Amino acid dipepetide frequency for Geodermatophilus sp. Leaf369

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.788AlaAla: 23.788 ± 0.215	0.932AlaCys: 0.932 ± 0.025	9.848AlaAsp: 9.848 ± 0.095	8.521AlaGlu: 8.521 ± 0.097	3.395AlaPhe: 3.395 ± 0.059	14.891AlaGly: 14.891 ± 0.127	2.717AlaHis: 2.717 ± 0.046	3.321AlaIle: 3.321 ± 0.055	1.788AlaLys: 1.788 ± 0.05	15.184AlaLeu: 15.184 ± 0.135	2.433AlaMet: 2.433 ± 0.042	1.697AlaAsn: 1.697 ± 0.043	7.272AlaPro: 7.272 ± 0.111	4.002AlaGln: 4.002 ± 0.062	10.344AlaArg: 10.344 ± 0.101	5.785AlaSer: 5.785 ± 0.078	8.217AlaThr: 8.217 ± 0.097	14.893AlaVal: 14.893 ± 0.135	1.903AlaTrp: 1.903 ± 0.043	2.161AlaTyr: 2.161 ± 0.038	0.001AlaXaa: 0.001 ± 0.001
Cys	0.822CysAla: 0.822 ± 0.027	0.066CysCys: 0.066 ± 0.007	0.436CysAsp: 0.436 ± 0.018	0.265CysGlu: 0.265 ± 0.016	0.174CysPhe: 0.174 ± 0.012	0.803CysGly: 0.803 ± 0.028	0.143CysHis: 0.143 ± 0.011	0.172CysIle: 0.172 ± 0.012	0.06CysLys: 0.06 ± 0.007	0.614CysLeu: 0.614 ± 0.021	0.088CysMet: 0.088 ± 0.009	0.099CysAsn: 0.099 ± 0.01	0.42CysPro: 0.42 ± 0.02	0.155CysGln: 0.155 ± 0.01	0.496CysArg: 0.496 ± 0.021	0.363CysSer: 0.363 ± 0.017	0.475CysThr: 0.475 ± 0.021	0.572CysVal: 0.572 ± 0.02	0.097CysTrp: 0.097 ± 0.008	0.102CysTyr: 0.102 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.8AspAla: 8.8 ± 0.091	0.373AspCys: 0.373 ± 0.018	4.42AspAsp: 4.42 ± 0.07	3.78AspGlu: 3.78 ± 0.068	1.436AspPhe: 1.436 ± 0.037	6.748AspGly: 6.748 ± 0.088	1.336AspHis: 1.336 ± 0.035	1.211AspIle: 1.211 ± 0.033	0.663AspLys: 0.663 ± 0.026	7.41AspLeu: 7.41 ± 0.098	0.682AspMet: 0.682 ± 0.021	0.634AspAsn: 0.634 ± 0.021	5.002AspPro: 5.002 ± 0.07	1.72AspGln: 1.72 ± 0.036	5.438AspArg: 5.438 ± 0.075	2.305AspSer: 2.305 ± 0.046	3.367AspThr: 3.367 ± 0.051	7.252AspVal: 7.252 ± 0.077	0.987AspTrp: 0.987 ± 0.031	0.958AspTyr: 0.958 ± 0.03	0.002AspXaa: 0.002 ± 0.001
Glu	6.752GluAla: 6.752 ± 0.085	0.271GluCys: 0.271 ± 0.013	3.057GluAsp: 3.057 ± 0.052	2.814GluGlu: 2.814 ± 0.052	1.305GluPhe: 1.305 ± 0.03	4.047GluGly: 4.047 ± 0.064	1.548GluHis: 1.548 ± 0.036	1.688GluIle: 1.688 ± 0.037	0.93GluLys: 0.93 ± 0.031	6.963GluLeu: 6.963 ± 0.081	0.779GluMet: 0.779 ± 0.025	0.748GluAsn: 0.748 ± 0.025	3.035GluPro: 3.035 ± 0.054	2.311GluGln: 2.311 ± 0.044	4.377GluArg: 4.377 ± 0.068	2.261GluSer: 2.261 ± 0.039	2.859GluThr: 2.859 ± 0.046	5.426GluVal: 5.426 ± 0.063	0.656GluTrp: 0.656 ± 0.025	0.803GluTyr: 0.803 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.579PheAla: 3.579 ± 0.058	0.233PheCys: 0.233 ± 0.013	1.883PheAsp: 1.883 ± 0.044	1.181PheGlu: 1.181 ± 0.03	0.849PhePhe: 0.849 ± 0.029	2.907PheGly: 2.907 ± 0.049	0.476PheHis: 0.476 ± 0.015	0.641PheIle: 0.641 ± 0.021	0.316PheLys: 0.316 ± 0.016	2.569PheLeu: 2.569 ± 0.053	0.315PheMet: 0.315 ± 0.018	0.425PheAsn: 0.425 ± 0.019	1.316PhePro: 1.316 ± 0.036	0.571PheGln: 0.571 ± 0.022	1.524PheArg: 1.524 ± 0.034	1.425PheSer: 1.425 ± 0.032	1.831PheThr: 1.831 ± 0.038	2.451PheVal: 2.451 ± 0.048	0.383PheTrp: 0.383 ± 0.019	0.516PheTyr: 0.516 ± 0.021	0.001PheXaa: 0.001 ± 0.001
Gly	11.586GlyAla: 11.586 ± 0.112	0.724GlyCys: 0.724 ± 0.027	5.723GlyAsp: 5.723 ± 0.075	4.935GlyGlu: 4.935 ± 0.062	2.876GlyPhe: 2.876 ± 0.055	9.127GlyGly: 9.127 ± 0.144	1.997GlyHis: 1.997 ± 0.046	3.249GlyIle: 3.249 ± 0.054	1.698GlyLys: 1.698 ± 0.044	10.571GlyLeu: 10.571 ± 0.099	1.896GlyMet: 1.896 ± 0.041	1.519GlyAsn: 1.519 ± 0.041	5.275GlyPro: 5.275 ± 0.071	3.023GlyGln: 3.023 ± 0.069	7.624GlyArg: 7.624 ± 0.082	5.646GlySer: 5.646 ± 0.073	6.586GlyThr: 6.586 ± 0.099	9.286GlyVal: 9.286 ± 0.096	1.893GlyTrp: 1.893 ± 0.041	2.019GlyTyr: 2.019 ± 0.044	0.002GlyXaa: 0.002 ± 0.001
His	2.561HisAla: 2.561 ± 0.044	0.152HisCys: 0.152 ± 0.011	1.323HisAsp: 1.323 ± 0.032	1.052HisGlu: 1.052 ± 0.03	0.475HisPhe: 0.475 ± 0.02	2.167HisGly: 2.167 ± 0.042	0.637HisHis: 0.637 ± 0.027	0.334HisIle: 0.334 ± 0.017	0.202HisLys: 0.202 ± 0.013	2.264HisLeu: 2.264 ± 0.045	0.229HisMet: 0.229 ± 0.014	0.236HisAsn: 0.236 ± 0.014	1.712HisPro: 1.712 ± 0.041	0.552HisGln: 0.552 ± 0.021	1.883HisArg: 1.883 ± 0.038	0.81HisSer: 0.81 ± 0.028	1.067HisThr: 1.067 ± 0.027	2.021HisVal: 2.021 ± 0.042	0.327HisTrp: 0.327 ± 0.018	0.335HisTyr: 0.335 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.567IleAla: 4.567 ± 0.065	0.192IleCys: 0.192 ± 0.012	1.958IleAsp: 1.958 ± 0.039	1.63IleGlu: 1.63 ± 0.042	0.32IlePhe: 0.32 ± 0.02	3.313IleGly: 3.313 ± 0.057	0.353IleHis: 0.353 ± 0.018	0.585IleIle: 0.585 ± 0.023	0.403IleLys: 0.403 ± 0.022	1.435IleLeu: 1.435 ± 0.036	0.285IleMet: 0.285 ± 0.015	0.487IleAsn: 0.487 ± 0.021	1.342IlePro: 1.342 ± 0.036	0.511IleGln: 0.511 ± 0.02	1.587IleArg: 1.587 ± 0.034	1.448IleSer: 1.448 ± 0.034	1.974IleThr: 1.974 ± 0.044	2.417IleVal: 2.417 ± 0.051	0.247IleTrp: 0.247 ± 0.012	0.325IleTyr: 0.325 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	1.847LysAla: 1.847 ± 0.048	0.058LysCys: 0.058 ± 0.007	0.813LysAsp: 0.813 ± 0.027	0.651LysGlu: 0.651 ± 0.024	0.266LysPhe: 0.266 ± 0.014	1.063LysGly: 1.063 ± 0.033	0.298LysHis: 0.298 ± 0.015	0.51LysIle: 0.51 ± 0.023	0.447LysLys: 0.447 ± 0.023	1.381LysLeu: 1.381 ± 0.043	0.237LysMet: 0.237 ± 0.016	0.316LysAsn: 0.316 ± 0.015	0.865LysPro: 0.865 ± 0.027	0.502LysGln: 0.502 ± 0.021	1.051LysArg: 1.051 ± 0.027	0.695LysSer: 0.695 ± 0.025	0.968LysThr: 0.968 ± 0.035	1.246LysVal: 1.246 ± 0.04	0.147LysTrp: 0.147 ± 0.013	0.276LysTyr: 0.276 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	17.078LeuAla: 17.078 ± 0.152	0.624LeuCys: 0.624 ± 0.022	7.242LeuAsp: 7.242 ± 0.082	4.767LeuGlu: 4.767 ± 0.061	2.535LeuPhe: 2.535 ± 0.054	10.183LeuGly: 10.183 ± 0.101	2.052LeuHis: 2.052 ± 0.042	2.264LeuIle: 2.264 ± 0.048	1.199LeuLys: 1.199 ± 0.036	12.063LeuLeu: 12.063 ± 0.142	1.32LeuMet: 1.32 ± 0.028	1.25LeuAsn: 1.25 ± 0.035	6.618LeuPro: 6.618 ± 0.081	2.807LeuGln: 2.807 ± 0.054	7.896LeuArg: 7.896 ± 0.085	5.269LeuSer: 5.269 ± 0.06	7.483LeuThr: 7.483 ± 0.076	11.98LeuVal: 11.98 ± 0.123	1.139LeuTrp: 1.139 ± 0.033	1.423LeuTyr: 1.423 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.14MetAla: 2.14 ± 0.04	0.103MetCys: 0.103 ± 0.009	0.81MetAsp: 0.81 ± 0.026	0.564MetGlu: 0.564 ± 0.021	0.282MetPhe: 0.282 ± 0.014	1.257MetGly: 1.257 ± 0.03	0.296MetHis: 0.296 ± 0.013	0.487MetIle: 0.487 ± 0.021	0.265MetLys: 0.265 ± 0.014	1.388MetLeu: 1.388 ± 0.033	0.235MetMet: 0.235 ± 0.014	0.294MetAsn: 0.294 ± 0.015	0.931MetPro: 0.931 ± 0.024	0.426MetGln: 0.426 ± 0.017	1.219MetArg: 1.219 ± 0.033	1.231MetSer: 1.231 ± 0.027	1.678MetThr: 1.678 ± 0.037	1.311MetVal: 1.311 ± 0.034	0.142MetTrp: 0.142 ± 0.01	0.21MetTyr: 0.21 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	1.893AsnAla: 1.893 ± 0.043	0.131AsnCys: 0.131 ± 0.011	0.758AsnAsp: 0.758 ± 0.027	0.611AsnGlu: 0.611 ± 0.022	0.325AsnPhe: 0.325 ± 0.016	1.37AsnGly: 1.37 ± 0.038	0.264AsnHis: 0.264 ± 0.015	0.417AsnIle: 0.417 ± 0.02	0.247AsnLys: 0.247 ± 0.014	1.375AsnLeu: 1.375 ± 0.037	0.217AsnMet: 0.217 ± 0.014	0.296AsnAsn: 0.296 ± 0.015	1.096AsnPro: 1.096 ± 0.032	0.418AsnGln: 0.418 ± 0.019	0.988AsnArg: 0.988 ± 0.029	0.677AsnSer: 0.677 ± 0.025	0.926AsnThr: 0.926 ± 0.035	1.273AsnVal: 1.273 ± 0.032	0.202AsnTrp: 0.202 ± 0.014	0.28AsnTyr: 0.28 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	9.164ProAla: 9.164 ± 0.115	0.265ProCys: 0.265 ± 0.016	4.693ProAsp: 4.693 ± 0.069	3.871ProGlu: 3.871 ± 0.057	1.489ProPhe: 1.489 ± 0.036	6.64ProGly: 6.64 ± 0.098	1.171ProHis: 1.171 ± 0.03	1.224ProIle: 1.224 ± 0.034	0.741ProLys: 0.741 ± 0.031	5.29ProLeu: 5.29 ± 0.067	0.943ProMet: 0.943 ± 0.023	0.68ProAsn: 0.68 ± 0.024	3.376ProPro: 3.376 ± 0.085	1.499ProGln: 1.499 ± 0.035	3.807ProArg: 3.807 ± 0.062	2.949ProSer: 2.949 ± 0.059	4.189ProThr: 4.189 ± 0.072	6.471ProVal: 6.471 ± 0.085	0.943ProTrp: 0.943 ± 0.027	0.925ProTyr: 0.925 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.983GlnAla: 3.983 ± 0.054	0.134GlnCys: 0.134 ± 0.011	1.295GlnAsp: 1.295 ± 0.029	1.231GlnGlu: 1.231 ± 0.031	0.649GlnPhe: 0.649 ± 0.025	2.177GlnGly: 2.177 ± 0.047	0.651GlnHis: 0.651 ± 0.024	0.874GlnIle: 0.874 ± 0.029	0.434GlnLys: 0.434 ± 0.02	3.671GlnLeu: 3.671 ± 0.057	0.429GlnMet: 0.429 ± 0.018	0.386GlnAsn: 0.386 ± 0.019	1.66GlnPro: 1.66 ± 0.043	1.25GlnGln: 1.25 ± 0.047	2.277GlnArg: 2.277 ± 0.045	1.238GlnSer: 1.238 ± 0.039	1.649GlnThr: 1.649 ± 0.039	3.145GlnVal: 3.145 ± 0.053	0.411GlnTrp: 0.411 ± 0.016	0.483GlnTyr: 0.483 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.873ArgAla: 9.873 ± 0.104	0.469ArgCys: 0.469 ± 0.021	4.281ArgAsp: 4.281 ± 0.061	4.175ArgGlu: 4.175 ± 0.057	2.168ArgPhe: 2.168 ± 0.044	5.918ArgGly: 5.918 ± 0.07	1.595ArgHis: 1.595 ± 0.035	2.188ArgIle: 2.188 ± 0.048	1.068ArgLys: 1.068 ± 0.032	8.027ArgLeu: 8.027 ± 0.093	1.596ArgMet: 1.596 ± 0.032	0.979ArgAsn: 0.979 ± 0.024	4.805ArgPro: 4.805 ± 0.067	2.086ArgGln: 2.086 ± 0.043	7.378ArgArg: 7.378 ± 0.091	4.102ArgSer: 4.102 ± 0.06	5.05ArgThr: 5.05 ± 0.058	7.069ArgVal: 7.069 ± 0.072	1.495ArgTrp: 1.495 ± 0.039	1.452ArgTyr: 1.452 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.674SerAla: 6.674 ± 0.079	0.32SerCys: 0.32 ± 0.016	2.722SerAsp: 2.722 ± 0.052	2.052SerGlu: 2.052 ± 0.036	1.508SerPhe: 1.508 ± 0.038	5.497SerGly: 5.497 ± 0.073	0.84SerHis: 0.84 ± 0.028	1.572SerIle: 1.572 ± 0.039	0.68SerLys: 0.68 ± 0.024	4.872SerLeu: 4.872 ± 0.056	1.055SerMet: 1.055 ± 0.027	0.726SerAsn: 0.726 ± 0.024	3.198SerPro: 3.198 ± 0.046	1.175SerGln: 1.175 ± 0.029	3.599SerArg: 3.599 ± 0.063	3.214SerSer: 3.214 ± 0.075	3.581SerThr: 3.581 ± 0.064	4.486SerVal: 4.486 ± 0.066	0.89SerTrp: 0.89 ± 0.024	0.972SerTyr: 0.972 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	9.656ThrAla: 9.656 ± 0.096	0.402ThrCys: 0.402 ± 0.017	4.306ThrAsp: 4.306 ± 0.062	3.421ThrGlu: 3.421 ± 0.052	1.511ThrPhe: 1.511 ± 0.033	7.309ThrGly: 7.309 ± 0.089	1.164ThrHis: 1.164 ± 0.03	1.698ThrIle: 1.698 ± 0.044	0.815ThrLys: 0.815 ± 0.029	5.957ThrLeu: 5.957 ± 0.066	0.876ThrMet: 0.876 ± 0.023	0.915ThrAsn: 0.915 ± 0.027	4.662ThrPro: 4.662 ± 0.073	1.438ThrGln: 1.438 ± 0.035	4.279ThrArg: 4.279 ± 0.058	3.4ThrSer: 3.4 ± 0.065	4.964ThrThr: 4.964 ± 0.095	7.094ThrVal: 7.094 ± 0.094	0.983ThrTrp: 0.983 ± 0.026	1.082ThrTyr: 1.082 ± 0.03	0.001ThrXaa: 0.001 ± 0.001
Val	14.261ValAla: 14.261 ± 0.133	0.718ValCys: 0.718 ± 0.029	6.913ValAsp: 6.913 ± 0.084	5.573ValGlu: 5.573 ± 0.072	2.881ValPhe: 2.881 ± 0.057	8.886ValGly: 8.886 ± 0.098	2.213ValHis: 2.213 ± 0.043	2.298ValIle: 2.298 ± 0.054	1.237ValLys: 1.237 ± 0.035	12.591ValLeu: 12.591 ± 0.134	1.265ValMet: 1.265 ± 0.037	1.558ValAsn: 1.558 ± 0.039	6.087ValPro: 6.087 ± 0.085	2.635ValGln: 2.635 ± 0.044	7.37ValArg: 7.37 ± 0.09	5.003ValSer: 5.003 ± 0.071	7.031ValThr: 7.031 ± 0.109	12.912ValVal: 12.912 ± 0.123	1.234ValTrp: 1.234 ± 0.032	1.588ValTyr: 1.588 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.782TrpAla: 1.782 ± 0.035	0.114TrpCys: 0.114 ± 0.011	0.83TrpAsp: 0.83 ± 0.028	0.602TrpGlu: 0.602 ± 0.024	0.483TrpPhe: 0.483 ± 0.02	1.128TrpGly: 1.128 ± 0.027	0.333TrpHis: 0.333 ± 0.017	0.358TrpIle: 0.358 ± 0.018	0.2TrpLys: 0.2 ± 0.013	1.774TrpLeu: 1.774 ± 0.044	0.234TrpMet: 0.234 ± 0.012	0.258TrpAsn: 0.258 ± 0.016	0.81TrpPro: 0.81 ± 0.029	0.511TrpGln: 0.511 ± 0.02	1.207TrpArg: 1.207 ± 0.03	0.995TrpSer: 0.995 ± 0.027	1.063TrpThr: 1.063 ± 0.03	1.374TrpVal: 1.374 ± 0.036	0.36TrpTrp: 0.36 ± 0.016	0.263TrpTyr: 0.263 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.286TyrAla: 2.286 ± 0.043	0.141TyrCys: 0.141 ± 0.01	1.213TyrAsp: 1.213 ± 0.032	0.932TyrGlu: 0.932 ± 0.031	0.464TyrPhe: 0.464 ± 0.02	1.824TyrGly: 1.824 ± 0.046	0.253TyrHis: 0.253 ± 0.013	0.289TyrIle: 0.289 ± 0.016	0.243TyrLys: 0.243 ± 0.015	1.794TyrLeu: 1.794 ± 0.04	0.155TyrMet: 0.155 ± 0.012	0.26TyrAsn: 0.26 ± 0.014	0.846TyrPro: 0.846 ± 0.028	0.436TyrGln: 0.436 ± 0.02	1.428TyrArg: 1.428 ± 0.038	0.817TyrSer: 0.817 ± 0.025	0.974TyrThr: 0.974 ± 0.026	1.575TyrVal: 1.575 ± 0.035	0.24TyrTrp: 0.24 ± 0.014	0.308TyrTyr: 0.308 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4093 proteins (1301898 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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