Amino acid dipepetide frequency for Grapevine leafroll-associated virus 13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.222AlaAla: 5.222 ± 1.139
1.547AlaCys: 1.547 ± 0.465
2.128AlaAsp: 2.128 ± 0.914
4.642AlaGlu: 4.642 ± 0.988
2.901AlaPhe: 2.901 ± 0.673
4.642AlaGly: 4.642 ± 0.472
0.967AlaHis: 0.967 ± 0.61
4.449AlaIle: 4.449 ± 0.855
4.062AlaLys: 4.062 ± 0.832
6.77AlaLeu: 6.77 ± 1.077
1.547AlaMet: 1.547 ± 0.547
4.062AlaAsn: 4.062 ± 0.938
2.321AlaPro: 2.321 ± 0.648
1.547AlaGln: 1.547 ± 0.593
4.255AlaArg: 4.255 ± 0.675
7.35AlaSer: 7.35 ± 1.006
5.029AlaThr: 5.029 ± 1.03
4.642AlaVal: 4.642 ± 1.064
0.774AlaTrp: 0.774 ± 0.528
2.901AlaTyr: 2.901 ± 0.709
0.0AlaXaa: 0.0 ± 0.0
Cys
0.387CysAla: 0.387 ± 0.258
0.58CysCys: 0.58 ± 0.263
0.774CysAsp: 0.774 ± 0.566
0.774CysGlu: 0.774 ± 0.366
0.58CysPhe: 0.58 ± 0.273
1.161CysGly: 1.161 ± 0.548
0.193CysHis: 0.193 ± 0.121
0.58CysIle: 0.58 ± 0.261
0.387CysLys: 0.387 ± 0.224
1.741CysLeu: 1.741 ± 0.68
0.58CysMet: 0.58 ± 0.295
1.547CysAsn: 1.547 ± 0.544
0.774CysPro: 0.774 ± 0.484
0.193CysGln: 0.193 ± 0.121
0.58CysArg: 0.58 ± 0.502
1.741CysSer: 1.741 ± 0.53
0.774CysThr: 0.774 ± 0.342
0.58CysVal: 0.58 ± 0.273
0.193CysTrp: 0.193 ± 0.121
1.741CysTyr: 1.741 ± 0.498
0.0CysXaa: 0.0 ± 0.0
Asp
4.449AspAla: 4.449 ± 1.032
0.193AspCys: 0.193 ± 0.246
4.062AspAsp: 4.062 ± 0.92
3.868AspGlu: 3.868 ± 0.984
1.547AspPhe: 1.547 ± 0.696
4.255AspGly: 4.255 ± 0.796
0.193AspHis: 0.193 ± 0.121
3.482AspIle: 3.482 ± 0.715
3.482AspLys: 3.482 ± 0.58
5.609AspLeu: 5.609 ± 1.155
1.934AspMet: 1.934 ± 0.617
2.128AspAsn: 2.128 ± 0.621
1.741AspPro: 1.741 ± 0.588
0.58AspGln: 0.58 ± 0.263
1.741AspArg: 1.741 ± 0.399
4.836AspSer: 4.836 ± 1.616
2.515AspThr: 2.515 ± 0.695
5.803AspVal: 5.803 ± 0.831
0.193AspTrp: 0.193 ± 0.238
1.741AspTyr: 1.741 ± 0.786
0.0AspXaa: 0.0 ± 0.0
Glu
5.803GluAla: 5.803 ± 1.631
0.967GluCys: 0.967 ± 0.806
3.482GluAsp: 3.482 ± 0.454
4.642GluGlu: 4.642 ± 0.889
1.354GluPhe: 1.354 ± 0.51
4.062GluGly: 4.062 ± 0.822
0.774GluHis: 0.774 ± 0.307
4.836GluIle: 4.836 ± 1.072
3.288GluLys: 3.288 ± 0.751
4.062GluLeu: 4.062 ± 0.673
1.547GluMet: 1.547 ± 0.519
2.901GluAsn: 2.901 ± 0.928
1.741GluPro: 1.741 ± 0.533
0.967GluGln: 0.967 ± 0.32
3.675GluArg: 3.675 ± 0.94
3.288GluSer: 3.288 ± 0.824
2.515GluThr: 2.515 ± 0.579
6.19GluVal: 6.19 ± 0.979
0.387GluTrp: 0.387 ± 0.261
1.161GluTyr: 1.161 ± 0.569
0.0GluXaa: 0.0 ± 0.0
Phe
1.547PheAla: 1.547 ± 0.479
1.354PheCys: 1.354 ± 0.527
2.901PheAsp: 2.901 ± 0.941
2.321PheGlu: 2.321 ± 0.529
1.934PhePhe: 1.934 ± 0.859
2.128PheGly: 2.128 ± 0.537
1.161PheHis: 1.161 ± 0.507
2.515PheIle: 2.515 ± 0.628
2.321PheLys: 2.321 ± 0.376
3.288PheLeu: 3.288 ± 1.214
0.967PheMet: 0.967 ± 0.441
1.934PheAsn: 1.934 ± 0.646
1.354PhePro: 1.354 ± 0.449
1.547PheGln: 1.547 ± 0.437
2.321PheArg: 2.321 ± 0.655
4.642PheSer: 4.642 ± 0.748
2.708PheThr: 2.708 ± 0.803
3.095PheVal: 3.095 ± 0.76
0.0PheTrp: 0.0 ± 0.0
0.387PheTyr: 0.387 ± 0.242
0.0PheXaa: 0.0 ± 0.0
Gly
3.095GlyAla: 3.095 ± 0.456
0.967GlyCys: 0.967 ± 0.497
3.868GlyAsp: 3.868 ± 0.918
2.708GlyGlu: 2.708 ± 0.408
0.967GlyPhe: 0.967 ± 0.318
5.803GlyGly: 5.803 ± 1.292
0.774GlyHis: 0.774 ± 0.362
1.741GlyIle: 1.741 ± 0.528
5.803GlyLys: 5.803 ± 1.378
6.963GlyLeu: 6.963 ± 0.984
1.547GlyMet: 1.547 ± 0.553
2.515GlyAsn: 2.515 ± 0.72
1.547GlyPro: 1.547 ± 0.469
0.774GlyGln: 0.774 ± 0.348
4.062GlyArg: 4.062 ± 0.659
6.576GlySer: 6.576 ± 1.294
3.095GlyThr: 3.095 ± 0.598
7.35GlyVal: 7.35 ± 1.428
0.967GlyTrp: 0.967 ± 0.466
2.515GlyTyr: 2.515 ± 0.524
0.0GlyXaa: 0.0 ± 0.0
His
1.354HisAla: 1.354 ± 0.383
0.193HisCys: 0.193 ± 0.121
0.387HisAsp: 0.387 ± 0.23
0.774HisGlu: 0.774 ± 0.283
0.774HisPhe: 0.774 ± 0.296
1.354HisGly: 1.354 ± 0.514
0.387HisHis: 0.387 ± 0.261
2.708HisIle: 2.708 ± 0.768
2.321HisLys: 2.321 ± 0.861
0.58HisLeu: 0.58 ± 0.609
0.193HisMet: 0.193 ± 0.185
1.161HisAsn: 1.161 ± 0.338
0.387HisPro: 0.387 ± 0.242
0.193HisGln: 0.193 ± 0.121
0.387HisArg: 0.387 ± 0.208
2.128HisSer: 2.128 ± 0.715
0.58HisThr: 0.58 ± 0.363
0.58HisVal: 0.58 ± 0.527
0.0HisTrp: 0.0 ± 0.0
0.387HisTyr: 0.387 ± 0.242
0.0HisXaa: 0.0 ± 0.0
Ile
4.642IleAla: 4.642 ± 0.882
0.58IleCys: 0.58 ± 0.334
3.482IleAsp: 3.482 ± 0.93
3.675IleGlu: 3.675 ± 0.768
2.515IlePhe: 2.515 ± 0.585
3.095IleGly: 3.095 ± 0.729
1.741IleHis: 1.741 ± 0.55
4.062IleIle: 4.062 ± 2.195
3.095IleLys: 3.095 ± 0.604
5.803IleLeu: 5.803 ± 1.495
0.967IleMet: 0.967 ± 0.611
2.321IleAsn: 2.321 ± 0.815
2.708IlePro: 2.708 ± 0.649
2.708IleGln: 2.708 ± 0.852
3.868IleArg: 3.868 ± 0.934
6.383IleSer: 6.383 ± 0.718
2.515IleThr: 2.515 ± 0.708
3.675IleVal: 3.675 ± 0.53
0.193IleTrp: 0.193 ± 0.121
2.128IleTyr: 2.128 ± 0.677
0.0IleXaa: 0.0 ± 0.0
Lys
4.062LysAla: 4.062 ± 1.135
1.161LysCys: 1.161 ± 0.395
3.482LysAsp: 3.482 ± 0.569
4.062LysGlu: 4.062 ± 0.555
1.934LysPhe: 1.934 ± 0.785
4.642LysGly: 4.642 ± 1.117
1.354LysHis: 1.354 ± 0.566
2.901LysIle: 2.901 ± 1.08
1.741LysLys: 1.741 ± 0.489
4.836LysLeu: 4.836 ± 1.234
1.934LysMet: 1.934 ± 0.453
2.321LysAsn: 2.321 ± 0.551
5.029LysPro: 5.029 ± 0.838
0.774LysGln: 0.774 ± 0.343
4.642LysArg: 4.642 ± 0.864
3.868LysSer: 3.868 ± 1.192
3.675LysThr: 3.675 ± 0.976
4.642LysVal: 4.642 ± 0.811
0.774LysTrp: 0.774 ± 0.348
3.482LysTyr: 3.482 ± 0.918
0.0LysXaa: 0.0 ± 0.0
Leu
5.996LeuAla: 5.996 ± 1.226
1.934LeuCys: 1.934 ± 0.453
6.77LeuAsp: 6.77 ± 1.308
3.482LeuGlu: 3.482 ± 0.75
2.708LeuPhe: 2.708 ± 0.979
3.868LeuGly: 3.868 ± 1.027
1.161LeuHis: 1.161 ± 0.425
5.609LeuIle: 5.609 ± 1.239
5.803LeuLys: 5.803 ± 1.193
5.609LeuLeu: 5.609 ± 1.228
2.515LeuMet: 2.515 ± 0.871
3.868LeuAsn: 3.868 ± 0.634
4.449LeuPro: 4.449 ± 1.295
1.741LeuGln: 1.741 ± 0.328
6.963LeuArg: 6.963 ± 1.044
6.576LeuSer: 6.576 ± 1.123
5.996LeuThr: 5.996 ± 1.284
5.996LeuVal: 5.996 ± 1.625
0.58LeuTrp: 0.58 ± 0.395
3.675LeuTyr: 3.675 ± 0.963
0.0LeuXaa: 0.0 ± 0.0
Met
2.515MetAla: 2.515 ± 0.871
0.387MetCys: 0.387 ± 0.242
0.967MetAsp: 0.967 ± 0.563
0.967MetGlu: 0.967 ± 0.538
1.161MetPhe: 1.161 ± 0.504
1.161MetGly: 1.161 ± 0.434
0.774MetHis: 0.774 ± 0.352
1.161MetIle: 1.161 ± 0.451
2.128MetLys: 2.128 ± 0.659
2.128MetLeu: 2.128 ± 0.623
0.58MetMet: 0.58 ± 0.402
1.354MetAsn: 1.354 ± 0.426
0.387MetPro: 0.387 ± 0.212
0.387MetGln: 0.387 ± 0.261
1.741MetArg: 1.741 ± 0.759
2.128MetSer: 2.128 ± 0.531
2.321MetThr: 2.321 ± 0.658
2.128MetVal: 2.128 ± 0.576
0.193MetTrp: 0.193 ± 0.121
0.58MetTyr: 0.58 ± 0.363
0.0MetXaa: 0.0 ± 0.0
Asn
3.482AsnAla: 3.482 ± 0.892
0.0AsnCys: 0.0 ± 0.0
2.321AsnAsp: 2.321 ± 0.947
3.288AsnGlu: 3.288 ± 0.634
2.128AsnPhe: 2.128 ± 0.543
2.515AsnGly: 2.515 ± 0.477
0.387AsnHis: 0.387 ± 0.306
1.934AsnIle: 1.934 ± 0.57
3.868AsnLys: 3.868 ± 0.737
3.675AsnLeu: 3.675 ± 0.58
0.193AsnMet: 0.193 ± 0.225
1.547AsnAsn: 1.547 ± 0.649
1.741AsnPro: 1.741 ± 0.414
2.128AsnGln: 2.128 ± 0.945
2.708AsnArg: 2.708 ± 1.024
4.836AsnSer: 4.836 ± 1.117
3.288AsnThr: 3.288 ± 0.597
4.836AsnVal: 4.836 ± 0.981
0.387AsnTrp: 0.387 ± 0.476
2.128AsnTyr: 2.128 ± 0.677
0.0AsnXaa: 0.0 ± 0.0
Pro
2.708ProAla: 2.708 ± 0.742
0.387ProCys: 0.387 ± 0.224
2.128ProAsp: 2.128 ± 0.632
1.547ProGlu: 1.547 ± 0.4
2.901ProPhe: 2.901 ± 0.611
2.321ProGly: 2.321 ± 0.525
0.774ProHis: 0.774 ± 0.362
2.128ProIle: 2.128 ± 0.635
2.901ProLys: 2.901 ± 0.919
3.095ProLeu: 3.095 ± 0.565
0.774ProMet: 0.774 ± 0.429
1.547ProAsn: 1.547 ± 0.431
1.161ProPro: 1.161 ± 0.497
2.515ProGln: 2.515 ± 0.622
1.547ProArg: 1.547 ± 0.609
3.288ProSer: 3.288 ± 0.955
2.128ProThr: 2.128 ± 0.711
2.901ProVal: 2.901 ± 0.643
0.193ProTrp: 0.193 ± 0.121
0.774ProTyr: 0.774 ± 0.458
0.0ProXaa: 0.0 ± 0.0
Gln
2.515GlnAla: 2.515 ± 0.545
0.967GlnCys: 0.967 ± 0.48
0.387GlnAsp: 0.387 ± 0.208
1.547GlnGlu: 1.547 ± 0.477
0.774GlnPhe: 0.774 ± 0.36
2.515GlnGly: 2.515 ± 0.733
1.354GlnHis: 1.354 ± 0.425
1.934GlnIle: 1.934 ± 0.669
1.547GlnLys: 1.547 ± 0.4
1.161GlnLeu: 1.161 ± 0.463
1.161GlnMet: 1.161 ± 0.327
0.967GlnAsn: 0.967 ± 0.386
0.193GlnPro: 0.193 ± 0.121
0.967GlnGln: 0.967 ± 0.254
2.321GlnArg: 2.321 ± 0.657
1.741GlnSer: 1.741 ± 0.521
2.321GlnThr: 2.321 ± 0.735
1.354GlnVal: 1.354 ± 0.965
0.193GlnTrp: 0.193 ± 0.121
1.161GlnTyr: 1.161 ± 0.574
0.0GlnXaa: 0.0 ± 0.0
Arg
5.416ArgAla: 5.416 ± 0.823
1.161ArgCys: 1.161 ± 0.51
2.321ArgAsp: 2.321 ± 0.593
5.029ArgGlu: 5.029 ± 1.184
2.515ArgPhe: 2.515 ± 0.739
2.708ArgGly: 2.708 ± 0.62
1.161ArgHis: 1.161 ± 0.579
2.515ArgIle: 2.515 ± 0.552
3.095ArgLys: 3.095 ± 0.852
4.642ArgLeu: 4.642 ± 0.812
0.774ArgMet: 0.774 ± 0.578
3.868ArgAsn: 3.868 ± 1.412
1.741ArgPro: 1.741 ± 0.483
1.741ArgGln: 1.741 ± 1.067
4.642ArgArg: 4.642 ± 1.148
5.803ArgSer: 5.803 ± 0.943
2.515ArgThr: 2.515 ± 0.511
3.675ArgVal: 3.675 ± 0.983
1.161ArgTrp: 1.161 ± 0.27
2.128ArgTyr: 2.128 ± 0.774
0.0ArgXaa: 0.0 ± 0.0
Ser
5.222SerAla: 5.222 ± 0.81
0.58SerCys: 0.58 ± 0.261
5.416SerAsp: 5.416 ± 0.925
4.836SerGlu: 4.836 ± 0.638
3.482SerPhe: 3.482 ± 0.745
6.383SerGly: 6.383 ± 1.049
1.741SerHis: 1.741 ± 0.603
5.609SerIle: 5.609 ± 1.191
3.675SerLys: 3.675 ± 0.878
8.317SerLeu: 8.317 ± 0.855
2.708SerMet: 2.708 ± 0.532
3.482SerAsn: 3.482 ± 1.154
2.515SerPro: 2.515 ± 0.785
3.675SerGln: 3.675 ± 0.766
4.449SerArg: 4.449 ± 0.829
8.704SerSer: 8.704 ± 1.874
5.222SerThr: 5.222 ± 1.636
9.091SerVal: 9.091 ± 1.249
0.967SerTrp: 0.967 ± 0.579
4.062SerTyr: 4.062 ± 1.008
0.0SerXaa: 0.0 ± 0.0
Thr
4.062ThrAla: 4.062 ± 0.855
0.774ThrCys: 0.774 ± 0.279
2.128ThrAsp: 2.128 ± 0.923
3.288ThrGlu: 3.288 ± 0.757
5.029ThrPhe: 5.029 ± 0.719
2.515ThrGly: 2.515 ± 0.472
0.387ThrHis: 0.387 ± 0.261
3.675ThrIle: 3.675 ± 0.834
2.901ThrLys: 2.901 ± 0.642
5.416ThrLeu: 5.416 ± 1.263
2.321ThrMet: 2.321 ± 0.933
2.901ThrAsn: 2.901 ± 0.676
3.675ThrPro: 3.675 ± 0.992
1.934ThrGln: 1.934 ± 0.744
2.901ThrArg: 2.901 ± 1.036
5.222ThrSer: 5.222 ± 0.89
5.609ThrThr: 5.609 ± 0.915
3.288ThrVal: 3.288 ± 0.565
0.387ThrTrp: 0.387 ± 0.317
2.128ThrTyr: 2.128 ± 1.125
0.0ThrXaa: 0.0 ± 0.0
Val
6.19ValAla: 6.19 ± 0.93
0.774ValCys: 0.774 ± 0.348
5.609ValAsp: 5.609 ± 1.094
4.062ValGlu: 4.062 ± 0.871
3.482ValPhe: 3.482 ± 0.652
5.416ValGly: 5.416 ± 1.22
0.967ValHis: 0.967 ± 0.387
5.222ValIle: 5.222 ± 1.013
5.996ValLys: 5.996 ± 0.65
7.157ValLeu: 7.157 ± 1.762
1.161ValMet: 1.161 ± 0.514
3.675ValAsn: 3.675 ± 0.712
2.708ValPro: 2.708 ± 0.901
1.934ValGln: 1.934 ± 0.603
3.868ValArg: 3.868 ± 1.103
6.576ValSer: 6.576 ± 0.988
4.642ValThr: 4.642 ± 0.817
6.19ValVal: 6.19 ± 1.55
0.193ValTrp: 0.193 ± 0.191
4.255ValTyr: 4.255 ± 0.764
0.0ValXaa: 0.0 ± 0.0
Trp
0.967TrpAla: 0.967 ± 0.456
0.387TrpCys: 0.387 ± 0.48
0.0TrpAsp: 0.0 ± 0.0
0.193TrpGlu: 0.193 ± 0.121
0.774TrpPhe: 0.774 ± 0.343
0.193TrpGly: 0.193 ± 0.121
0.0TrpHis: 0.0 ± 0.0
0.967TrpIle: 0.967 ± 0.416
0.774TrpLys: 0.774 ± 0.537
0.967TrpLeu: 0.967 ± 0.292
0.193TrpMet: 0.193 ± 0.121
0.193TrpAsn: 0.193 ± 0.225
0.387TrpPro: 0.387 ± 0.459
0.193TrpGln: 0.193 ± 0.262
0.58TrpArg: 0.58 ± 0.311
0.387TrpSer: 0.387 ± 0.311
0.193TrpThr: 0.193 ± 0.121
0.58TrpVal: 0.58 ± 0.261
0.193TrpTrp: 0.193 ± 0.209
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.128TyrAla: 2.128 ± 0.453
0.967TyrCys: 0.967 ± 0.425
1.741TyrAsp: 1.741 ± 0.451
1.934TyrGlu: 1.934 ± 0.527
0.967TyrPhe: 0.967 ± 0.407
2.901TyrGly: 2.901 ± 0.45
0.58TyrHis: 0.58 ± 0.363
2.128TyrIle: 2.128 ± 0.592
2.128TyrLys: 2.128 ± 0.609
3.482TyrLeu: 3.482 ± 0.785
1.354TyrMet: 1.354 ± 0.525
3.095TyrAsn: 3.095 ± 0.742
1.161TyrPro: 1.161 ± 0.336
0.58TyrGln: 0.58 ± 0.363
1.354TyrArg: 1.354 ± 0.442
4.062TyrSer: 4.062 ± 1.298
2.901TyrThr: 2.901 ± 0.525
3.675TyrVal: 3.675 ± 0.555
0.193TyrTrp: 0.193 ± 0.262
0.58TyrTyr: 0.58 ± 0.358
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (5171 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski