Amino acid dipepetide frequency for endosymbiont TC1 of Trimyema compressum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.066AlaAla: 4.066 ± 0.12
0.673AlaCys: 0.673 ± 0.044
2.812AlaAsp: 2.812 ± 0.099
3.83AlaGlu: 3.83 ± 0.116
3.004AlaPhe: 3.004 ± 0.094
4.473AlaGly: 4.473 ± 0.103
1.023AlaHis: 1.023 ± 0.054
6.204AlaIle: 6.204 ± 0.132
4.47AlaLys: 4.47 ± 0.119
7.35AlaLeu: 7.35 ± 0.147
1.718AlaMet: 1.718 ± 0.071
2.676AlaAsn: 2.676 ± 0.099
1.702AlaPro: 1.702 ± 0.08
1.647AlaGln: 1.647 ± 0.072
2.19AlaArg: 2.19 ± 0.083
3.477AlaSer: 3.477 ± 0.093
3.3AlaThr: 3.3 ± 0.101
4.611AlaVal: 4.611 ± 0.118
0.345AlaTrp: 0.345 ± 0.033
2.535AlaTyr: 2.535 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
0.51CysAla: 0.51 ± 0.039
0.179CysCys: 0.179 ± 0.024
0.535CysAsp: 0.535 ± 0.039
0.63CysGlu: 0.63 ± 0.043
0.51CysPhe: 0.51 ± 0.04
1.083CysGly: 1.083 ± 0.061
0.261CysHis: 0.261 ± 0.028
0.844CysIle: 0.844 ± 0.046
0.681CysLys: 0.681 ± 0.041
0.915CysLeu: 0.915 ± 0.043
0.252CysMet: 0.252 ± 0.029
0.51CysAsn: 0.51 ± 0.042
0.494CysPro: 0.494 ± 0.036
0.418CysGln: 0.418 ± 0.031
0.413CysArg: 0.413 ± 0.029
0.708CysSer: 0.708 ± 0.041
0.529CysThr: 0.529 ± 0.039
0.603CysVal: 0.603 ± 0.043
0.076CysTrp: 0.076 ± 0.016
0.437CysTyr: 0.437 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
2.92AspAla: 2.92 ± 0.092
0.516AspCys: 0.516 ± 0.036
2.451AspAsp: 2.451 ± 0.084
3.911AspGlu: 3.911 ± 0.114
2.698AspPhe: 2.698 ± 0.084
3.599AspGly: 3.599 ± 0.101
0.7AspHis: 0.7 ± 0.035
4.823AspIle: 4.823 ± 0.128
4.172AspLys: 4.172 ± 0.126
4.853AspLeu: 4.853 ± 0.115
1.346AspMet: 1.346 ± 0.059
2.657AspAsn: 2.657 ± 0.083
1.422AspPro: 1.422 ± 0.065
1.151AspGln: 1.151 ± 0.049
1.732AspArg: 1.732 ± 0.08
3.241AspSer: 3.241 ± 0.093
2.643AspThr: 2.643 ± 0.092
3.68AspVal: 3.68 ± 0.109
0.375AspTrp: 0.375 ± 0.032
2.576AspTyr: 2.576 ± 0.081
0.0AspXaa: 0.0 ± 0.0
Glu
5.596GluAla: 5.596 ± 0.115
0.546GluCys: 0.546 ± 0.044
4.267GluAsp: 4.267 ± 0.12
6.525GluGlu: 6.525 ± 0.146
2.274GluPhe: 2.274 ± 0.086
5.021GluGly: 5.021 ± 0.115
0.972GluHis: 0.972 ± 0.054
6.001GluIle: 6.001 ± 0.139
7.996GluLys: 7.996 ± 0.163
5.86GluLeu: 5.86 ± 0.148
2.166GluMet: 2.166 ± 0.077
4.69GluAsn: 4.69 ± 0.108
1.81GluPro: 1.81 ± 0.073
1.913GluGln: 1.913 ± 0.068
2.657GluArg: 2.657 ± 0.092
3.843GluSer: 3.843 ± 0.097
3.846GluThr: 3.846 ± 0.122
4.986GluVal: 4.986 ± 0.135
0.407GluTrp: 0.407 ± 0.035
2.364GluTyr: 2.364 ± 0.091
0.0GluXaa: 0.0 ± 0.0
Phe
2.467PheAla: 2.467 ± 0.081
0.57PheCys: 0.57 ± 0.038
2.179PheAsp: 2.179 ± 0.089
2.562PheGlu: 2.562 ± 0.08
2.348PhePhe: 2.348 ± 0.096
3.045PheGly: 3.045 ± 0.088
0.619PheHis: 0.619 ± 0.041
3.995PheIle: 3.995 ± 0.147
3.656PheLys: 3.656 ± 0.091
5.029PheLeu: 5.029 ± 0.147
1.308PheMet: 1.308 ± 0.069
2.54PheAsn: 2.54 ± 0.089
1.468PhePro: 1.468 ± 0.068
1.205PheGln: 1.205 ± 0.061
1.487PheArg: 1.487 ± 0.066
3.224PheSer: 3.224 ± 0.097
2.266PheThr: 2.266 ± 0.073
2.714PheVal: 2.714 ± 0.095
0.309PheTrp: 0.309 ± 0.032
1.859PheTyr: 1.859 ± 0.073
0.0PheXaa: 0.0 ± 0.0
Gly
4.915GlyAla: 4.915 ± 0.129
0.869GlyCys: 0.869 ± 0.055
3.515GlyAsp: 3.515 ± 0.109
4.75GlyGlu: 4.75 ± 0.112
3.542GlyPhe: 3.542 ± 0.113
4.918GlyGly: 4.918 ± 0.166
1.379GlyHis: 1.379 ± 0.065
6.818GlyIle: 6.818 ± 0.135
5.77GlyLys: 5.77 ± 0.134
6.647GlyLeu: 6.647 ± 0.139
1.884GlyMet: 1.884 ± 0.071
3.539GlyAsn: 3.539 ± 0.109
1.593GlyPro: 1.593 ± 0.074
2.025GlyGln: 2.025 ± 0.077
2.676GlyArg: 2.676 ± 0.097
4.391GlySer: 4.391 ± 0.119
3.979GlyThr: 3.979 ± 0.102
5.132GlyVal: 5.132 ± 0.122
0.518GlyTrp: 0.518 ± 0.036
3.075GlyTyr: 3.075 ± 0.098
0.0GlyXaa: 0.0 ± 0.0
His
0.755HisAla: 0.755 ± 0.045
0.233HisCys: 0.233 ± 0.026
0.586HisAsp: 0.586 ± 0.036
0.782HisGlu: 0.782 ± 0.047
0.863HisPhe: 0.863 ± 0.05
1.243HisGly: 1.243 ± 0.065
0.347HisHis: 0.347 ± 0.034
1.373HisIle: 1.373 ± 0.061
1.099HisLys: 1.099 ± 0.05
1.832HisLeu: 1.832 ± 0.076
0.407HisMet: 0.407 ± 0.034
0.831HisAsn: 0.831 ± 0.054
0.774HisPro: 0.774 ± 0.047
0.537HisGln: 0.537 ± 0.039
0.676HisArg: 0.676 ± 0.042
1.001HisSer: 1.001 ± 0.058
0.839HisThr: 0.839 ± 0.047
0.909HisVal: 0.909 ± 0.051
0.1HisTrp: 0.1 ± 0.018
0.725HisTyr: 0.725 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.058IleAla: 6.058 ± 0.143
0.942IleCys: 0.942 ± 0.05
5.032IleAsp: 5.032 ± 0.105
6.772IleGlu: 6.772 ± 0.164
3.843IlePhe: 3.843 ± 0.121
6.5IleGly: 6.5 ± 0.141
1.457IleHis: 1.457 ± 0.063
7.751IleIle: 7.751 ± 0.157
6.875IleLys: 6.875 ± 0.144
9.13IleLeu: 9.13 ± 0.177
2.076IleMet: 2.076 ± 0.075
4.527IleAsn: 4.527 ± 0.122
3.471IlePro: 3.471 ± 0.085
2.112IleGln: 2.112 ± 0.087
2.918IleArg: 2.918 ± 0.106
5.472IleSer: 5.472 ± 0.135
4.741IleThr: 4.741 ± 0.106
6.009IleVal: 6.009 ± 0.127
0.546IleTrp: 0.546 ± 0.038
3.08IleTyr: 3.08 ± 0.097
0.0IleXaa: 0.0 ± 0.0
Lys
5.143LysAla: 5.143 ± 0.134
0.6LysCys: 0.6 ± 0.042
4.842LysAsp: 4.842 ± 0.125
8.511LysGlu: 8.511 ± 0.15
1.908LysPhe: 1.908 ± 0.067
6.123LysGly: 6.123 ± 0.149
1.17LysHis: 1.17 ± 0.056
7.228LysIle: 7.228 ± 0.13
8.365LysLys: 8.365 ± 0.166
5.789LysLeu: 5.789 ± 0.119
2.597LysMet: 2.597 ± 0.083
5.089LysAsn: 5.089 ± 0.131
2.307LysPro: 2.307 ± 0.088
2.125LysGln: 2.125 ± 0.077
3.444LysArg: 3.444 ± 0.104
4.372LysSer: 4.372 ± 0.098
4.332LysThr: 4.332 ± 0.094
5.311LysVal: 5.311 ± 0.133
0.619LysTrp: 0.619 ± 0.039
2.511LysTyr: 2.511 ± 0.088
0.0LysXaa: 0.0 ± 0.0
Leu
6.09LeuAla: 6.09 ± 0.116
0.961LeuCys: 0.961 ± 0.055
5.17LeuAsp: 5.17 ± 0.13
7.665LeuGlu: 7.665 ± 0.157
4.606LeuPhe: 4.606 ± 0.151
7.203LeuGly: 7.203 ± 0.123
1.33LeuHis: 1.33 ± 0.062
8.354LeuIle: 8.354 ± 0.205
8.704LeuLys: 8.704 ± 0.15
10.381LeuLeu: 10.381 ± 0.243
2.524LeuMet: 2.524 ± 0.076
5.081LeuAsn: 5.081 ± 0.138
3.83LeuPro: 3.83 ± 0.122
2.378LeuGln: 2.378 ± 0.082
3.336LeuArg: 3.336 ± 0.093
6.367LeuSer: 6.367 ± 0.116
5.311LeuThr: 5.311 ± 0.142
6.25LeuVal: 6.25 ± 0.124
0.616LeuTrp: 0.616 ± 0.046
3.129LeuTyr: 3.129 ± 0.096
0.0LeuXaa: 0.0 ± 0.0
Met
2.269MetAla: 2.269 ± 0.073
0.239MetCys: 0.239 ± 0.026
1.639MetAsp: 1.639 ± 0.061
2.087MetGlu: 2.087 ± 0.082
0.871MetPhe: 0.871 ± 0.046
1.951MetGly: 1.951 ± 0.082
0.358MetHis: 0.358 ± 0.033
2.093MetIle: 2.093 ± 0.076
2.321MetLys: 2.321 ± 0.069
2.239MetLeu: 2.239 ± 0.073
0.668MetMet: 0.668 ± 0.045
1.466MetAsn: 1.466 ± 0.054
1.14MetPro: 1.14 ± 0.059
0.562MetGln: 0.562 ± 0.043
1.031MetArg: 1.031 ± 0.054
1.574MetSer: 1.574 ± 0.068
1.403MetThr: 1.403 ± 0.063
1.943MetVal: 1.943 ± 0.067
0.117MetTrp: 0.117 ± 0.021
0.624MetTyr: 0.624 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
2.662AsnAla: 2.662 ± 0.095
0.66AsnCys: 0.66 ± 0.039
2.293AsnAsp: 2.293 ± 0.076
3.577AsnGlu: 3.577 ± 0.111
2.098AsnPhe: 2.098 ± 0.085
3.669AsnGly: 3.669 ± 0.095
0.901AsnHis: 0.901 ± 0.052
4.972AsnIle: 4.972 ± 0.129
4.693AsnLys: 4.693 ± 0.11
4.969AsnLeu: 4.969 ± 0.134
1.419AsnMet: 1.419 ± 0.064
3.325AsnAsn: 3.325 ± 0.113
2.147AsnPro: 2.147 ± 0.077
1.943AsnGln: 1.943 ± 0.077
2.071AsnArg: 2.071 ± 0.068
3.018AsnSer: 3.018 ± 0.106
2.63AsnThr: 2.63 ± 0.091
3.004AsnVal: 3.004 ± 0.085
0.41AsnTrp: 0.41 ± 0.028
2.12AsnTyr: 2.12 ± 0.092
0.0AsnXaa: 0.0 ± 0.0
Pro
1.647ProAla: 1.647 ± 0.064
0.358ProCys: 0.358 ± 0.031
1.569ProAsp: 1.569 ± 0.06
2.662ProGlu: 2.662 ± 0.086
1.867ProPhe: 1.867 ± 0.069
2.011ProGly: 2.011 ± 0.074
0.575ProHis: 0.575 ± 0.041
3.254ProIle: 3.254 ± 0.086
2.114ProLys: 2.114 ± 0.083
3.602ProLeu: 3.602 ± 0.103
0.793ProMet: 0.793 ± 0.056
1.721ProAsn: 1.721 ± 0.065
0.801ProPro: 0.801 ± 0.053
0.774ProGln: 0.774 ± 0.05
0.89ProArg: 0.89 ± 0.05
1.962ProSer: 1.962 ± 0.072
1.704ProThr: 1.704 ± 0.071
2.595ProVal: 2.595 ± 0.083
0.223ProTrp: 0.223 ± 0.022
1.523ProTyr: 1.523 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
1.39GlnAla: 1.39 ± 0.064
0.293GlnCys: 0.293 ± 0.033
1.167GlnAsp: 1.167 ± 0.055
1.87GlnGlu: 1.87 ± 0.071
1.202GlnPhe: 1.202 ± 0.051
1.856GlnGly: 1.856 ± 0.066
0.437GlnHis: 0.437 ± 0.033
2.413GlnIle: 2.413 ± 0.086
2.467GlnLys: 2.467 ± 0.082
3.129GlnLeu: 3.129 ± 0.094
0.85GlnMet: 0.85 ± 0.05
1.292GlnAsn: 1.292 ± 0.058
0.738GlnPro: 0.738 ± 0.049
0.885GlnGln: 0.885 ± 0.062
1.053GlnArg: 1.053 ± 0.046
1.547GlnSer: 1.547 ± 0.059
1.2GlnThr: 1.2 ± 0.058
1.878GlnVal: 1.878 ± 0.069
0.312GlnTrp: 0.312 ± 0.028
0.974GlnTyr: 0.974 ± 0.062
0.0GlnXaa: 0.0 ± 0.0
Arg
1.911ArgAla: 1.911 ± 0.07
0.388ArgCys: 0.388 ± 0.031
1.905ArgAsp: 1.905 ± 0.087
3.018ArgGlu: 3.018 ± 0.099
1.498ArgPhe: 1.498 ± 0.063
2.606ArgGly: 2.606 ± 0.095
0.603ArgHis: 0.603 ± 0.035
3.01ArgIle: 3.01 ± 0.1
3.384ArgLys: 3.384 ± 0.102
3.436ArgLeu: 3.436 ± 0.114
0.961ArgMet: 0.961 ± 0.053
1.867ArgAsn: 1.867 ± 0.063
1.064ArgPro: 1.064 ± 0.055
1.194ArgGln: 1.194 ± 0.049
1.832ArgArg: 1.832 ± 0.066
1.829ArgSer: 1.829 ± 0.07
1.683ArgThr: 1.683 ± 0.07
2.326ArgVal: 2.326 ± 0.08
0.236ArgTrp: 0.236 ± 0.027
1.238ArgTyr: 1.238 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
3.11SerAla: 3.11 ± 0.094
0.657SerCys: 0.657 ± 0.044
2.738SerAsp: 2.738 ± 0.083
3.602SerGlu: 3.602 ± 0.092
3.572SerPhe: 3.572 ± 0.12
4.267SerGly: 4.267 ± 0.106
1.099SerHis: 1.099 ± 0.054
5.689SerIle: 5.689 ± 0.127
4.348SerLys: 4.348 ± 0.11
6.617SerLeu: 6.617 ± 0.136
1.569SerMet: 1.569 ± 0.058
2.839SerAsn: 2.839 ± 0.081
1.873SerPro: 1.873 ± 0.074
1.843SerGln: 1.843 ± 0.072
2.095SerArg: 2.095 ± 0.081
3.496SerSer: 3.496 ± 0.114
2.937SerThr: 2.937 ± 0.096
4.128SerVal: 4.128 ± 0.086
0.459SerTrp: 0.459 ± 0.036
2.44SerTyr: 2.44 ± 0.082
0.0SerXaa: 0.0 ± 0.0
Thr
3.327ThrAla: 3.327 ± 0.107
0.48ThrCys: 0.48 ± 0.032
2.622ThrAsp: 2.622 ± 0.081
3.281ThrGlu: 3.281 ± 0.095
2.397ThrPhe: 2.397 ± 0.081
4.511ThrGly: 4.511 ± 0.118
0.887ThrHis: 0.887 ± 0.048
5.173ThrIle: 5.173 ± 0.128
3.355ThrLys: 3.355 ± 0.09
5.624ThrLeu: 5.624 ± 0.137
1.33ThrMet: 1.33 ± 0.058
2.413ThrAsn: 2.413 ± 0.082
1.987ThrPro: 1.987 ± 0.066
1.248ThrGln: 1.248 ± 0.068
1.666ThrArg: 1.666 ± 0.073
2.866ThrSer: 2.866 ± 0.091
2.893ThrThr: 2.893 ± 0.079
3.933ThrVal: 3.933 ± 0.104
0.334ThrTrp: 0.334 ± 0.029
2.0ThrTyr: 2.0 ± 0.081
0.0ThrXaa: 0.0 ± 0.0
Val
4.891ValAla: 4.891 ± 0.123
0.741ValCys: 0.741 ± 0.05
3.716ValAsp: 3.716 ± 0.1
4.644ValGlu: 4.644 ± 0.133
3.219ValPhe: 3.219 ± 0.104
4.739ValGly: 4.739 ± 0.126
0.991ValHis: 0.991 ± 0.058
5.89ValIle: 5.89 ± 0.145
4.85ValLys: 4.85 ± 0.122
7.0ValLeu: 7.0 ± 0.155
1.661ValMet: 1.661 ± 0.069
3.211ValAsn: 3.211 ± 0.099
2.407ValPro: 2.407 ± 0.083
1.512ValGln: 1.512 ± 0.067
2.22ValArg: 2.22 ± 0.083
4.229ValSer: 4.229 ± 0.109
3.794ValThr: 3.794 ± 0.094
5.062ValVal: 5.062 ± 0.129
0.423ValTrp: 0.423 ± 0.032
2.402ValTyr: 2.402 ± 0.093
0.0ValXaa: 0.0 ± 0.0
Trp
0.399TrpAla: 0.399 ± 0.032
0.087TrpCys: 0.087 ± 0.018
0.331TrpAsp: 0.331 ± 0.03
0.475TrpGlu: 0.475 ± 0.034
0.337TrpPhe: 0.337 ± 0.033
0.388TrpGly: 0.388 ± 0.029
0.171TrpHis: 0.171 ± 0.023
0.535TrpIle: 0.535 ± 0.04
0.459TrpLys: 0.459 ± 0.036
0.793TrpLeu: 0.793 ± 0.053
0.179TrpMet: 0.179 ± 0.022
0.345TrpAsn: 0.345 ± 0.031
0.166TrpPro: 0.166 ± 0.022
0.331TrpGln: 0.331 ± 0.03
0.244TrpArg: 0.244 ± 0.026
0.391TrpSer: 0.391 ± 0.035
0.342TrpThr: 0.342 ± 0.033
0.434TrpVal: 0.434 ± 0.037
0.073TrpTrp: 0.073 ± 0.016
0.277TrpTyr: 0.277 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.979TyrAla: 1.979 ± 0.076
0.597TyrCys: 0.597 ± 0.039
2.095TyrAsp: 2.095 ± 0.09
2.587TyrGlu: 2.587 ± 0.077
2.196TyrPhe: 2.196 ± 0.086
2.728TyrGly: 2.728 ± 0.085
0.632TyrHis: 0.632 ± 0.039
2.893TyrIle: 2.893 ± 0.09
2.611TyrLys: 2.611 ± 0.093
4.093TyrLeu: 4.093 ± 0.127
0.885TyrMet: 0.885 ± 0.044
1.965TyrAsn: 1.965 ± 0.069
1.452TyrPro: 1.452 ± 0.061
1.151TyrGln: 1.151 ± 0.055
1.357TyrArg: 1.357 ± 0.061
2.367TyrSer: 2.367 ± 0.09
1.954TyrThr: 1.954 ± 0.074
2.09TyrVal: 2.09 ± 0.07
0.258TyrTrp: 0.258 ± 0.028
1.713TyrTyr: 1.713 ± 0.083
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1674 proteins (368452 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski