Amino acid dipepetide frequency for Rabies virus (strain SAD B19) (RABV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.997AlaAla: 2.997 ± 1.387
1.153AlaCys: 1.153 ± 0.518
2.075AlaAsp: 2.075 ± 1.059
4.381AlaGlu: 4.381 ± 1.401
0.692AlaPhe: 0.692 ± 0.378
1.383AlaGly: 1.383 ± 0.486
3.228AlaHis: 3.228 ± 1.493
2.767AlaIle: 2.767 ± 0.718
2.536AlaLys: 2.536 ± 1.174
7.148AlaLeu: 7.148 ± 0.478
0.461AlaMet: 0.461 ± 0.245
2.075AlaAsn: 2.075 ± 0.48
1.383AlaPro: 1.383 ± 0.844
2.536AlaGln: 2.536 ± 0.598
3.92AlaArg: 3.92 ± 0.729
3.459AlaSer: 3.459 ± 0.307
1.845AlaThr: 1.845 ± 0.542
2.997AlaVal: 2.997 ± 0.677
0.461AlaTrp: 0.461 ± 0.252
1.153AlaTyr: 1.153 ± 0.592
0.0AlaXaa: 0.0 ± 0.0
Cys
0.692CysAla: 0.692 ± 0.521
0.461CysCys: 0.461 ± 0.234
0.461CysAsp: 0.461 ± 0.234
0.0CysGlu: 0.0 ± 0.0
0.461CysPhe: 0.461 ± 0.234
0.922CysGly: 0.922 ± 0.468
0.461CysHis: 0.461 ± 0.377
0.922CysIle: 0.922 ± 0.68
0.231CysLys: 0.231 ± 0.236
1.845CysLeu: 1.845 ± 0.769
0.692CysMet: 0.692 ± 0.63
0.461CysAsn: 0.461 ± 0.252
1.153CysPro: 1.153 ± 0.41
0.692CysGln: 0.692 ± 0.317
0.461CysArg: 0.461 ± 0.473
2.767CysSer: 2.767 ± 0.593
0.692CysThr: 0.692 ± 0.453
1.383CysVal: 1.383 ± 0.563
0.231CysTrp: 0.231 ± 0.126
0.692CysTyr: 0.692 ± 0.261
0.0CysXaa: 0.0 ± 0.0
Asp
2.306AspAla: 2.306 ± 0.729
0.231AspCys: 0.231 ± 0.289
6.917AspAsp: 6.917 ± 2.864
3.459AspGlu: 3.459 ± 1.096
3.228AspPhe: 3.228 ± 0.816
3.689AspGly: 3.689 ± 0.869
0.231AspHis: 0.231 ± 0.126
2.767AspIle: 2.767 ± 0.48
4.15AspLys: 4.15 ± 1.13
9.223AspLeu: 9.223 ± 1.27
0.922AspMet: 0.922 ± 0.7
2.997AspAsn: 2.997 ± 0.952
4.15AspPro: 4.15 ± 0.562
2.306AspGln: 2.306 ± 1.007
1.383AspArg: 1.383 ± 0.374
2.306AspSer: 2.306 ± 0.779
1.614AspThr: 1.614 ± 0.693
2.075AspVal: 2.075 ± 0.667
0.692AspTrp: 0.692 ± 0.261
2.767AspTyr: 2.767 ± 0.936
0.0AspXaa: 0.0 ± 0.0
Glu
4.15GluAla: 4.15 ± 1.332
0.461GluCys: 0.461 ± 0.234
7.609GluAsp: 7.609 ± 2.948
5.764GluGlu: 5.764 ± 1.462
1.614GluPhe: 1.614 ± 0.558
4.842GluGly: 4.842 ± 0.734
0.922GluHis: 0.922 ± 0.852
5.995GluIle: 5.995 ± 1.481
2.306GluLys: 2.306 ± 1.007
4.842GluLeu: 4.842 ± 0.518
1.845GluMet: 1.845 ± 0.381
1.845GluAsn: 1.845 ± 0.478
2.075GluPro: 2.075 ± 0.386
1.153GluGln: 1.153 ± 0.82
3.228GluArg: 3.228 ± 0.388
7.148GluSer: 7.148 ± 1.342
3.689GluThr: 3.689 ± 1.295
2.536GluVal: 2.536 ± 0.726
1.383GluTrp: 1.383 ± 0.563
1.153GluTyr: 1.153 ± 0.859
0.0GluXaa: 0.0 ± 0.0
Phe
0.922PheAla: 0.922 ± 0.329
0.231PheCys: 0.231 ± 0.316
1.383PheAsp: 1.383 ± 0.582
2.767PheGlu: 2.767 ± 1.447
2.767PhePhe: 2.767 ± 1.137
1.614PheGly: 1.614 ± 0.46
1.614PheHis: 1.614 ± 0.647
1.614PheIle: 1.614 ± 0.558
2.306PheLys: 2.306 ± 0.718
5.073PheLeu: 5.073 ± 0.721
0.231PheMet: 0.231 ± 0.126
1.845PheAsn: 1.845 ± 0.53
4.611PhePro: 4.611 ± 0.878
3.92PheGln: 3.92 ± 1.558
3.689PheArg: 3.689 ± 0.8
4.15PheSer: 4.15 ± 0.581
1.153PheThr: 1.153 ± 0.41
2.536PheVal: 2.536 ± 0.906
0.231PheTrp: 0.231 ± 0.126
0.692PheTyr: 0.692 ± 0.378
0.0PheXaa: 0.0 ± 0.0
Gly
1.845GlyAla: 1.845 ± 0.769
1.153GlyCys: 1.153 ± 0.41
2.536GlyAsp: 2.536 ± 0.824
5.764GlyGlu: 5.764 ± 2.447
1.845GlyPhe: 1.845 ± 0.829
4.15GlyGly: 4.15 ± 1.229
0.692GlyHis: 0.692 ± 0.261
2.306GlyIle: 2.306 ± 0.391
5.764GlyLys: 5.764 ± 1.795
6.917GlyLeu: 6.917 ± 1.637
1.153GlyMet: 1.153 ± 0.455
2.997GlyAsn: 2.997 ± 0.79
2.997GlyPro: 2.997 ± 0.438
1.153GlyGln: 1.153 ± 0.761
4.15GlyArg: 4.15 ± 0.899
3.228GlySer: 3.228 ± 0.281
2.997GlyThr: 2.997 ± 1.104
3.92GlyVal: 3.92 ± 1.396
1.153GlyTrp: 1.153 ± 0.635
1.845GlyTyr: 1.845 ± 0.437
0.0GlyXaa: 0.0 ± 0.0
His
0.922HisAla: 0.922 ± 0.329
0.0HisCys: 0.0 ± 0.0
2.075HisAsp: 2.075 ± 0.555
0.461HisGlu: 0.461 ± 0.245
1.383HisPhe: 1.383 ± 0.436
1.153HisGly: 1.153 ± 0.414
0.692HisHis: 0.692 ± 0.267
1.614HisIle: 1.614 ± 0.626
1.153HisLys: 1.153 ± 0.455
3.689HisLeu: 3.689 ± 0.915
0.231HisMet: 0.231 ± 0.236
0.692HisAsn: 0.692 ± 0.709
1.614HisPro: 1.614 ± 0.671
1.383HisGln: 1.383 ± 0.717
0.922HisArg: 0.922 ± 0.385
1.383HisSer: 1.383 ± 0.374
0.231HisThr: 0.231 ± 0.289
1.153HisVal: 1.153 ± 0.292
0.692HisTrp: 0.692 ± 0.378
0.692HisTyr: 0.692 ± 0.292
0.0HisXaa: 0.0 ± 0.0
Ile
5.073IleAla: 5.073 ± 2.66
0.692IleCys: 0.692 ± 0.378
2.536IleAsp: 2.536 ± 1.214
2.536IleGlu: 2.536 ± 0.837
2.536IlePhe: 2.536 ± 0.633
1.845IleGly: 1.845 ± 0.769
1.845IleHis: 1.845 ± 0.502
4.611IleIle: 4.611 ± 0.751
2.306IleLys: 2.306 ± 0.696
6.456IleLeu: 6.456 ± 1.213
2.536IleMet: 2.536 ± 0.324
2.075IleAsn: 2.075 ± 0.636
2.075IlePro: 2.075 ± 0.669
0.922IleGln: 0.922 ± 0.385
3.689IleArg: 3.689 ± 1.039
4.842IleSer: 4.842 ± 0.981
3.689IleThr: 3.689 ± 1.32
4.611IleVal: 4.611 ± 1.384
1.845IleTrp: 1.845 ± 0.478
2.075IleTyr: 2.075 ± 0.761
0.0IleXaa: 0.0 ± 0.0
Lys
2.306LysAla: 2.306 ± 0.637
0.231LysCys: 0.231 ± 0.236
2.997LysAsp: 2.997 ± 0.968
3.459LysGlu: 3.459 ± 1.166
2.767LysPhe: 2.767 ± 1.164
2.075LysGly: 2.075 ± 0.637
0.461LysHis: 0.461 ± 0.234
5.073LysIle: 5.073 ± 1.364
4.381LysLys: 4.381 ± 1.837
5.303LysLeu: 5.303 ± 1.013
2.075LysMet: 2.075 ± 0.483
1.845LysAsn: 1.845 ± 1.036
1.845LysPro: 1.845 ± 0.657
0.922LysGln: 0.922 ± 0.371
2.997LysArg: 2.997 ± 0.805
6.456LysSer: 6.456 ± 1.304
2.997LysThr: 2.997 ± 0.779
4.611LysVal: 4.611 ± 0.8
0.692LysTrp: 0.692 ± 0.292
2.536LysTyr: 2.536 ± 1.062
0.0LysXaa: 0.0 ± 0.0
Leu
6.687LeuAla: 6.687 ± 0.532
1.614LeuCys: 1.614 ± 0.671
5.764LeuAsp: 5.764 ± 1.005
7.378LeuGlu: 7.378 ± 1.161
3.689LeuPhe: 3.689 ± 0.89
5.995LeuGly: 5.995 ± 0.748
2.075LeuHis: 2.075 ± 0.709
5.534LeuIle: 5.534 ± 1.883
7.84LeuLys: 7.84 ± 1.074
9.684LeuLeu: 9.684 ± 1.124
3.92LeuMet: 3.92 ± 1.352
3.689LeuAsn: 3.689 ± 0.971
3.92LeuPro: 3.92 ± 0.728
2.075LeuGln: 2.075 ± 0.659
8.07LeuArg: 8.07 ± 1.955
11.068LeuSer: 11.068 ± 1.834
3.92LeuThr: 3.92 ± 1.071
7.609LeuVal: 7.609 ± 1.3
1.153LeuTrp: 1.153 ± 0.594
4.842LeuTyr: 4.842 ± 0.763
0.0LeuXaa: 0.0 ± 0.0
Met
2.075MetAla: 2.075 ± 0.906
0.692MetCys: 0.692 ± 0.261
1.614MetAsp: 1.614 ± 0.699
0.922MetGlu: 0.922 ± 0.71
0.922MetPhe: 0.922 ± 0.49
0.922MetGly: 0.922 ± 0.633
0.0MetHis: 0.0 ± 0.0
1.383MetIle: 1.383 ± 0.582
0.231MetLys: 0.231 ± 0.126
2.075MetLeu: 2.075 ± 0.967
0.461MetMet: 0.461 ± 0.245
1.845MetAsn: 1.845 ± 1.036
0.231MetPro: 0.231 ± 0.236
1.845MetGln: 1.845 ± 0.758
2.075MetArg: 2.075 ± 0.537
3.689MetSer: 3.689 ± 0.93
2.075MetThr: 2.075 ± 0.618
0.922MetVal: 0.922 ± 0.384
0.0MetTrp: 0.0 ± 0.0
0.231MetTyr: 0.231 ± 0.126
0.0MetXaa: 0.0 ± 0.0
Asn
1.383AsnAla: 1.383 ± 0.522
0.692AsnCys: 0.692 ± 0.378
1.383AsnAsp: 1.383 ± 0.756
1.614AsnGlu: 1.614 ± 0.72
2.997AsnPhe: 2.997 ± 1.595
1.845AsnGly: 1.845 ± 0.803
1.845AsnHis: 1.845 ± 0.556
3.228AsnIle: 3.228 ± 1.028
1.153AsnLys: 1.153 ± 0.455
5.303AsnLeu: 5.303 ± 0.51
0.922AsnMet: 0.922 ± 0.581
0.692AsnAsn: 0.692 ± 0.267
3.689AsnPro: 3.689 ± 0.346
1.153AsnGln: 1.153 ± 0.523
4.381AsnArg: 4.381 ± 0.721
3.92AsnSer: 3.92 ± 0.484
0.692AsnThr: 0.692 ± 0.261
2.997AsnVal: 2.997 ± 1.086
1.383AsnTrp: 1.383 ± 0.676
1.383AsnTyr: 1.383 ± 0.532
0.0AsnXaa: 0.0 ± 0.0
Pro
2.075ProAla: 2.075 ± 0.639
0.692ProCys: 0.692 ± 0.261
3.228ProAsp: 3.228 ± 1.224
3.92ProGlu: 3.92 ± 0.939
0.231ProPhe: 0.231 ± 0.289
3.228ProGly: 3.228 ± 1.29
1.153ProHis: 1.153 ± 0.455
2.997ProIle: 2.997 ± 0.91
1.153ProLys: 1.153 ± 0.63
5.764ProLeu: 5.764 ± 1.088
0.231ProMet: 0.231 ± 0.126
3.689ProAsn: 3.689 ± 1.032
3.92ProPro: 3.92 ± 1.108
0.922ProGln: 0.922 ± 0.468
2.075ProArg: 2.075 ± 0.688
7.148ProSer: 7.148 ± 1.335
2.767ProThr: 2.767 ± 0.35
1.845ProVal: 1.845 ± 0.81
0.231ProTrp: 0.231 ± 0.236
1.845ProTyr: 1.845 ± 0.53
0.0ProXaa: 0.0 ± 0.0
Gln
1.383GlnAla: 1.383 ± 0.441
0.231GlnCys: 0.231 ± 0.316
1.614GlnAsp: 1.614 ± 0.511
1.845GlnGlu: 1.845 ± 0.586
0.922GlnPhe: 0.922 ± 0.329
1.383GlnGly: 1.383 ± 0.42
1.153GlnHis: 1.153 ± 0.514
4.842GlnIle: 4.842 ± 1.822
1.153GlnLys: 1.153 ± 0.477
3.228GlnLeu: 3.228 ± 1.112
1.614GlnMet: 1.614 ± 1.21
0.692GlnAsn: 0.692 ± 0.261
0.231GlnPro: 0.231 ± 0.126
0.461GlnGln: 0.461 ± 0.234
3.228GlnArg: 3.228 ± 0.699
3.689GlnSer: 3.689 ± 0.956
2.997GlnThr: 2.997 ± 1.225
2.767GlnVal: 2.767 ± 0.87
0.461GlnTrp: 0.461 ± 0.29
0.231GlnTyr: 0.231 ± 0.289
0.0GlnXaa: 0.0 ± 0.0
Arg
2.997ArgAla: 2.997 ± 0.942
1.845ArgCys: 1.845 ± 0.478
2.767ArgAsp: 2.767 ± 0.888
5.995ArgGlu: 5.995 ± 1.006
3.459ArgPhe: 3.459 ± 0.594
4.15ArgGly: 4.15 ± 1.586
1.153ArgHis: 1.153 ± 0.477
2.306ArgIle: 2.306 ± 0.788
2.536ArgLys: 2.536 ± 0.659
5.995ArgLeu: 5.995 ± 0.575
2.306ArgMet: 2.306 ± 0.56
2.306ArgAsn: 2.306 ± 0.637
1.845ArgPro: 1.845 ± 0.587
2.075ArgGln: 2.075 ± 0.496
2.767ArgArg: 2.767 ± 0.819
5.764ArgSer: 5.764 ± 0.976
2.767ArgThr: 2.767 ± 0.73
4.842ArgVal: 4.842 ± 1.377
1.153ArgTrp: 1.153 ± 0.492
2.536ArgTyr: 2.536 ± 0.324
0.0ArgXaa: 0.0 ± 0.0
Ser
3.92SerAla: 3.92 ± 0.383
2.306SerCys: 2.306 ± 0.5
4.842SerAsp: 4.842 ± 0.675
5.303SerGlu: 5.303 ± 1.296
5.995SerPhe: 5.995 ± 0.737
7.84SerGly: 7.84 ± 1.931
1.845SerHis: 1.845 ± 0.53
3.228SerIle: 3.228 ± 1.587
8.762SerLys: 8.762 ± 2.504
8.992SerLeu: 8.992 ± 2.224
1.614SerMet: 1.614 ± 0.478
2.536SerAsn: 2.536 ± 0.763
4.611SerPro: 4.611 ± 0.756
4.842SerGln: 4.842 ± 1.601
5.995SerArg: 5.995 ± 1.332
9.223SerSer: 9.223 ± 0.659
4.381SerThr: 4.381 ± 0.651
5.303SerVal: 5.303 ± 0.688
1.614SerTrp: 1.614 ± 0.725
3.92SerTyr: 3.92 ± 1.231
0.0SerXaa: 0.0 ± 0.0
Thr
1.845ThrAla: 1.845 ± 0.949
1.383ThrCys: 1.383 ± 0.621
1.845ThrAsp: 1.845 ± 0.657
0.922ThrGlu: 0.922 ± 0.33
1.153ThrPhe: 1.153 ± 0.344
4.15ThrGly: 4.15 ± 0.416
0.922ThrHis: 0.922 ± 0.329
1.845ThrIle: 1.845 ± 0.629
1.383ThrLys: 1.383 ± 0.621
3.92ThrLeu: 3.92 ± 1.45
1.614ThrMet: 1.614 ± 0.882
2.767ThrAsn: 2.767 ± 0.851
3.459ThrPro: 3.459 ± 1.099
2.997ThrGln: 2.997 ± 0.593
3.92ThrArg: 3.92 ± 0.516
3.228ThrSer: 3.228 ± 0.388
3.92ThrThr: 3.92 ± 1.24
3.459ThrVal: 3.459 ± 1.352
1.614ThrTrp: 1.614 ± 0.537
2.536ThrTyr: 2.536 ± 0.659
0.0ThrXaa: 0.0 ± 0.0
Val
3.689ValAla: 3.689 ± 1.004
0.922ValCys: 0.922 ± 0.371
3.228ValAsp: 3.228 ± 0.744
5.534ValGlu: 5.534 ± 1.763
4.842ValPhe: 4.842 ± 1.541
5.073ValGly: 5.073 ± 1.032
1.383ValHis: 1.383 ± 0.702
2.997ValIle: 2.997 ± 0.684
2.767ValLys: 2.767 ± 1.068
4.842ValLeu: 4.842 ± 0.571
0.0ValMet: 0.0 ± 0.0
4.15ValAsn: 4.15 ± 0.65
3.92ValPro: 3.92 ± 0.652
2.075ValGln: 2.075 ± 0.496
2.306ValArg: 2.306 ± 0.534
6.226ValSer: 6.226 ± 1.718
3.689ValThr: 3.689 ± 0.442
2.536ValVal: 2.536 ± 0.621
0.461ValTrp: 0.461 ± 0.29
1.383ValTyr: 1.383 ± 0.431
0.0ValXaa: 0.0 ± 0.0
Trp
0.922TrpAla: 0.922 ± 0.371
0.461TrpCys: 0.461 ± 0.377
0.461TrpAsp: 0.461 ± 0.29
0.692TrpGlu: 0.692 ± 0.292
0.231TrpPhe: 0.231 ± 0.126
1.153TrpGly: 1.153 ± 0.492
0.461TrpHis: 0.461 ± 0.252
1.153TrpIle: 1.153 ± 0.63
0.692TrpLys: 0.692 ± 0.292
1.614TrpLeu: 1.614 ± 0.544
0.231TrpMet: 0.231 ± 0.236
0.922TrpAsn: 0.922 ± 0.384
0.461TrpPro: 0.461 ± 0.252
0.0TrpGln: 0.0 ± 0.0
0.231TrpArg: 0.231 ± 0.126
3.228TrpSer: 3.228 ± 1.267
0.461TrpThr: 0.461 ± 0.245
1.845TrpVal: 1.845 ± 0.634
0.0TrpTrp: 0.0 ± 0.0
0.231TrpTyr: 0.231 ± 0.126
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.461TyrAla: 0.461 ± 0.252
0.461TyrCys: 0.461 ± 0.234
2.075TyrAsp: 2.075 ± 0.703
1.845TyrGlu: 1.845 ± 0.661
1.614TyrPhe: 1.614 ± 0.729
1.153TyrGly: 1.153 ± 0.424
0.0TyrHis: 0.0 ± 0.0
1.614TyrIle: 1.614 ± 0.725
3.228TyrLys: 3.228 ± 0.829
4.611TyrLeu: 4.611 ± 1.054
0.922TyrMet: 0.922 ± 0.25
2.536TyrAsn: 2.536 ± 0.449
0.922TyrPro: 0.922 ± 0.25
0.692TyrGln: 0.692 ± 0.378
2.075TyrArg: 2.075 ± 0.298
4.15TyrSer: 4.15 ± 1.292
2.306TyrThr: 2.306 ± 1.04
2.075TyrVal: 2.075 ± 0.852
0.0TyrTrp: 0.0 ± 0.0
0.461TyrTyr: 0.461 ± 0.252
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (4338 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski