Amino acid dipepetide frequency for Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.101AlaAla: 6.101 ± 0.028	1.251AlaCys: 1.251 ± 0.01	3.087AlaAsp: 3.087 ± 0.015	4.197AlaGlu: 4.197 ± 0.017	2.797AlaPhe: 2.797 ± 0.013	4.127AlaGly: 4.127 ± 0.023	1.287AlaHis: 1.287 ± 0.009	4.064AlaIle: 4.064 ± 0.02	4.05AlaLys: 4.05 ± 0.018	6.697AlaLeu: 6.697 ± 0.026	1.837AlaMet: 1.837 ± 0.012	2.831AlaAsn: 2.831 ± 0.012	2.61AlaPro: 2.61 ± 0.016	2.195AlaGln: 2.195 ± 0.017	3.42AlaArg: 3.42 ± 0.015	5.902AlaSer: 5.902 ± 0.021	3.62AlaThr: 3.62 ± 0.018	4.752AlaVal: 4.752 ± 0.02	0.811AlaTrp: 0.811 ± 0.008	1.933AlaTyr: 1.933 ± 0.012	0.0AlaXaa: 0.0 ± 0.0
Cys	0.982CysAla: 0.982 ± 0.007	0.494CysCys: 0.494 ± 0.006	0.901CysAsp: 0.901 ± 0.007	0.959CysGlu: 0.959 ± 0.008	0.901CysPhe: 0.901 ± 0.008	1.427CysGly: 1.427 ± 0.01	0.475CysHis: 0.475 ± 0.006	0.992CysIle: 0.992 ± 0.008	1.183CysLys: 1.183 ± 0.009	1.909CysLeu: 1.909 ± 0.012	0.446CysMet: 0.446 ± 0.006	0.908CysAsn: 0.908 ± 0.008	0.96CysPro: 0.96 ± 0.009	0.649CysGln: 0.649 ± 0.006	1.01CysArg: 1.01 ± 0.009	1.768CysSer: 1.768 ± 0.011	0.839CysThr: 0.839 ± 0.006	1.032CysVal: 1.032 ± 0.008	0.278CysTrp: 0.278 ± 0.004	0.552CysTyr: 0.552 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	3.503AspAla: 3.503 ± 0.017	1.003AspCys: 1.003 ± 0.008	3.504AspAsp: 3.504 ± 0.018	3.953AspGlu: 3.953 ± 0.018	2.418AspPhe: 2.418 ± 0.013	3.874AspGly: 3.874 ± 0.016	1.197AspHis: 1.197 ± 0.008	3.092AspIle: 3.092 ± 0.014	2.819AspLys: 2.819 ± 0.012	5.236AspLeu: 5.236 ± 0.021	1.381AspMet: 1.381 ± 0.009	2.225AspAsn: 2.225 ± 0.012	2.572AspPro: 2.572 ± 0.014	1.739AspGln: 1.739 ± 0.011	2.322AspArg: 2.322 ± 0.012	4.217AspSer: 4.217 ± 0.016	2.199AspThr: 2.199 ± 0.011	3.649AspVal: 3.649 ± 0.016	0.749AspTrp: 0.749 ± 0.006	1.622AspTyr: 1.622 ± 0.01	0.0AspXaa: 0.0 ± 0.0
Glu	4.83GluAla: 4.83 ± 0.019	0.949GluCys: 0.949 ± 0.008	3.986GluAsp: 3.986 ± 0.018	6.19GluGlu: 6.19 ± 0.032	2.504GluPhe: 2.504 ± 0.012	3.862GluGly: 3.862 ± 0.015	1.259GluHis: 1.259 ± 0.01	4.066GluIle: 4.066 ± 0.018	4.699GluLys: 4.699 ± 0.023	6.28GluLeu: 6.28 ± 0.026	1.905GluMet: 1.905 ± 0.011	3.278GluAsn: 3.278 ± 0.014	2.067GluPro: 2.067 ± 0.011	2.242GluGln: 2.242 ± 0.015	3.371GluArg: 3.371 ± 0.019	4.634GluSer: 4.634 ± 0.019	3.055GluThr: 3.055 ± 0.015	4.25GluVal: 4.25 ± 0.017	0.799GluTrp: 0.799 ± 0.008	1.691GluTyr: 1.691 ± 0.01	0.0GluXaa: 0.0 ± 0.0
Phe	2.589PheAla: 2.589 ± 0.013	0.903PheCys: 0.903 ± 0.007	2.417PheAsp: 2.417 ± 0.014	2.393PheGlu: 2.393 ± 0.012	1.875PhePhe: 1.875 ± 0.01	3.03PheGly: 3.03 ± 0.014	1.087PheHis: 1.087 ± 0.009	2.086PheIle: 2.086 ± 0.011	2.16PheLys: 2.16 ± 0.012	4.249PheLeu: 4.249 ± 0.017	0.974PheMet: 0.974 ± 0.008	1.852PheAsn: 1.852 ± 0.011	2.046PhePro: 2.046 ± 0.012	1.586PheGln: 1.586 ± 0.011	1.982PheArg: 1.982 ± 0.012	4.003PheSer: 4.003 ± 0.017	2.005PheThr: 2.005 ± 0.012	2.658PheVal: 2.658 ± 0.013	0.557PheTrp: 0.557 ± 0.007	1.288PheTyr: 1.288 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	3.902GlyAla: 3.902 ± 0.02	1.344GlyCys: 1.344 ± 0.009	3.402GlyAsp: 3.402 ± 0.016	3.695GlyGlu: 3.695 ± 0.017	3.16GlyPhe: 3.16 ± 0.015	5.091GlyGly: 5.091 ± 0.04	1.587GlyHis: 1.587 ± 0.011	3.862GlyIle: 3.862 ± 0.017	4.249GlyLys: 4.249 ± 0.017	6.132GlyLeu: 6.132 ± 0.021	1.618GlyMet: 1.618 ± 0.008	3.351GlyAsn: 3.351 ± 0.021	2.48GlyPro: 2.48 ± 0.017	2.16GlyGln: 2.16 ± 0.011	3.62GlyArg: 3.62 ± 0.016	6.002GlySer: 6.002 ± 0.021	3.313GlyThr: 3.313 ± 0.019	4.213GlyVal: 4.213 ± 0.019	0.914GlyTrp: 0.914 ± 0.008	2.139GlyTyr: 2.139 ± 0.014	0.0GlyXaa: 0.0 ± 0.0
His	1.39HisAla: 1.39 ± 0.01	0.526HisCys: 0.526 ± 0.006	1.117HisAsp: 1.117 ± 0.01	1.292HisGlu: 1.292 ± 0.01	1.062HisPhe: 1.062 ± 0.01	1.749HisGly: 1.749 ± 0.011	0.836HisHis: 0.836 ± 0.009	1.2HisIle: 1.2 ± 0.008	1.183HisLys: 1.183 ± 0.01	2.498HisLeu: 2.498 ± 0.012	0.565HisMet: 0.565 ± 0.006	0.98HisAsn: 0.98 ± 0.009	1.291HisPro: 1.291 ± 0.008	0.995HisGln: 0.995 ± 0.009	1.321HisArg: 1.321 ± 0.01	1.906HisSer: 1.906 ± 0.012	0.915HisThr: 0.915 ± 0.009	1.511HisVal: 1.511 ± 0.01	0.328HisTrp: 0.328 ± 0.005	0.706HisTyr: 0.706 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	3.817IleAla: 3.817 ± 0.016	1.127IleCys: 1.127 ± 0.01	3.063IleAsp: 3.063 ± 0.015	3.452IleGlu: 3.452 ± 0.016	2.302IlePhe: 2.302 ± 0.013	3.674IleGly: 3.674 ± 0.017	1.31IleHis: 1.31 ± 0.009	2.926IleIle: 2.926 ± 0.015	3.001IleLys: 3.001 ± 0.013	5.346IleLeu: 5.346 ± 0.021	1.252IleMet: 1.252 ± 0.009	2.3IleAsn: 2.3 ± 0.01	3.083IlePro: 3.083 ± 0.017	2.045IleGln: 2.045 ± 0.012	2.683IleArg: 2.683 ± 0.013	4.986IleSer: 4.986 ± 0.02	2.608IleThr: 2.608 ± 0.013	3.577IleVal: 3.577 ± 0.016	0.751IleTrp: 0.751 ± 0.008	1.491IleTyr: 1.491 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	4.121LysAla: 4.121 ± 0.02	1.006LysCys: 1.006 ± 0.009	3.308LysAsp: 3.308 ± 0.014	4.787LysGlu: 4.787 ± 0.022	2.294LysPhe: 2.294 ± 0.012	3.737LysGly: 3.737 ± 0.017	1.322LysHis: 1.322 ± 0.009	3.423LysIle: 3.423 ± 0.018	4.515LysLys: 4.515 ± 0.021	6.292LysLeu: 6.292 ± 0.024	1.587LysMet: 1.587 ± 0.01	2.738LysAsn: 2.738 ± 0.013	2.653LysPro: 2.653 ± 0.013	2.327LysGln: 2.327 ± 0.013	3.522LysArg: 3.522 ± 0.018	4.595LysSer: 4.595 ± 0.018	2.727LysThr: 2.727 ± 0.014	3.868LysVal: 3.868 ± 0.019	0.84LysTrp: 0.84 ± 0.007	1.642LysTyr: 1.642 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	6.735LeuAla: 6.735 ± 0.023	1.815LeuCys: 1.815 ± 0.011	5.307LeuAsp: 5.307 ± 0.021	6.68LeuGlu: 6.68 ± 0.028	3.699LeuPhe: 3.699 ± 0.016	5.956LeuGly: 5.956 ± 0.023	2.593LeuHis: 2.593 ± 0.014	4.726LeuIle: 4.726 ± 0.02	6.537LeuLys: 6.537 ± 0.027	9.774LeuLeu: 9.774 ± 0.032	2.27LeuMet: 2.27 ± 0.011	4.133LeuAsn: 4.133 ± 0.016	5.196LeuPro: 5.196 ± 0.021	4.499LeuGln: 4.499 ± 0.019	5.462LeuArg: 5.462 ± 0.022	8.656LeuSer: 8.656 ± 0.03	4.441LeuThr: 4.441 ± 0.018	6.37LeuVal: 6.37 ± 0.02	1.208LeuTrp: 1.208 ± 0.009	2.488LeuTyr: 2.488 ± 0.015	0.0LeuXaa: 0.0 ± 0.0
Met	2.119MetAla: 2.119 ± 0.013	0.343MetCys: 0.343 ± 0.004	1.503MetAsp: 1.503 ± 0.009	2.112MetGlu: 2.112 ± 0.012	0.813MetPhe: 0.813 ± 0.008	1.726MetGly: 1.726 ± 0.011	0.596MetHis: 0.596 ± 0.006	1.276MetIle: 1.276 ± 0.01	1.718MetLys: 1.718 ± 0.012	2.28MetLeu: 2.28 ± 0.011	0.693MetMet: 0.693 ± 0.007	1.075MetAsn: 1.075 ± 0.008	1.113MetPro: 1.113 ± 0.008	0.986MetGln: 0.986 ± 0.008	1.239MetArg: 1.239 ± 0.009	1.763MetSer: 1.763 ± 0.01	1.054MetThr: 1.054 ± 0.007	1.711MetVal: 1.711 ± 0.011	0.285MetTrp: 0.285 ± 0.004	0.567MetTyr: 0.567 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.841AsnAla: 2.841 ± 0.016	0.956AsnCys: 0.956 ± 0.009	2.179AsnAsp: 2.179 ± 0.01	2.748AsnGlu: 2.748 ± 0.013	2.082AsnPhe: 2.082 ± 0.012	3.481AsnGly: 3.481 ± 0.016	1.106AsnHis: 1.106 ± 0.01	2.477AsnIle: 2.477 ± 0.012	2.448AsnLys: 2.448 ± 0.013	5.037AsnLeu: 5.037 ± 0.027	1.133AsnMet: 1.133 ± 0.01	2.353AsnAsn: 2.353 ± 0.017	2.326AsnPro: 2.326 ± 0.014	1.744AsnGln: 1.744 ± 0.011	2.017AsnArg: 2.017 ± 0.011	4.108AsnSer: 4.108 ± 0.016	1.923AsnThr: 1.923 ± 0.01	2.932AsnVal: 2.932 ± 0.015	0.617AsnTrp: 0.617 ± 0.007	1.353AsnTyr: 1.353 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	2.905ProAla: 2.905 ± 0.015	0.775ProCys: 0.775 ± 0.007	2.433ProAsp: 2.433 ± 0.012	3.119ProGlu: 3.119 ± 0.015	1.942ProPhe: 1.942 ± 0.011	2.649ProGly: 2.649 ± 0.016	1.048ProHis: 1.048 ± 0.009	2.387ProIle: 2.387 ± 0.013	2.681ProLys: 2.681 ± 0.016	4.179ProLeu: 4.179 ± 0.019	1.0ProMet: 1.0 ± 0.008	2.328ProAsn: 2.328 ± 0.011	3.354ProPro: 3.354 ± 0.034	1.756ProGln: 1.756 ± 0.012	2.287ProArg: 2.287 ± 0.015	4.938ProSer: 4.938 ± 0.02	2.529ProThr: 2.529 ± 0.013	2.985ProVal: 2.985 ± 0.016	0.593ProTrp: 0.593 ± 0.006	1.303ProTyr: 1.303 ± 0.01	0.0ProXaa: 0.0 ± 0.0
Gln	2.45GlnAla: 2.45 ± 0.012	0.603GlnCys: 0.603 ± 0.006	1.703GlnAsp: 1.703 ± 0.01	2.587GlnGlu: 2.587 ± 0.014	1.433GlnPhe: 1.433 ± 0.008	2.205GlnGly: 2.205 ± 0.016	0.914GlnHis: 0.914 ± 0.007	2.066GlnIle: 2.066 ± 0.012	2.349GlnLys: 2.349 ± 0.013	3.824GlnLeu: 3.824 ± 0.015	1.003GlnMet: 1.003 ± 0.007	1.875GlnAsn: 1.875 ± 0.013	1.719GlnPro: 1.719 ± 0.012	2.018GlnGln: 2.018 ± 0.021	2.068GlnArg: 2.068 ± 0.012	2.834GlnSer: 2.834 ± 0.014	1.638GlnThr: 1.638 ± 0.01	2.383GlnVal: 2.383 ± 0.012	0.496GlnTrp: 0.496 ± 0.006	0.963GlnTyr: 0.963 ± 0.008	0.0GlnXaa: 0.0 ± 0.0
Arg	3.176ArgAla: 3.176 ± 0.016	0.967ArgCys: 0.967 ± 0.008	2.656ArgAsp: 2.656 ± 0.014	3.351ArgGlu: 3.351 ± 0.018	2.137ArgPhe: 2.137 ± 0.01	3.163ArgGly: 3.163 ± 0.015	1.215ArgHis: 1.215 ± 0.009	2.943ArgIle: 2.943 ± 0.014	3.698ArgLys: 3.698 ± 0.017	5.025ArgLeu: 5.025 ± 0.018	1.36ArgMet: 1.36 ± 0.009	2.468ArgAsn: 2.468 ± 0.014	2.227ArgPro: 2.227 ± 0.014	1.858ArgGln: 1.858 ± 0.013	3.678ArgArg: 3.678 ± 0.021	4.133ArgSer: 4.133 ± 0.02	2.362ArgThr: 2.362 ± 0.012	3.254ArgVal: 3.254 ± 0.015	0.736ArgTrp: 0.736 ± 0.008	1.445ArgTyr: 1.445 ± 0.01	0.0ArgXaa: 0.0 ± 0.0
Ser	5.241SerAla: 5.241 ± 0.02	1.717SerCys: 1.717 ± 0.01	4.291SerAsp: 4.291 ± 0.017	4.736SerGlu: 4.736 ± 0.02	3.92SerPhe: 3.92 ± 0.017	5.951SerGly: 5.951 ± 0.025	1.995SerHis: 1.995 ± 0.012	4.752SerIle: 4.752 ± 0.017	4.93SerLys: 4.93 ± 0.018	8.772SerLeu: 8.772 ± 0.027	2.124SerMet: 2.124 ± 0.012	4.29SerAsn: 4.29 ± 0.02	4.189SerPro: 4.189 ± 0.023	3.017SerGln: 3.017 ± 0.016	4.24SerArg: 4.24 ± 0.019	10.394SerSer: 10.394 ± 0.039	4.513SerThr: 4.513 ± 0.019	5.153SerVal: 5.153 ± 0.019	1.217SerTrp: 1.217 ± 0.009	2.337SerTyr: 2.337 ± 0.013	0.0SerXaa: 0.0 ± 0.0
Thr	3.385ThrAla: 3.385 ± 0.016	0.895ThrCys: 0.895 ± 0.008	2.278ThrAsp: 2.278 ± 0.012	2.742ThrGlu: 2.742 ± 0.015	1.969ThrPhe: 1.969 ± 0.012	3.369ThrGly: 3.369 ± 0.02	1.001ThrHis: 1.001 ± 0.008	2.809ThrIle: 2.809 ± 0.014	2.583ThrLys: 2.583 ± 0.013	4.565ThrLeu: 4.565 ± 0.019	1.171ThrMet: 1.171 ± 0.008	2.057ThrAsn: 2.057 ± 0.012	2.365ThrPro: 2.365 ± 0.014	1.523ThrGln: 1.523 ± 0.009	2.289ThrArg: 2.289 ± 0.012	4.405ThrSer: 4.405 ± 0.021	2.752ThrThr: 2.752 ± 0.016	3.347ThrVal: 3.347 ± 0.014	0.663ThrTrp: 0.663 ± 0.007	1.32ThrTyr: 1.32 ± 0.01	0.0ThrXaa: 0.0 ± 0.0
Val	4.847ValAla: 4.847 ± 0.021	1.094ValCys: 1.094 ± 0.008	3.833ValAsp: 3.833 ± 0.017	4.496ValGlu: 4.496 ± 0.021	2.623ValPhe: 2.623 ± 0.014	4.225ValGly: 4.225 ± 0.02	1.516ValHis: 1.516 ± 0.01	3.453ValIle: 3.453 ± 0.014	3.97ValLys: 3.97 ± 0.019	6.365ValLeu: 6.365 ± 0.022	1.548ValMet: 1.548 ± 0.01	2.711ValAsn: 2.711 ± 0.014	3.18ValPro: 3.18 ± 0.015	2.313ValGln: 2.313 ± 0.012	3.024ValArg: 3.024 ± 0.013	5.312ValSer: 5.312 ± 0.021	3.13ValThr: 3.13 ± 0.015	4.746ValVal: 4.746 ± 0.02	0.797ValTrp: 0.797 ± 0.007	1.847ValTyr: 1.847 ± 0.012	0.0ValXaa: 0.0 ± 0.0
Trp	0.828TrpAla: 0.828 ± 0.008	0.24TrpCys: 0.24 ± 0.004	0.754TrpAsp: 0.754 ± 0.008	0.808TrpGlu: 0.808 ± 0.007	0.547TrpPhe: 0.547 ± 0.006	0.736TrpGly: 0.736 ± 0.008	0.313TrpHis: 0.313 ± 0.004	0.752TrpIle: 0.752 ± 0.006	0.987TrpLys: 0.987 ± 0.008	1.289TrpLeu: 1.289 ± 0.01	0.377TrpMet: 0.377 ± 0.005	0.768TrpAsn: 0.768 ± 0.008	0.503TrpPro: 0.503 ± 0.005	0.504TrpGln: 0.504 ± 0.005	0.831TrpArg: 0.831 ± 0.007	1.007TrpSer: 1.007 ± 0.008	0.627TrpThr: 0.627 ± 0.006	0.851TrpVal: 0.851 ± 0.008	0.251TrpTrp: 0.251 ± 0.004	0.336TrpTyr: 0.336 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.805TyrAla: 1.805 ± 0.013	0.657TyrCys: 0.657 ± 0.007	1.553TyrAsp: 1.553 ± 0.01	1.62TyrGlu: 1.62 ± 0.01	1.263TyrPhe: 1.263 ± 0.009	2.203TyrGly: 2.203 ± 0.013	0.713TyrHis: 0.713 ± 0.007	1.443TyrIle: 1.443 ± 0.008	1.542TyrLys: 1.542 ± 0.01	2.793TyrLeu: 2.793 ± 0.015	0.73TyrMet: 0.73 ± 0.008	1.342TyrAsn: 1.342 ± 0.01	1.255TyrPro: 1.255 ± 0.01	0.972TyrGln: 0.972 ± 0.008	1.465TyrArg: 1.465 ± 0.009	2.218TyrSer: 2.218 ± 0.013	1.238TyrThr: 1.238 ± 0.009	1.788TyrVal: 1.788 ± 0.013	0.422TyrTrp: 0.422 ± 0.005	0.951TyrTyr: 0.951 ± 0.009	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 43024 proteins (16386060 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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