Amino acid dipepetide frequency for Pleurocapsa sp. CCALA 161

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.863AlaAla: 6.863 ± 0.083
0.758AlaCys: 0.758 ± 0.026
4.043AlaAsp: 4.043 ± 0.06
5.403AlaGlu: 5.403 ± 0.077
2.776AlaPhe: 2.776 ± 0.045
5.31AlaGly: 5.31 ± 0.068
1.27AlaHis: 1.27 ± 0.03
7.513AlaIle: 7.513 ± 0.078
4.691AlaLys: 4.691 ± 0.059
8.027AlaLeu: 8.027 ± 0.085
1.642AlaMet: 1.642 ± 0.036
3.704AlaAsn: 3.704 ± 0.062
2.581AlaPro: 2.581 ± 0.044
4.52AlaGln: 4.52 ± 0.058
3.328AlaArg: 3.328 ± 0.054
4.717AlaSer: 4.717 ± 0.054
4.683AlaThr: 4.683 ± 0.061
5.248AlaVal: 5.248 ± 0.062
0.987AlaTrp: 0.987 ± 0.029
2.353AlaTyr: 2.353 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.642CysAla: 0.642 ± 0.024
0.178CysCys: 0.178 ± 0.011
0.624CysAsp: 0.624 ± 0.022
0.464CysGlu: 0.464 ± 0.019
0.426CysPhe: 0.426 ± 0.016
0.769CysGly: 0.769 ± 0.023
0.25CysHis: 0.25 ± 0.012
0.549CysIle: 0.549 ± 0.02
0.368CysLys: 0.368 ± 0.018
1.29CysLeu: 1.29 ± 0.035
0.159CysMet: 0.159 ± 0.01
0.38CysAsn: 0.38 ± 0.017
0.524CysPro: 0.524 ± 0.02
0.652CysGln: 0.652 ± 0.021
0.509CysArg: 0.509 ± 0.02
0.715CysSer: 0.715 ± 0.027
0.437CysThr: 0.437 ± 0.017
0.529CysVal: 0.529 ± 0.017
0.159CysTrp: 0.159 ± 0.009
0.371CysTyr: 0.371 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.524AspAla: 3.524 ± 0.057
0.604AspCys: 0.604 ± 0.019
2.4AspAsp: 2.4 ± 0.053
2.921AspGlu: 2.921 ± 0.054
2.456AspPhe: 2.456 ± 0.043
3.188AspGly: 3.188 ± 0.068
0.836AspHis: 0.836 ± 0.023
3.306AspIle: 3.306 ± 0.053
2.253AspLys: 2.253 ± 0.045
6.57AspLeu: 6.57 ± 0.077
0.731AspMet: 0.731 ± 0.027
2.436AspAsn: 2.436 ± 0.05
2.286AspPro: 2.286 ± 0.047
1.788AspGln: 1.788 ± 0.037
4.201AspArg: 4.201 ± 0.061
3.3AspSer: 3.3 ± 0.054
2.581AspThr: 2.581 ± 0.048
2.779AspVal: 2.779 ± 0.044
0.912AspTrp: 0.912 ± 0.026
2.105AspTyr: 2.105 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
5.219GluAla: 5.219 ± 0.067
0.46GluCys: 0.46 ± 0.019
2.873GluAsp: 2.873 ± 0.059
3.672GluGlu: 3.672 ± 0.065
2.362GluPhe: 2.362 ± 0.044
3.126GluGly: 3.126 ± 0.058
1.056GluHis: 1.056 ± 0.027
5.446GluIle: 5.446 ± 0.076
3.247GluLys: 3.247 ± 0.057
7.26GluLeu: 7.26 ± 0.084
1.25GluMet: 1.25 ± 0.032
2.719GluAsn: 2.719 ± 0.051
2.225GluPro: 2.225 ± 0.038
4.264GluGln: 4.264 ± 0.062
2.976GluArg: 2.976 ± 0.053
3.711GluSer: 3.711 ± 0.055
3.415GluThr: 3.415 ± 0.057
4.066GluVal: 4.066 ± 0.054
0.663GluTrp: 0.663 ± 0.023
2.03GluTyr: 2.03 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.241PheAla: 3.241 ± 0.052
0.525PheCys: 0.525 ± 0.02
2.304PheAsp: 2.304 ± 0.041
2.233PheGlu: 2.233 ± 0.044
1.689PhePhe: 1.689 ± 0.036
2.8PheGly: 2.8 ± 0.057
0.635PheHis: 0.635 ± 0.024
2.526PheIle: 2.526 ± 0.048
1.827PheLys: 1.827 ± 0.037
3.936PheLeu: 3.936 ± 0.064
0.661PheMet: 0.661 ± 0.023
2.038PheAsn: 2.038 ± 0.041
1.694PhePro: 1.694 ± 0.033
1.691PheGln: 1.691 ± 0.038
1.598PheArg: 1.598 ± 0.039
2.89PheSer: 2.89 ± 0.045
2.215PheThr: 2.215 ± 0.04
2.369PheVal: 2.369 ± 0.047
0.696PheTrp: 0.696 ± 0.026
1.404PheTyr: 1.404 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
4.607GlyAla: 4.607 ± 0.078
0.758GlyCys: 0.758 ± 0.026
3.384GlyAsp: 3.384 ± 0.06
3.95GlyGlu: 3.95 ± 0.063
2.873GlyPhe: 2.873 ± 0.051
4.516GlyGly: 4.516 ± 0.082
1.149GlyHis: 1.149 ± 0.033
5.436GlyIle: 5.436 ± 0.057
4.352GlyLys: 4.352 ± 0.06
6.574GlyLeu: 6.574 ± 0.071
1.544GlyMet: 1.544 ± 0.033
2.958GlyAsn: 2.958 ± 0.069
0.919GlyPro: 0.919 ± 0.027
2.737GlyGln: 2.737 ± 0.046
2.714GlyArg: 2.714 ± 0.049
4.034GlySer: 4.034 ± 0.058
3.591GlyThr: 3.591 ± 0.067
4.517GlyVal: 4.517 ± 0.067
1.023GlyTrp: 1.023 ± 0.03
2.413GlyTyr: 2.413 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
0.967HisAla: 0.967 ± 0.028
0.291HisCys: 0.291 ± 0.022
0.811HisAsp: 0.811 ± 0.027
0.833HisGlu: 0.833 ± 0.026
0.757HisPhe: 0.757 ± 0.024
1.083HisGly: 1.083 ± 0.027
0.642HisHis: 0.642 ± 0.029
1.018HisIle: 1.018 ± 0.029
0.785HisLys: 0.785 ± 0.024
2.216HisLeu: 2.216 ± 0.048
0.242HisMet: 0.242 ± 0.014
0.885HisAsn: 0.885 ± 0.026
1.171HisPro: 1.171 ± 0.03
1.385HisGln: 1.385 ± 0.029
1.004HisArg: 1.004 ± 0.029
1.144HisSer: 1.144 ± 0.036
0.846HisThr: 0.846 ± 0.026
0.708HisVal: 0.708 ± 0.024
0.328HisTrp: 0.328 ± 0.015
0.698HisTyr: 0.698 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
8.245IleAla: 8.245 ± 0.092
0.821IleCys: 0.821 ± 0.021
4.247IleAsp: 4.247 ± 0.061
4.988IleGlu: 4.988 ± 0.068
2.801IlePhe: 2.801 ± 0.049
4.576IleGly: 4.576 ± 0.072
1.144IleHis: 1.144 ± 0.032
4.822IleIle: 4.822 ± 0.06
3.988IleLys: 3.988 ± 0.057
7.123IleLeu: 7.123 ± 0.089
1.093IleMet: 1.093 ± 0.028
3.594IleAsn: 3.594 ± 0.048
3.54IlePro: 3.54 ± 0.05
2.906IleGln: 2.906 ± 0.051
2.902IleArg: 2.902 ± 0.051
4.964IleSer: 4.964 ± 0.062
4.025IleThr: 4.025 ± 0.047
4.641IleVal: 4.641 ± 0.058
0.865IleTrp: 0.865 ± 0.029
2.267IleTyr: 2.267 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
4.084LysAla: 4.084 ± 0.056
0.315LysCys: 0.315 ± 0.015
2.382LysAsp: 2.382 ± 0.043
3.063LysGlu: 3.063 ± 0.056
1.876LysPhe: 1.876 ± 0.041
2.677LysGly: 2.677 ± 0.044
0.893LysHis: 0.893 ± 0.022
4.483LysIle: 4.483 ± 0.059
2.708LysLys: 2.708 ± 0.059
6.161LysLeu: 6.161 ± 0.079
1.104LysMet: 1.104 ± 0.028
2.404LysAsn: 2.404 ± 0.042
2.463LysPro: 2.463 ± 0.039
3.291LysGln: 3.291 ± 0.054
2.255LysArg: 2.255 ± 0.048
3.441LysSer: 3.441 ± 0.053
3.249LysThr: 3.249 ± 0.052
3.408LysVal: 3.408 ± 0.049
0.489LysTrp: 0.489 ± 0.019
1.719LysTyr: 1.719 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
9.881LeuAla: 9.881 ± 0.091
0.994LeuCys: 0.994 ± 0.028
5.787LeuAsp: 5.787 ± 0.072
7.456LeuGlu: 7.456 ± 0.075
3.904LeuPhe: 3.904 ± 0.06
7.463LeuGly: 7.463 ± 0.076
1.689LeuHis: 1.689 ± 0.037
7.824LeuIle: 7.824 ± 0.094
6.286LeuLys: 6.286 ± 0.062
11.11LeuLeu: 11.11 ± 0.123
1.99LeuMet: 1.99 ± 0.041
5.269LeuAsn: 5.269 ± 0.072
5.403LeuPro: 5.403 ± 0.073
5.104LeuGln: 5.104 ± 0.071
4.766LeuArg: 4.766 ± 0.057
7.68LeuSer: 7.68 ± 0.081
6.409LeuThr: 6.409 ± 0.072
7.155LeuVal: 7.155 ± 0.082
1.395LeuTrp: 1.395 ± 0.034
2.652LeuTyr: 2.652 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
1.694MetAla: 1.694 ± 0.035
0.127MetCys: 0.127 ± 0.01
0.743MetAsp: 0.743 ± 0.024
0.929MetGlu: 0.929 ± 0.025
0.619MetPhe: 0.619 ± 0.024
1.363MetGly: 1.363 ± 0.036
0.261MetHis: 0.261 ± 0.014
1.255MetIle: 1.255 ± 0.033
0.969MetLys: 0.969 ± 0.027
1.932MetLeu: 1.932 ± 0.038
0.505MetMet: 0.505 ± 0.02
0.938MetAsn: 0.938 ± 0.026
0.914MetPro: 0.914 ± 0.024
0.819MetGln: 0.819 ± 0.028
0.856MetArg: 0.856 ± 0.026
1.462MetSer: 1.462 ± 0.031
1.304MetThr: 1.304 ± 0.032
1.252MetVal: 1.252 ± 0.028
0.148MetTrp: 0.148 ± 0.01
0.384MetTyr: 0.384 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.819AsnAla: 2.819 ± 0.055
0.577AsnCys: 0.577 ± 0.021
1.927AsnAsp: 1.927 ± 0.053
1.906AsnGlu: 1.906 ± 0.041
2.059AsnPhe: 2.059 ± 0.042
2.485AsnGly: 2.485 ± 0.051
1.004AsnHis: 1.004 ± 0.031
3.139AsnIle: 3.139 ± 0.045
2.112AsnLys: 2.112 ± 0.036
6.254AsnLeu: 6.254 ± 0.097
0.765AsnMet: 0.765 ± 0.022
2.518AsnAsn: 2.518 ± 0.053
2.766AsnPro: 2.766 ± 0.045
3.112AsnGln: 3.112 ± 0.051
2.331AsnArg: 2.331 ± 0.038
3.616AsnSer: 3.616 ± 0.057
2.408AsnThr: 2.408 ± 0.05
2.232AsnVal: 2.232 ± 0.046
0.791AsnTrp: 0.791 ± 0.023
1.878AsnTyr: 1.878 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
2.916ProAla: 2.916 ± 0.049
0.351ProCys: 0.351 ± 0.018
2.662ProAsp: 2.662 ± 0.042
3.746ProGlu: 3.746 ± 0.053
1.611ProPhe: 1.611 ± 0.035
2.728ProGly: 2.728 ± 0.049
0.856ProHis: 0.856 ± 0.025
2.965ProIle: 2.965 ± 0.044
2.124ProLys: 2.124 ± 0.035
4.293ProLeu: 4.293 ± 0.067
0.676ProMet: 0.676 ± 0.025
2.045ProAsn: 2.045 ± 0.047
1.753ProPro: 1.753 ± 0.047
2.797ProGln: 2.797 ± 0.048
1.514ProArg: 1.514 ± 0.032
2.421ProSer: 2.421 ± 0.043
2.397ProThr: 2.397 ± 0.043
2.897ProVal: 2.897 ± 0.047
0.599ProTrp: 0.599 ± 0.021
1.293ProTyr: 1.293 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.838GlnAla: 4.838 ± 0.083
0.337GlnCys: 0.337 ± 0.016
2.619GlnAsp: 2.619 ± 0.04
3.707GlnGlu: 3.707 ± 0.065
1.707GlnPhe: 1.707 ± 0.031
3.317GlnGly: 3.317 ± 0.044
0.938GlnHis: 0.938 ± 0.027
4.146GlnIle: 4.146 ± 0.057
3.03GlnLys: 3.03 ± 0.044
6.085GlnLeu: 6.085 ± 0.069
1.057GlnMet: 1.057 ± 0.029
2.284GlnAsn: 2.284 ± 0.042
2.515GlnPro: 2.515 ± 0.051
4.198GlnGln: 4.198 ± 0.076
2.449GlnArg: 2.449 ± 0.045
3.274GlnSer: 3.274 ± 0.05
3.057GlnThr: 3.057 ± 0.045
3.61GlnVal: 3.61 ± 0.052
0.689GlnTrp: 0.689 ± 0.025
1.375GlnTyr: 1.375 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.983ArgAla: 2.983 ± 0.049
0.415ArgCys: 0.415 ± 0.019
2.499ArgAsp: 2.499 ± 0.05
2.931ArgGlu: 2.931 ± 0.043
1.926ArgPhe: 1.926 ± 0.035
2.696ArgGly: 2.696 ± 0.043
0.977ArgHis: 0.977 ± 0.029
3.116ArgIle: 3.116 ± 0.054
2.206ArgLys: 2.206 ± 0.037
5.561ArgLeu: 5.561 ± 0.058
0.839ArgMet: 0.839 ± 0.024
2.05ArgAsn: 2.05 ± 0.037
1.748ArgPro: 1.748 ± 0.036
3.1ArgGln: 3.1 ± 0.047
2.539ArgArg: 2.539 ± 0.048
3.187ArgSer: 3.187 ± 0.05
2.212ArgThr: 2.212 ± 0.042
2.96ArgVal: 2.96 ± 0.042
0.71ArgTrp: 0.71 ± 0.021
1.741ArgTyr: 1.741 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
4.673SerAla: 4.673 ± 0.062
0.722SerCys: 0.722 ± 0.023
3.453SerAsp: 3.453 ± 0.053
3.697SerGlu: 3.697 ± 0.053
2.69SerPhe: 2.69 ± 0.046
4.47SerGly: 4.47 ± 0.065
1.278SerHis: 1.278 ± 0.035
4.526SerIle: 4.526 ± 0.062
3.247SerLys: 3.247 ± 0.048
7.931SerLeu: 7.931 ± 0.085
1.267SerMet: 1.267 ± 0.031
3.153SerAsn: 3.153 ± 0.051
3.053SerPro: 3.053 ± 0.052
3.855SerGln: 3.855 ± 0.061
3.004SerArg: 3.004 ± 0.041
4.856SerSer: 4.856 ± 0.081
3.512SerThr: 3.512 ± 0.053
3.798SerVal: 3.798 ± 0.055
0.977SerTrp: 0.977 ± 0.031
2.012SerTyr: 2.012 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.797ThrAla: 4.797 ± 0.06
0.508ThrCys: 0.508 ± 0.02
2.644ThrAsp: 2.644 ± 0.048
3.503ThrGlu: 3.503 ± 0.059
1.964ThrPhe: 1.964 ± 0.039
4.027ThrGly: 4.027 ± 0.064
0.895ThrHis: 0.895 ± 0.029
4.276ThrIle: 4.276 ± 0.053
2.956ThrLys: 2.956 ± 0.046
5.715ThrLeu: 5.715 ± 0.072
0.849ThrMet: 0.849 ± 0.027
2.505ThrAsn: 2.505 ± 0.046
2.906ThrPro: 2.906 ± 0.043
2.731ThrGln: 2.731 ± 0.04
2.05ThrArg: 2.05 ± 0.041
3.457ThrSer: 3.457 ± 0.053
3.316ThrThr: 3.316 ± 0.055
3.99ThrVal: 3.99 ± 0.061
0.68ThrTrp: 0.68 ± 0.023
1.648ThrTyr: 1.648 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
5.64ValAla: 5.64 ± 0.084
0.642ValCys: 0.642 ± 0.022
3.519ValAsp: 3.519 ± 0.052
4.291ValGlu: 4.291 ± 0.055
2.445ValPhe: 2.445 ± 0.044
4.373ValGly: 4.373 ± 0.067
0.984ValHis: 0.984 ± 0.029
4.505ValIle: 4.505 ± 0.062
3.596ValLys: 3.596 ± 0.056
6.096ValLeu: 6.096 ± 0.065
1.403ValMet: 1.403 ± 0.033
2.967ValAsn: 2.967 ± 0.054
2.391ValPro: 2.391 ± 0.049
2.454ValGln: 2.454 ± 0.047
2.715ValArg: 2.715 ± 0.048
4.172ValSer: 4.172 ± 0.052
3.663ValThr: 3.663 ± 0.055
4.323ValVal: 4.323 ± 0.067
0.771ValTrp: 0.771 ± 0.024
1.842ValTyr: 1.842 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
0.788TrpAla: 0.788 ± 0.026
0.159TrpCys: 0.159 ± 0.01
0.628TrpAsp: 0.628 ± 0.025
0.664TrpGlu: 0.664 ± 0.022
0.558TrpPhe: 0.558 ± 0.021
0.919TrpGly: 0.919 ± 0.027
0.356TrpHis: 0.356 ± 0.014
0.875TrpIle: 0.875 ± 0.027
0.53TrpLys: 0.53 ± 0.02
1.986TrpLeu: 1.986 ± 0.047
0.278TrpMet: 0.278 ± 0.018
0.603TrpAsn: 0.603 ± 0.023
0.15TrpPro: 0.15 ± 0.01
1.44TrpGln: 1.44 ± 0.034
0.724TrpArg: 0.724 ± 0.023
1.04TrpSer: 1.04 ± 0.028
0.624TrpThr: 0.624 ± 0.024
0.705TrpVal: 0.705 ± 0.027
0.245TrpTrp: 0.245 ± 0.014
0.427TrpTyr: 0.427 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.998TyrAla: 1.998 ± 0.037
0.453TyrCys: 0.453 ± 0.02
1.627TyrAsp: 1.627 ± 0.035
1.684TyrGlu: 1.684 ± 0.038
1.471TyrPhe: 1.471 ± 0.034
2.163TyrGly: 2.163 ± 0.041
0.699TyrHis: 0.699 ± 0.022
1.826TyrIle: 1.826 ± 0.039
1.189TyrLys: 1.189 ± 0.034
4.102TyrLeu: 4.102 ± 0.055
0.414TyrMet: 0.414 ± 0.018
1.249TyrAsn: 1.249 ± 0.032
1.642TyrPro: 1.642 ± 0.036
2.388TyrGln: 2.388 ± 0.047
1.962TyrArg: 1.962 ± 0.039
2.091TyrSer: 2.091 ± 0.039
1.474TyrThr: 1.474 ± 0.033
1.603TyrVal: 1.603 ± 0.034
0.575TyrTrp: 0.575 ± 0.018
1.168TyrTyr: 1.168 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4800 proteins (1462054 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski