Amino acid dipepetide frequency for Dyella sp. OK004

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.665AlaAla: 15.665 ± 0.156	1.116AlaCys: 1.116 ± 0.034	6.513AlaAsp: 6.513 ± 0.076	6.185AlaGlu: 6.185 ± 0.086	3.858AlaPhe: 3.858 ± 0.054	10.093AlaGly: 10.093 ± 0.111	2.675AlaHis: 2.675 ± 0.044	5.539AlaIle: 5.539 ± 0.082	3.915AlaLys: 3.915 ± 0.07	13.988AlaLeu: 13.988 ± 0.167	3.324AlaMet: 3.324 ± 0.056	3.476AlaAsn: 3.476 ± 0.092	5.773AlaPro: 5.773 ± 0.094	5.154AlaGln: 5.154 ± 0.073	7.788AlaArg: 7.788 ± 0.11	7.053AlaSer: 7.053 ± 0.074	6.519AlaThr: 6.519 ± 0.094	8.451AlaVal: 8.451 ± 0.093	1.963AlaTrp: 1.963 ± 0.04	2.717AlaTyr: 2.717 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.934CysAla: 0.934 ± 0.029	0.11CysCys: 0.11 ± 0.01	0.459CysAsp: 0.459 ± 0.02	0.429CysGlu: 0.429 ± 0.017	0.278CysPhe: 0.278 ± 0.015	0.859CysGly: 0.859 ± 0.027	0.252CysHis: 0.252 ± 0.016	0.348CysIle: 0.348 ± 0.015	0.184CysLys: 0.184 ± 0.012	0.806CysLeu: 0.806 ± 0.023	0.169CysMet: 0.169 ± 0.01	0.224CysAsn: 0.224 ± 0.015	0.385CysPro: 0.385 ± 0.019	0.23CysGln: 0.23 ± 0.013	0.52CysArg: 0.52 ± 0.018	0.462CysSer: 0.462 ± 0.018	0.442CysThr: 0.442 ± 0.021	0.646CysVal: 0.646 ± 0.024	0.116CysTrp: 0.116 ± 0.008	0.215CysTyr: 0.215 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.465AspAla: 7.465 ± 0.088	0.408AspCys: 0.408 ± 0.017	3.154AspAsp: 3.154 ± 0.053	2.993AspGlu: 2.993 ± 0.05	2.052AspPhe: 2.052 ± 0.041	5.394AspGly: 5.394 ± 0.099	1.353AspHis: 1.353 ± 0.035	2.555AspIle: 2.555 ± 0.048	1.756AspLys: 1.756 ± 0.042	5.283AspLeu: 5.283 ± 0.061	1.182AspMet: 1.182 ± 0.025	1.621AspAsn: 1.621 ± 0.044	3.108AspPro: 3.108 ± 0.053	1.887AspGln: 1.887 ± 0.039	3.447AspArg: 3.447 ± 0.055	2.693AspSer: 2.693 ± 0.045	2.974AspThr: 2.974 ± 0.055	4.185AspVal: 4.185 ± 0.067	1.052AspTrp: 1.052 ± 0.03	1.712AspTyr: 1.712 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.084GluAla: 6.084 ± 0.092	0.323GluCys: 0.323 ± 0.014	2.107GluAsp: 2.107 ± 0.044	2.193GluGlu: 2.193 ± 0.053	1.58GluPhe: 1.58 ± 0.038	3.679GluGly: 3.679 ± 0.06	1.588GluHis: 1.588 ± 0.038	2.154GluIle: 2.154 ± 0.041	1.607GluLys: 1.607 ± 0.038	5.828GluLeu: 5.828 ± 0.091	1.021GluMet: 1.021 ± 0.027	1.201GluAsn: 1.201 ± 0.031	2.341GluPro: 2.341 ± 0.047	2.781GluGln: 2.781 ± 0.057	4.486GluArg: 4.486 ± 0.077	2.529GluSer: 2.529 ± 0.048	2.41GluThr: 2.41 ± 0.046	3.489GluVal: 3.489 ± 0.054	0.68GluTrp: 0.68 ± 0.025	1.076GluTyr: 1.076 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.183PheAla: 4.183 ± 0.063	0.31PheCys: 0.31 ± 0.016	2.534PheAsp: 2.534 ± 0.048	1.75PheGlu: 1.75 ± 0.04	1.239PhePhe: 1.239 ± 0.032	3.432PheGly: 3.432 ± 0.066	0.843PheHis: 0.843 ± 0.024	1.319PheIle: 1.319 ± 0.028	1.012PheLys: 1.012 ± 0.026	2.881PheLeu: 2.881 ± 0.055	0.689PheMet: 0.689 ± 0.023	1.248PheAsn: 1.248 ± 0.037	1.456PhePro: 1.456 ± 0.034	1.033PheGln: 1.033 ± 0.028	2.041PheArg: 2.041 ± 0.043	2.106PheSer: 2.106 ± 0.037	1.949PheThr: 1.949 ± 0.042	2.549PheVal: 2.549 ± 0.045	0.458PheTrp: 0.458 ± 0.018	0.927PheTyr: 0.927 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	8.865GlyAla: 8.865 ± 0.14	0.79GlyCys: 0.79 ± 0.023	4.656GlyAsp: 4.656 ± 0.075	4.373GlyGlu: 4.373 ± 0.069	3.226GlyPhe: 3.226 ± 0.058	7.156GlyGly: 7.156 ± 0.116	2.191GlyHis: 2.191 ± 0.041	4.056GlyIle: 4.056 ± 0.062	3.514GlyLys: 3.514 ± 0.059	8.276GlyLeu: 8.276 ± 0.088	2.306GlyMet: 2.306 ± 0.041	2.849GlyAsn: 2.849 ± 0.083	2.967GlyPro: 2.967 ± 0.044	3.378GlyGln: 3.378 ± 0.065	5.23GlyArg: 5.23 ± 0.069	5.401GlySer: 5.401 ± 0.101	4.997GlyThr: 4.997 ± 0.118	6.543GlyVal: 6.543 ± 0.072	1.584GlyTrp: 1.584 ± 0.038	2.79GlyTyr: 2.79 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	3.147HisAla: 3.147 ± 0.054	0.248HisCys: 0.248 ± 0.013	1.453HisAsp: 1.453 ± 0.033	1.195HisGlu: 1.195 ± 0.031	0.964HisPhe: 0.964 ± 0.023	2.439HisGly: 2.439 ± 0.046	0.677HisHis: 0.677 ± 0.026	0.961HisIle: 0.961 ± 0.026	0.559HisLys: 0.559 ± 0.019	2.336HisLeu: 2.336 ± 0.044	0.583HisMet: 0.583 ± 0.021	0.57HisAsn: 0.57 ± 0.02	1.599HisPro: 1.599 ± 0.032	0.813HisGln: 0.813 ± 0.022	1.667HisArg: 1.667 ± 0.038	1.201HisSer: 1.201 ± 0.028	1.214HisThr: 1.214 ± 0.032	1.733HisVal: 1.733 ± 0.035	0.535HisTrp: 0.535 ± 0.022	0.774HisTyr: 0.774 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.235IleAla: 6.235 ± 0.077	0.396IleCys: 0.396 ± 0.018	3.387IleAsp: 3.387 ± 0.052	2.844IleGlu: 2.844 ± 0.05	1.202IlePhe: 1.202 ± 0.036	4.496IleGly: 4.496 ± 0.065	0.959IleHis: 0.959 ± 0.024	1.404IleIle: 1.404 ± 0.036	1.32IleLys: 1.32 ± 0.033	3.079IleLeu: 3.079 ± 0.056	0.598IleMet: 0.598 ± 0.023	1.596IleAsn: 1.596 ± 0.039	2.012IlePro: 2.012 ± 0.035	1.297IleGln: 1.297 ± 0.031	2.585IleArg: 2.585 ± 0.048	2.541IleSer: 2.541 ± 0.043	2.661IleThr: 2.661 ± 0.048	3.345IleVal: 3.345 ± 0.057	0.494IleTrp: 0.494 ± 0.018	1.135IleTyr: 1.135 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.774LysAla: 3.774 ± 0.067	0.129LysCys: 0.129 ± 0.009	1.693LysAsp: 1.693 ± 0.042	1.357LysGlu: 1.357 ± 0.039	0.799LysPhe: 0.799 ± 0.026	2.318LysGly: 2.318 ± 0.048	0.796LysHis: 0.796 ± 0.028	1.212LysIle: 1.212 ± 0.036	1.14LysLys: 1.14 ± 0.047	3.551LysLeu: 3.551 ± 0.06	0.605LysMet: 0.605 ± 0.023	0.878LysAsn: 0.878 ± 0.027	2.18LysPro: 2.18 ± 0.045	1.437LysGln: 1.437 ± 0.037	2.157LysArg: 2.157 ± 0.041	1.653LysSer: 1.653 ± 0.04	1.765LysThr: 1.765 ± 0.036	2.385LysVal: 2.385 ± 0.052	0.31LysTrp: 0.31 ± 0.015	0.735LysTyr: 0.735 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.862LeuAla: 13.862 ± 0.134	0.951LeuCys: 0.951 ± 0.024	6.237LeuAsp: 6.237 ± 0.072	4.824LeuGlu: 4.824 ± 0.075	3.455LeuPhe: 3.455 ± 0.057	8.865LeuGly: 8.865 ± 0.102	2.638LeuHis: 2.638 ± 0.041	4.51LeuIle: 4.51 ± 0.076	3.361LeuLys: 3.361 ± 0.052	11.732LeuLeu: 11.732 ± 0.153	2.242LeuMet: 2.242 ± 0.038	2.82LeuAsn: 2.82 ± 0.065	6.387LeuPro: 6.387 ± 0.077	3.806LeuGln: 3.806 ± 0.052	7.82LeuArg: 7.82 ± 0.106	6.74LeuSer: 6.74 ± 0.085	5.496LeuThr: 5.496 ± 0.092	7.089LeuVal: 7.089 ± 0.094	1.491LeuTrp: 1.491 ± 0.039	2.333LeuTyr: 2.333 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.687MetAla: 2.687 ± 0.042	0.142MetCys: 0.142 ± 0.01	1.116MetAsp: 1.116 ± 0.03	0.944MetGlu: 0.944 ± 0.024	0.68MetPhe: 0.68 ± 0.026	1.548MetGly: 1.548 ± 0.041	0.586MetHis: 0.586 ± 0.022	0.902MetIle: 0.902 ± 0.029	0.855MetLys: 0.855 ± 0.027	2.561MetLeu: 2.561 ± 0.046	0.482MetMet: 0.482 ± 0.02	0.744MetAsn: 0.744 ± 0.022	1.458MetPro: 1.458 ± 0.033	1.028MetGln: 1.028 ± 0.025	1.721MetArg: 1.721 ± 0.043	1.674MetSer: 1.674 ± 0.043	1.364MetThr: 1.364 ± 0.027	1.498MetVal: 1.498 ± 0.035	0.23MetTrp: 0.23 ± 0.014	0.406MetTyr: 0.406 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.687AsnAla: 3.687 ± 0.081	0.193AsnCys: 0.193 ± 0.013	1.721AsnAsp: 1.721 ± 0.046	1.256AsnGlu: 1.256 ± 0.032	1.044AsnPhe: 1.044 ± 0.032	3.088AsnGly: 3.088 ± 0.094	0.647AsnHis: 0.647 ± 0.022	1.299AsnIle: 1.299 ± 0.038	0.767AsnLys: 0.767 ± 0.023	2.902AsnLeu: 2.902 ± 0.065	0.506AsnMet: 0.506 ± 0.021	1.055AsnAsn: 1.055 ± 0.049	1.809AsnPro: 1.809 ± 0.044	1.104AsnGln: 1.104 ± 0.036	1.699AsnArg: 1.699 ± 0.038	1.537AsnSer: 1.537 ± 0.062	1.73AsnThr: 1.73 ± 0.062	2.205AsnVal: 2.205 ± 0.06	0.474AsnTrp: 0.474 ± 0.025	0.961AsnTyr: 0.961 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	6.592ProAla: 6.592 ± 0.075	0.333ProCys: 0.333 ± 0.015	3.202ProAsp: 3.202 ± 0.055	2.879ProGlu: 2.879 ± 0.054	1.71ProPhe: 1.71 ± 0.034	4.562ProGly: 4.562 ± 0.068	1.189ProHis: 1.189 ± 0.03	2.009ProIle: 2.009 ± 0.041	1.51ProLys: 1.51 ± 0.035	5.264ProLeu: 5.264 ± 0.062	1.384ProMet: 1.384 ± 0.028	1.465ProAsn: 1.465 ± 0.035	2.725ProPro: 2.725 ± 0.058	2.106ProGln: 2.106 ± 0.038	2.907ProArg: 2.907 ± 0.05	3.143ProSer: 3.143 ± 0.047	2.652ProThr: 2.652 ± 0.051	4.058ProVal: 4.058 ± 0.062	0.836ProTrp: 0.836 ± 0.025	1.334ProTyr: 1.334 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.2GlnAla: 5.2 ± 0.068	0.231GlnCys: 0.231 ± 0.011	1.572GlnAsp: 1.572 ± 0.034	1.448GlnGlu: 1.448 ± 0.031	1.195GlnPhe: 1.195 ± 0.029	3.102GlnGly: 3.102 ± 0.06	1.043GlnHis: 1.043 ± 0.026	1.75GlnIle: 1.75 ± 0.035	1.015GlnLys: 1.015 ± 0.03	4.582GlnLeu: 4.582 ± 0.062	0.835GlnMet: 0.835 ± 0.025	0.999GlnAsn: 0.999 ± 0.032	2.376GlnPro: 2.376 ± 0.039	2.117GlnGln: 2.117 ± 0.051	3.436GlnArg: 3.436 ± 0.069	2.196GlnSer: 2.196 ± 0.041	1.914GlnThr: 1.914 ± 0.042	3.02GlnVal: 3.02 ± 0.044	0.709GlnTrp: 0.709 ± 0.023	0.92GlnTyr: 0.92 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.997ArgAla: 6.997 ± 0.082	0.565ArgCys: 0.565 ± 0.022	3.926ArgAsp: 3.926 ± 0.055	4.12ArgGlu: 4.12 ± 0.081	2.651ArgPhe: 2.651 ± 0.038	4.718ArgGly: 4.718 ± 0.071	1.901ArgHis: 1.901 ± 0.042	3.366ArgIle: 3.366 ± 0.055	2.049ArgLys: 2.049 ± 0.047	7.669ArgLeu: 7.669 ± 0.107	1.766ArgMet: 1.766 ± 0.034	1.825ArgAsn: 1.825 ± 0.037	3.043ArgPro: 3.043 ± 0.051	2.834ArgGln: 2.834 ± 0.058	5.247ArgArg: 5.247 ± 0.09	3.605ArgSer: 3.605 ± 0.059	3.135ArgThr: 3.135 ± 0.054	4.851ArgVal: 4.851 ± 0.07	1.277ArgTrp: 1.277 ± 0.034	2.274ArgTyr: 2.274 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.667SerAla: 6.667 ± 0.082	0.436SerCys: 0.436 ± 0.02	3.035SerAsp: 3.035 ± 0.054	2.544SerGlu: 2.544 ± 0.053	2.145SerPhe: 2.145 ± 0.049	5.69SerGly: 5.69 ± 0.101	1.382SerHis: 1.382 ± 0.034	2.593SerIle: 2.593 ± 0.046	1.717SerLys: 1.717 ± 0.037	6.315SerLeu: 6.315 ± 0.08	1.356SerMet: 1.356 ± 0.036	1.835SerAsn: 1.835 ± 0.052	2.924SerPro: 2.924 ± 0.045	2.087SerGln: 2.087 ± 0.047	3.566SerArg: 3.566 ± 0.06	3.714SerSer: 3.714 ± 0.069	3.408SerThr: 3.408 ± 0.09	4.25SerVal: 4.25 ± 0.07	0.925SerTrp: 0.925 ± 0.027	1.702SerTyr: 1.702 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	6.269ThrAla: 6.269 ± 0.097	0.393ThrCys: 0.393 ± 0.018	2.915ThrAsp: 2.915 ± 0.062	2.272ThrGlu: 2.272 ± 0.042	1.759ThrPhe: 1.759 ± 0.041	4.888ThrGly: 4.888 ± 0.098	1.363ThrHis: 1.363 ± 0.03	2.312ThrIle: 2.312 ± 0.05	1.35ThrLys: 1.35 ± 0.033	6.465ThrLeu: 6.465 ± 0.104	1.024ThrMet: 1.024 ± 0.028	1.555ThrAsn: 1.555 ± 0.065	3.618ThrPro: 3.618 ± 0.063	2.063ThrGln: 2.063 ± 0.042	3.318ThrArg: 3.318 ± 0.054	3.111ThrSer: 3.111 ± 0.075	3.104ThrThr: 3.104 ± 0.083	4.408ThrVal: 4.408 ± 0.082	0.758ThrTrp: 0.758 ± 0.026	1.459ThrTyr: 1.459 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	9.012ValAla: 9.012 ± 0.103	0.635ValCys: 0.635 ± 0.022	4.304ValAsp: 4.304 ± 0.06	3.811ValGlu: 3.811 ± 0.07	2.537ValPhe: 2.537 ± 0.044	5.419ValGly: 5.419 ± 0.073	1.586ValHis: 1.586 ± 0.039	3.63ValIle: 3.63 ± 0.056	2.09ValLys: 2.09 ± 0.046	8.184ValLeu: 8.184 ± 0.111	1.68ValMet: 1.68 ± 0.035	2.289ValAsn: 2.289 ± 0.058	3.692ValPro: 3.692 ± 0.057	2.574ValGln: 2.574 ± 0.045	4.771ValArg: 4.771 ± 0.068	4.537ValSer: 4.537 ± 0.065	4.277ValThr: 4.277 ± 0.073	5.803ValVal: 5.803 ± 0.081	0.961ValTrp: 0.961 ± 0.031	1.697ValTyr: 1.697 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.273TrpAla: 1.273 ± 0.034	0.15TrpCys: 0.15 ± 0.011	0.674TrpAsp: 0.674 ± 0.025	0.548TrpGlu: 0.548 ± 0.019	0.573TrpPhe: 0.573 ± 0.025	0.942TrpGly: 0.942 ± 0.026	0.452TrpHis: 0.452 ± 0.017	0.715TrpIle: 0.715 ± 0.021	0.484TrpLys: 0.484 ± 0.02	2.234TrpLeu: 2.234 ± 0.051	0.448TrpMet: 0.448 ± 0.018	0.564TrpAsn: 0.564 ± 0.023	0.765TrpPro: 0.765 ± 0.023	0.844TrpGln: 0.844 ± 0.028	1.312TrpArg: 1.312 ± 0.03	1.027TrpSer: 1.027 ± 0.029	0.838TrpThr: 0.838 ± 0.032	1.026TrpVal: 1.026 ± 0.028	0.312TrpTrp: 0.312 ± 0.016	0.412TrpTyr: 0.412 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.168TyrAla: 3.168 ± 0.046	0.208TyrCys: 0.208 ± 0.012	1.618TyrAsp: 1.618 ± 0.048	1.192TyrGlu: 1.192 ± 0.029	1.013TyrPhe: 1.013 ± 0.03	2.459TyrGly: 2.459 ± 0.051	0.546TyrHis: 0.546 ± 0.022	0.954TyrIle: 0.954 ± 0.026	0.669TyrLys: 0.669 ± 0.026	2.724TyrLeu: 2.724 ± 0.046	0.424TyrMet: 0.424 ± 0.02	0.871TyrAsn: 0.871 ± 0.031	1.241TyrPro: 1.241 ± 0.032	1.088TyrGln: 1.088 ± 0.032	2.102TyrArg: 2.102 ± 0.042	1.369TyrSer: 1.369 ± 0.035	1.555TyrThr: 1.555 ± 0.055	1.951TyrVal: 1.951 ± 0.041	0.429TyrTrp: 0.429 ± 0.017	0.834TyrTyr: 0.834 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4204 proteins (1469863 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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