Amino acid dipepetide frequency for Enterobacter cloacae S611

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.131AlaAla: 11.131 ± 0.124	1.117AlaCys: 1.117 ± 0.032	5.12AlaAsp: 5.12 ± 0.066	5.82AlaGlu: 5.82 ± 0.08	3.788AlaPhe: 3.788 ± 0.056	7.877AlaGly: 7.877 ± 0.104	2.017AlaHis: 2.017 ± 0.044	5.894AlaIle: 5.894 ± 0.079	3.838AlaLys: 3.838 ± 0.063	13.088AlaLeu: 13.088 ± 0.157	3.086AlaMet: 3.086 ± 0.055	3.118AlaAsn: 3.118 ± 0.051	3.984AlaPro: 3.984 ± 0.07	5.239AlaGln: 5.239 ± 0.079	6.092AlaArg: 6.092 ± 0.079	5.874AlaSer: 5.874 ± 0.075	4.98AlaThr: 4.98 ± 0.075	6.958AlaVal: 6.958 ± 0.085	1.787AlaTrp: 1.787 ± 0.04	1.969AlaTyr: 1.969 ± 0.039	0.002AlaXaa: 0.002 ± 0.001
Cys	1.061CysAla: 1.061 ± 0.036	0.163CysCys: 0.163 ± 0.013	0.628CysAsp: 0.628 ± 0.024	0.58CysGlu: 0.58 ± 0.023	0.411CysPhe: 0.411 ± 0.02	1.004CysGly: 1.004 ± 0.03	0.32CysHis: 0.32 ± 0.016	0.507CysIle: 0.507 ± 0.021	0.301CysLys: 0.301 ± 0.014	0.991CysLeu: 0.991 ± 0.029	0.222CysMet: 0.222 ± 0.015	0.303CysAsn: 0.303 ± 0.016	0.483CysPro: 0.483 ± 0.023	0.431CysGln: 0.431 ± 0.02	0.608CysArg: 0.608 ± 0.023	0.597CysSer: 0.597 ± 0.022	0.45CysThr: 0.45 ± 0.021	0.718CysVal: 0.718 ± 0.025	0.205CysTrp: 0.205 ± 0.013	0.304CysTyr: 0.304 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.522AspAla: 5.522 ± 0.073	0.48AspCys: 0.48 ± 0.02	2.809AspAsp: 2.809 ± 0.052	3.871AspGlu: 3.871 ± 0.08	2.088AspPhe: 2.088 ± 0.044	3.729AspGly: 3.729 ± 0.077	0.997AspHis: 0.997 ± 0.029	3.237AspIle: 3.237 ± 0.051	2.442AspLys: 2.442 ± 0.047	4.791AspLeu: 4.791 ± 0.072	1.251AspMet: 1.251 ± 0.036	2.163AspAsn: 2.163 ± 0.048	2.269AspPro: 2.269 ± 0.044	1.598AspGln: 1.598 ± 0.039	2.756AspArg: 2.756 ± 0.049	2.695AspSer: 2.695 ± 0.046	2.455AspThr: 2.455 ± 0.05	3.623AspVal: 3.623 ± 0.053	0.739AspTrp: 0.739 ± 0.026	1.783AspTyr: 1.783 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.809GluAla: 5.809 ± 0.082	0.472GluCys: 0.472 ± 0.021	2.227GluAsp: 2.227 ± 0.047	3.624GluGlu: 3.624 ± 0.068	1.803GluPhe: 1.803 ± 0.044	3.765GluGly: 3.765 ± 0.058	1.382GluHis: 1.382 ± 0.035	3.349GluIle: 3.349 ± 0.063	3.148GluLys: 3.148 ± 0.061	5.806GluLeu: 5.806 ± 0.085	1.861GluMet: 1.861 ± 0.039	2.286GluAsn: 2.286 ± 0.046	2.128GluPro: 2.128 ± 0.049	3.397GluGln: 3.397 ± 0.065	3.717GluArg: 3.717 ± 0.067	3.142GluSer: 3.142 ± 0.05	3.032GluThr: 3.032 ± 0.05	3.904GluVal: 3.904 ± 0.058	0.827GluTrp: 0.827 ± 0.027	1.394GluTyr: 1.394 ± 0.038	0.002GluXaa: 0.002 ± 0.001
Phe	4.054PheAla: 4.054 ± 0.063	0.508PheCys: 0.508 ± 0.021	2.362PheAsp: 2.362 ± 0.044	1.721PheGlu: 1.721 ± 0.038	1.664PhePhe: 1.664 ± 0.046	3.204PheGly: 3.204 ± 0.054	0.828PheHis: 0.828 ± 0.028	2.47PheIle: 2.47 ± 0.051	1.229PheLys: 1.229 ± 0.031	3.274PheLeu: 3.274 ± 0.059	0.975PheMet: 0.975 ± 0.026	1.727PheAsn: 1.727 ± 0.033	1.598PhePro: 1.598 ± 0.041	1.131PheGln: 1.131 ± 0.028	2.021PheArg: 2.021 ± 0.044	3.096PheSer: 3.096 ± 0.048	2.499PheThr: 2.499 ± 0.042	2.546PheVal: 2.546 ± 0.048	0.664PheTrp: 0.664 ± 0.026	1.211PheTyr: 1.211 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	6.487GlyAla: 6.487 ± 0.079	1.007GlyCys: 1.007 ± 0.031	3.826GlyAsp: 3.826 ± 0.063	4.8GlyGlu: 4.8 ± 0.069	3.392GlyPhe: 3.392 ± 0.059	5.428GlyGly: 5.428 ± 0.117	1.603GlyHis: 1.603 ± 0.035	4.709GlyIle: 4.709 ± 0.069	3.854GlyLys: 3.854 ± 0.068	7.657GlyLeu: 7.657 ± 0.089	2.268GlyMet: 2.268 ± 0.047	2.652GlyAsn: 2.652 ± 0.065	2.029GlyPro: 2.029 ± 0.036	2.943GlyGln: 2.943 ± 0.061	3.882GlyArg: 3.882 ± 0.057	4.211GlySer: 4.211 ± 0.073	3.687GlyThr: 3.687 ± 0.082	5.773GlyVal: 5.773 ± 0.072	1.32GlyTrp: 1.32 ± 0.032	2.51GlyTyr: 2.51 ± 0.052	0.002GlyXaa: 0.002 ± 0.002
His	2.12HisAla: 2.12 ± 0.039	0.331HisCys: 0.331 ± 0.017	1.228HisAsp: 1.228 ± 0.031	1.123HisGlu: 1.123 ± 0.032	1.148HisPhe: 1.148 ± 0.031	1.715HisGly: 1.715 ± 0.036	0.861HisHis: 0.861 ± 0.034	1.288HisIle: 1.288 ± 0.03	0.708HisLys: 0.708 ± 0.027	2.357HisLeu: 2.357 ± 0.041	0.531HisMet: 0.531 ± 0.021	0.847HisAsn: 0.847 ± 0.025	1.28HisPro: 1.28 ± 0.035	1.15HisGln: 1.15 ± 0.033	1.252HisArg: 1.252 ± 0.036	1.26HisSer: 1.26 ± 0.029	1.077HisThr: 1.077 ± 0.027	1.267HisVal: 1.267 ± 0.033	0.412HisTrp: 0.412 ± 0.018	0.959HisTyr: 0.959 ± 0.027	0.002HisXaa: 0.002 ± 0.001
Ile	6.609IleAla: 6.609 ± 0.071	0.656IleCys: 0.656 ± 0.027	3.516IleAsp: 3.516 ± 0.049	3.213IleGlu: 3.213 ± 0.064	1.998IlePhe: 1.998 ± 0.048	4.464IleGly: 4.464 ± 0.076	1.125IleHis: 1.125 ± 0.031	3.082IleIle: 3.082 ± 0.066	2.123IleLys: 2.123 ± 0.051	4.596IleLeu: 4.596 ± 0.067	1.129IleMet: 1.129 ± 0.027	2.617IleAsn: 2.617 ± 0.051	2.603IlePro: 2.603 ± 0.053	1.598IleGln: 1.598 ± 0.033	2.906IleArg: 2.906 ± 0.05	3.641IleSer: 3.641 ± 0.056	3.385IleThr: 3.385 ± 0.045	3.798IleVal: 3.798 ± 0.06	0.701IleTrp: 0.701 ± 0.028	1.493IleTyr: 1.493 ± 0.039	0.002IleXaa: 0.002 ± 0.001
Lys	4.193LysAla: 4.193 ± 0.071	0.236LysCys: 0.236 ± 0.016	1.778LysAsp: 1.778 ± 0.042	2.441LysGlu: 2.441 ± 0.048	1.098LysPhe: 1.098 ± 0.029	2.87LysGly: 2.87 ± 0.049	0.805LysHis: 0.805 ± 0.025	2.125LysIle: 2.125 ± 0.048	2.055LysLys: 2.055 ± 0.052	4.206LysLeu: 4.206 ± 0.07	1.182LysMet: 1.182 ± 0.039	1.501LysAsn: 1.501 ± 0.036	2.083LysPro: 2.083 ± 0.038	1.832LysGln: 1.832 ± 0.04	2.598LysArg: 2.598 ± 0.046	2.269LysSer: 2.269 ± 0.046	2.372LysThr: 2.372 ± 0.043	2.896LysVal: 2.896 ± 0.052	0.438LysTrp: 0.438 ± 0.02	1.031LysTyr: 1.031 ± 0.029	0.003LysXaa: 0.003 ± 0.002
Leu	12.25LeuAla: 12.25 ± 0.139	1.253LeuCys: 1.253 ± 0.036	5.433LeuAsp: 5.433 ± 0.073	5.477LeuGlu: 5.477 ± 0.077	4.59LeuPhe: 4.59 ± 0.071	7.384LeuGly: 7.384 ± 0.11	2.465LeuHis: 2.465 ± 0.046	5.756LeuIle: 5.756 ± 0.084	4.346LeuLys: 4.346 ± 0.067	12.733LeuLeu: 12.733 ± 0.157	2.943LeuMet: 2.943 ± 0.052	4.271LeuAsn: 4.271 ± 0.077	5.835LeuPro: 5.835 ± 0.072	4.276LeuGln: 4.276 ± 0.071	6.648LeuArg: 6.648 ± 0.077	7.425LeuSer: 7.425 ± 0.092	6.445LeuThr: 6.445 ± 0.089	7.224LeuVal: 7.224 ± 0.091	1.516LeuTrp: 1.516 ± 0.036	2.533LeuTyr: 2.533 ± 0.046	0.005LeuXaa: 0.005 ± 0.002
Met	2.848MetAla: 2.848 ± 0.046	0.182MetCys: 0.182 ± 0.014	1.115MetAsp: 1.115 ± 0.026	1.286MetGlu: 1.286 ± 0.037	0.822MetPhe: 0.822 ± 0.022	1.819MetGly: 1.819 ± 0.042	0.531MetHis: 0.531 ± 0.019	1.429MetIle: 1.429 ± 0.036	1.313MetLys: 1.313 ± 0.031	3.172MetLeu: 3.172 ± 0.052	0.83MetMet: 0.83 ± 0.026	1.008MetAsn: 1.008 ± 0.033	1.322MetPro: 1.322 ± 0.032	1.329MetGln: 1.329 ± 0.032	1.521MetArg: 1.521 ± 0.036	1.841MetSer: 1.841 ± 0.038	1.672MetThr: 1.672 ± 0.033	1.983MetVal: 1.983 ± 0.043	0.256MetTrp: 0.256 ± 0.012	0.463MetTyr: 0.463 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.737AsnAla: 3.737 ± 0.059	0.32AsnCys: 0.32 ± 0.016	1.983AsnAsp: 1.983 ± 0.043	1.903AsnGlu: 1.903 ± 0.041	1.328AsnPhe: 1.328 ± 0.033	3.0AsnGly: 3.0 ± 0.065	0.815AsnHis: 0.815 ± 0.028	2.183AsnIle: 2.183 ± 0.047	1.447AsnLys: 1.447 ± 0.036	3.48AsnLeu: 3.48 ± 0.052	0.836AsnMet: 0.836 ± 0.029	1.515AsnAsn: 1.515 ± 0.05	2.036AsnPro: 2.036 ± 0.04	1.566AsnGln: 1.566 ± 0.042	2.058AsnArg: 2.058 ± 0.038	2.059AsnSer: 2.059 ± 0.056	1.864AsnThr: 1.864 ± 0.045	2.465AsnVal: 2.465 ± 0.044	0.543AsnTrp: 0.543 ± 0.023	1.144AsnTyr: 1.144 ± 0.032	0.002AsnXaa: 0.002 ± 0.001
Pro	4.897ProAla: 4.897 ± 0.069	0.38ProCys: 0.38 ± 0.019	2.724ProAsp: 2.724 ± 0.042	3.313ProGlu: 3.313 ± 0.06	1.843ProPhe: 1.843 ± 0.037	3.545ProGly: 3.545 ± 0.052	1.114ProHis: 1.114 ± 0.03	1.769ProIle: 1.769 ± 0.045	1.42ProLys: 1.42 ± 0.034	5.432ProLeu: 5.432 ± 0.081	1.074ProMet: 1.074 ± 0.03	1.183ProAsn: 1.183 ± 0.03	1.721ProPro: 1.721 ± 0.043	2.464ProGln: 2.464 ± 0.049	2.099ProArg: 2.099 ± 0.041	2.069ProSer: 2.069 ± 0.036	2.045ProThr: 2.045 ± 0.045	3.873ProVal: 3.873 ± 0.063	0.805ProTrp: 0.805 ± 0.031	1.099ProTyr: 1.099 ± 0.027	0.001ProXaa: 0.001 ± 0.001
Gln	4.99GlnAla: 4.99 ± 0.083	0.367GlnCys: 0.367 ± 0.017	1.721GlnAsp: 1.721 ± 0.041	2.251GlnGlu: 2.251 ± 0.038	1.507GlnPhe: 1.507 ± 0.031	3.153GlnGly: 3.153 ± 0.067	1.283GlnHis: 1.283 ± 0.036	2.161GlnIle: 2.161 ± 0.04	1.773GlnLys: 1.773 ± 0.039	5.159GlnLeu: 5.159 ± 0.075	1.225GlnMet: 1.225 ± 0.033	1.476GlnAsn: 1.476 ± 0.033	2.343GlnPro: 2.343 ± 0.055	3.53GlnGln: 3.53 ± 0.084	3.205GlnArg: 3.205 ± 0.069	2.39GlnSer: 2.39 ± 0.046	2.305GlnThr: 2.305 ± 0.049	3.006GlnVal: 3.006 ± 0.052	0.682GlnTrp: 0.682 ± 0.026	1.08GlnTyr: 1.08 ± 0.029	0.001GlnXaa: 0.001 ± 0.001
Arg	5.139ArgAla: 5.139 ± 0.079	0.576ArgCys: 0.576 ± 0.021	3.281ArgAsp: 3.281 ± 0.054	3.892ArgGlu: 3.892 ± 0.055	2.694ArgPhe: 2.694 ± 0.047	3.555ArgGly: 3.555 ± 0.058	1.673ArgHis: 1.673 ± 0.043	3.348ArgIle: 3.348 ± 0.054	2.284ArgLys: 2.284 ± 0.048	6.742ArgLeu: 6.742 ± 0.081	1.609ArgMet: 1.609 ± 0.037	2.107ArgAsn: 2.107 ± 0.039	2.25ArgPro: 2.25 ± 0.041	3.121ArgGln: 3.121 ± 0.057	3.656ArgArg: 3.656 ± 0.065	2.91ArgSer: 2.91 ± 0.05	2.586ArgThr: 2.586 ± 0.046	4.009ArgVal: 4.009 ± 0.058	1.021ArgTrp: 1.021 ± 0.031	2.166ArgTyr: 2.166 ± 0.04	0.002ArgXaa: 0.002 ± 0.001
Ser	6.059SerAla: 6.059 ± 0.086	0.513SerCys: 0.513 ± 0.022	3.098SerAsp: 3.098 ± 0.053	3.334SerGlu: 3.334 ± 0.05	2.237SerPhe: 2.237 ± 0.047	5.402SerGly: 5.402 ± 0.091	1.394SerHis: 1.394 ± 0.031	2.73SerIle: 2.73 ± 0.047	1.925SerLys: 1.925 ± 0.041	6.755SerLeu: 6.755 ± 0.091	1.428SerMet: 1.428 ± 0.031	1.855SerAsn: 1.855 ± 0.043	2.586SerPro: 2.586 ± 0.045	2.448SerGln: 2.448 ± 0.052	3.631SerArg: 3.631 ± 0.055	3.486SerSer: 3.486 ± 0.062	2.923SerThr: 2.923 ± 0.051	4.36SerVal: 4.36 ± 0.07	1.093SerTrp: 1.093 ± 0.033	1.566SerTyr: 1.566 ± 0.036	0.002SerXaa: 0.002 ± 0.002
Thr	5.073ThrAla: 5.073 ± 0.082	0.438ThrCys: 0.438 ± 0.02	2.532ThrAsp: 2.532 ± 0.054	2.522ThrGlu: 2.522 ± 0.044	2.075ThrPhe: 2.075 ± 0.047	4.264ThrGly: 4.264 ± 0.061	1.204ThrHis: 1.204 ± 0.026	2.772ThrIle: 2.772 ± 0.054	1.353ThrLys: 1.353 ± 0.034	7.875ThrLeu: 7.875 ± 0.095	1.119ThrMet: 1.119 ± 0.036	1.476ThrAsn: 1.476 ± 0.034	3.308ThrPro: 3.308 ± 0.06	2.309ThrGln: 2.309 ± 0.051	3.166ThrArg: 3.166 ± 0.049	2.784ThrSer: 2.784 ± 0.051	2.791ThrThr: 2.791 ± 0.056	3.93ThrVal: 3.93 ± 0.093	0.788ThrTrp: 0.788 ± 0.025	1.109ThrTyr: 1.109 ± 0.036	0.001ThrXaa: 0.001 ± 0.001
Val	7.289ValAla: 7.289 ± 0.091	0.757ValCys: 0.757 ± 0.024	3.74ValAsp: 3.74 ± 0.059	4.089ValGlu: 4.089 ± 0.06	2.464ValPhe: 2.464 ± 0.053	4.84ValGly: 4.84 ± 0.079	1.288ValHis: 1.288 ± 0.03	4.434ValIle: 4.434 ± 0.071	3.054ValLys: 3.054 ± 0.053	7.347ValLeu: 7.347 ± 0.089	2.205ValMet: 2.205 ± 0.045	2.74ValAsn: 2.74 ± 0.061	2.994ValPro: 2.994 ± 0.047	2.469ValGln: 2.469 ± 0.047	3.752ValArg: 3.752 ± 0.059	4.55ValSer: 4.55 ± 0.059	4.332ValThr: 4.332 ± 0.073	5.783ValVal: 5.783 ± 0.082	0.974ValTrp: 0.974 ± 0.03	1.6ValTyr: 1.6 ± 0.037	0.004ValXaa: 0.004 ± 0.002
Trp	1.066TrpAla: 1.066 ± 0.03	0.192TrpCys: 0.192 ± 0.013	0.646TrpAsp: 0.646 ± 0.024	0.625TrpGlu: 0.625 ± 0.021	0.705TrpPhe: 0.705 ± 0.027	0.904TrpGly: 0.904 ± 0.029	0.508TrpHis: 0.508 ± 0.022	0.729TrpIle: 0.729 ± 0.023	0.515TrpLys: 0.515 ± 0.021	2.404TrpLeu: 2.404 ± 0.047	0.435TrpMet: 0.435 ± 0.018	0.489TrpAsn: 0.489 ± 0.021	0.701TrpPro: 0.701 ± 0.023	1.276TrpGln: 1.276 ± 0.035	1.187TrpArg: 1.187 ± 0.033	0.848TrpSer: 0.848 ± 0.031	0.588TrpThr: 0.588 ± 0.022	0.958TrpVal: 0.958 ± 0.028	0.264TrpTrp: 0.264 ± 0.016	0.437TrpTyr: 0.437 ± 0.018	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.443TyrAla: 2.443 ± 0.043	0.336TyrCys: 0.336 ± 0.018	1.532TyrAsp: 1.532 ± 0.039	1.187TyrGlu: 1.187 ± 0.031	1.126TyrPhe: 1.126 ± 0.029	2.115TyrGly: 2.115 ± 0.04	0.702TyrHis: 0.702 ± 0.025	1.28TyrIle: 1.28 ± 0.03	0.885TyrLys: 0.885 ± 0.031	2.941TyrLeu: 2.941 ± 0.053	0.531TyrMet: 0.531 ± 0.02	0.949TyrAsn: 0.949 ± 0.027	1.311TyrPro: 1.311 ± 0.032	1.499TyrGln: 1.499 ± 0.036	1.862TyrArg: 1.862 ± 0.043	1.676TyrSer: 1.676 ± 0.04	1.4TyrThr: 1.4 ± 0.036	1.631TyrVal: 1.631 ± 0.034	0.446TyrTrp: 0.446 ± 0.018	0.85TyrTyr: 0.85 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.002	0.002XaaPhe: 0.002 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.003XaaIle: 0.003 ± 0.002	0.002XaaLys: 0.002 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.006XaaPro: 0.006 ± 0.003	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.003XaaSer: 0.003 ± 0.003	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.004XaaXaa: 0.004 ± 0.003

Statistics based on 3989 proteins (1290228 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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