Amino acid dipepetide frequency for Clunio marinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.478AlaAla: 3.478 ± 0.032	0.952AlaCys: 0.952 ± 0.015	2.476AlaAsp: 2.476 ± 0.019	3.174AlaGlu: 3.174 ± 0.026	2.423AlaPhe: 2.423 ± 0.02	2.428AlaGly: 2.428 ± 0.023	1.114AlaHis: 1.114 ± 0.012	3.535AlaIle: 3.535 ± 0.024	3.384AlaLys: 3.384 ± 0.023	4.834AlaLeu: 4.834 ± 0.035	1.362AlaMet: 1.362 ± 0.014	2.721AlaAsn: 2.721 ± 0.02	2.132AlaPro: 2.132 ± 0.027	2.026AlaGln: 2.026 ± 0.021	2.244AlaArg: 2.244 ± 0.019	4.223AlaSer: 4.223 ± 0.024	3.064AlaThr: 3.064 ± 0.022	3.071AlaVal: 3.071 ± 0.021	0.437AlaTrp: 0.437 ± 0.009	1.47AlaTyr: 1.47 ± 0.015	0.0AlaXaa: 0.0 ± 0.0
Cys	0.912CysAla: 0.912 ± 0.014	0.553CysCys: 0.553 ± 0.012	1.251CysAsp: 1.251 ± 0.019	1.34CysGlu: 1.34 ± 0.018	1.025CysPhe: 1.025 ± 0.014	1.261CysGly: 1.261 ± 0.027	0.538CysHis: 0.538 ± 0.009	1.164CysIle: 1.164 ± 0.02	1.225CysLys: 1.225 ± 0.018	1.863CysLeu: 1.863 ± 0.023	0.418CysMet: 0.418 ± 0.008	1.05CysAsn: 1.05 ± 0.018	0.915CysPro: 0.915 ± 0.024	0.743CysGln: 0.743 ± 0.016	1.007CysArg: 1.007 ± 0.019	1.634CysSer: 1.634 ± 0.029	0.895CysThr: 0.895 ± 0.014	1.166CysVal: 1.166 ± 0.018	0.219CysTrp: 0.219 ± 0.007	0.64CysTyr: 0.64 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	2.532AspAla: 2.532 ± 0.023	1.025AspCys: 1.025 ± 0.015	4.418AspAsp: 4.418 ± 0.038	4.913AspGlu: 4.913 ± 0.037	2.753AspPhe: 2.753 ± 0.02	2.869AspGly: 2.869 ± 0.025	1.162AspHis: 1.162 ± 0.013	3.601AspIle: 3.601 ± 0.024	3.36AspLys: 3.36 ± 0.022	4.824AspLeu: 4.824 ± 0.031	1.186AspMet: 1.186 ± 0.012	2.998AspAsn: 2.998 ± 0.023	2.166AspPro: 2.166 ± 0.029	1.806AspGln: 1.806 ± 0.017	2.194AspArg: 2.194 ± 0.02	4.13AspSer: 4.13 ± 0.033	2.309AspThr: 2.309 ± 0.019	3.348AspVal: 3.348 ± 0.021	0.536AspTrp: 0.536 ± 0.01	1.861AspTyr: 1.861 ± 0.016	0.001AspXaa: 0.001 ± 0.0
Glu	3.522GluAla: 3.522 ± 0.033	1.254GluCys: 1.254 ± 0.026	3.741GluAsp: 3.741 ± 0.027	5.529GluGlu: 5.529 ± 0.055	2.744GluPhe: 2.744 ± 0.019	2.542GluGly: 2.542 ± 0.02	1.392GluHis: 1.392 ± 0.015	5.22GluIle: 5.22 ± 0.03	6.213GluLys: 6.213 ± 0.037	5.67GluLeu: 5.67 ± 0.037	1.952GluMet: 1.952 ± 0.019	4.946GluAsn: 4.946 ± 0.027	2.125GluPro: 2.125 ± 0.024	2.495GluGln: 2.495 ± 0.023	3.354GluArg: 3.354 ± 0.027	5.005GluSer: 5.005 ± 0.034	3.976GluThr: 3.976 ± 0.037	3.668GluVal: 3.668 ± 0.03	0.605GluTrp: 0.605 ± 0.011	1.87GluTyr: 1.87 ± 0.018	0.001GluXaa: 0.001 ± 0.0
Phe	2.231PheAla: 2.231 ± 0.019	1.048PheCys: 1.048 ± 0.014	2.684PheAsp: 2.684 ± 0.021	2.868PheGlu: 2.868 ± 0.019	2.247PhePhe: 2.247 ± 0.023	2.45PheGly: 2.45 ± 0.021	1.292PheHis: 1.292 ± 0.013	3.267PheIle: 3.267 ± 0.028	3.053PheLys: 3.053 ± 0.021	4.427PheLeu: 4.427 ± 0.036	1.222PheMet: 1.222 ± 0.013	2.836PheAsn: 2.836 ± 0.024	1.871PhePro: 1.871 ± 0.016	1.786PheGln: 1.786 ± 0.017	2.044PheArg: 2.044 ± 0.02	3.768PheSer: 3.768 ± 0.027	2.469PheThr: 2.469 ± 0.019	2.807PheVal: 2.807 ± 0.024	0.488PheTrp: 0.488 ± 0.008	1.762PheTyr: 1.762 ± 0.02	0.001PheXaa: 0.001 ± 0.0
Gly	2.375GlyAla: 2.375 ± 0.022	0.9GlyCys: 0.9 ± 0.016	2.503GlyAsp: 2.503 ± 0.028	2.735GlyGlu: 2.735 ± 0.026	2.384GlyPhe: 2.384 ± 0.02	3.25GlyGly: 3.25 ± 0.05	1.141GlyHis: 1.141 ± 0.017	3.178GlyIle: 3.178 ± 0.025	3.428GlyLys: 3.428 ± 0.024	3.868GlyLeu: 3.868 ± 0.031	1.156GlyMet: 1.156 ± 0.014	2.843GlyAsn: 2.843 ± 0.027	1.587GlyPro: 1.587 ± 0.026	1.637GlyGln: 1.637 ± 0.018	2.291GlyArg: 2.291 ± 0.019	4.053GlySer: 4.053 ± 0.037	2.538GlyThr: 2.538 ± 0.019	2.694GlyVal: 2.694 ± 0.021	0.562GlyTrp: 0.562 ± 0.009	1.646GlyTyr: 1.646 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.078HisAla: 1.078 ± 0.013	0.555HisCys: 0.555 ± 0.009	1.204HisAsp: 1.204 ± 0.014	1.587HisGlu: 1.587 ± 0.015	1.249HisPhe: 1.249 ± 0.013	1.157HisGly: 1.157 ± 0.014	1.174HisHis: 1.174 ± 0.02	1.516HisIle: 1.516 ± 0.015	1.629HisLys: 1.629 ± 0.016	2.444HisLeu: 2.444 ± 0.02	0.637HisMet: 0.637 ± 0.01	1.33HisAsn: 1.33 ± 0.013	1.169HisPro: 1.169 ± 0.013	1.439HisGln: 1.439 ± 0.017	1.253HisArg: 1.253 ± 0.014	2.033HisSer: 2.033 ± 0.017	1.058HisThr: 1.058 ± 0.013	1.341HisVal: 1.341 ± 0.013	0.245HisTrp: 0.245 ± 0.006	0.847HisTyr: 0.847 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.542IleAla: 3.542 ± 0.028	1.48IleCys: 1.48 ± 0.025	3.888IleAsp: 3.888 ± 0.027	4.64IleGlu: 4.64 ± 0.034	3.336IlePhe: 3.336 ± 0.029	2.958IleGly: 2.958 ± 0.026	1.662IleHis: 1.662 ± 0.015	4.577IleIle: 4.577 ± 0.031	4.907IleLys: 4.907 ± 0.032	5.953IleLeu: 5.953 ± 0.037	1.509IleMet: 1.509 ± 0.016	4.107IleAsn: 4.107 ± 0.027	2.988IlePro: 2.988 ± 0.022	2.768IleGln: 2.768 ± 0.023	2.982IleArg: 2.982 ± 0.022	5.519IleSer: 5.519 ± 0.032	3.65IleThr: 3.65 ± 0.026	3.932IleVal: 3.932 ± 0.029	0.586IleTrp: 0.586 ± 0.011	2.173IleTyr: 2.173 ± 0.022	0.001IleXaa: 0.001 ± 0.0
Lys	3.627LysAla: 3.627 ± 0.023	1.518LysCys: 1.518 ± 0.024	3.591LysAsp: 3.591 ± 0.026	5.129LysGlu: 5.129 ± 0.034	3.338LysPhe: 3.338 ± 0.021	2.596LysGly: 2.596 ± 0.027	1.852LysHis: 1.852 ± 0.017	5.429LysIle: 5.429 ± 0.031	6.707LysLys: 6.707 ± 0.053	6.863LysLeu: 6.863 ± 0.044	1.93LysMet: 1.93 ± 0.017	4.621LysAsn: 4.621 ± 0.025	2.914LysPro: 2.914 ± 0.031	2.981LysGln: 2.981 ± 0.023	3.966LysArg: 3.966 ± 0.028	6.044LysSer: 6.044 ± 0.039	4.302LysThr: 4.302 ± 0.028	3.943LysVal: 3.943 ± 0.024	0.707LysTrp: 0.707 ± 0.011	2.327LysTyr: 2.327 ± 0.022	0.002LysXaa: 0.002 ± 0.0
Leu	4.602LeuAla: 4.602 ± 0.029	1.798LeuCys: 1.798 ± 0.018	4.393LeuAsp: 4.393 ± 0.028	5.907LeuGlu: 5.907 ± 0.051	3.873LeuPhe: 3.873 ± 0.031	3.782LeuGly: 3.782 ± 0.027	2.229LeuHis: 2.229 ± 0.02	5.799LeuIle: 5.799 ± 0.035	7.455LeuLys: 7.455 ± 0.043	8.401LeuLeu: 8.401 ± 0.046	2.426LeuMet: 2.426 ± 0.018	5.703LeuAsn: 5.703 ± 0.031	4.091LeuPro: 4.091 ± 0.028	4.14LeuGln: 4.14 ± 0.029	4.646LeuArg: 4.646 ± 0.034	7.473LeuSer: 7.473 ± 0.042	5.093LeuThr: 5.093 ± 0.029	4.562LeuVal: 4.562 ± 0.025	0.863LeuTrp: 0.863 ± 0.011	2.461LeuTyr: 2.461 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	1.291MetAla: 1.291 ± 0.014	0.421MetCys: 0.421 ± 0.008	1.203MetAsp: 1.203 ± 0.013	1.771MetGlu: 1.771 ± 0.018	1.146MetPhe: 1.146 ± 0.014	1.057MetGly: 1.057 ± 0.014	0.496MetHis: 0.496 ± 0.008	1.633MetIle: 1.633 ± 0.014	2.493MetLys: 2.493 ± 0.02	2.207MetLeu: 2.207 ± 0.021	0.83MetMet: 0.83 ± 0.012	1.651MetAsn: 1.651 ± 0.014	1.01MetPro: 1.01 ± 0.013	0.973MetGln: 0.973 ± 0.013	1.221MetArg: 1.221 ± 0.013	2.093MetSer: 2.093 ± 0.018	1.502MetThr: 1.502 ± 0.016	1.095MetVal: 1.095 ± 0.012	0.232MetTrp: 0.232 ± 0.005	0.633MetTyr: 0.633 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.853AsnAla: 2.853 ± 0.028	1.188AsnCys: 1.188 ± 0.016	3.619AsnAsp: 3.619 ± 0.023	4.549AsnGlu: 4.549 ± 0.026	3.121AsnPhe: 3.121 ± 0.028	3.273AsnGly: 3.273 ± 0.028	1.552AsnHis: 1.552 ± 0.015	4.315AsnIle: 4.315 ± 0.029	3.945AsnLys: 3.945 ± 0.024	5.684AsnLeu: 5.684 ± 0.036	1.376AsnMet: 1.376 ± 0.017	4.613AsnAsn: 4.613 ± 0.051	2.434AsnPro: 2.434 ± 0.026	2.723AsnGln: 2.723 ± 0.027	2.663AsnArg: 2.663 ± 0.022	5.139AsnSer: 5.139 ± 0.036	2.693AsnThr: 2.693 ± 0.018	3.758AsnVal: 3.758 ± 0.025	0.527AsnTrp: 0.527 ± 0.01	2.096AsnTyr: 2.096 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	2.159ProAla: 2.159 ± 0.026	0.693ProCys: 0.693 ± 0.027	2.103ProAsp: 2.103 ± 0.02	2.901ProGlu: 2.901 ± 0.025	1.857ProPhe: 1.857 ± 0.02	1.948ProGly: 1.948 ± 0.032	0.977ProHis: 0.977 ± 0.012	2.747ProIle: 2.747 ± 0.024	3.011ProLys: 3.011 ± 0.024	3.536ProLeu: 3.536 ± 0.025	0.979ProMet: 0.979 ± 0.016	2.491ProAsn: 2.491 ± 0.024	3.08ProPro: 3.08 ± 0.049	2.048ProGln: 2.048 ± 0.025	1.851ProArg: 1.851 ± 0.026	4.058ProSer: 4.058 ± 0.034	2.887ProThr: 2.887 ± 0.033	2.352ProVal: 2.352 ± 0.024	0.377ProTrp: 0.377 ± 0.008	1.281ProTyr: 1.281 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	2.09GlnAla: 2.09 ± 0.02	0.775GlnCys: 0.775 ± 0.016	1.662GlnAsp: 1.662 ± 0.018	2.6GlnGlu: 2.6 ± 0.024	1.736GlnPhe: 1.736 ± 0.018	1.542GlnGly: 1.542 ± 0.016	1.343GlnHis: 1.343 ± 0.017	2.809GlnIle: 2.809 ± 0.022	3.191GlnLys: 3.191 ± 0.024	3.867GlnLeu: 3.867 ± 0.027	1.221GlnMet: 1.221 ± 0.016	2.795GlnAsn: 2.795 ± 0.026	1.953GlnPro: 1.953 ± 0.025	3.662GlnGln: 3.662 ± 0.069	2.269GlnArg: 2.269 ± 0.024	3.439GlnSer: 3.439 ± 0.026	2.464GlnThr: 2.464 ± 0.022	1.995GlnVal: 1.995 ± 0.018	0.393GlnTrp: 0.393 ± 0.008	1.19GlnTyr: 1.19 ± 0.019	0.001GlnXaa: 0.001 ± 0.0
Arg	2.195ArgAla: 2.195 ± 0.021	0.925ArgCys: 0.925 ± 0.016	2.523ArgAsp: 2.523 ± 0.025	3.12ArgGlu: 3.12 ± 0.026	2.167ArgPhe: 2.167 ± 0.019	2.103ArgGly: 2.103 ± 0.024	1.299ArgHis: 1.299 ± 0.013	3.059ArgIle: 3.059 ± 0.019	4.146ArgLys: 4.146 ± 0.031	4.152ArgLeu: 4.152 ± 0.03	1.172ArgMet: 1.172 ± 0.012	3.19ArgAsn: 3.19 ± 0.022	1.94ArgPro: 1.94 ± 0.028	2.108ArgGln: 2.108 ± 0.019	3.183ArgArg: 3.183 ± 0.027	3.73ArgSer: 3.73 ± 0.036	2.373ArgThr: 2.373 ± 0.019	2.437ArgVal: 2.437 ± 0.02	0.469ArgTrp: 0.469 ± 0.008	1.52ArgTyr: 1.52 ± 0.016	0.001ArgXaa: 0.001 ± 0.0
Ser	4.024SerAla: 4.024 ± 0.029	1.574SerCys: 1.574 ± 0.026	4.597SerAsp: 4.597 ± 0.037	5.18SerGlu: 5.18 ± 0.035	3.92SerPhe: 3.92 ± 0.025	4.265SerGly: 4.265 ± 0.026	2.064SerHis: 2.064 ± 0.018	5.219SerIle: 5.219 ± 0.031	5.462SerLys: 5.462 ± 0.032	7.444SerLeu: 7.444 ± 0.037	1.882SerMet: 1.882 ± 0.018	5.258SerAsn: 5.258 ± 0.039	4.029SerPro: 4.029 ± 0.038	3.479SerGln: 3.479 ± 0.025	3.807SerArg: 3.807 ± 0.035	9.884SerSer: 9.884 ± 0.099	5.289SerThr: 5.289 ± 0.031	4.385SerVal: 4.385 ± 0.026	0.743SerTrp: 0.743 ± 0.011	2.437SerTyr: 2.437 ± 0.022	0.001SerXaa: 0.001 ± 0.0
Thr	2.979ThrAla: 2.979 ± 0.023	1.096ThrCys: 1.096 ± 0.019	2.561ThrAsp: 2.561 ± 0.021	3.351ThrGlu: 3.351 ± 0.031	2.721ThrPhe: 2.721 ± 0.023	2.486ThrGly: 2.486 ± 0.025	1.246ThrHis: 1.246 ± 0.013	3.877ThrIle: 3.877 ± 0.025	3.896ThrLys: 3.896 ± 0.026	4.956ThrLeu: 4.956 ± 0.025	1.325ThrMet: 1.325 ± 0.012	3.327ThrAsn: 3.327 ± 0.024	2.936ThrPro: 2.936 ± 0.028	2.237ThrGln: 2.237 ± 0.023	2.341ThrArg: 2.341 ± 0.023	5.418ThrSer: 5.418 ± 0.034	4.433ThrThr: 4.433 ± 0.088	3.122ThrVal: 3.122 ± 0.025	0.486ThrTrp: 0.486 ± 0.01	1.549ThrTyr: 1.549 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	3.109ValAla: 3.109 ± 0.024	1.179ValCys: 1.179 ± 0.018	3.164ValAsp: 3.164 ± 0.025	3.86ValGlu: 3.86 ± 0.028	2.487ValPhe: 2.487 ± 0.02	2.64ValGly: 2.64 ± 0.023	1.308ValHis: 1.308 ± 0.015	3.722ValIle: 3.722 ± 0.028	4.125ValLys: 4.125 ± 0.026	4.861ValLeu: 4.861 ± 0.031	1.396ValMet: 1.396 ± 0.014	3.205ValAsn: 3.205 ± 0.023	2.408ValPro: 2.408 ± 0.021	2.163ValGln: 2.163 ± 0.018	2.387ValArg: 2.387 ± 0.02	4.209ValSer: 4.209 ± 0.024	3.376ValThr: 3.376 ± 0.026	3.527ValVal: 3.527 ± 0.025	0.549ValTrp: 0.549 ± 0.009	1.652ValTyr: 1.652 ± 0.018	0.001ValXaa: 0.001 ± 0.0
Trp	0.406TrpAla: 0.406 ± 0.009	0.187TrpCys: 0.187 ± 0.006	0.504TrpAsp: 0.504 ± 0.009	0.549TrpGlu: 0.549 ± 0.01	0.459TrpPhe: 0.459 ± 0.008	0.449TrpGly: 0.449 ± 0.009	0.233TrpHis: 0.233 ± 0.006	0.718TrpIle: 0.718 ± 0.011	0.776TrpLys: 0.776 ± 0.011	0.93TrpLeu: 0.93 ± 0.014	0.294TrpMet: 0.294 ± 0.007	0.67TrpAsn: 0.67 ± 0.01	0.314TrpPro: 0.314 ± 0.008	0.368TrpGln: 0.368 ± 0.007	0.539TrpArg: 0.539 ± 0.009	0.704TrpSer: 0.704 ± 0.011	0.493TrpThr: 0.493 ± 0.009	0.452TrpVal: 0.452 ± 0.008	0.154TrpTrp: 0.154 ± 0.006	0.306TrpTyr: 0.306 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.542TyrAla: 1.542 ± 0.017	0.697TyrCys: 0.697 ± 0.01	1.906TyrAsp: 1.906 ± 0.02	2.122TyrGlu: 2.122 ± 0.016	1.634TyrPhe: 1.634 ± 0.018	1.716TyrGly: 1.716 ± 0.02	0.871TyrHis: 0.871 ± 0.012	1.769TyrIle: 1.769 ± 0.018	1.977TyrLys: 1.977 ± 0.019	2.915TyrLeu: 2.915 ± 0.026	0.684TyrMet: 0.684 ± 0.01	1.766TyrAsn: 1.766 ± 0.016	1.271TyrPro: 1.271 ± 0.015	1.414TyrGln: 1.414 ± 0.016	1.571TyrArg: 1.571 ± 0.015	2.384TyrSer: 2.384 ± 0.021	1.481TyrThr: 1.481 ± 0.016	1.673TyrVal: 1.673 ± 0.019	0.327TyrTrp: 0.327 ± 0.007	1.162TyrTyr: 1.162 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.0

Statistics based on 22544 proteins (8391700 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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