Amino acid dipepetide frequency for Nestor notabilis (Kea)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.583AlaAla: 5.583 ± 0.058	1.314AlaCys: 1.314 ± 0.02	3.042AlaAsp: 3.042 ± 0.026	4.561AlaGlu: 4.561 ± 0.044	2.623AlaPhe: 2.623 ± 0.026	3.838AlaGly: 3.838 ± 0.043	1.35AlaHis: 1.35 ± 0.02	3.128AlaIle: 3.128 ± 0.029	3.716AlaLys: 3.716 ± 0.031	6.354AlaLeu: 6.354 ± 0.048	1.495AlaMet: 1.495 ± 0.022	2.249AlaAsn: 2.249 ± 0.029	2.903AlaPro: 2.903 ± 0.035	2.738AlaGln: 2.738 ± 0.033	2.922AlaArg: 2.922 ± 0.03	5.162AlaSer: 5.162 ± 0.05	3.349AlaThr: 3.349 ± 0.029	4.85AlaVal: 4.85 ± 0.041	0.716AlaTrp: 0.716 ± 0.014	1.658AlaTyr: 1.658 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.175CysAla: 1.175 ± 0.021	0.673CysCys: 0.673 ± 0.019	1.052CysAsp: 1.052 ± 0.019	1.343CysGlu: 1.343 ± 0.026	0.954CysPhe: 0.954 ± 0.017	1.454CysGly: 1.454 ± 0.025	0.657CysHis: 0.657 ± 0.015	1.175CysIle: 1.175 ± 0.023	1.333CysLys: 1.333 ± 0.022	2.207CysLeu: 2.207 ± 0.029	0.472CysMet: 0.472 ± 0.012	0.94CysAsn: 0.94 ± 0.017	1.228CysPro: 1.228 ± 0.029	1.077CysGln: 1.077 ± 0.024	1.217CysArg: 1.217 ± 0.017	2.039CysSer: 2.039 ± 0.03	1.23CysThr: 1.23 ± 0.021	1.359CysVal: 1.359 ± 0.028	0.303CysTrp: 0.303 ± 0.009	0.693CysTyr: 0.693 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	2.859AspAla: 2.859 ± 0.027	1.12AspCys: 1.12 ± 0.018	2.904AspAsp: 2.904 ± 0.036	3.751AspGlu: 3.751 ± 0.042	2.316AspPhe: 2.316 ± 0.026	3.253AspGly: 3.253 ± 0.034	1.178AspHis: 1.178 ± 0.02	3.023AspIle: 3.023 ± 0.028	2.846AspLys: 2.846 ± 0.032	5.067AspLeu: 5.067 ± 0.039	1.175AspMet: 1.175 ± 0.016	1.979AspAsn: 1.979 ± 0.027	2.662AspPro: 2.662 ± 0.026	1.859AspGln: 1.859 ± 0.022	2.391AspArg: 2.391 ± 0.033	4.114AspSer: 4.114 ± 0.042	2.557AspThr: 2.557 ± 0.027	3.29AspVal: 3.29 ± 0.029	0.653AspTrp: 0.653 ± 0.014	1.699AspTyr: 1.699 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	4.643GluAla: 4.643 ± 0.046	1.345GluCys: 1.345 ± 0.031	4.588GluAsp: 4.588 ± 0.043	7.956GluGlu: 7.956 ± 0.094	2.263GluPhe: 2.263 ± 0.023	3.854GluGly: 3.854 ± 0.037	1.554GluHis: 1.554 ± 0.019	3.565GluIle: 3.565 ± 0.03	5.776GluLys: 5.776 ± 0.06	6.376GluLeu: 6.376 ± 0.063	1.807GluMet: 1.807 ± 0.025	3.532GluAsn: 3.532 ± 0.032	2.564GluPro: 2.564 ± 0.03	3.249GluGln: 3.249 ± 0.035	3.864GluArg: 3.864 ± 0.056	4.504GluSer: 4.504 ± 0.039	3.552GluThr: 3.552 ± 0.034	4.284GluVal: 4.284 ± 0.038	0.736GluTrp: 0.736 ± 0.016	1.856GluTyr: 1.856 ± 0.024	0.001GluXaa: 0.001 ± 0.0
Phe	2.199PheAla: 2.199 ± 0.027	1.027PheCys: 1.027 ± 0.018	1.847PheAsp: 1.847 ± 0.023	2.183PheGlu: 2.183 ± 0.026	1.827PhePhe: 1.827 ± 0.028	2.317PheGly: 2.317 ± 0.029	1.12PheHis: 1.12 ± 0.019	2.19PheIle: 2.19 ± 0.024	2.103PheLys: 2.103 ± 0.026	4.27PheLeu: 4.27 ± 0.041	0.816PheMet: 0.816 ± 0.016	1.541PheAsn: 1.541 ± 0.021	1.979PhePro: 1.979 ± 0.025	1.847PheGln: 1.847 ± 0.021	1.912PheArg: 1.912 ± 0.022	3.51PheSer: 3.51 ± 0.036	2.264PheThr: 2.264 ± 0.025	2.425PheVal: 2.425 ± 0.029	0.528PheTrp: 0.528 ± 0.014	1.37PheTyr: 1.37 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	3.46GlyAla: 3.46 ± 0.039	1.234GlyCys: 1.234 ± 0.02	2.925GlyAsp: 2.925 ± 0.032	3.717GlyGlu: 3.717 ± 0.042	2.492GlyPhe: 2.492 ± 0.034	3.791GlyGly: 3.791 ± 0.054	1.5GlyHis: 1.5 ± 0.022	3.153GlyIle: 3.153 ± 0.033	4.045GlyLys: 4.045 ± 0.045	5.138GlyLeu: 5.138 ± 0.051	1.384GlyMet: 1.384 ± 0.022	2.631GlyAsn: 2.631 ± 0.029	2.665GlyPro: 2.665 ± 0.061	2.471GlyGln: 2.471 ± 0.029	3.075GlyArg: 3.075 ± 0.035	5.013GlySer: 5.013 ± 0.049	3.384GlyThr: 3.384 ± 0.038	3.458GlyVal: 3.458 ± 0.031	0.769GlyTrp: 0.769 ± 0.018	1.907GlyTyr: 1.907 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	1.318HisAla: 1.318 ± 0.019	0.724HisCys: 0.724 ± 0.016	0.932HisAsp: 0.932 ± 0.017	1.364HisGlu: 1.364 ± 0.021	1.099HisPhe: 1.099 ± 0.016	1.483HisGly: 1.483 ± 0.023	0.85HisHis: 0.85 ± 0.018	1.338HisIle: 1.338 ± 0.02	1.411HisLys: 1.411 ± 0.02	2.784HisLeu: 2.784 ± 0.032	0.591HisMet: 0.591 ± 0.014	0.997HisAsn: 0.997 ± 0.018	1.495HisPro: 1.495 ± 0.022	1.175HisGln: 1.175 ± 0.021	1.424HisArg: 1.424 ± 0.024	2.212HisSer: 2.212 ± 0.029	1.329HisThr: 1.329 ± 0.023	1.557HisVal: 1.557 ± 0.021	0.362HisTrp: 0.362 ± 0.009	0.873HisTyr: 0.873 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	3.081IleAla: 3.081 ± 0.031	1.246IleCys: 1.246 ± 0.023	2.403IleAsp: 2.403 ± 0.03	2.938IleGlu: 2.938 ± 0.028	2.244IlePhe: 2.244 ± 0.03	2.545IleGly: 2.545 ± 0.028	1.413IleHis: 1.413 ± 0.019	2.835IleIle: 2.835 ± 0.035	3.096IleLys: 3.096 ± 0.032	5.067IleLeu: 5.067 ± 0.046	1.091IleMet: 1.091 ± 0.017	2.215IleAsn: 2.215 ± 0.026	2.916IlePro: 2.916 ± 0.03	2.478IleGln: 2.478 ± 0.028	2.559IleArg: 2.559 ± 0.025	4.162IleSer: 4.162 ± 0.035	2.941IleThr: 2.941 ± 0.034	2.952IleVal: 2.952 ± 0.034	0.583IleTrp: 0.583 ± 0.013	1.655IleTyr: 1.655 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	4.184LysAla: 4.184 ± 0.04	1.236LysCys: 1.236 ± 0.022	3.548LysAsp: 3.548 ± 0.032	5.789LysGlu: 5.789 ± 0.058	1.96LysPhe: 1.96 ± 0.026	3.494LysGly: 3.494 ± 0.048	1.6LysHis: 1.6 ± 0.024	3.235LysIle: 3.235 ± 0.033	5.43LysLys: 5.43 ± 0.06	5.842LysLeu: 5.842 ± 0.051	1.576LysMet: 1.576 ± 0.022	2.818LysAsn: 2.818 ± 0.034	3.114LysPro: 3.114 ± 0.036	3.051LysGln: 3.051 ± 0.035	3.527LysArg: 3.527 ± 0.035	4.354LysSer: 4.354 ± 0.039	3.436LysThr: 3.436 ± 0.031	3.814LysVal: 3.814 ± 0.032	0.686LysTrp: 0.686 ± 0.015	1.88LysTyr: 1.88 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	6.165LeuAla: 6.165 ± 0.049	2.228LeuCys: 2.228 ± 0.03	4.864LeuAsp: 4.864 ± 0.043	7.014LeuGlu: 7.014 ± 0.071	3.667LeuPhe: 3.667 ± 0.038	5.159LeuGly: 5.159 ± 0.042	2.7LeuHis: 2.7 ± 0.032	4.325LeuIle: 4.325 ± 0.036	6.55LeuLys: 6.55 ± 0.057	10.126LeuLeu: 10.126 ± 0.083	2.108LeuMet: 2.108 ± 0.022	3.929LeuAsn: 3.929 ± 0.038	5.344LeuPro: 5.344 ± 0.046	5.691LeuGln: 5.691 ± 0.053	5.047LeuArg: 5.047 ± 0.045	7.8LeuSer: 7.8 ± 0.055	5.041LeuThr: 5.041 ± 0.041	5.479LeuVal: 5.479 ± 0.043	1.084LeuTrp: 1.084 ± 0.016	2.819LeuTyr: 2.819 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	1.626MetAla: 1.626 ± 0.022	0.462MetCys: 0.462 ± 0.013	1.328MetAsp: 1.328 ± 0.019	1.886MetGlu: 1.886 ± 0.026	0.868MetPhe: 0.868 ± 0.017	1.301MetGly: 1.301 ± 0.022	0.516MetHis: 0.516 ± 0.012	1.002MetIle: 1.002 ± 0.016	1.665MetLys: 1.665 ± 0.021	2.105MetLeu: 2.105 ± 0.025	0.618MetMet: 0.618 ± 0.012	1.029MetAsn: 1.029 ± 0.019	1.052MetPro: 1.052 ± 0.023	1.052MetGln: 1.052 ± 0.018	1.06MetArg: 1.06 ± 0.017	1.584MetSer: 1.584 ± 0.025	1.17MetThr: 1.17 ± 0.016	1.487MetVal: 1.487 ± 0.019	0.266MetTrp: 0.266 ± 0.008	0.683MetTyr: 0.683 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.353AsnAla: 2.353 ± 0.026	0.991AsnCys: 0.991 ± 0.019	1.743AsnAsp: 1.743 ± 0.023	2.624AsnGlu: 2.624 ± 0.028	1.643AsnPhe: 1.643 ± 0.023	2.793AsnGly: 2.793 ± 0.038	1.025AsnHis: 1.025 ± 0.016	2.569AsnIle: 2.569 ± 0.027	2.612AsnLys: 2.612 ± 0.033	4.133AsnLeu: 4.133 ± 0.04	1.054AsnMet: 1.054 ± 0.017	1.84AsnAsn: 1.84 ± 0.026	2.301AsnPro: 2.301 ± 0.027	1.74AsnGln: 1.74 ± 0.021	2.018AsnArg: 2.018 ± 0.022	3.498AsnSer: 3.498 ± 0.041	2.318AsnThr: 2.318 ± 0.028	2.503AsnVal: 2.503 ± 0.026	0.515AsnTrp: 0.515 ± 0.011	1.349AsnTyr: 1.349 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	3.643ProAla: 3.643 ± 0.044	1.05ProCys: 1.05 ± 0.022	2.639ProAsp: 2.639 ± 0.028	3.85ProGlu: 3.85 ± 0.036	1.939ProPhe: 1.939 ± 0.023	3.586ProGly: 3.586 ± 0.1	1.244ProHis: 1.244 ± 0.02	2.024ProIle: 2.024 ± 0.025	2.816ProLys: 2.816 ± 0.035	4.658ProLeu: 4.658 ± 0.037	0.952ProMet: 0.952 ± 0.018	1.91ProAsn: 1.91 ± 0.028	4.157ProPro: 4.157 ± 0.079	2.281ProGln: 2.281 ± 0.03	2.425ProArg: 2.425 ± 0.027	4.89ProSer: 4.89 ± 0.056	2.651ProThr: 2.651 ± 0.033	3.713ProVal: 3.713 ± 0.04	0.585ProTrp: 0.585 ± 0.013	1.466ProTyr: 1.466 ± 0.021	0.001ProXaa: 0.001 ± 0.001
Gln	3.034GlnAla: 3.034 ± 0.034	1.003GlnCys: 1.003 ± 0.021	2.271GlnAsp: 2.271 ± 0.026	3.712GlnGlu: 3.712 ± 0.037	1.458GlnPhe: 1.458 ± 0.023	2.438GlnGly: 2.438 ± 0.027	1.316GlnHis: 1.316 ± 0.019	2.262GlnIle: 2.262 ± 0.025	3.212GlnLys: 3.212 ± 0.035	4.609GlnLeu: 4.609 ± 0.042	1.148GlnMet: 1.148 ± 0.017	2.014GlnAsn: 2.014 ± 0.024	2.344GlnPro: 2.344 ± 0.034	3.092GlnGln: 3.092 ± 0.061	2.599GlnArg: 2.599 ± 0.029	3.213GlnSer: 3.213 ± 0.031	2.361GlnThr: 2.361 ± 0.026	2.829GlnVal: 2.829 ± 0.028	0.535GlnTrp: 0.535 ± 0.013	1.323GlnTyr: 1.323 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	3.005ArgAla: 3.005 ± 0.031	1.111ArgCys: 1.111 ± 0.021	2.597ArgAsp: 2.597 ± 0.035	3.651ArgGlu: 3.651 ± 0.051	1.889ArgPhe: 1.889 ± 0.022	2.798ArgGly: 2.798 ± 0.034	1.384ArgHis: 1.384 ± 0.02	2.592ArgIle: 2.592 ± 0.026	3.912ArgLys: 3.912 ± 0.037	4.755ArgLeu: 4.755 ± 0.038	1.202ArgMet: 1.202 ± 0.018	2.261ArgAsn: 2.261 ± 0.023	2.367ArgPro: 2.367 ± 0.027	2.46ArgGln: 2.46 ± 0.031	3.608ArgArg: 3.608 ± 0.041	3.897ArgSer: 3.897 ± 0.049	2.694ArgThr: 2.694 ± 0.023	2.899ArgVal: 2.899 ± 0.03	0.626ArgTrp: 0.626 ± 0.013	1.583ArgTyr: 1.583 ± 0.021	0.001ArgXaa: 0.001 ± 0.0
Ser	5.085SerAla: 5.085 ± 0.044	1.896SerCys: 1.896 ± 0.03	4.043SerAsp: 4.043 ± 0.036	5.157SerGlu: 5.157 ± 0.04	3.175SerPhe: 3.175 ± 0.025	4.94SerGly: 4.94 ± 0.045	2.007SerHis: 2.007 ± 0.027	3.692SerIle: 3.692 ± 0.032	4.585SerLys: 4.585 ± 0.04	7.956SerLeu: 7.956 ± 0.055	1.675SerMet: 1.675 ± 0.021	3.085SerAsn: 3.085 ± 0.031	5.021SerPro: 5.021 ± 0.057	3.66SerGln: 3.66 ± 0.038	4.046SerArg: 4.046 ± 0.044	9.339SerSer: 9.339 ± 0.109	4.598SerThr: 4.598 ± 0.04	5.082SerVal: 5.082 ± 0.047	0.971SerTrp: 0.971 ± 0.018	2.335SerTyr: 2.335 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	3.8ThrAla: 3.8 ± 0.034	1.335ThrCys: 1.335 ± 0.026	2.751ThrAsp: 2.751 ± 0.026	3.749ThrGlu: 3.749 ± 0.034	2.222ThrPhe: 2.222 ± 0.027	3.392ThrGly: 3.392 ± 0.03	1.185ThrHis: 1.185 ± 0.018	2.667ThrIle: 2.667 ± 0.031	2.943ThrLys: 2.943 ± 0.029	5.199ThrLeu: 5.199 ± 0.035	1.154ThrMet: 1.154 ± 0.019	1.994ThrAsn: 1.994 ± 0.023	3.112ThrPro: 3.112 ± 0.035	2.14ThrGln: 2.14 ± 0.026	2.343ThrArg: 2.343 ± 0.026	4.728ThrSer: 4.728 ± 0.049	3.046ThrThr: 3.046 ± 0.042	4.141ThrVal: 4.141 ± 0.04	0.663ThrTrp: 0.663 ± 0.014	1.6ThrTyr: 1.6 ± 0.023	0.001ThrXaa: 0.001 ± 0.0
Val	4.043ValAla: 4.043 ± 0.034	1.549ValCys: 1.549 ± 0.024	3.063ValAsp: 3.063 ± 0.03	3.998ValGlu: 3.998 ± 0.041	2.71ValPhe: 2.71 ± 0.034	3.287ValGly: 3.287 ± 0.037	1.602ValHis: 1.602 ± 0.021	3.298ValIle: 3.298 ± 0.033	3.929ValLys: 3.929 ± 0.037	6.356ValLeu: 6.356 ± 0.051	1.405ValMet: 1.405 ± 0.018	2.668ValAsn: 2.668 ± 0.029	3.419ValPro: 3.419 ± 0.037	2.841ValGln: 2.841 ± 0.028	2.907ValArg: 2.907 ± 0.029	4.975ValSer: 4.975 ± 0.044	3.9ValThr: 3.9 ± 0.038	4.256ValVal: 4.256 ± 0.04	0.721ValTrp: 0.721 ± 0.018	1.901ValTyr: 1.901 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	0.683TrpAla: 0.683 ± 0.015	0.259TrpCys: 0.259 ± 0.008	0.648TrpAsp: 0.648 ± 0.014	0.769TrpGlu: 0.769 ± 0.016	0.472TrpPhe: 0.472 ± 0.012	0.648TrpGly: 0.648 ± 0.018	0.304TrpHis: 0.304 ± 0.009	0.628TrpIle: 0.628 ± 0.013	0.894TrpLys: 0.894 ± 0.015	1.17TrpLeu: 1.17 ± 0.019	0.317TrpMet: 0.317 ± 0.009	0.634TrpAsn: 0.634 ± 0.015	0.44TrpPro: 0.44 ± 0.012	0.552TrpGln: 0.552 ± 0.013	0.64TrpArg: 0.64 ± 0.015	0.91TrpSer: 0.91 ± 0.017	0.672TrpThr: 0.672 ± 0.014	0.686TrpVal: 0.686 ± 0.014	0.2TrpTrp: 0.2 ± 0.008	0.373TrpTyr: 0.373 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.61TyrAla: 1.61 ± 0.022	0.777TyrCys: 0.777 ± 0.016	1.508TyrAsp: 1.508 ± 0.023	1.852TyrGlu: 1.852 ± 0.025	1.456TyrPhe: 1.456 ± 0.023	1.839TyrGly: 1.839 ± 0.026	0.812TyrHis: 0.812 ± 0.015	1.719TyrIle: 1.719 ± 0.021	1.701TyrLys: 1.701 ± 0.022	2.968TyrLeu: 2.968 ± 0.028	0.718TyrMet: 0.718 ± 0.015	1.358TyrAsn: 1.358 ± 0.019	1.397TyrPro: 1.397 ± 0.018	1.321TyrGln: 1.321 ± 0.023	1.706TyrArg: 1.706 ± 0.024	2.443TyrSer: 2.443 ± 0.028	1.672TyrThr: 1.672 ± 0.023	1.767TyrVal: 1.767 ± 0.026	0.395TyrTrp: 0.395 ± 0.012	1.139TyrTyr: 1.139 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.031XaaXaa: 0.031 ± 0.007

Statistics based on 9137 proteins (4004254 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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