Amino acid dipepetide frequency for Methyloglobulus morosus KoM1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.188AlaAla: 8.188 ± 0.125	0.994AlaCys: 0.994 ± 0.033	4.8AlaAsp: 4.8 ± 0.074	5.652AlaGlu: 5.652 ± 0.077	3.499AlaPhe: 3.499 ± 0.054	6.142AlaGly: 6.142 ± 0.084	1.779AlaHis: 1.779 ± 0.042	6.292AlaIle: 6.292 ± 0.072	4.999AlaLys: 4.999 ± 0.086	9.886AlaLeu: 9.886 ± 0.115	2.3AlaMet: 2.3 ± 0.047	3.82AlaAsn: 3.82 ± 0.07	2.861AlaPro: 2.861 ± 0.052	3.49AlaGln: 3.49 ± 0.065	3.656AlaArg: 3.656 ± 0.066	5.067AlaSer: 5.067 ± 0.071	4.606AlaThr: 4.606 ± 0.07	6.132AlaVal: 6.132 ± 0.082	1.101AlaTrp: 1.101 ± 0.035	2.546AlaTyr: 2.546 ± 0.045	0.007AlaXaa: 0.007 ± 0.003
Cys	0.846CysAla: 0.846 ± 0.027	0.167CysCys: 0.167 ± 0.012	0.544CysAsp: 0.544 ± 0.022	0.596CysGlu: 0.596 ± 0.025	0.445CysPhe: 0.445 ± 0.02	0.944CysGly: 0.944 ± 0.033	0.371CysHis: 0.371 ± 0.021	0.567CysIle: 0.567 ± 0.025	0.455CysLys: 0.455 ± 0.019	1.125CysLeu: 1.125 ± 0.034	0.236CysMet: 0.236 ± 0.013	0.434CysAsn: 0.434 ± 0.02	0.485CysPro: 0.485 ± 0.021	0.433CysGln: 0.433 ± 0.021	0.583CysArg: 0.583 ± 0.024	0.648CysSer: 0.648 ± 0.022	0.511CysThr: 0.511 ± 0.023	0.698CysVal: 0.698 ± 0.025	0.14CysTrp: 0.14 ± 0.011	0.358CysTyr: 0.358 ± 0.015	0.002CysXaa: 0.002 ± 0.001
Asp	4.485AspAla: 4.485 ± 0.073	0.622AspCys: 0.622 ± 0.024	2.901AspAsp: 2.901 ± 0.058	3.509AspGlu: 3.509 ± 0.057	2.596AspPhe: 2.596 ± 0.06	3.831AspGly: 3.831 ± 0.07	1.166AspHis: 1.166 ± 0.034	3.857AspIle: 3.857 ± 0.065	3.41AspLys: 3.41 ± 0.062	5.424AspLeu: 5.424 ± 0.07	1.268AspMet: 1.268 ± 0.034	2.427AspAsn: 2.427 ± 0.044	2.375AspPro: 2.375 ± 0.055	2.007AspGln: 2.007 ± 0.043	2.6AspArg: 2.6 ± 0.044	3.06AspSer: 3.06 ± 0.053	2.718AspThr: 2.718 ± 0.049	3.461AspVal: 3.461 ± 0.058	0.907AspTrp: 0.907 ± 0.029	2.05AspTyr: 2.05 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.169GluAla: 5.169 ± 0.079	0.509GluCys: 0.509 ± 0.023	2.614GluAsp: 2.614 ± 0.054	3.198GluGlu: 3.198 ± 0.058	2.293GluPhe: 2.293 ± 0.045	3.502GluGly: 3.502 ± 0.06	1.41GluHis: 1.41 ± 0.041	4.292GluIle: 4.292 ± 0.059	3.713GluLys: 3.713 ± 0.059	6.415GluLeu: 6.415 ± 0.082	1.507GluMet: 1.507 ± 0.034	2.675GluAsn: 2.675 ± 0.056	2.085GluPro: 2.085 ± 0.039	3.129GluGln: 3.129 ± 0.065	3.148GluArg: 3.148 ± 0.055	3.297GluSer: 3.297 ± 0.06	3.366GluThr: 3.366 ± 0.048	3.456GluVal: 3.456 ± 0.064	0.751GluTrp: 0.751 ± 0.027	1.536GluTyr: 1.536 ± 0.036	0.003GluXaa: 0.003 ± 0.002
Phe	3.472PheAla: 3.472 ± 0.061	0.534PheCys: 0.534 ± 0.025	2.639PheAsp: 2.639 ± 0.053	2.21PheGlu: 2.21 ± 0.048	1.883PhePhe: 1.883 ± 0.039	3.173PheGly: 3.173 ± 0.058	0.899PheHis: 0.899 ± 0.028	2.683PheIle: 2.683 ± 0.054	2.059PheLys: 2.059 ± 0.049	4.002PheLeu: 4.002 ± 0.056	0.968PheMet: 0.968 ± 0.029	1.974PheAsn: 1.974 ± 0.043	1.721PhePro: 1.721 ± 0.045	1.417PheGln: 1.417 ± 0.038	1.839PheArg: 1.839 ± 0.038	3.092PheSer: 3.092 ± 0.055	2.269PheThr: 2.269 ± 0.043	2.673PheVal: 2.673 ± 0.049	0.581PheTrp: 0.581 ± 0.024	1.369PheTyr: 1.369 ± 0.038	0.001PheXaa: 0.001 ± 0.001
Gly	5.16GlyAla: 5.16 ± 0.073	1.012GlyCys: 1.012 ± 0.033	3.621GlyAsp: 3.621 ± 0.061	3.894GlyGlu: 3.894 ± 0.058	3.43GlyPhe: 3.43 ± 0.053	5.077GlyGly: 5.077 ± 0.099	1.728GlyHis: 1.728 ± 0.042	5.317GlyIle: 5.317 ± 0.084	4.457GlyLys: 4.457 ± 0.069	7.744GlyLeu: 7.744 ± 0.089	1.962GlyMet: 1.962 ± 0.043	3.219GlyAsn: 3.219 ± 0.074	1.708GlyPro: 1.708 ± 0.043	3.034GlyGln: 3.034 ± 0.051	3.421GlyArg: 3.421 ± 0.057	4.267GlySer: 4.267 ± 0.078	3.733GlyThr: 3.733 ± 0.068	4.845GlyVal: 4.845 ± 0.077	1.014GlyTrp: 1.014 ± 0.032	2.512GlyTyr: 2.512 ± 0.049	0.004GlyXaa: 0.004 ± 0.002
His	1.738HisAla: 1.738 ± 0.043	0.334HisCys: 0.334 ± 0.017	1.238HisAsp: 1.238 ± 0.035	1.247HisGlu: 1.247 ± 0.034	1.054HisPhe: 1.054 ± 0.029	1.636HisGly: 1.636 ± 0.044	0.768HisHis: 0.768 ± 0.03	1.485HisIle: 1.485 ± 0.039	1.038HisLys: 1.038 ± 0.033	2.338HisLeu: 2.338 ± 0.043	0.413HisMet: 0.413 ± 0.021	0.938HisAsn: 0.938 ± 0.03	1.342HisPro: 1.342 ± 0.034	1.026HisGln: 1.026 ± 0.032	1.224HisArg: 1.224 ± 0.039	1.37HisSer: 1.37 ± 0.038	1.108HisThr: 1.108 ± 0.028	1.355HisVal: 1.355 ± 0.034	0.41HisTrp: 0.41 ± 0.019	0.906HisTyr: 0.906 ± 0.028	0.003HisXaa: 0.003 ± 0.001
Ile	6.736IleAla: 6.736 ± 0.082	0.678IleCys: 0.678 ± 0.027	4.091IleAsp: 4.091 ± 0.057	4.198IleGlu: 4.198 ± 0.067	2.365IlePhe: 2.365 ± 0.057	4.841IleGly: 4.841 ± 0.075	1.451IleHis: 1.451 ± 0.038	3.965IleIle: 3.965 ± 0.064	3.866IleLys: 3.866 ± 0.062	5.9IleLeu: 5.9 ± 0.08	1.353IleMet: 1.353 ± 0.033	3.175IleAsn: 3.175 ± 0.052	3.281IlePro: 3.281 ± 0.053	2.323IleGln: 2.323 ± 0.046	3.206IleArg: 3.206 ± 0.052	4.09IleSer: 4.09 ± 0.061	3.771IleThr: 3.771 ± 0.062	4.229IleVal: 4.229 ± 0.074	0.634IleTrp: 0.634 ± 0.021	1.812IleTyr: 1.812 ± 0.039	0.002IleXaa: 0.002 ± 0.001
Lys	5.173LysAla: 5.173 ± 0.075	0.34LysCys: 0.34 ± 0.019	2.883LysAsp: 2.883 ± 0.058	3.223LysGlu: 3.223 ± 0.063	1.667LysPhe: 1.667 ± 0.048	3.495LysGly: 3.495 ± 0.071	1.251LysHis: 1.251 ± 0.039	3.745LysIle: 3.745 ± 0.067	3.222LysLys: 3.222 ± 0.061	5.636LysLeu: 5.636 ± 0.082	1.34LysMet: 1.34 ± 0.035	2.547LysAsn: 2.547 ± 0.05	2.99LysPro: 2.99 ± 0.056	2.827LysGln: 2.827 ± 0.054	2.64LysArg: 2.64 ± 0.053	3.193LysSer: 3.193 ± 0.052	3.372LysThr: 3.372 ± 0.057	3.392LysVal: 3.392 ± 0.069	0.504LysTrp: 0.504 ± 0.019	1.391LysTyr: 1.391 ± 0.038	0.004LysXaa: 0.004 ± 0.002
Leu	10.097LeuAla: 10.097 ± 0.114	1.1LeuCys: 1.1 ± 0.034	5.875LeuAsp: 5.875 ± 0.074	5.95LeuGlu: 5.95 ± 0.086	4.37LeuPhe: 4.37 ± 0.066	7.381LeuGly: 7.381 ± 0.079	2.186LeuHis: 2.186 ± 0.048	6.63LeuIle: 6.63 ± 0.095	5.775LeuLys: 5.775 ± 0.085	11.378LeuLeu: 11.378 ± 0.14	2.562LeuMet: 2.562 ± 0.049	4.483LeuAsn: 4.483 ± 0.071	5.386LeuPro: 5.386 ± 0.077	3.958LeuGln: 3.958 ± 0.062	4.956LeuArg: 4.956 ± 0.078	7.321LeuSer: 7.321 ± 0.085	6.013LeuThr: 6.013 ± 0.068	6.799LeuVal: 6.799 ± 0.086	1.176LeuTrp: 1.176 ± 0.039	2.683LeuTyr: 2.683 ± 0.057	0.003LeuXaa: 0.003 ± 0.001
Met	2.435MetAla: 2.435 ± 0.054	0.165MetCys: 0.165 ± 0.011	1.268MetAsp: 1.268 ± 0.034	1.27MetGlu: 1.27 ± 0.036	0.751MetPhe: 0.751 ± 0.029	1.715MetGly: 1.715 ± 0.041	0.504MetHis: 0.504 ± 0.023	1.358MetIle: 1.358 ± 0.034	1.355MetLys: 1.355 ± 0.037	2.532MetLeu: 2.532 ± 0.049	0.648MetMet: 0.648 ± 0.026	1.081MetAsn: 1.081 ± 0.027	1.381MetPro: 1.381 ± 0.028	1.104MetGln: 1.104 ± 0.032	1.142MetArg: 1.142 ± 0.029	1.503MetSer: 1.503 ± 0.037	1.456MetThr: 1.456 ± 0.037	1.586MetVal: 1.586 ± 0.038	0.166MetTrp: 0.166 ± 0.013	0.413MetTyr: 0.413 ± 0.019	0.001MetXaa: 0.001 ± 0.001
Asn	3.795AsnAla: 3.795 ± 0.06	0.435AsnCys: 0.435 ± 0.02	2.254AsnAsp: 2.254 ± 0.038	2.248AsnGlu: 2.248 ± 0.049	1.654AsnPhe: 1.654 ± 0.039	3.146AsnGly: 3.146 ± 0.062	0.98AsnHis: 0.98 ± 0.031	2.863AsnIle: 2.863 ± 0.056	2.392AsnLys: 2.392 ± 0.055	4.45AsnLeu: 4.45 ± 0.07	0.913AsnMet: 0.913 ± 0.026	2.035AsnAsn: 2.035 ± 0.043	2.744AsnPro: 2.744 ± 0.055	2.014AsnGln: 2.014 ± 0.049	2.256AsnArg: 2.256 ± 0.044	2.506AsnSer: 2.506 ± 0.051	2.422AsnThr: 2.422 ± 0.053	2.462AsnVal: 2.462 ± 0.048	0.672AsnTrp: 0.672 ± 0.024	1.345AsnTyr: 1.345 ± 0.036	0.003AsnXaa: 0.003 ± 0.001
Pro	3.485ProAla: 3.485 ± 0.067	0.401ProCys: 0.401 ± 0.02	3.106ProAsp: 3.106 ± 0.049	3.379ProGlu: 3.379 ± 0.054	1.83ProPhe: 1.83 ± 0.041	3.239ProGly: 3.239 ± 0.062	0.906ProHis: 0.906 ± 0.03	2.823ProIle: 2.823 ± 0.055	2.332ProLys: 2.332 ± 0.046	4.378ProLeu: 4.378 ± 0.067	1.055ProMet: 1.055 ± 0.026	1.933ProAsn: 1.933 ± 0.041	1.857ProPro: 1.857 ± 0.053	1.546ProGln: 1.546 ± 0.038	1.546ProArg: 1.546 ± 0.035	2.701ProSer: 2.701 ± 0.059	2.445ProThr: 2.445 ± 0.052	3.397ProVal: 3.397 ± 0.059	0.546ProTrp: 0.546 ± 0.021	1.393ProTyr: 1.393 ± 0.035	0.002ProXaa: 0.002 ± 0.001
Gln	4.161GlnAla: 4.161 ± 0.074	0.398GlnCys: 0.398 ± 0.02	2.021GlnAsp: 2.021 ± 0.041	2.337GlnGlu: 2.337 ± 0.051	1.709GlnPhe: 1.709 ± 0.035	2.89GlnGly: 2.89 ± 0.052	1.144GlnHis: 1.144 ± 0.035	2.491GlnIle: 2.491 ± 0.048	2.187GlnLys: 2.187 ± 0.046	4.589GlnLeu: 4.589 ± 0.077	0.985GlnMet: 0.985 ± 0.033	1.671GlnAsn: 1.671 ± 0.042	1.985GlnPro: 1.985 ± 0.046	2.515GlnGln: 2.515 ± 0.049	2.247GlnArg: 2.247 ± 0.047	2.381GlnSer: 2.381 ± 0.049	2.275GlnThr: 2.275 ± 0.045	2.869GlnVal: 2.869 ± 0.051	0.555GlnTrp: 0.555 ± 0.024	1.165GlnTyr: 1.165 ± 0.029	0.002GlnXaa: 0.002 ± 0.001
Arg	3.33ArgAla: 3.33 ± 0.055	0.485ArgCys: 0.485 ± 0.021	2.475ArgAsp: 2.475 ± 0.049	2.805ArgGlu: 2.805 ± 0.06	2.392ArgPhe: 2.392 ± 0.047	2.706ArgGly: 2.706 ± 0.049	1.281ArgHis: 1.281 ± 0.032	3.5ArgIle: 3.5 ± 0.06	2.645ArgLys: 2.645 ± 0.049	5.709ArgLeu: 5.709 ± 0.074	1.234ArgMet: 1.234 ± 0.035	2.054ArgAsn: 2.054 ± 0.039	1.862ArgPro: 1.862 ± 0.041	2.349ArgGln: 2.349 ± 0.05	2.549ArgArg: 2.549 ± 0.062	2.672ArgSer: 2.672 ± 0.044	2.247ArgThr: 2.247 ± 0.044	3.061ArgVal: 3.061 ± 0.064	0.763ArgTrp: 0.763 ± 0.023	1.872ArgTyr: 1.872 ± 0.042	0.003ArgXaa: 0.003 ± 0.002
Ser	5.531SerAla: 5.531 ± 0.076	0.64SerCys: 0.64 ± 0.026	3.113SerAsp: 3.113 ± 0.053	3.278SerGlu: 3.278 ± 0.057	2.665SerPhe: 2.665 ± 0.057	5.156SerGly: 5.156 ± 0.075	1.445SerHis: 1.445 ± 0.039	3.94SerIle: 3.94 ± 0.059	2.989SerLys: 2.989 ± 0.053	6.381SerLeu: 6.381 ± 0.074	1.437SerMet: 1.437 ± 0.038	2.481SerAsn: 2.481 ± 0.051	2.726SerPro: 2.726 ± 0.055	2.464SerGln: 2.464 ± 0.046	2.954SerArg: 2.954 ± 0.057	3.791SerSer: 3.791 ± 0.069	3.206SerThr: 3.206 ± 0.056	4.183SerVal: 4.183 ± 0.059	0.814SerTrp: 0.814 ± 0.027	1.82SerTyr: 1.82 ± 0.042	0.002SerXaa: 0.002 ± 0.001
Thr	4.825ThrAla: 4.825 ± 0.077	0.512ThrCys: 0.512 ± 0.022	2.991ThrAsp: 2.991 ± 0.053	3.072ThrGlu: 3.072 ± 0.056	1.964ThrPhe: 1.964 ± 0.043	4.622ThrGly: 4.622 ± 0.079	1.291ThrHis: 1.291 ± 0.033	3.446ThrIle: 3.446 ± 0.063	2.443ThrLys: 2.443 ± 0.044	6.123ThrLeu: 6.123 ± 0.072	1.067ThrMet: 1.067 ± 0.029	2.014ThrAsn: 2.014 ± 0.045	2.841ThrPro: 2.841 ± 0.061	2.288ThrGln: 2.288 ± 0.037	2.38ThrArg: 2.38 ± 0.05	3.012ThrSer: 3.012 ± 0.056	2.936ThrThr: 2.936 ± 0.06	4.165ThrVal: 4.165 ± 0.073	0.671ThrTrp: 0.671 ± 0.027	1.565ThrTyr: 1.565 ± 0.044	0.002ThrXaa: 0.002 ± 0.001
Val	5.957ValAla: 5.957 ± 0.08	0.735ValCys: 0.735 ± 0.026	3.862ValAsp: 3.862 ± 0.063	3.832ValGlu: 3.832 ± 0.066	2.892ValPhe: 2.892 ± 0.063	4.534ValGly: 4.534 ± 0.075	1.263ValHis: 1.263 ± 0.035	4.521ValIle: 4.521 ± 0.063	3.566ValLys: 3.566 ± 0.06	6.889ValLeu: 6.889 ± 0.086	1.737ValMet: 1.737 ± 0.043	3.041ValAsn: 3.041 ± 0.054	2.628ValPro: 2.628 ± 0.049	2.195ValGln: 2.195 ± 0.044	3.023ValArg: 3.023 ± 0.052	4.433ValSer: 4.433 ± 0.063	3.745ValThr: 3.745 ± 0.064	4.683ValVal: 4.683 ± 0.082	0.794ValTrp: 0.794 ± 0.025	1.776ValTyr: 1.776 ± 0.034	0.003ValXaa: 0.003 ± 0.001
Trp	0.889TrpAla: 0.889 ± 0.029	0.124TrpCys: 0.124 ± 0.011	0.713TrpAsp: 0.713 ± 0.025	0.644TrpGlu: 0.644 ± 0.025	0.571TrpPhe: 0.571 ± 0.023	0.836TrpGly: 0.836 ± 0.028	0.383TrpHis: 0.383 ± 0.018	0.669TrpIle: 0.669 ± 0.025	0.565TrpLys: 0.565 ± 0.022	1.841TrpLeu: 1.841 ± 0.048	0.294TrpMet: 0.294 ± 0.015	0.515TrpAsn: 0.515 ± 0.021	0.496TrpPro: 0.496 ± 0.022	0.84TrpGln: 0.84 ± 0.032	0.747TrpArg: 0.747 ± 0.028	0.677TrpSer: 0.677 ± 0.028	0.569TrpThr: 0.569 ± 0.021	0.889TrpVal: 0.889 ± 0.028	0.189TrpTrp: 0.189 ± 0.013	0.362TrpTyr: 0.362 ± 0.018	0.002TrpXaa: 0.002 ± 0.001
Tyr	2.337TyrAla: 2.337 ± 0.041	0.402TyrCys: 0.402 ± 0.016	1.663TyrAsp: 1.663 ± 0.048	1.524TyrGlu: 1.524 ± 0.038	1.426TyrPhe: 1.426 ± 0.037	2.291TyrGly: 2.291 ± 0.048	0.761TyrHis: 0.761 ± 0.028	1.522TyrIle: 1.522 ± 0.044	1.368TyrLys: 1.368 ± 0.035	3.337TyrLeu: 3.337 ± 0.062	0.552TyrMet: 0.552 ± 0.019	1.072TyrAsn: 1.072 ± 0.031	1.54TyrPro: 1.54 ± 0.043	1.613TyrGln: 1.613 ± 0.041	1.874TyrArg: 1.874 ± 0.043	1.935TyrSer: 1.935 ± 0.04	1.462TyrThr: 1.462 ± 0.038	1.77TyrVal: 1.77 ± 0.042	0.425TyrTrp: 0.425 ± 0.025	0.994TyrTyr: 0.994 ± 0.031	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.005XaaAla: 0.005 ± 0.002	0.002XaaCys: 0.002 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.002XaaGlu: 0.002 ± 0.001	0.003XaaPhe: 0.003 ± 0.002	0.004XaaGly: 0.004 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.003XaaLeu: 0.003 ± 0.002	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.005XaaPro: 0.005 ± 0.002	0.003XaaGln: 0.003 ± 0.001	0.005XaaArg: 0.005 ± 0.002	0.002XaaSer: 0.002 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.003XaaVal: 0.003 ± 0.002	0.001XaaTrp: 0.001 ± 0.001	0.002XaaTyr: 0.002 ± 0.001	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 3732 proteins (1172009 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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