Amino acid dipepetide frequency for Streptococcus satellite phage Javan650

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.404AlaAla: 0.404 ± 0.349
0.0AlaCys: 0.0 ± 0.0
2.826AlaAsp: 2.826 ± 1.723
4.845AlaGlu: 4.845 ± 1.586
2.422AlaPhe: 2.422 ± 0.851
2.422AlaGly: 2.422 ± 1.278
0.807AlaHis: 0.807 ± 0.411
4.441AlaIle: 4.441 ± 2.157
4.441AlaLys: 4.441 ± 1.084
6.056AlaLeu: 6.056 ± 1.875
1.211AlaMet: 1.211 ± 0.554
2.019AlaAsn: 2.019 ± 0.803
3.633AlaPro: 3.633 ± 1.107
2.826AlaGln: 2.826 ± 1.104
3.23AlaArg: 3.23 ± 0.716
3.23AlaSer: 3.23 ± 1.332
5.652AlaThr: 5.652 ± 1.181
1.615AlaVal: 1.615 ± 0.524
1.211AlaTrp: 1.211 ± 0.758
4.037AlaTyr: 4.037 ± 0.922
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.807CysAsp: 0.807 ± 0.552
0.404CysGlu: 0.404 ± 0.364
1.211CysPhe: 1.211 ± 0.755
0.404CysGly: 0.404 ± 0.416
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.807CysLys: 0.807 ± 0.515
0.807CysLeu: 0.807 ± 0.491
0.0CysMet: 0.0 ± 0.0
0.404CysAsn: 0.404 ± 0.416
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.404CysArg: 0.404 ± 0.349
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.404CysTrp: 0.404 ± 0.325
0.807CysTyr: 0.807 ± 0.614
0.0CysXaa: 0.0 ± 0.0
Asp
1.211AspAla: 1.211 ± 0.654
1.211AspCys: 1.211 ± 0.922
3.633AspAsp: 3.633 ± 1.484
3.633AspGlu: 3.633 ± 0.888
3.23AspPhe: 3.23 ± 0.452
1.211AspGly: 1.211 ± 0.591
0.0AspHis: 0.0 ± 0.0
5.652AspIle: 5.652 ± 1.664
8.074AspLys: 8.074 ± 1.788
5.248AspLeu: 5.248 ± 1.458
3.23AspMet: 3.23 ± 0.853
6.056AspAsn: 6.056 ± 1.453
0.404AspPro: 0.404 ± 0.416
0.404AspGln: 0.404 ± 0.366
2.826AspArg: 2.826 ± 0.826
1.615AspSer: 1.615 ± 0.78
3.23AspThr: 3.23 ± 1.435
3.633AspVal: 3.633 ± 1.262
1.211AspTrp: 1.211 ± 0.589
3.633AspTyr: 3.633 ± 0.891
0.0AspXaa: 0.0 ± 0.0
Glu
2.826GluAla: 2.826 ± 1.066
0.404GluCys: 0.404 ± 0.433
6.863GluAsp: 6.863 ± 1.893
6.459GluGlu: 6.459 ± 2.395
3.633GluPhe: 3.633 ± 1.179
2.019GluGly: 2.019 ± 0.692
2.019GluHis: 2.019 ± 1.072
6.863GluIle: 6.863 ± 2.09
7.267GluLys: 7.267 ± 1.914
10.093GluLeu: 10.093 ± 2.638
1.211GluMet: 1.211 ± 0.698
4.037GluAsn: 4.037 ± 1.018
2.019GluPro: 2.019 ± 0.668
6.459GluGln: 6.459 ± 2.059
6.056GluArg: 6.056 ± 1.702
1.615GluSer: 1.615 ± 1.04
4.441GluThr: 4.441 ± 1.155
6.056GluVal: 6.056 ± 1.702
0.404GluTrp: 0.404 ± 0.349
6.056GluTyr: 6.056 ± 2.043
0.0GluXaa: 0.0 ± 0.0
Phe
0.807PheAla: 0.807 ± 0.707
0.0PheCys: 0.0 ± 0.0
4.441PheAsp: 4.441 ± 1.421
2.019PheGlu: 2.019 ± 0.745
0.404PhePhe: 0.404 ± 0.416
2.422PheGly: 2.422 ± 0.985
0.404PheHis: 0.404 ± 0.349
2.826PheIle: 2.826 ± 0.788
3.633PheLys: 3.633 ± 1.14
3.23PheLeu: 3.23 ± 0.79
1.211PheMet: 1.211 ± 0.507
4.441PheAsn: 4.441 ± 1.138
0.404PhePro: 0.404 ± 0.325
0.807PheGln: 0.807 ± 0.402
2.422PheArg: 2.422 ± 1.032
4.037PheSer: 4.037 ± 0.819
1.211PheThr: 1.211 ± 0.654
0.807PheVal: 0.807 ± 0.485
0.807PheTrp: 0.807 ± 0.402
2.826PheTyr: 2.826 ± 1.048
0.0PheXaa: 0.0 ± 0.0
Gly
3.23GlyAla: 3.23 ± 1.413
0.404GlyCys: 0.404 ± 0.349
2.422GlyAsp: 2.422 ± 1.209
3.23GlyGlu: 3.23 ± 1.041
2.019GlyPhe: 2.019 ± 0.644
2.019GlyGly: 2.019 ± 1.173
0.807GlyHis: 0.807 ± 0.6
5.248GlyIle: 5.248 ± 1.387
3.633GlyLys: 3.633 ± 1.005
3.23GlyLeu: 3.23 ± 1.036
0.807GlyMet: 0.807 ± 0.52
0.0GlyAsn: 0.0 ± 0.0
0.0GlyPro: 0.0 ± 0.0
1.211GlyGln: 1.211 ± 0.739
2.422GlyArg: 2.422 ± 1.044
0.807GlySer: 0.807 ± 0.457
2.019GlyThr: 2.019 ± 0.811
3.23GlyVal: 3.23 ± 1.176
0.807GlyTrp: 0.807 ± 0.485
3.23GlyTyr: 3.23 ± 0.893
0.0GlyXaa: 0.0 ± 0.0
His
1.211HisAla: 1.211 ± 1.046
0.0HisCys: 0.0 ± 0.0
0.404HisAsp: 0.404 ± 0.457
1.211HisGlu: 1.211 ± 0.482
0.404HisPhe: 0.404 ± 0.325
0.404HisGly: 0.404 ± 0.366
0.404HisHis: 0.404 ± 0.457
2.019HisIle: 2.019 ± 1.058
1.211HisLys: 1.211 ± 0.767
2.019HisLeu: 2.019 ± 0.702
0.0HisMet: 0.0 ± 0.0
1.211HisAsn: 1.211 ± 1.043
1.211HisPro: 1.211 ± 0.725
0.807HisGln: 0.807 ± 0.411
1.211HisArg: 1.211 ± 0.689
0.404HisSer: 0.404 ± 0.355
0.404HisThr: 0.404 ± 0.349
0.404HisVal: 0.404 ± 0.407
0.0HisTrp: 0.0 ± 0.0
1.211HisTyr: 1.211 ± 1.121
0.0HisXaa: 0.0 ± 0.0
Ile
6.863IleAla: 6.863 ± 2.096
0.807IleCys: 0.807 ± 0.575
6.056IleAsp: 6.056 ± 1.451
6.863IleGlu: 6.863 ± 1.955
2.019IlePhe: 2.019 ± 0.612
2.422IleGly: 2.422 ± 0.851
2.019IleHis: 2.019 ± 0.719
3.633IleIle: 3.633 ± 1.226
9.689IleLys: 9.689 ± 1.92
7.267IleLeu: 7.267 ± 1.369
2.422IleMet: 2.422 ± 0.895
7.267IleAsn: 7.267 ± 1.527
4.441IlePro: 4.441 ± 1.385
3.23IleGln: 3.23 ± 1.227
1.615IleArg: 1.615 ± 0.452
3.633IleSer: 3.633 ± 1.745
2.826IleThr: 2.826 ± 0.992
2.019IleVal: 2.019 ± 0.722
0.807IleTrp: 0.807 ± 0.544
2.422IleTyr: 2.422 ± 0.725
0.0IleXaa: 0.0 ± 0.0
Lys
5.248LysAla: 5.248 ± 1.508
0.404LysCys: 0.404 ± 0.416
4.037LysAsp: 4.037 ± 1.536
13.323LysGlu: 13.323 ± 1.943
3.23LysPhe: 3.23 ± 1.163
4.037LysGly: 4.037 ± 1.539
2.422LysHis: 2.422 ± 0.899
7.671LysIle: 7.671 ± 1.57
6.863LysLys: 6.863 ± 2.106
7.267LysLeu: 7.267 ± 1.947
1.211LysMet: 1.211 ± 0.458
3.23LysAsn: 3.23 ± 0.898
2.422LysPro: 2.422 ± 0.973
5.652LysGln: 5.652 ± 1.189
5.248LysArg: 5.248 ± 1.352
5.652LysSer: 5.652 ± 1.36
6.459LysThr: 6.459 ± 1.321
4.845LysVal: 4.845 ± 1.115
0.404LysTrp: 0.404 ± 0.457
1.211LysTyr: 1.211 ± 0.441
0.0LysXaa: 0.0 ± 0.0
Leu
8.882LeuAla: 8.882 ± 0.985
0.404LeuCys: 0.404 ± 0.416
6.863LeuAsp: 6.863 ± 1.621
14.13LeuGlu: 14.13 ± 2.599
4.037LeuPhe: 4.037 ± 1.257
2.826LeuGly: 2.826 ± 0.973
1.211LeuHis: 1.211 ± 0.682
6.056LeuIle: 6.056 ± 1.437
7.267LeuLys: 7.267 ± 1.798
9.285LeuLeu: 9.285 ± 1.523
2.422LeuMet: 2.422 ± 0.894
8.478LeuAsn: 8.478 ± 2.464
4.037LeuPro: 4.037 ± 1.106
5.248LeuGln: 5.248 ± 1.245
2.826LeuArg: 2.826 ± 0.828
4.441LeuSer: 4.441 ± 1.259
4.845LeuThr: 4.845 ± 0.998
6.056LeuVal: 6.056 ± 1.198
0.404LeuTrp: 0.404 ± 0.349
4.441LeuTyr: 4.441 ± 1.406
0.0LeuXaa: 0.0 ± 0.0
Met
1.211MetAla: 1.211 ± 0.775
0.0MetCys: 0.0 ± 0.0
0.807MetAsp: 0.807 ± 0.436
1.211MetGlu: 1.211 ± 0.811
0.404MetPhe: 0.404 ± 0.325
0.807MetGly: 0.807 ± 0.681
0.0MetHis: 0.0 ± 0.0
2.019MetIle: 2.019 ± 1.208
2.019MetLys: 2.019 ± 0.665
2.826MetLeu: 2.826 ± 0.886
0.807MetMet: 0.807 ± 0.454
2.019MetAsn: 2.019 ± 0.533
1.211MetPro: 1.211 ± 0.892
1.211MetGln: 1.211 ± 0.791
0.0MetArg: 0.0 ± 0.0
0.404MetSer: 0.404 ± 0.325
4.441MetThr: 4.441 ± 1.019
0.807MetVal: 0.807 ± 0.491
0.404MetTrp: 0.404 ± 0.453
0.807MetTyr: 0.807 ± 0.663
0.0MetXaa: 0.0 ± 0.0
Asn
5.248AsnAla: 5.248 ± 1.23
0.807AsnCys: 0.807 ± 0.727
2.422AsnAsp: 2.422 ± 1.006
4.037AsnGlu: 4.037 ± 1.364
2.422AsnPhe: 2.422 ± 1.025
3.23AsnGly: 3.23 ± 1.202
1.211AsnHis: 1.211 ± 0.642
3.23AsnIle: 3.23 ± 0.977
6.056AsnLys: 6.056 ± 1.531
6.056AsnLeu: 6.056 ± 1.689
2.019AsnMet: 2.019 ± 0.915
6.056AsnAsn: 6.056 ± 2.161
4.037AsnPro: 4.037 ± 1.277
2.826AsnGln: 2.826 ± 1.123
4.441AsnArg: 4.441 ± 1.304
2.019AsnSer: 2.019 ± 0.991
3.23AsnThr: 3.23 ± 1.246
1.615AsnVal: 1.615 ± 0.559
0.0AsnTrp: 0.0 ± 0.0
2.826AsnTyr: 2.826 ± 1.203
0.0AsnXaa: 0.0 ± 0.0
Pro
2.422ProAla: 2.422 ± 1.097
0.404ProCys: 0.404 ± 0.416
3.23ProAsp: 3.23 ± 1.189
2.826ProGlu: 2.826 ± 0.89
1.211ProPhe: 1.211 ± 0.47
0.0ProGly: 0.0 ± 0.0
0.404ProHis: 0.404 ± 0.355
2.826ProIle: 2.826 ± 0.829
2.826ProLys: 2.826 ± 0.786
3.23ProLeu: 3.23 ± 1.369
0.807ProMet: 0.807 ± 0.727
1.615ProAsn: 1.615 ± 0.947
0.807ProPro: 0.807 ± 0.485
2.019ProGln: 2.019 ± 1.007
1.211ProArg: 1.211 ± 0.526
0.807ProSer: 0.807 ± 0.402
2.826ProThr: 2.826 ± 0.957
1.615ProVal: 1.615 ± 0.656
0.0ProTrp: 0.0 ± 0.0
1.211ProTyr: 1.211 ± 0.974
0.0ProXaa: 0.0 ± 0.0
Gln
2.826GlnAla: 2.826 ± 0.777
0.0GlnCys: 0.0 ± 0.0
2.422GlnAsp: 2.422 ± 0.782
4.037GlnGlu: 4.037 ± 1.313
1.615GlnPhe: 1.615 ± 0.883
2.826GlnGly: 2.826 ± 0.926
0.404GlnHis: 0.404 ± 0.349
5.248GlnIle: 5.248 ± 1.448
4.037GlnLys: 4.037 ± 1.042
8.478GlnLeu: 8.478 ± 1.15
0.404GlnMet: 0.404 ± 0.349
2.826GlnAsn: 2.826 ± 1.0
0.807GlnPro: 0.807 ± 0.454
1.211GlnGln: 1.211 ± 0.587
2.422GlnArg: 2.422 ± 0.983
3.23GlnSer: 3.23 ± 1.267
2.422GlnThr: 2.422 ± 0.675
1.615GlnVal: 1.615 ± 0.869
0.0GlnTrp: 0.0 ± 0.0
2.019GlnTyr: 2.019 ± 0.693
0.0GlnXaa: 0.0 ± 0.0
Arg
2.422ArgAla: 2.422 ± 0.847
0.404ArgCys: 0.404 ± 0.349
1.211ArgAsp: 1.211 ± 0.719
2.826ArgGlu: 2.826 ± 0.83
0.807ArgPhe: 0.807 ± 0.649
3.633ArgGly: 3.633 ± 1.065
2.019ArgHis: 2.019 ± 1.157
3.633ArgIle: 3.633 ± 0.94
2.826ArgLys: 2.826 ± 1.251
5.248ArgLeu: 5.248 ± 1.453
0.807ArgMet: 0.807 ± 0.39
2.019ArgAsn: 2.019 ± 0.932
1.211ArgPro: 1.211 ± 0.692
3.633ArgGln: 3.633 ± 0.762
1.615ArgArg: 1.615 ± 1.551
1.211ArgSer: 1.211 ± 0.607
4.037ArgThr: 4.037 ± 0.903
2.019ArgVal: 2.019 ± 0.736
0.404ArgTrp: 0.404 ± 0.355
2.422ArgTyr: 2.422 ± 1.168
0.0ArgXaa: 0.0 ± 0.0
Ser
2.019SerAla: 2.019 ± 0.939
0.0SerCys: 0.0 ± 0.0
3.633SerAsp: 3.633 ± 1.086
4.037SerGlu: 4.037 ± 1.832
1.211SerPhe: 1.211 ± 0.594
0.0SerGly: 0.0 ± 0.0
0.404SerHis: 0.404 ± 0.349
3.23SerIle: 3.23 ± 0.912
3.633SerLys: 3.633 ± 0.87
6.056SerLeu: 6.056 ± 1.585
1.211SerMet: 1.211 ± 0.582
2.826SerAsn: 2.826 ± 0.542
1.615SerPro: 1.615 ± 0.695
2.019SerGln: 2.019 ± 0.7
1.211SerArg: 1.211 ± 0.423
1.211SerSer: 1.211 ± 0.682
3.23SerThr: 3.23 ± 0.743
3.23SerVal: 3.23 ± 0.506
0.404SerTrp: 0.404 ± 0.349
2.422SerTyr: 2.422 ± 1.323
0.0SerXaa: 0.0 ± 0.0
Thr
4.037ThrAla: 4.037 ± 1.048
0.404ThrCys: 0.404 ± 0.364
3.633ThrAsp: 3.633 ± 1.164
3.633ThrGlu: 3.633 ± 1.331
4.441ThrPhe: 4.441 ± 1.093
5.248ThrGly: 5.248 ± 1.106
0.807ThrHis: 0.807 ± 0.697
7.267ThrIle: 7.267 ± 1.079
3.633ThrLys: 3.633 ± 1.552
5.248ThrLeu: 5.248 ± 1.397
1.211ThrMet: 1.211 ± 0.607
2.019ThrAsn: 2.019 ± 1.497
1.615ThrPro: 1.615 ± 0.947
1.615ThrGln: 1.615 ± 0.869
2.826ThrArg: 2.826 ± 0.943
2.826ThrSer: 2.826 ± 1.069
4.037ThrThr: 4.037 ± 1.049
3.633ThrVal: 3.633 ± 1.18
0.0ThrTrp: 0.0 ± 0.0
2.826ThrTyr: 2.826 ± 0.86
0.0ThrXaa: 0.0 ± 0.0
Val
3.23ValAla: 3.23 ± 0.762
0.404ValCys: 0.404 ± 0.364
1.211ValAsp: 1.211 ± 0.586
3.633ValGlu: 3.633 ± 1.01
3.23ValPhe: 3.23 ± 1.168
2.019ValGly: 2.019 ± 0.903
0.0ValHis: 0.0 ± 0.0
2.422ValIle: 2.422 ± 1.015
6.056ValLys: 6.056 ± 1.187
5.248ValLeu: 5.248 ± 1.237
0.807ValMet: 0.807 ± 0.555
2.422ValAsn: 2.422 ± 1.117
1.211ValPro: 1.211 ± 0.521
1.615ValGln: 1.615 ± 0.769
1.615ValArg: 1.615 ± 0.735
2.826ValSer: 2.826 ± 0.763
4.845ValThr: 4.845 ± 1.022
0.807ValVal: 0.807 ± 0.411
0.404ValTrp: 0.404 ± 0.416
1.211ValTyr: 1.211 ± 0.791
0.0ValXaa: 0.0 ± 0.0
Trp
1.211TrpAla: 1.211 ± 0.78
0.0TrpCys: 0.0 ± 0.0
0.404TrpAsp: 0.404 ± 0.453
0.807TrpGlu: 0.807 ± 0.52
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.807TrpIle: 0.807 ± 0.53
1.211TrpLys: 1.211 ± 0.6
1.615TrpLeu: 1.615 ± 0.671
0.0TrpMet: 0.0 ± 0.0
0.404TrpAsn: 0.404 ± 0.325
0.0TrpPro: 0.0 ± 0.0
0.404TrpGln: 0.404 ± 0.407
0.0TrpArg: 0.0 ± 0.0
0.404TrpSer: 0.404 ± 0.349
0.0TrpThr: 0.0 ± 0.0
1.211TrpVal: 1.211 ± 0.632
0.0TrpTrp: 0.0 ± 0.0
0.404TrpTyr: 0.404 ± 0.325
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.019TyrAla: 2.019 ± 0.957
0.404TyrCys: 0.404 ± 0.325
2.019TyrAsp: 2.019 ± 0.73
3.633TyrGlu: 3.633 ± 1.264
1.211TyrPhe: 1.211 ± 0.692
2.826TyrGly: 2.826 ± 1.082
0.807TyrHis: 0.807 ± 0.564
3.633TyrIle: 3.633 ± 1.01
5.652TyrLys: 5.652 ± 1.282
5.652TyrLeu: 5.652 ± 1.571
1.211TyrMet: 1.211 ± 0.578
4.441TyrAsn: 4.441 ± 1.038
1.211TyrPro: 1.211 ± 0.526
5.652TyrGln: 5.652 ± 1.41
0.807TyrArg: 0.807 ± 0.697
3.23TyrSer: 3.23 ± 0.668
0.807TyrThr: 0.807 ± 0.649
0.0TyrVal: 0.0 ± 0.0
0.807TyrTrp: 0.807 ± 0.402
3.23TyrTyr: 3.23 ± 1.119
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (2478 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski