Amino acid dipepetide frequency for La Gloria virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.283AlaAla: 4.283 ± 2.731
1.26AlaCys: 1.26 ± 0.349
1.26AlaAsp: 1.26 ± 0.349
2.52AlaGlu: 2.52 ± 0.786
1.764AlaPhe: 1.764 ± 0.764
2.268AlaGly: 2.268 ± 0.829
1.26AlaHis: 1.26 ± 0.822
2.771AlaIle: 2.771 ± 1.104
3.527AlaLys: 3.527 ± 1.459
6.299AlaLeu: 6.299 ± 2.281
2.016AlaMet: 2.016 ± 0.731
3.023AlaAsn: 3.023 ± 0.261
1.008AlaPro: 1.008 ± 0.318
2.52AlaGln: 2.52 ± 0.697
4.031AlaArg: 4.031 ± 1.25
4.031AlaSer: 4.031 ± 0.212
3.527AlaThr: 3.527 ± 2.695
3.527AlaVal: 3.527 ± 1.207
0.504AlaTrp: 0.504 ± 0.343
2.268AlaTyr: 2.268 ± 0.944
0.0AlaXaa: 0.0 ± 0.0
Cys
0.756CysAla: 0.756 ± 0.224
0.756CysCys: 0.756 ± 0.224
1.512CysAsp: 1.512 ± 0.477
1.008CysGlu: 1.008 ± 0.366
1.26CysPhe: 1.26 ± 0.52
1.008CysGly: 1.008 ± 0.61
1.26CysHis: 1.26 ± 1.217
0.504CysIle: 0.504 ± 0.159
2.771CysLys: 2.771 ± 1.592
2.52CysLeu: 2.52 ± 1.263
0.504CysMet: 0.504 ± 0.56
1.008CysAsn: 1.008 ± 0.61
1.512CysPro: 1.512 ± 0.448
2.268CysGln: 2.268 ± 0.856
1.008CysArg: 1.008 ± 0.973
3.023CysSer: 3.023 ± 1.086
1.512CysThr: 1.512 ± 0.611
0.756CysVal: 0.756 ± 0.73
0.0CysTrp: 0.0 ± 0.0
1.26CysTyr: 1.26 ± 1.353
0.0CysXaa: 0.0 ± 0.0
Asp
3.275AspAla: 3.275 ± 2.012
1.008AspCys: 1.008 ± 0.911
4.031AspAsp: 4.031 ± 1.13
4.787AspGlu: 4.787 ± 1.119
1.512AspPhe: 1.512 ± 0.475
3.275AspGly: 3.275 ± 1.254
1.764AspHis: 1.764 ± 0.661
4.283AspIle: 4.283 ± 0.423
2.52AspLys: 2.52 ± 0.402
5.291AspLeu: 5.291 ± 1.93
3.023AspMet: 3.023 ± 1.955
3.023AspAsn: 3.023 ± 0.896
3.023AspPro: 3.023 ± 1.439
1.008AspGln: 1.008 ± 0.61
2.268AspArg: 2.268 ± 0.889
5.039AspSer: 5.039 ± 0.872
2.268AspThr: 2.268 ± 1.158
1.764AspVal: 1.764 ± 0.46
1.008AspTrp: 1.008 ± 0.521
2.016AspTyr: 2.016 ± 1.349
0.0AspXaa: 0.0 ± 0.0
Glu
4.031GluAla: 4.031 ± 0.951
2.52GluCys: 2.52 ± 1.701
4.031GluAsp: 4.031 ± 1.611
6.551GluGlu: 6.551 ± 0.529
4.787GluPhe: 4.787 ± 1.452
4.787GluGly: 4.787 ± 1.073
0.756GluHis: 0.756 ± 0.514
6.047GluIle: 6.047 ± 1.592
2.771GluLys: 2.771 ± 1.111
7.055GluLeu: 7.055 ± 1.565
0.756GluMet: 0.756 ± 0.634
3.023GluAsn: 3.023 ± 0.261
1.008GluPro: 1.008 ± 0.318
0.756GluGln: 0.756 ± 0.73
4.535GluArg: 4.535 ± 1.18
6.299GluSer: 6.299 ± 1.902
1.512GluThr: 1.512 ± 0.448
3.023GluVal: 3.023 ± 0.261
1.26GluTrp: 1.26 ± 0.688
1.764GluTyr: 1.764 ± 0.46
0.0GluXaa: 0.0 ± 0.0
Phe
2.52PheAla: 2.52 ± 1.265
1.764PheCys: 1.764 ± 1.335
2.771PheAsp: 2.771 ± 0.388
3.275PheGlu: 3.275 ± 0.956
2.016PhePhe: 2.016 ± 0.731
1.26PheGly: 1.26 ± 0.525
0.504PheHis: 0.504 ± 0.343
2.771PheIle: 2.771 ± 1.373
2.771PheLys: 2.771 ± 0.862
4.535PheLeu: 4.535 ± 0.547
1.512PheMet: 1.512 ± 0.866
2.268PheAsn: 2.268 ± 0.645
1.26PhePro: 1.26 ± 0.809
1.008PheGln: 1.008 ± 0.911
2.771PheArg: 2.771 ± 0.862
6.047PheSer: 6.047 ± 0.682
2.268PheThr: 2.268 ± 0.6
2.52PheVal: 2.52 ± 0.802
0.756PheTrp: 0.756 ± 0.224
0.756PheTyr: 0.756 ± 0.374
0.0PheXaa: 0.0 ± 0.0
Gly
3.275GlyAla: 3.275 ± 0.91
2.016GlyCys: 2.016 ± 0.62
2.52GlyAsp: 2.52 ± 0.755
2.771GlyGlu: 2.771 ± 0.54
5.039GlyPhe: 5.039 ± 1.1
3.779GlyGly: 3.779 ± 0.446
1.764GlyHis: 1.764 ± 0.858
2.52GlyIle: 2.52 ± 0.546
3.275GlyLys: 3.275 ± 1.191
4.031GlyLeu: 4.031 ± 2.916
1.512GlyMet: 1.512 ± 0.652
1.26GlyAsn: 1.26 ± 0.876
2.268GlyPro: 2.268 ± 0.493
1.512GlyGln: 1.512 ± 0.477
2.268GlyArg: 2.268 ± 0.672
7.811GlySer: 7.811 ± 2.794
1.512GlyThr: 1.512 ± 0.448
3.779GlyVal: 3.779 ± 0.446
0.252GlyTrp: 0.252 ± 0.496
1.26GlyTyr: 1.26 ± 0.349
0.252GlyXaa: 0.252 ± 0.243
His
1.008HisAla: 1.008 ± 0.736
0.252HisCys: 0.252 ± 0.171
0.756HisAsp: 0.756 ± 0.435
1.008HisGlu: 1.008 ± 0.404
0.756HisPhe: 0.756 ± 0.224
1.512HisGly: 1.512 ± 0.536
0.252HisHis: 0.252 ± 0.243
2.016HisIle: 2.016 ± 0.805
1.26HisLys: 1.26 ± 0.349
1.512HisLeu: 1.512 ± 0.448
0.252HisMet: 0.252 ± 0.496
0.504HisAsn: 0.504 ± 0.159
1.764HisPro: 1.764 ± 0.889
0.504HisGln: 0.504 ± 0.343
1.512HisArg: 1.512 ± 0.448
2.771HisSer: 2.771 ± 0.938
1.008HisThr: 1.008 ± 0.61
1.764HisVal: 1.764 ± 0.493
0.0HisTrp: 0.0 ± 0.0
1.764HisTyr: 1.764 ± 0.764
0.0HisXaa: 0.0 ± 0.0
Ile
4.535IleAla: 4.535 ± 1.477
1.764IleCys: 1.764 ± 0.764
3.779IleAsp: 3.779 ± 1.082
5.795IleGlu: 5.795 ± 0.526
1.512IlePhe: 1.512 ± 0.477
4.535IleGly: 4.535 ± 1.258
1.512IleHis: 1.512 ± 1.131
3.779IleIle: 3.779 ± 0.834
5.039IleLys: 5.039 ± 1.344
4.787IleLeu: 4.787 ± 0.853
2.016IleMet: 2.016 ± 0.507
3.527IleAsn: 3.527 ± 1.243
4.283IlePro: 4.283 ± 0.743
1.764IleGln: 1.764 ± 0.764
3.527IleArg: 3.527 ± 1.345
6.551IleSer: 6.551 ± 1.435
3.527IleThr: 3.527 ± 1.345
4.535IleVal: 4.535 ± 0.636
0.252IleTrp: 0.252 ± 0.171
1.764IleTyr: 1.764 ± 0.858
0.0IleXaa: 0.0 ± 0.0
Lys
3.023LysAla: 3.023 ± 1.055
1.512LysCys: 1.512 ± 0.747
3.779LysAsp: 3.779 ± 0.797
4.535LysGlu: 4.535 ± 1.314
2.016LysPhe: 2.016 ± 0.41
1.512LysGly: 1.512 ± 0.39
1.26LysHis: 1.26 ± 0.716
5.291LysIle: 5.291 ± 1.213
6.551LysLys: 6.551 ± 2.275
6.299LysLeu: 6.299 ± 1.216
3.275LysMet: 3.275 ± 1.927
2.52LysAsn: 2.52 ± 1.355
2.52LysPro: 2.52 ± 1.497
1.764LysGln: 1.764 ± 0.661
2.52LysArg: 2.52 ± 0.723
5.291LysSer: 5.291 ± 1.567
5.543LysThr: 5.543 ± 0.719
4.031LysVal: 4.031 ± 1.291
1.26LysTrp: 1.26 ± 0.857
2.268LysTyr: 2.268 ± 0.493
0.0LysXaa: 0.0 ± 0.0
Leu
4.535LeuAla: 4.535 ± 1.369
2.268LeuCys: 2.268 ± 0.889
4.283LeuAsp: 4.283 ± 1.006
4.787LeuGlu: 4.787 ± 2.167
4.535LeuPhe: 4.535 ± 1.18
4.283LeuGly: 4.283 ± 0.743
1.512LeuHis: 1.512 ± 1.028
8.314LeuIle: 8.314 ± 2.781
6.551LeuLys: 6.551 ± 0.46
9.574LeuLeu: 9.574 ± 2.556
3.023LeuMet: 3.023 ± 0.299
4.535LeuAsn: 4.535 ± 1.274
2.771LeuPro: 2.771 ± 0.661
4.535LeuGln: 4.535 ± 1.072
5.795LeuArg: 5.795 ± 0.82
8.818LeuSer: 8.818 ± 0.776
5.291LeuThr: 5.291 ± 0.851
4.031LeuVal: 4.031 ± 0.876
0.252LeuTrp: 0.252 ± 0.171
2.771LeuTyr: 2.771 ± 0.946
0.0LeuXaa: 0.0 ± 0.0
Met
2.52MetAla: 2.52 ± 1.263
0.504MetCys: 0.504 ± 0.343
1.764MetAsp: 1.764 ± 0.661
1.764MetGlu: 1.764 ± 0.46
2.016MetPhe: 2.016 ± 1.027
2.268MetGly: 2.268 ± 1.097
1.008MetHis: 1.008 ± 0.598
2.52MetIle: 2.52 ± 0.92
2.771MetLys: 2.771 ± 0.938
2.771MetLeu: 2.771 ± 1.853
1.764MetMet: 1.764 ± 0.889
1.26MetAsn: 1.26 ± 0.865
1.26MetPro: 1.26 ± 0.822
1.512MetGln: 1.512 ± 0.536
0.756MetArg: 0.756 ± 0.224
2.771MetSer: 2.771 ± 0.815
2.771MetThr: 2.771 ± 0.377
1.26MetVal: 1.26 ± 0.857
0.0MetTrp: 0.0 ± 0.0
0.252MetTyr: 0.252 ± 0.171
0.0MetXaa: 0.0 ± 0.0
Asn
2.268AsnAla: 2.268 ± 1.271
0.756AsnCys: 0.756 ± 0.73
3.275AsnAsp: 3.275 ± 0.322
1.764AsnGlu: 1.764 ± 0.424
3.023AsnPhe: 3.023 ± 1.192
1.512AsnGly: 1.512 ± 0.448
0.756AsnHis: 0.756 ± 0.374
2.268AsnIle: 2.268 ± 0.889
3.527AsnLys: 3.527 ± 0.311
4.787AsnLeu: 4.787 ± 1.447
1.26AsnMet: 1.26 ± 0.52
1.008AsnAsn: 1.008 ± 0.577
3.275AsnPro: 3.275 ± 0.699
1.26AsnGln: 1.26 ± 0.525
3.527AsnArg: 3.527 ± 0.834
2.52AsnSer: 2.52 ± 0.661
1.26AsnThr: 1.26 ± 0.851
1.26AsnVal: 1.26 ± 0.427
0.504AsnTrp: 0.504 ± 0.343
1.764AsnTyr: 1.764 ± 0.999
0.0AsnXaa: 0.0 ± 0.0
Pro
1.764ProAla: 1.764 ± 0.929
0.252ProCys: 0.252 ± 0.745
2.016ProAsp: 2.016 ± 0.731
3.527ProGlu: 3.527 ± 1.717
1.26ProPhe: 1.26 ± 0.52
2.52ProGly: 2.52 ± 1.041
0.504ProHis: 0.504 ± 0.487
2.52ProIle: 2.52 ± 1.435
1.512ProLys: 1.512 ± 0.475
5.291ProLeu: 5.291 ± 2.27
1.512ProMet: 1.512 ± 1.032
1.512ProAsn: 1.512 ± 0.866
0.756ProPro: 0.756 ± 0.374
1.26ProGln: 1.26 ± 0.427
2.268ProArg: 2.268 ± 0.682
4.535ProSer: 4.535 ± 1.094
1.26ProThr: 1.26 ± 0.857
2.52ProVal: 2.52 ± 1.497
1.26ProTrp: 1.26 ± 0.546
1.512ProTyr: 1.512 ± 0.691
0.0ProXaa: 0.0 ± 0.0
Gln
1.26GlnAla: 1.26 ± 1.033
1.764GlnCys: 1.764 ± 0.46
2.268GlnAsp: 2.268 ± 1.461
3.275GlnGlu: 3.275 ± 0.797
1.008GlnPhe: 1.008 ± 0.521
2.771GlnGly: 2.771 ± 0.549
1.008GlnHis: 1.008 ± 0.686
4.031GlnIle: 4.031 ± 0.67
2.268GlnLys: 2.268 ± 0.642
1.008GlnLeu: 1.008 ± 0.318
1.008GlnMet: 1.008 ± 0.598
0.756GlnAsn: 0.756 ± 0.224
1.512GlnPro: 1.512 ± 0.852
0.504GlnGln: 0.504 ± 0.343
1.512GlnArg: 1.512 ± 0.891
4.283GlnSer: 4.283 ± 1.974
1.008GlnThr: 1.008 ± 0.366
1.26GlnVal: 1.26 ± 1.314
0.504GlnTrp: 0.504 ± 0.727
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
3.275ArgAla: 3.275 ± 1.054
0.756ArgCys: 0.756 ± 0.73
2.771ArgAsp: 2.771 ± 0.946
3.779ArgGlu: 3.779 ± 0.735
1.008ArgPhe: 1.008 ± 0.577
2.771ArgGly: 2.771 ± 0.798
0.756ArgHis: 0.756 ± 0.73
4.283ArgIle: 4.283 ± 1.107
2.016ArgLys: 2.016 ± 0.564
3.779ArgLeu: 3.779 ± 0.79
2.016ArgMet: 2.016 ± 0.804
2.268ArgAsn: 2.268 ± 1.202
2.016ArgPro: 2.016 ± 0.517
1.26ArgGln: 1.26 ± 0.525
1.764ArgArg: 1.764 ± 0.424
6.551ArgSer: 6.551 ± 0.529
3.527ArgThr: 3.527 ± 1.163
5.039ArgVal: 5.039 ± 1.15
0.504ArgTrp: 0.504 ± 0.343
2.016ArgTyr: 2.016 ± 0.507
0.0ArgXaa: 0.0 ± 0.0
Ser
5.795SerAla: 5.795 ± 0.983
2.52SerCys: 2.52 ± 2.063
6.803SerAsp: 6.803 ± 1.616
7.559SerGlu: 7.559 ± 1.216
3.779SerPhe: 3.779 ± 1.588
6.551SerGly: 6.551 ± 1.353
2.52SerHis: 2.52 ± 0.402
7.055SerIle: 7.055 ± 3.553
7.307SerLys: 7.307 ± 0.483
8.314SerLeu: 8.314 ± 1.182
3.275SerMet: 3.275 ± 0.519
3.275SerAsn: 3.275 ± 0.91
5.291SerPro: 5.291 ± 0.409
3.527SerGln: 3.527 ± 1.041
3.779SerArg: 3.779 ± 0.981
11.338SerSer: 11.338 ± 2.147
5.291SerThr: 5.291 ± 0.883
4.535SerVal: 4.535 ± 1.527
1.764SerTrp: 1.764 ± 1.424
1.764SerTyr: 1.764 ± 0.858
0.0SerXaa: 0.0 ± 0.0
Thr
1.008ThrAla: 1.008 ± 0.686
1.764ThrCys: 1.764 ± 0.476
3.023ThrAsp: 3.023 ± 0.839
3.779ThrGlu: 3.779 ± 1.046
2.771ThrPhe: 2.771 ± 1.52
3.023ThrGly: 3.023 ± 1.542
0.756ThrHis: 0.756 ± 0.511
2.771ThrIle: 2.771 ± 0.938
3.023ThrLys: 3.023 ± 0.669
7.307ThrLeu: 7.307 ± 0.766
1.26ThrMet: 1.26 ± 0.759
3.023ThrAsn: 3.023 ± 0.95
0.504ThrPro: 0.504 ± 0.159
2.52ThrGln: 2.52 ± 1.008
2.52ThrArg: 2.52 ± 0.593
4.535ThrSer: 4.535 ± 0.724
1.764ThrThr: 1.764 ± 0.982
2.771ThrVal: 2.771 ± 0.549
0.504ThrTrp: 0.504 ± 0.159
1.008ThrTyr: 1.008 ± 1.454
0.0ThrXaa: 0.0 ± 0.0
Val
2.268ValAla: 2.268 ± 1.271
1.512ValCys: 1.512 ± 0.477
3.023ValAsp: 3.023 ± 0.839
2.52ValGlu: 2.52 ± 0.855
3.527ValPhe: 3.527 ± 2.436
2.268ValGly: 2.268 ± 0.672
2.016ValHis: 2.016 ± 0.564
2.771ValIle: 2.771 ± 0.549
3.527ValLys: 3.527 ± 1.041
4.031ValLeu: 4.031 ± 1.297
1.512ValMet: 1.512 ± 1.028
1.764ValAsn: 1.764 ± 0.424
1.26ValPro: 1.26 ± 0.851
2.771ValGln: 2.771 ± 0.914
4.535ValArg: 4.535 ± 0.963
6.551ValSer: 6.551 ± 1.695
2.52ValThr: 2.52 ± 0.524
3.527ValVal: 3.527 ± 1.666
0.252ValTrp: 0.252 ± 0.171
2.016ValTyr: 2.016 ± 1.236
0.0ValXaa: 0.0 ± 0.0
Trp
0.252TrpAla: 0.252 ± 0.243
0.252TrpCys: 0.252 ± 0.171
0.252TrpAsp: 0.252 ± 0.171
0.504TrpGlu: 0.504 ± 0.159
0.504TrpPhe: 0.504 ± 0.343
1.008TrpGly: 1.008 ± 0.577
0.252TrpHis: 0.252 ± 0.171
0.504TrpIle: 0.504 ± 0.343
0.756TrpLys: 0.756 ± 0.511
0.756TrpLeu: 0.756 ± 0.224
0.252TrpMet: 0.252 ± 0.171
0.252TrpAsn: 0.252 ± 0.171
1.008TrpPro: 1.008 ± 0.655
0.0TrpGln: 0.0 ± 0.0
0.504TrpArg: 0.504 ± 0.159
1.26TrpSer: 1.26 ± 0.569
1.512TrpThr: 1.512 ± 0.39
1.008TrpVal: 1.008 ± 0.824
0.252TrpTrp: 0.252 ± 0.171
0.252TrpTyr: 0.252 ± 0.171
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.016TyrAla: 2.016 ± 0.636
1.008TyrCys: 1.008 ± 1.374
2.268TyrAsp: 2.268 ± 1.955
1.764TyrGlu: 1.764 ± 0.493
1.26TyrPhe: 1.26 ± 0.525
1.764TyrGly: 1.764 ± 0.661
0.756TyrHis: 0.756 ± 0.224
1.764TyrIle: 1.764 ± 0.582
3.023TyrLys: 3.023 ± 1.012
2.52TyrLeu: 2.52 ± 0.802
1.512TyrMet: 1.512 ± 1.396
1.764TyrAsn: 1.764 ± 0.46
1.26TyrPro: 1.26 ± 0.822
0.756TyrGln: 0.756 ± 0.99
0.756TyrArg: 0.756 ± 0.511
2.016TyrSer: 2.016 ± 0.599
0.756TyrThr: 0.756 ± 0.224
1.26TyrVal: 1.26 ± 0.809
0.252TyrTrp: 0.252 ± 0.243
0.756TyrTyr: 0.756 ± 0.224
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.252XaaLeu: 0.252 ± 0.243
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3970 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski