Amino acid dipepetide frequency for Streptococcus satellite phage Javan54

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.235AlaAla: 0.235 ± 0.229
0.706AlaCys: 0.706 ± 0.344
3.531AlaAsp: 3.531 ± 1.159
4.002AlaGlu: 4.002 ± 1.358
2.119AlaPhe: 2.119 ± 0.762
1.883AlaGly: 1.883 ± 0.764
0.0AlaHis: 0.0 ± 0.0
4.473AlaIle: 4.473 ± 0.665
7.062AlaLys: 7.062 ± 1.373
6.591AlaLeu: 6.591 ± 1.14
1.883AlaMet: 1.883 ± 0.648
2.589AlaAsn: 2.589 ± 0.846
1.412AlaPro: 1.412 ± 0.44
2.119AlaGln: 2.119 ± 0.718
2.354AlaArg: 2.354 ± 0.619
4.002AlaSer: 4.002 ± 1.042
3.296AlaThr: 3.296 ± 1.278
3.296AlaVal: 3.296 ± 0.802
0.471AlaTrp: 0.471 ± 0.293
3.531AlaTyr: 3.531 ± 0.675
0.0AlaXaa: 0.0 ± 0.0
Cys
0.706CysAla: 0.706 ± 0.372
0.0CysCys: 0.0 ± 0.0
0.942CysAsp: 0.942 ± 0.441
0.942CysGlu: 0.942 ± 0.759
0.235CysPhe: 0.235 ± 0.219
0.706CysGly: 0.706 ± 0.469
0.0CysHis: 0.0 ± 0.0
0.706CysIle: 0.706 ± 0.355
0.706CysLys: 0.706 ± 0.41
0.471CysLeu: 0.471 ± 0.309
0.0CysMet: 0.0 ± 0.0
0.471CysAsn: 0.471 ± 0.38
0.235CysPro: 0.235 ± 0.219
0.706CysGln: 0.706 ± 0.504
1.412CysArg: 1.412 ± 0.481
0.0CysSer: 0.0 ± 0.0
0.235CysThr: 0.235 ± 0.247
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.235CysTyr: 0.235 ± 0.232
0.0CysXaa: 0.0 ± 0.0
Asp
0.471AspAla: 0.471 ± 0.309
1.648AspCys: 1.648 ± 0.688
3.296AspAsp: 3.296 ± 0.767
3.531AspGlu: 3.531 ± 0.917
4.002AspPhe: 4.002 ± 0.904
2.119AspGly: 2.119 ± 0.577
0.471AspHis: 0.471 ± 0.348
6.121AspIle: 6.121 ± 1.272
3.766AspLys: 3.766 ± 0.891
5.179AspLeu: 5.179 ± 0.915
1.883AspMet: 1.883 ± 0.552
3.766AspAsn: 3.766 ± 0.839
0.706AspPro: 0.706 ± 0.361
1.412AspGln: 1.412 ± 0.478
3.06AspArg: 3.06 ± 0.905
3.531AspSer: 3.531 ± 1.114
3.06AspThr: 3.06 ± 1.22
1.883AspVal: 1.883 ± 0.653
1.177AspTrp: 1.177 ± 0.516
4.237AspTyr: 4.237 ± 0.953
0.0AspXaa: 0.0 ± 0.0
Glu
6.827GluAla: 6.827 ± 1.234
0.706GluCys: 0.706 ± 0.338
3.296GluAsp: 3.296 ± 0.91
7.062GluGlu: 7.062 ± 1.518
2.825GluPhe: 2.825 ± 0.594
3.531GluGly: 3.531 ± 1.095
1.412GluHis: 1.412 ± 0.511
4.473GluIle: 4.473 ± 0.892
6.356GluLys: 6.356 ± 1.503
9.416GluLeu: 9.416 ± 1.47
0.706GluMet: 0.706 ± 0.399
5.414GluAsn: 5.414 ± 0.911
1.883GluPro: 1.883 ± 0.5
2.825GluGln: 2.825 ± 0.91
2.825GluArg: 2.825 ± 0.954
4.944GluSer: 4.944 ± 0.976
5.179GluThr: 5.179 ± 0.921
2.589GluVal: 2.589 ± 0.615
0.706GluTrp: 0.706 ± 0.39
3.296GluTyr: 3.296 ± 0.966
0.0GluXaa: 0.0 ± 0.0
Phe
2.119PheAla: 2.119 ± 0.693
0.471PheCys: 0.471 ± 0.271
3.06PheAsp: 3.06 ± 0.769
3.531PheGlu: 3.531 ± 0.851
1.883PhePhe: 1.883 ± 0.596
2.589PheGly: 2.589 ± 0.683
1.177PheHis: 1.177 ± 0.469
2.825PheIle: 2.825 ± 0.775
3.766PheLys: 3.766 ± 0.923
4.473PheLeu: 4.473 ± 1.084
0.706PheMet: 0.706 ± 0.442
3.531PheAsn: 3.531 ± 1.084
0.942PhePro: 0.942 ± 0.437
2.119PheGln: 2.119 ± 0.804
2.119PheArg: 2.119 ± 0.691
3.296PheSer: 3.296 ± 0.833
3.531PheThr: 3.531 ± 1.068
1.412PheVal: 1.412 ± 0.566
0.706PheTrp: 0.706 ± 0.367
2.119PheTyr: 2.119 ± 0.639
0.0PheXaa: 0.0 ± 0.0
Gly
3.531GlyAla: 3.531 ± 0.771
0.471GlyCys: 0.471 ± 0.29
2.119GlyAsp: 2.119 ± 0.848
2.119GlyGlu: 2.119 ± 0.642
3.531GlyPhe: 3.531 ± 1.093
2.589GlyGly: 2.589 ± 0.752
0.471GlyHis: 0.471 ± 0.306
3.766GlyIle: 3.766 ± 0.812
5.414GlyLys: 5.414 ± 0.942
5.414GlyLeu: 5.414 ± 1.37
0.942GlyMet: 0.942 ± 0.472
2.589GlyAsn: 2.589 ± 0.973
0.706GlyPro: 0.706 ± 0.348
2.119GlyGln: 2.119 ± 0.764
2.825GlyArg: 2.825 ± 0.669
1.177GlySer: 1.177 ± 0.605
2.119GlyThr: 2.119 ± 0.675
3.06GlyVal: 3.06 ± 0.92
0.706GlyTrp: 0.706 ± 0.449
2.825GlyTyr: 2.825 ± 0.709
0.0GlyXaa: 0.0 ± 0.0
His
1.412HisAla: 1.412 ± 0.541
0.0HisCys: 0.0 ± 0.0
0.706HisAsp: 0.706 ± 0.545
1.177HisGlu: 1.177 ± 0.461
0.235HisPhe: 0.235 ± 0.233
2.119HisGly: 2.119 ± 0.623
0.0HisHis: 0.0 ± 0.0
0.706HisIle: 0.706 ± 0.414
1.412HisLys: 1.412 ± 0.483
1.412HisLeu: 1.412 ± 0.705
0.235HisMet: 0.235 ± 0.22
0.706HisAsn: 0.706 ± 0.378
0.235HisPro: 0.235 ± 0.244
0.706HisGln: 0.706 ± 0.424
1.177HisArg: 1.177 ± 0.57
1.177HisSer: 1.177 ± 0.531
2.354HisThr: 2.354 ± 0.648
0.471HisVal: 0.471 ± 0.306
0.235HisTrp: 0.235 ± 0.244
0.706HisTyr: 0.706 ± 0.338
0.0HisXaa: 0.0 ± 0.0
Ile
4.944IleAla: 4.944 ± 1.251
0.706IleCys: 0.706 ± 0.54
4.708IleAsp: 4.708 ± 0.831
6.591IleGlu: 6.591 ± 1.373
3.06IlePhe: 3.06 ± 0.936
2.825IleGly: 2.825 ± 0.595
1.177IleHis: 1.177 ± 0.58
4.944IleIle: 4.944 ± 1.278
6.121IleLys: 6.121 ± 1.077
6.356IleLeu: 6.356 ± 1.318
1.883IleMet: 1.883 ± 0.543
4.237IleAsn: 4.237 ± 0.999
2.589IlePro: 2.589 ± 0.882
3.296IleGln: 3.296 ± 1.094
2.354IleArg: 2.354 ± 0.883
5.179IleSer: 5.179 ± 1.314
4.473IleThr: 4.473 ± 0.944
3.531IleVal: 3.531 ± 0.977
0.235IleTrp: 0.235 ± 0.24
3.766IleTyr: 3.766 ± 0.869
0.0IleXaa: 0.0 ± 0.0
Lys
6.356LysAla: 6.356 ± 1.551
0.471LysCys: 0.471 ± 0.302
3.531LysAsp: 3.531 ± 1.177
6.827LysGlu: 6.827 ± 1.135
2.825LysPhe: 2.825 ± 0.789
5.65LysGly: 5.65 ± 1.221
2.825LysHis: 2.825 ± 0.799
5.65LysIle: 5.65 ± 1.131
6.591LysLys: 6.591 ± 1.785
8.475LysLeu: 8.475 ± 1.273
3.06LysMet: 3.06 ± 0.857
4.237LysAsn: 4.237 ± 0.774
4.473LysPro: 4.473 ± 1.253
3.296LysGln: 3.296 ± 1.088
8.004LysArg: 8.004 ± 1.153
4.237LysSer: 4.237 ± 0.958
6.827LysThr: 6.827 ± 1.01
5.885LysVal: 5.885 ± 1.172
0.942LysTrp: 0.942 ± 0.463
4.002LysTyr: 4.002 ± 0.979
0.0LysXaa: 0.0 ± 0.0
Leu
5.65LeuAla: 5.65 ± 0.994
0.942LeuCys: 0.942 ± 0.498
8.239LeuAsp: 8.239 ± 0.853
9.887LeuGlu: 9.887 ± 1.992
4.944LeuPhe: 4.944 ± 1.023
4.944LeuGly: 4.944 ± 1.476
1.177LeuHis: 1.177 ± 0.5
8.475LeuIle: 8.475 ± 1.786
9.416LeuLys: 9.416 ± 1.159
6.827LeuLeu: 6.827 ± 1.032
2.825LeuMet: 2.825 ± 0.642
4.473LeuAsn: 4.473 ± 1.151
2.354LeuPro: 2.354 ± 0.949
3.06LeuGln: 3.06 ± 0.724
3.531LeuArg: 3.531 ± 1.008
7.298LeuSer: 7.298 ± 1.338
5.414LeuThr: 5.414 ± 1.147
4.944LeuVal: 4.944 ± 1.176
1.177LeuTrp: 1.177 ± 0.448
3.766LeuTyr: 3.766 ± 0.851
0.0LeuXaa: 0.0 ± 0.0
Met
2.354MetAla: 2.354 ± 0.809
0.235MetCys: 0.235 ± 0.219
1.177MetAsp: 1.177 ± 0.452
2.589MetGlu: 2.589 ± 0.738
1.177MetPhe: 1.177 ± 0.547
1.177MetGly: 1.177 ± 0.388
0.235MetHis: 0.235 ± 0.219
1.412MetIle: 1.412 ± 0.56
2.825MetLys: 2.825 ± 0.816
2.119MetLeu: 2.119 ± 0.808
0.0MetMet: 0.0 ± 0.0
2.119MetAsn: 2.119 ± 0.775
0.471MetPro: 0.471 ± 0.314
0.706MetGln: 0.706 ± 0.428
0.942MetArg: 0.942 ± 0.383
1.412MetSer: 1.412 ± 0.569
2.119MetThr: 2.119 ± 0.659
0.471MetVal: 0.471 ± 0.312
0.235MetTrp: 0.235 ± 0.232
0.706MetTyr: 0.706 ± 0.414
0.0MetXaa: 0.0 ± 0.0
Asn
3.06AsnAla: 3.06 ± 0.785
0.235AsnCys: 0.235 ± 0.292
2.354AsnAsp: 2.354 ± 0.888
3.766AsnGlu: 3.766 ± 1.032
1.883AsnPhe: 1.883 ± 0.739
3.06AsnGly: 3.06 ± 0.832
1.412AsnHis: 1.412 ± 0.546
4.473AsnIle: 4.473 ± 1.008
4.708AsnLys: 4.708 ± 0.97
5.414AsnLeu: 5.414 ± 1.133
1.412AsnMet: 1.412 ± 0.529
2.589AsnAsn: 2.589 ± 0.606
2.354AsnPro: 2.354 ± 0.782
3.06AsnGln: 3.06 ± 0.967
4.002AsnArg: 4.002 ± 1.166
3.531AsnSer: 3.531 ± 0.911
3.766AsnThr: 3.766 ± 0.865
2.119AsnVal: 2.119 ± 0.746
0.942AsnTrp: 0.942 ± 0.456
1.883AsnTyr: 1.883 ± 0.701
0.0AsnXaa: 0.0 ± 0.0
Pro
1.648ProAla: 1.648 ± 0.627
0.0ProCys: 0.0 ± 0.0
1.648ProAsp: 1.648 ± 0.54
2.119ProGlu: 2.119 ± 1.154
1.883ProPhe: 1.883 ± 0.806
1.412ProGly: 1.412 ± 0.572
0.235ProHis: 0.235 ± 0.219
1.412ProIle: 1.412 ± 0.524
4.002ProLys: 4.002 ± 0.937
2.119ProLeu: 2.119 ± 0.622
0.471ProMet: 0.471 ± 0.312
3.531ProAsn: 3.531 ± 1.036
0.706ProPro: 0.706 ± 0.327
1.883ProGln: 1.883 ± 0.648
1.648ProArg: 1.648 ± 0.608
1.412ProSer: 1.412 ± 0.597
0.942ProThr: 0.942 ± 0.372
1.648ProVal: 1.648 ± 0.629
0.235ProTrp: 0.235 ± 0.19
1.412ProTyr: 1.412 ± 0.501
0.0ProXaa: 0.0 ± 0.0
Gln
1.412GlnAla: 1.412 ± 0.554
0.235GlnCys: 0.235 ± 0.24
1.412GlnAsp: 1.412 ± 0.58
3.06GlnGlu: 3.06 ± 0.923
0.706GlnPhe: 0.706 ± 0.419
1.883GlnGly: 1.883 ± 0.822
0.0GlnHis: 0.0 ± 0.0
3.296GlnIle: 3.296 ± 0.882
4.708GlnLys: 4.708 ± 0.895
4.944GlnLeu: 4.944 ± 1.011
0.235GlnMet: 0.235 ± 0.278
2.119GlnAsn: 2.119 ± 0.797
0.235GlnPro: 0.235 ± 0.19
0.942GlnGln: 0.942 ± 0.419
2.119GlnArg: 2.119 ± 0.779
2.119GlnSer: 2.119 ± 0.704
2.119GlnThr: 2.119 ± 0.917
2.354GlnVal: 2.354 ± 0.63
0.471GlnTrp: 0.471 ± 0.27
4.002GlnTyr: 4.002 ± 0.93
0.0GlnXaa: 0.0 ± 0.0
Arg
3.06ArgAla: 3.06 ± 0.815
0.235ArgCys: 0.235 ± 0.219
3.06ArgAsp: 3.06 ± 0.687
4.002ArgGlu: 4.002 ± 0.862
3.06ArgPhe: 3.06 ± 0.844
2.589ArgGly: 2.589 ± 0.924
1.177ArgHis: 1.177 ± 0.444
3.06ArgIle: 3.06 ± 0.641
4.708ArgLys: 4.708 ± 1.298
4.473ArgLeu: 4.473 ± 1.353
1.177ArgMet: 1.177 ± 0.484
2.825ArgAsn: 2.825 ± 0.923
1.177ArgPro: 1.177 ± 0.612
2.354ArgGln: 2.354 ± 0.782
0.942ArgArg: 0.942 ± 0.529
3.296ArgSer: 3.296 ± 0.815
3.06ArgThr: 3.06 ± 0.811
2.354ArgVal: 2.354 ± 0.639
0.0ArgTrp: 0.0 ± 0.0
4.002ArgTyr: 4.002 ± 1.051
0.0ArgXaa: 0.0 ± 0.0
Ser
2.354SerAla: 2.354 ± 1.15
0.471SerCys: 0.471 ± 0.307
3.766SerAsp: 3.766 ± 0.912
4.708SerGlu: 4.708 ± 1.351
4.002SerPhe: 4.002 ± 1.032
2.119SerGly: 2.119 ± 0.832
1.412SerHis: 1.412 ± 0.474
5.885SerIle: 5.885 ± 1.098
6.356SerLys: 6.356 ± 1.103
5.414SerLeu: 5.414 ± 0.895
0.942SerMet: 0.942 ± 0.421
3.531SerAsn: 3.531 ± 0.78
2.119SerPro: 2.119 ± 0.617
1.648SerGln: 1.648 ± 0.56
2.354SerArg: 2.354 ± 0.726
1.883SerSer: 1.883 ± 0.862
2.825SerThr: 2.825 ± 0.917
2.589SerVal: 2.589 ± 0.808
1.177SerTrp: 1.177 ± 0.405
1.883SerTyr: 1.883 ± 0.63
0.0SerXaa: 0.0 ± 0.0
Thr
4.237ThrAla: 4.237 ± 0.718
0.235ThrCys: 0.235 ± 0.219
2.119ThrAsp: 2.119 ± 0.721
4.473ThrGlu: 4.473 ± 1.151
3.766ThrPhe: 3.766 ± 1.151
3.296ThrGly: 3.296 ± 0.988
1.412ThrHis: 1.412 ± 0.61
4.473ThrIle: 4.473 ± 1.042
4.237ThrLys: 4.237 ± 0.878
5.885ThrLeu: 5.885 ± 1.024
2.354ThrMet: 2.354 ± 0.798
3.06ThrAsn: 3.06 ± 0.774
3.296ThrPro: 3.296 ± 0.983
2.119ThrGln: 2.119 ± 0.591
4.237ThrArg: 4.237 ± 0.918
2.119ThrSer: 2.119 ± 0.588
2.354ThrThr: 2.354 ± 0.763
2.589ThrVal: 2.589 ± 0.866
0.471ThrTrp: 0.471 ± 0.316
3.06ThrTyr: 3.06 ± 1.083
0.0ThrXaa: 0.0 ± 0.0
Val
2.589ValAla: 2.589 ± 0.751
0.706ValCys: 0.706 ± 0.327
1.883ValAsp: 1.883 ± 0.73
2.354ValGlu: 2.354 ± 0.674
2.119ValPhe: 2.119 ± 0.602
1.177ValGly: 1.177 ± 0.441
0.706ValHis: 0.706 ± 0.383
3.06ValIle: 3.06 ± 0.66
4.944ValLys: 4.944 ± 1.305
6.121ValLeu: 6.121 ± 1.059
1.648ValMet: 1.648 ± 0.549
2.825ValAsn: 2.825 ± 0.664
2.354ValPro: 2.354 ± 0.76
1.177ValGln: 1.177 ± 0.381
1.648ValArg: 1.648 ± 0.668
3.296ValSer: 3.296 ± 0.938
3.296ValThr: 3.296 ± 1.03
2.825ValVal: 2.825 ± 0.737
0.706ValTrp: 0.706 ± 0.371
1.883ValTyr: 1.883 ± 0.688
0.0ValXaa: 0.0 ± 0.0
Trp
0.235TrpAla: 0.235 ± 0.213
0.0TrpCys: 0.0 ± 0.0
1.177TrpAsp: 1.177 ± 0.64
0.942TrpGlu: 0.942 ± 0.396
0.0TrpPhe: 0.0 ± 0.0
0.706TrpGly: 0.706 ± 0.375
0.471TrpHis: 0.471 ± 0.293
0.706TrpIle: 0.706 ± 0.426
0.942TrpLys: 0.942 ± 0.395
2.119TrpLeu: 2.119 ± 0.733
0.471TrpMet: 0.471 ± 0.337
0.235TrpAsn: 0.235 ± 0.24
0.235TrpPro: 0.235 ± 0.19
0.235TrpGln: 0.235 ± 0.19
0.471TrpArg: 0.471 ± 0.298
1.177TrpSer: 1.177 ± 0.436
0.471TrpThr: 0.471 ± 0.298
0.942TrpVal: 0.942 ± 0.434
0.471TrpTrp: 0.471 ± 0.33
0.235TrpTyr: 0.235 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.354TyrAla: 2.354 ± 0.921
0.235TyrCys: 0.235 ± 0.219
3.296TyrAsp: 3.296 ± 0.618
2.589TyrGlu: 2.589 ± 0.936
2.119TyrPhe: 2.119 ± 0.734
2.119TyrGly: 2.119 ± 0.594
1.412TyrHis: 1.412 ± 0.507
3.06TyrIle: 3.06 ± 0.87
6.121TyrLys: 6.121 ± 0.877
6.121TyrLeu: 6.121 ± 1.201
1.412TyrMet: 1.412 ± 0.471
1.412TyrAsn: 1.412 ± 0.66
1.883TyrPro: 1.883 ± 0.641
2.589TyrGln: 2.589 ± 0.515
2.589TyrArg: 2.589 ± 0.95
2.354TyrSer: 2.354 ± 0.593
2.354TyrThr: 2.354 ± 0.634
2.354TyrVal: 2.354 ± 0.737
1.177TyrTrp: 1.177 ± 0.744
1.412TyrTyr: 1.412 ± 0.484
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 29 proteins (4249 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski