Amino acid dipepetide frequency for Natrarchaeobius halalkaliphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.631AlaAla: 10.631 ± 0.132	0.675AlaCys: 0.675 ± 0.028	8.615AlaAsp: 8.615 ± 0.123	7.499AlaGlu: 7.499 ± 0.104	3.595AlaPhe: 3.595 ± 0.059	8.136AlaGly: 8.136 ± 0.102	1.686AlaHis: 1.686 ± 0.044	5.722AlaIle: 5.722 ± 0.092	1.751AlaLys: 1.751 ± 0.048	9.231AlaLeu: 9.231 ± 0.123	1.93AlaMet: 1.93 ± 0.054	2.362AlaAsn: 2.362 ± 0.045	3.194AlaPro: 3.194 ± 0.064	2.018AlaGln: 2.018 ± 0.048	5.728AlaArg: 5.728 ± 0.081	5.423AlaSer: 5.423 ± 0.088	6.865AlaThr: 6.865 ± 0.092	9.129AlaVal: 9.129 ± 0.115	0.909AlaTrp: 0.909 ± 0.032	2.49AlaTyr: 2.49 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.611CysAla: 0.611 ± 0.027	0.088CysCys: 0.088 ± 0.009	0.601CysAsp: 0.601 ± 0.026	0.644CysGlu: 0.644 ± 0.027	0.193CysPhe: 0.193 ± 0.014	0.888CysGly: 0.888 ± 0.034	0.214CysHis: 0.214 ± 0.016	0.275CysIle: 0.275 ± 0.017	0.109CysLys: 0.109 ± 0.01	0.641CysLeu: 0.641 ± 0.026	0.124CysMet: 0.124 ± 0.011	0.192CysAsn: 0.192 ± 0.015	0.515CysPro: 0.515 ± 0.025	0.173CysGln: 0.173 ± 0.013	0.551CysArg: 0.551 ± 0.026	0.507CysSer: 0.507 ± 0.022	0.45CysThr: 0.45 ± 0.025	0.521CysVal: 0.521 ± 0.026	0.091CysTrp: 0.091 ± 0.01	0.22CysTyr: 0.22 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.691AspAla: 8.691 ± 0.117	0.669AspCys: 0.669 ± 0.03	9.084AspAsp: 9.084 ± 0.176	9.15AspGlu: 9.15 ± 0.124	1.755AspPhe: 1.755 ± 0.047	8.582AspGly: 8.582 ± 0.121	2.055AspHis: 2.055 ± 0.059	2.995AspIle: 2.995 ± 0.055	0.887AspLys: 0.887 ± 0.032	6.971AspLeu: 6.971 ± 0.098	1.114AspMet: 1.114 ± 0.037	1.316AspAsn: 1.316 ± 0.044	4.64AspPro: 4.64 ± 0.065	1.719AspGln: 1.719 ± 0.05	7.224AspArg: 7.224 ± 0.092	4.196AspSer: 4.196 ± 0.082	3.749AspThr: 3.749 ± 0.065	8.474AspVal: 8.474 ± 0.108	0.986AspTrp: 0.986 ± 0.037	1.611AspTyr: 1.611 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.983GluAla: 7.983 ± 0.099	0.604GluCys: 0.604 ± 0.028	6.217GluAsp: 6.217 ± 0.093	7.046GluGlu: 7.046 ± 0.117	3.24GluPhe: 3.24 ± 0.058	5.349GluGly: 5.349 ± 0.093	2.077GluHis: 2.077 ± 0.048	5.112GluIle: 5.112 ± 0.092	1.971GluLys: 1.971 ± 0.051	8.227GluLeu: 8.227 ± 0.107	2.02GluMet: 2.02 ± 0.047	2.811GluAsn: 2.811 ± 0.056	4.484GluPro: 4.484 ± 0.075	2.6GluGln: 2.6 ± 0.055	8.158GluArg: 8.158 ± 0.112	6.011GluSer: 6.011 ± 0.093	7.607GluThr: 7.607 ± 0.091	5.282GluVal: 5.282 ± 0.082	1.147GluTrp: 1.147 ± 0.032	3.246GluTyr: 3.246 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	3.334PheAla: 3.334 ± 0.073	0.286PheCys: 0.286 ± 0.019	3.459PheAsp: 3.459 ± 0.062	3.365PheGlu: 3.365 ± 0.065	1.042PhePhe: 1.042 ± 0.039	3.065PheGly: 3.065 ± 0.064	0.633PheHis: 0.633 ± 0.024	1.161PheIle: 1.161 ± 0.041	0.455PheLys: 0.455 ± 0.02	2.699PheLeu: 2.699 ± 0.065	0.492PheMet: 0.492 ± 0.029	0.645PheAsn: 0.645 ± 0.024	1.34PhePro: 1.34 ± 0.035	0.742PheGln: 0.742 ± 0.03	1.713PheArg: 1.713 ± 0.044	1.806PheSer: 1.806 ± 0.047	1.787PheThr: 1.787 ± 0.042	3.421PheVal: 3.421 ± 0.066	0.407PheTrp: 0.407 ± 0.02	0.848PheTyr: 0.848 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.13GlyAla: 7.13 ± 0.103	0.731GlyCys: 0.731 ± 0.031	6.544GlyAsp: 6.544 ± 0.105	6.881GlyGlu: 6.881 ± 0.096	3.07GlyPhe: 3.07 ± 0.058	6.756GlyGly: 6.756 ± 0.105	1.706GlyHis: 1.706 ± 0.045	4.605GlyIle: 4.605 ± 0.071	1.881GlyLys: 1.881 ± 0.044	6.986GlyLeu: 6.986 ± 0.097	1.602GlyMet: 1.602 ± 0.042	1.993GlyAsn: 1.993 ± 0.058	3.007GlyPro: 3.007 ± 0.063	1.873GlyGln: 1.873 ± 0.048	5.051GlyArg: 5.051 ± 0.067	5.445GlySer: 5.445 ± 0.084	6.002GlyThr: 6.002 ± 0.088	7.04GlyVal: 7.04 ± 0.088	1.009GlyTrp: 1.009 ± 0.034	2.647GlyTyr: 2.647 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.988HisAla: 1.988 ± 0.049	0.24HisCys: 0.24 ± 0.016	1.949HisAsp: 1.949 ± 0.054	1.798HisGlu: 1.798 ± 0.049	0.523HisPhe: 0.523 ± 0.025	2.033HisGly: 2.033 ± 0.052	0.581HisHis: 0.581 ± 0.028	0.708HisIle: 0.708 ± 0.027	0.301HisLys: 0.301 ± 0.017	1.753HisLeu: 1.753 ± 0.042	0.318HisMet: 0.318 ± 0.018	0.453HisAsn: 0.453 ± 0.023	1.296HisPro: 1.296 ± 0.042	0.473HisGln: 0.473 ± 0.021	1.405HisArg: 1.405 ± 0.037	0.978HisSer: 0.978 ± 0.028	0.98HisThr: 0.98 ± 0.031	1.954HisVal: 1.954 ± 0.054	0.247HisTrp: 0.247 ± 0.014	0.549HisTyr: 0.549 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.406IleAla: 5.406 ± 0.084	0.34IleCys: 0.34 ± 0.018	5.116IleAsp: 5.116 ± 0.074	5.109IleGlu: 5.109 ± 0.086	1.137IlePhe: 1.137 ± 0.039	4.464IleGly: 4.464 ± 0.08	0.945IleHis: 0.945 ± 0.036	1.55IleIle: 1.55 ± 0.049	0.738IleLys: 0.738 ± 0.028	3.443IleLeu: 3.443 ± 0.075	0.587IleMet: 0.587 ± 0.024	1.045IleAsn: 1.045 ± 0.034	2.198IlePro: 2.198 ± 0.048	1.201IleGln: 1.201 ± 0.04	2.842IleArg: 2.842 ± 0.055	2.649IleSer: 2.649 ± 0.056	2.805IleThr: 2.805 ± 0.051	4.723IleVal: 4.723 ± 0.077	0.402IleTrp: 0.402 ± 0.02	1.056IleTyr: 1.056 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	1.699LysAla: 1.699 ± 0.045	0.12LysCys: 0.12 ± 0.012	1.0LysAsp: 1.0 ± 0.036	1.244LysGlu: 1.244 ± 0.04	0.49LysPhe: 0.49 ± 0.021	1.289LysGly: 1.289 ± 0.044	0.489LysHis: 0.489 ± 0.023	0.889LysIle: 0.889 ± 0.028	0.572LysLys: 0.572 ± 0.03	1.653LysLeu: 1.653 ± 0.047	0.405LysMet: 0.405 ± 0.021	0.631LysAsn: 0.631 ± 0.024	0.962LysPro: 0.962 ± 0.034	0.681LysGln: 0.681 ± 0.027	1.76LysArg: 1.76 ± 0.044	1.182LysSer: 1.182 ± 0.039	1.343LysThr: 1.343 ± 0.039	1.062LysVal: 1.062 ± 0.035	0.202LysTrp: 0.202 ± 0.015	0.543LysTyr: 0.543 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	9.627LeuAla: 9.627 ± 0.117	0.666LeuCys: 0.666 ± 0.025	6.095LeuAsp: 6.095 ± 0.082	11.572LeuGlu: 11.572 ± 0.131	3.028LeuPhe: 3.028 ± 0.075	6.906LeuGly: 6.906 ± 0.094	1.359LeuHis: 1.359 ± 0.039	3.447LeuIle: 3.447 ± 0.077	1.443LeuLys: 1.443 ± 0.039	7.883LeuLeu: 7.883 ± 0.13	1.202LeuMet: 1.202 ± 0.04	1.75LeuAsn: 1.75 ± 0.044	3.645LeuPro: 3.645 ± 0.059	1.861LeuGln: 1.861 ± 0.044	4.946LeuArg: 4.946 ± 0.073	6.007LeuSer: 6.007 ± 0.085	5.037LeuThr: 5.037 ± 0.074	7.89LeuVal: 7.89 ± 0.111	0.806LeuTrp: 0.806 ± 0.031	2.096LeuTyr: 2.096 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.764MetAla: 1.764 ± 0.044	0.11MetCys: 0.11 ± 0.01	1.224MetAsp: 1.224 ± 0.033	1.114MetGlu: 1.114 ± 0.033	0.547MetPhe: 0.547 ± 0.028	1.47MetGly: 1.47 ± 0.037	0.329MetHis: 0.329 ± 0.02	0.879MetIle: 0.879 ± 0.031	0.502MetLys: 0.502 ± 0.02	1.449MetLeu: 1.449 ± 0.04	0.343MetMet: 0.343 ± 0.021	0.695MetAsn: 0.695 ± 0.028	0.723MetPro: 0.723 ± 0.028	0.439MetGln: 0.439 ± 0.024	0.991MetArg: 0.991 ± 0.032	1.493MetSer: 1.493 ± 0.042	1.589MetThr: 1.589 ± 0.038	1.24MetVal: 1.24 ± 0.04	0.172MetTrp: 0.172 ± 0.013	0.433MetTyr: 0.433 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.726AsnAla: 2.726 ± 0.055	0.226AsnCys: 0.226 ± 0.014	1.88AsnAsp: 1.88 ± 0.044	2.203AsnGlu: 2.203 ± 0.054	0.673AsnPhe: 0.673 ± 0.028	2.268AsnGly: 2.268 ± 0.055	0.531AsnHis: 0.531 ± 0.022	0.917AsnIle: 0.917 ± 0.037	0.433AsnLys: 0.433 ± 0.019	1.867AsnLeu: 1.867 ± 0.05	0.416AsnMet: 0.416 ± 0.022	0.564AsnAsn: 0.564 ± 0.026	1.506AsnPro: 1.506 ± 0.042	0.651AsnGln: 0.651 ± 0.03	1.891AsnArg: 1.891 ± 0.045	1.099AsnSer: 1.099 ± 0.034	1.267AsnThr: 1.267 ± 0.041	2.425AsnVal: 2.425 ± 0.05	0.334AsnTrp: 0.334 ± 0.017	0.687AsnTyr: 0.687 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.047ProAla: 4.047 ± 0.068	0.24ProCys: 0.24 ± 0.016	4.711ProAsp: 4.711 ± 0.075	4.366ProGlu: 4.366 ± 0.061	1.543ProPhe: 1.543 ± 0.037	3.656ProGly: 3.656 ± 0.068	0.891ProHis: 0.891 ± 0.029	2.391ProIle: 2.391 ± 0.049	0.873ProLys: 0.873 ± 0.031	3.523ProLeu: 3.523 ± 0.07	0.889ProMet: 0.889 ± 0.033	1.263ProAsn: 1.263 ± 0.04	2.106ProPro: 2.106 ± 0.056	0.964ProGln: 0.964 ± 0.031	2.27ProArg: 2.27 ± 0.057	2.825ProSer: 2.825 ± 0.056	3.156ProThr: 3.156 ± 0.058	3.901ProVal: 3.901 ± 0.062	0.508ProTrp: 0.508 ± 0.024	1.122ProTyr: 1.122 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.125GlnAla: 2.125 ± 0.046	0.16GlnCys: 0.16 ± 0.013	1.311GlnAsp: 1.311 ± 0.04	1.686GlnGlu: 1.686 ± 0.048	0.992GlnPhe: 0.992 ± 0.031	1.515GlnGly: 1.515 ± 0.039	0.564GlnHis: 0.564 ± 0.027	1.265GlnIle: 1.265 ± 0.043	0.57GlnLys: 0.57 ± 0.025	2.424GlnLeu: 2.424 ± 0.051	0.527GlnMet: 0.527 ± 0.019	0.759GlnAsn: 0.759 ± 0.028	1.149GlnPro: 1.149 ± 0.033	0.987GlnGln: 0.987 ± 0.037	1.919GlnArg: 1.919 ± 0.049	1.55GlnSer: 1.55 ± 0.035	1.596GlnThr: 1.596 ± 0.042	1.551GlnVal: 1.551 ± 0.047	0.332GlnTrp: 0.332 ± 0.019	0.845GlnTyr: 0.845 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.9ArgAla: 5.9 ± 0.085	0.572ArgCys: 0.572 ± 0.025	5.07ArgAsp: 5.07 ± 0.08	6.422ArgGlu: 6.422 ± 0.092	2.37ArgPhe: 2.37 ± 0.052	4.383ArgGly: 4.383 ± 0.072	1.304ArgHis: 1.304 ± 0.034	3.681ArgIle: 3.681 ± 0.064	1.383ArgLys: 1.383 ± 0.042	6.113ArgLeu: 6.113 ± 0.089	1.357ArgMet: 1.357 ± 0.036	1.854ArgAsn: 1.854 ± 0.046	2.618ArgPro: 2.618 ± 0.053	1.725ArgGln: 1.725 ± 0.038	5.071ArgArg: 5.071 ± 0.086	4.471ArgSer: 4.471 ± 0.086	4.804ArgThr: 4.804 ± 0.077	4.99ArgVal: 4.99 ± 0.076	0.8ArgTrp: 0.8 ± 0.026	1.969ArgTyr: 1.969 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.238SerAla: 5.238 ± 0.089	0.396SerCys: 0.396 ± 0.019	5.161SerAsp: 5.161 ± 0.08	5.081SerGlu: 5.081 ± 0.079	2.087SerPhe: 2.087 ± 0.045	5.323SerGly: 5.323 ± 0.077	1.202SerHis: 1.202 ± 0.031	3.196SerIle: 3.196 ± 0.058	1.211SerLys: 1.211 ± 0.036	5.248SerLeu: 5.248 ± 0.079	1.162SerMet: 1.162 ± 0.035	1.59SerAsn: 1.59 ± 0.04	2.722SerPro: 2.722 ± 0.057	1.424SerGln: 1.424 ± 0.038	3.772SerArg: 3.772 ± 0.065	3.984SerSer: 3.984 ± 0.078	3.91SerThr: 3.91 ± 0.069	5.49SerVal: 5.49 ± 0.09	0.643SerTrp: 0.643 ± 0.029	1.53SerTyr: 1.53 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.582ThrAla: 6.582 ± 0.09	0.418ThrCys: 0.418 ± 0.024	6.231ThrAsp: 6.231 ± 0.094	5.172ThrGlu: 5.172 ± 0.079	2.14ThrPhe: 2.14 ± 0.046	5.751ThrGly: 5.751 ± 0.086	1.264ThrHis: 1.264 ± 0.035	3.71ThrIle: 3.71 ± 0.066	1.123ThrLys: 1.123 ± 0.034	5.561ThrLeu: 5.561 ± 0.067	1.128ThrMet: 1.128 ± 0.036	1.677ThrAsn: 1.677 ± 0.045	3.126ThrPro: 3.126 ± 0.059	1.39ThrGln: 1.39 ± 0.042	3.439ThrArg: 3.439 ± 0.049	3.216ThrSer: 3.216 ± 0.058	4.288ThrThr: 4.288 ± 0.077	6.96ThrVal: 6.96 ± 0.097	0.581ThrTrp: 0.581 ± 0.023	1.727ThrTyr: 1.727 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	8.557ValAla: 8.557 ± 0.114	0.721ValCys: 0.721 ± 0.027	8.001ValAsp: 8.001 ± 0.097	7.42ValGlu: 7.42 ± 0.106	2.975ValPhe: 2.975 ± 0.066	7.11ValGly: 7.11 ± 0.092	1.79ValHis: 1.79 ± 0.042	3.849ValIle: 3.849 ± 0.072	1.288ValLys: 1.288 ± 0.036	8.034ValLeu: 8.034 ± 0.137	1.252ValMet: 1.252 ± 0.037	1.922ValAsn: 1.922 ± 0.052	4.313ValPro: 4.313 ± 0.073	1.893ValGln: 1.893 ± 0.043	5.389ValArg: 5.389 ± 0.071	5.672ValSer: 5.672 ± 0.084	6.011ValThr: 6.011 ± 0.092	8.436ValVal: 8.436 ± 0.107	0.768ValTrp: 0.768 ± 0.028	2.194ValTyr: 2.194 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.814TrpAla: 0.814 ± 0.031	0.107TrpCys: 0.107 ± 0.011	0.815TrpAsp: 0.815 ± 0.029	0.842TrpGlu: 0.842 ± 0.037	0.441TrpPhe: 0.441 ± 0.021	0.77TrpGly: 0.77 ± 0.027	0.254TrpHis: 0.254 ± 0.016	0.606TrpIle: 0.606 ± 0.025	0.29TrpLys: 0.29 ± 0.018	1.139TrpLeu: 1.139 ± 0.036	0.238TrpMet: 0.238 ± 0.017	0.424TrpAsn: 0.424 ± 0.024	0.411TrpPro: 0.411 ± 0.021	0.34TrpGln: 0.34 ± 0.018	0.762TrpArg: 0.762 ± 0.035	0.599TrpSer: 0.599 ± 0.027	0.766TrpThr: 0.766 ± 0.031	0.712TrpVal: 0.712 ± 0.03	0.17TrpTrp: 0.17 ± 0.014	0.347TrpTyr: 0.347 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.737TyrAla: 2.737 ± 0.052	0.24TyrCys: 0.24 ± 0.016	2.785TyrAsp: 2.785 ± 0.056	2.578TyrGlu: 2.578 ± 0.057	0.858TyrPhe: 0.858 ± 0.036	2.246TyrGly: 2.246 ± 0.048	0.653TyrHis: 0.653 ± 0.029	0.797TyrIle: 0.797 ± 0.029	0.435TyrLys: 0.435 ± 0.021	2.423TyrLeu: 2.423 ± 0.052	0.4TyrMet: 0.4 ± 0.019	0.618TyrAsn: 0.618 ± 0.027	1.291TyrPro: 1.291 ± 0.043	0.672TyrGln: 0.672 ± 0.024	1.976TyrArg: 1.976 ± 0.049	1.255TyrSer: 1.255 ± 0.037	1.47TyrThr: 1.47 ± 0.041	2.395TyrVal: 2.395 ± 0.046	0.335TyrTrp: 0.335 ± 0.02	0.853TyrTyr: 0.853 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3330 proteins (976133 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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