± 0.025	0.66TrpGln: 0.66 ± 0.023	1.27TrpArg: 1.27 ± 0.031	0.824TrpSer: 0.824 ± 0.029	0.797TrpThr: 0.797 ± 0.025	0.838TrpVal: 0.838 ± 0.028	0.234TrpTrp: 0.234 ± 0.016	0.268TrpTyr: 0.268 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.433TyrAla: 2.433 ± 0.048	0.194TyrCys: 0.194 ± 0.011	1.494TyrAsp: 1.494 ± 0.034	1.176TyrGlu: 1.176 ± 0.035	0.779TyrPhe: 0.779 ± 0.027	1.995TyrGly: 1.995 ± 0.043	0.458TyrHis: 0.458 ± 0.021	0.853TyrIle: 0.853 ± 0.025	0.418TyrLys: 0.418 ± 0.022	2.255TyrLeu: 2.255 ± 0.047	0.461TyrMet: 0.461 ± 0.02	0.518TyrAsn: 0.518 ± 0.021	1.05TyrPro: 1.05 ± 0.03	0.597TyrGln: 0.597 ± 0.024	1.713TyrArg: 1.713 ± 0.041	1.041TyrSer: 1.041 ± 0.033	1.041TyrThr: 1.041 ± 0.031	1.477TyrVal: 1.477 ± 0.045	0.357TyrTrp: 0.357 ± 0.018	0.511TyrTyr: 0.511 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3806 proteins (1175726 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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