Amino acid dipepetide frequency for Sphingorhabdus sp. GY_G

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.155AlaAla: 16.155 ± 0.188	1.049AlaCys: 1.049 ± 0.038	7.114AlaAsp: 7.114 ± 0.099	7.756AlaGlu: 7.756 ± 0.109	4.275AlaPhe: 4.275 ± 0.072	10.046AlaGly: 10.046 ± 0.118	2.202AlaHis: 2.202 ± 0.054	7.106AlaIle: 7.106 ± 0.09	5.275AlaLys: 5.275 ± 0.098	12.578AlaLeu: 12.578 ± 0.164	3.826AlaMet: 3.826 ± 0.068	3.743AlaAsn: 3.743 ± 0.063	5.305AlaPro: 5.305 ± 0.086	4.318AlaGln: 4.318 ± 0.065	7.562AlaArg: 7.562 ± 0.109	6.684AlaSer: 6.684 ± 0.099	6.209AlaThr: 6.209 ± 0.101	7.919AlaVal: 7.919 ± 0.096	1.379AlaTrp: 1.379 ± 0.039	2.523AlaTyr: 2.523 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.03CysAla: 1.03 ± 0.032	0.098CysCys: 0.098 ± 0.011	0.586CysAsp: 0.586 ± 0.025	0.442CysGlu: 0.442 ± 0.019	0.302CysPhe: 0.302 ± 0.017	0.908CysGly: 0.908 ± 0.032	0.194CysHis: 0.194 ± 0.015	0.438CysIle: 0.438 ± 0.023	0.27CysLys: 0.27 ± 0.017	0.728CysLeu: 0.728 ± 0.027	0.15CysMet: 0.15 ± 0.012	0.274CysAsn: 0.274 ± 0.017	0.452CysPro: 0.452 ± 0.022	0.234CysGln: 0.234 ± 0.017	0.534CysArg: 0.534 ± 0.025	0.504CysSer: 0.504 ± 0.025	0.434CysThr: 0.434 ± 0.021	0.528CysVal: 0.528 ± 0.022	0.13CysTrp: 0.13 ± 0.012	0.189CysTyr: 0.189 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.113AspAla: 7.113 ± 0.106	0.513AspCys: 0.513 ± 0.024	3.252AspAsp: 3.252 ± 0.079	3.593AspGlu: 3.593 ± 0.064	2.323AspPhe: 2.323 ± 0.05	5.575AspGly: 5.575 ± 0.126	1.128AspHis: 1.128 ± 0.037	3.236AspIle: 3.236 ± 0.062	2.198AspLys: 2.198 ± 0.053	5.318AspLeu: 5.318 ± 0.082	1.522AspMet: 1.522 ± 0.045	1.657AspAsn: 1.657 ± 0.047	3.326AspPro: 3.326 ± 0.063	1.708AspGln: 1.708 ± 0.041	4.156AspArg: 4.156 ± 0.07	2.782AspSer: 2.782 ± 0.052	2.565AspThr: 2.565 ± 0.059	3.929AspVal: 3.929 ± 0.068	1.094AspTrp: 1.094 ± 0.035	1.752AspTyr: 1.752 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	7.796GluAla: 7.796 ± 0.122	0.385GluCys: 0.385 ± 0.019	2.804GluAsp: 2.804 ± 0.058	3.198GluGlu: 3.198 ± 0.064	1.916GluPhe: 1.916 ± 0.042	4.566GluGly: 4.566 ± 0.068	1.172GluHis: 1.172 ± 0.031	3.448GluIle: 3.448 ± 0.071	2.705GluLys: 2.705 ± 0.058	5.414GluLeu: 5.414 ± 0.09	1.657GluMet: 1.657 ± 0.044	1.712GluAsn: 1.712 ± 0.042	2.486GluPro: 2.486 ± 0.051	2.225GluGln: 2.225 ± 0.044	4.559GluArg: 4.559 ± 0.076	2.634GluSer: 2.634 ± 0.058	3.193GluThr: 3.193 ± 0.057	3.646GluVal: 3.646 ± 0.061	0.817GluTrp: 0.817 ± 0.032	1.218GluTyr: 1.218 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.979PheAla: 4.979 ± 0.077	0.347PheCys: 0.347 ± 0.018	2.894PheAsp: 2.894 ± 0.054	2.301PheGlu: 2.301 ± 0.055	1.449PhePhe: 1.449 ± 0.043	3.877PheGly: 3.877 ± 0.069	0.708PheHis: 0.708 ± 0.029	1.71PheIle: 1.71 ± 0.044	1.153PheLys: 1.153 ± 0.035	3.286PheLeu: 3.286 ± 0.068	0.801PheMet: 0.801 ± 0.029	1.25PheAsn: 1.25 ± 0.041	1.552PhePro: 1.552 ± 0.044	0.944PheGln: 0.944 ± 0.033	2.118PheArg: 2.118 ± 0.045	2.168PheSer: 2.168 ± 0.052	2.017PheThr: 2.017 ± 0.059	2.76PheVal: 2.76 ± 0.052	0.623PheTrp: 0.623 ± 0.027	0.943PheTyr: 0.943 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	8.791GlyAla: 8.791 ± 0.12	0.851GlyCys: 0.851 ± 0.031	4.751GlyAsp: 4.751 ± 0.109	4.819GlyGlu: 4.819 ± 0.077	3.749GlyPhe: 3.749 ± 0.078	7.825GlyGly: 7.825 ± 0.146	1.751GlyHis: 1.751 ± 0.042	4.692GlyIle: 4.692 ± 0.075	4.211GlyLys: 4.211 ± 0.081	8.406GlyLeu: 8.406 ± 0.107	2.413GlyMet: 2.413 ± 0.055	2.656GlyAsn: 2.656 ± 0.082	3.312GlyPro: 3.312 ± 0.059	3.075GlyGln: 3.075 ± 0.049	5.37GlyArg: 5.37 ± 0.08	5.199GlySer: 5.199 ± 0.103	4.652GlyThr: 4.652 ± 0.126	5.87GlyVal: 5.87 ± 0.096	1.646GlyTrp: 1.646 ± 0.042	2.423GlyTyr: 2.423 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.082HisAla: 2.082 ± 0.048	0.214HisCys: 0.214 ± 0.014	1.117HisAsp: 1.117 ± 0.038	0.959HisGlu: 0.959 ± 0.034	0.935HisPhe: 0.935 ± 0.03	1.816HisGly: 1.816 ± 0.046	0.561HisHis: 0.561 ± 0.028	1.118HisIle: 1.118 ± 0.033	0.671HisLys: 0.671 ± 0.024	1.836HisLeu: 1.836 ± 0.05	0.502HisMet: 0.502 ± 0.024	0.519HisAsn: 0.519 ± 0.025	1.245HisPro: 1.245 ± 0.036	0.556HisGln: 0.556 ± 0.02	1.28HisArg: 1.28 ± 0.041	1.028HisSer: 1.028 ± 0.031	0.596HisThr: 0.596 ± 0.024	1.361HisVal: 1.361 ± 0.039	0.361HisTrp: 0.361 ± 0.019	0.606HisTyr: 0.606 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.771IleAla: 7.771 ± 0.095	0.505IleCys: 0.505 ± 0.019	3.957IleAsp: 3.957 ± 0.064	3.881IleGlu: 3.881 ± 0.074	1.926IlePhe: 1.926 ± 0.045	5.148IleGly: 5.148 ± 0.092	0.926IleHis: 0.926 ± 0.032	2.71IleIle: 2.71 ± 0.055	1.762IleLys: 1.762 ± 0.044	4.456IleLeu: 4.456 ± 0.066	1.081IleMet: 1.081 ± 0.031	1.656IleAsn: 1.656 ± 0.047	2.449IlePro: 2.449 ± 0.052	1.261IleGln: 1.261 ± 0.04	3.195IleArg: 3.195 ± 0.057	3.287IleSer: 3.287 ± 0.06	2.773IleThr: 2.773 ± 0.068	4.139IleVal: 4.139 ± 0.076	0.78IleTrp: 0.78 ± 0.029	1.169IleTyr: 1.169 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	5.323LysAla: 5.323 ± 0.095	0.269LysCys: 0.269 ± 0.018	1.954LysAsp: 1.954 ± 0.058	1.809LysGlu: 1.809 ± 0.052	1.151LysPhe: 1.151 ± 0.032	3.351LysGly: 3.351 ± 0.068	0.713LysHis: 0.713 ± 0.03	2.03LysIle: 2.03 ± 0.051	1.642LysLys: 1.642 ± 0.055	4.189LysLeu: 4.189 ± 0.074	1.077LysMet: 1.077 ± 0.035	1.023LysAsn: 1.023 ± 0.033	2.469LysPro: 2.469 ± 0.054	1.296LysGln: 1.296 ± 0.039	2.651LysArg: 2.651 ± 0.054	2.218LysSer: 2.218 ± 0.048	2.076LysThr: 2.076 ± 0.048	2.718LysVal: 2.718 ± 0.071	0.566LysTrp: 0.566 ± 0.025	0.819LysTyr: 0.819 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	12.808LeuAla: 12.808 ± 0.174	0.802LeuCys: 0.802 ± 0.028	5.744LeuAsp: 5.744 ± 0.076	4.94LeuGlu: 4.94 ± 0.087	3.888LeuPhe: 3.888 ± 0.068	7.934LeuGly: 7.934 ± 0.101	1.793LeuHis: 1.793 ± 0.048	4.991LeuIle: 4.991 ± 0.082	3.735LeuLys: 3.735 ± 0.069	9.305LeuLeu: 9.305 ± 0.157	2.261LeuMet: 2.261 ± 0.052	2.859LeuAsn: 2.859 ± 0.067	5.249LeuPro: 5.249 ± 0.083	2.778LeuGln: 2.778 ± 0.058	5.872LeuArg: 5.872 ± 0.088	6.203LeuSer: 6.203 ± 0.098	5.321LeuThr: 5.321 ± 0.082	6.928LeuVal: 6.928 ± 0.091	1.199LeuTrp: 1.199 ± 0.035	1.987LeuTyr: 1.987 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.425MetAla: 3.425 ± 0.065	0.186MetCys: 0.186 ± 0.014	1.163MetAsp: 1.163 ± 0.038	1.234MetGlu: 1.234 ± 0.04	0.716MetPhe: 0.716 ± 0.028	2.064MetGly: 2.064 ± 0.051	0.492MetHis: 0.492 ± 0.021	1.392MetIle: 1.392 ± 0.036	1.134MetLys: 1.134 ± 0.032	2.794MetLeu: 2.794 ± 0.06	0.701MetMet: 0.701 ± 0.027	0.769MetAsn: 0.769 ± 0.03	1.536MetPro: 1.536 ± 0.04	0.918MetGln: 0.918 ± 0.03	1.846MetArg: 1.846 ± 0.042	1.49MetSer: 1.49 ± 0.036	1.687MetThr: 1.687 ± 0.047	1.731MetVal: 1.731 ± 0.048	0.236MetTrp: 0.236 ± 0.017	0.309MetTyr: 0.309 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.616AsnAla: 3.616 ± 0.073	0.321AsnCys: 0.321 ± 0.019	1.686AsnAsp: 1.686 ± 0.062	1.433AsnGlu: 1.433 ± 0.039	1.223AsnPhe: 1.223 ± 0.038	2.935AsnGly: 2.935 ± 0.07	0.538AsnHis: 0.538 ± 0.023	1.65AsnIle: 1.65 ± 0.04	0.901AsnLys: 0.901 ± 0.033	2.742AsnLeu: 2.742 ± 0.056	0.718AsnMet: 0.718 ± 0.028	0.945AsnAsn: 0.945 ± 0.046	2.065AsnPro: 2.065 ± 0.044	0.937AsnGln: 0.937 ± 0.032	2.067AsnArg: 2.067 ± 0.041	1.738AsnSer: 1.738 ± 0.057	1.184AsnThr: 1.184 ± 0.045	2.108AsnVal: 2.108 ± 0.053	0.566AsnTrp: 0.566 ± 0.025	0.818AsnTyr: 0.818 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.826ProAla: 5.826 ± 0.094	0.317ProCys: 0.317 ± 0.016	3.622ProAsp: 3.622 ± 0.061	3.652ProGlu: 3.652 ± 0.068	1.924ProPhe: 1.924 ± 0.046	3.977ProGly: 3.977 ± 0.057	1.018ProHis: 1.018 ± 0.03	2.504ProIle: 2.504 ± 0.051	2.125ProLys: 2.125 ± 0.051	4.68ProLeu: 4.68 ± 0.08	1.179ProMet: 1.179 ± 0.036	1.459ProAsn: 1.459 ± 0.046	2.387ProPro: 2.387 ± 0.063	1.622ProGln: 1.622 ± 0.039	2.457ProArg: 2.457 ± 0.048	2.693ProSer: 2.693 ± 0.06	2.499ProThr: 2.499 ± 0.057	4.165ProVal: 4.165 ± 0.069	0.643ProTrp: 0.643 ± 0.027	1.143ProTyr: 1.143 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.731GlnAla: 3.731 ± 0.067	0.255GlnCys: 0.255 ± 0.016	1.388GlnAsp: 1.388 ± 0.035	1.439GlnGlu: 1.439 ± 0.041	1.228GlnPhe: 1.228 ± 0.031	2.516GlnGly: 2.516 ± 0.05	0.644GlnHis: 0.644 ± 0.024	2.1GlnIle: 2.1 ± 0.045	1.252GlnLys: 1.252 ± 0.034	3.386GlnLeu: 3.386 ± 0.065	0.928GlnMet: 0.928 ± 0.031	0.936GlnAsn: 0.936 ± 0.037	1.825GlnPro: 1.825 ± 0.048	1.26GlnGln: 1.26 ± 0.043	2.331GlnArg: 2.331 ± 0.054	2.01GlnSer: 2.01 ± 0.045	1.681GlnThr: 1.681 ± 0.044	2.16GlnVal: 2.16 ± 0.047	0.445GlnTrp: 0.445 ± 0.023	0.701GlnTyr: 0.701 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.873ArgAla: 6.873 ± 0.105	0.495ArgCys: 0.495 ± 0.023	3.766ArgAsp: 3.766 ± 0.068	3.81ArgGlu: 3.81 ± 0.063	2.899ArgPhe: 2.899 ± 0.055	4.299ArgGly: 4.299 ± 0.08	1.423ArgHis: 1.423 ± 0.041	4.048ArgIle: 4.048 ± 0.07	2.618ArgLys: 2.618 ± 0.045	6.919ArgLeu: 6.919 ± 0.097	1.848ArgMet: 1.848 ± 0.047	2.067ArgAsn: 2.067 ± 0.045	2.961ArgPro: 2.961 ± 0.056	2.304ArgGln: 2.304 ± 0.052	4.205ArgArg: 4.205 ± 0.085	3.499ArgSer: 3.499 ± 0.065	3.148ArgThr: 3.148 ± 0.053	4.048ArgVal: 4.048 ± 0.065	1.055ArgTrp: 1.055 ± 0.037	1.758ArgTyr: 1.758 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.74SerAla: 6.74 ± 0.095	0.494SerCys: 0.494 ± 0.024	3.479SerAsp: 3.479 ± 0.068	3.167SerGlu: 3.167 ± 0.061	2.381SerPhe: 2.381 ± 0.056	5.814SerGly: 5.814 ± 0.106	0.986SerHis: 0.986 ± 0.03	3.112SerIle: 3.112 ± 0.061	2.078SerLys: 2.078 ± 0.049	5.307SerLeu: 5.307 ± 0.082	1.386SerMet: 1.386 ± 0.036	1.829SerAsn: 1.829 ± 0.054	2.742SerPro: 2.742 ± 0.055	1.719SerGln: 1.719 ± 0.039	3.361SerArg: 3.361 ± 0.07	3.112SerSer: 3.112 ± 0.067	2.849SerThr: 2.849 ± 0.066	3.982SerVal: 3.982 ± 0.063	0.857SerTrp: 0.857 ± 0.032	1.446SerTyr: 1.446 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.161ThrAla: 6.161 ± 0.105	0.401ThrCys: 0.401 ± 0.024	2.926ThrAsp: 2.926 ± 0.065	2.607ThrGlu: 2.607 ± 0.055	1.775ThrPhe: 1.775 ± 0.045	5.298ThrGly: 5.298 ± 0.106	0.949ThrHis: 0.949 ± 0.033	3.124ThrIle: 3.124 ± 0.067	1.718ThrLys: 1.718 ± 0.046	5.303ThrLeu: 5.303 ± 0.09	1.219ThrMet: 1.219 ± 0.038	1.523ThrAsn: 1.523 ± 0.047	3.163ThrPro: 3.163 ± 0.061	1.544ThrGln: 1.544 ± 0.044	2.854ThrArg: 2.854 ± 0.051	2.921ThrSer: 2.921 ± 0.072	2.662ThrThr: 2.662 ± 0.079	3.821ThrVal: 3.821 ± 0.101	0.53ThrTrp: 0.53 ± 0.025	1.169ThrTyr: 1.169 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.821ValAla: 8.821 ± 0.118	0.537ValCys: 0.537 ± 0.025	4.275ValAsp: 4.275 ± 0.065	4.632ValGlu: 4.632 ± 0.07	2.192ValPhe: 2.192 ± 0.047	5.298ValGly: 5.298 ± 0.081	1.316ValHis: 1.316 ± 0.044	3.717ValIle: 3.717 ± 0.072	2.563ValLys: 2.563 ± 0.058	5.976ValLeu: 5.976 ± 0.078	1.636ValMet: 1.636 ± 0.047	2.121ValAsn: 2.121 ± 0.059	3.611ValPro: 3.611 ± 0.065	2.1ValGln: 2.1 ± 0.053	4.566ValArg: 4.566 ± 0.072	4.31ValSer: 4.31 ± 0.067	4.246ValThr: 4.246 ± 0.096	4.948ValVal: 4.948 ± 0.085	0.873ValTrp: 0.873 ± 0.034	1.438ValTyr: 1.438 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.349TrpAla: 1.349 ± 0.044	0.127TrpCys: 0.127 ± 0.011	0.709TrpAsp: 0.709 ± 0.027	0.675TrpGlu: 0.675 ± 0.027	0.623TrpPhe: 0.623 ± 0.027	1.0TrpGly: 1.0 ± 0.032	0.355TrpHis: 0.355 ± 0.02	0.695TrpIle: 0.695 ± 0.03	0.594TrpLys: 0.594 ± 0.028	1.759TrpLeu: 1.759 ± 0.056	0.422TrpMet: 0.422 ± 0.021	0.491TrpAsn: 0.491 ± 0.022	0.689TrpPro: 0.689 ± 0.034	0.668TrpGln: 0.668 ± 0.027	1.184TrpArg: 1.184 ± 0.038	0.93TrpSer: 0.93 ± 0.028	0.781TrpThr: 0.781 ± 0.027	0.881TrpVal: 0.881 ± 0.029	0.255TrpTrp: 0.255 ± 0.017	0.312TrpTyr: 0.312 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.636TyrAla: 2.636 ± 0.047	0.263TyrCys: 0.263 ± 0.017	1.552TyrAsp: 1.552 ± 0.045	1.206TyrGlu: 1.206 ± 0.028	1.004TyrPhe: 1.004 ± 0.029	2.213TyrGly: 2.213 ± 0.049	0.495TyrHis: 0.495 ± 0.024	1.009TyrIle: 1.009 ± 0.04	0.739TyrLys: 0.739 ± 0.031	2.213TyrLeu: 2.213 ± 0.047	0.496TyrMet: 0.496 ± 0.022	0.702TyrAsn: 0.702 ± 0.032	1.069TyrPro: 1.069 ± 0.034	0.747TyrGln: 0.747 ± 0.032	1.875TyrArg: 1.875 ± 0.048	1.432TyrSer: 1.432 ± 0.046	1.097TyrThr: 1.097 ± 0.053	1.533TyrVal: 1.533 ± 0.039	0.444TyrTrp: 0.444 ± 0.021	0.706TyrTyr: 0.706 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3125 proteins (992764 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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