Amino acid dipepetide frequency for Karang Sari virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.801AlaAla: 1.801 ± 0.883
0.491AlaCys: 0.491 ± 0.35
3.11AlaAsp: 3.11 ± 0.997
3.765AlaGlu: 3.765 ± 1.014
2.455AlaPhe: 2.455 ± 0.973
1.31AlaGly: 1.31 ± 0.384
1.473AlaHis: 1.473 ± 0.117
4.911AlaIle: 4.911 ± 0.508
2.946AlaLys: 2.946 ± 0.304
5.074AlaLeu: 5.074 ± 0.484
1.146AlaMet: 1.146 ± 0.203
3.274AlaAsn: 3.274 ± 0.627
1.964AlaPro: 1.964 ± 0.681
2.128AlaGln: 2.128 ± 0.306
2.292AlaArg: 2.292 ± 0.635
3.438AlaSer: 3.438 ± 0.589
5.238AlaThr: 5.238 ± 0.402
2.455AlaVal: 2.455 ± 0.984
0.164AlaTrp: 0.164 ± 0.131
4.092AlaTyr: 4.092 ± 1.247
0.0AlaXaa: 0.0 ± 0.0
Cys
0.655CysAla: 0.655 ± 0.174
0.327CysCys: 0.327 ± 0.096
1.146CysAsp: 1.146 ± 0.335
1.31CysGlu: 1.31 ± 0.412
0.982CysPhe: 0.982 ± 0.287
1.146CysGly: 1.146 ± 0.324
0.818CysHis: 0.818 ± 0.282
0.982CysIle: 0.982 ± 0.336
1.637CysLys: 1.637 ± 0.644
1.637CysLeu: 1.637 ± 0.546
0.327CysMet: 0.327 ± 0.096
1.473CysAsn: 1.473 ± 0.293
1.31CysPro: 1.31 ± 0.587
0.327CysGln: 0.327 ± 0.263
0.655CysArg: 0.655 ± 0.174
0.982CysSer: 0.982 ± 0.138
1.964CysThr: 1.964 ± 0.681
1.473CysVal: 1.473 ± 0.594
0.0CysTrp: 0.0 ± 0.0
0.818CysTyr: 0.818 ± 0.282
0.0CysXaa: 0.0 ± 0.0
Asp
3.11AspAla: 3.11 ± 0.265
1.146AspCys: 1.146 ± 0.519
2.455AspAsp: 2.455 ± 0.517
2.292AspGlu: 2.292 ± 0.285
3.601AspPhe: 3.601 ± 0.72
1.637AspGly: 1.637 ± 0.507
1.637AspHis: 1.637 ± 0.564
4.42AspIle: 4.42 ± 0.445
2.292AspLys: 2.292 ± 0.743
5.729AspLeu: 5.729 ± 0.582
0.655AspMet: 0.655 ± 0.191
4.583AspAsn: 4.583 ± 0.929
2.619AspPro: 2.619 ± 0.835
2.292AspGln: 2.292 ± 0.743
1.473AspArg: 1.473 ± 0.594
3.274AspSer: 3.274 ± 0.418
3.929AspThr: 3.929 ± 0.747
2.128AspVal: 2.128 ± 0.071
0.491AspTrp: 0.491 ± 0.168
3.601AspTyr: 3.601 ± 0.705
0.0AspXaa: 0.0 ± 0.0
Glu
3.11GluAla: 3.11 ± 1.428
0.982GluCys: 0.982 ± 0.327
1.801GluAsp: 1.801 ± 0.449
1.31GluGlu: 1.31 ± 0.101
3.765GluPhe: 3.765 ± 0.652
1.146GluGly: 1.146 ± 0.459
2.946GluHis: 2.946 ± 0.808
4.092GluIle: 4.092 ± 0.91
2.946GluLys: 2.946 ± 1.477
6.711GluLeu: 6.711 ± 0.986
0.818GluMet: 0.818 ± 0.254
3.601GluAsn: 3.601 ± 0.493
1.964GluPro: 1.964 ± 0.254
1.964GluGln: 1.964 ± 0.076
1.637GluArg: 1.637 ± 0.262
2.128GluSer: 2.128 ± 0.486
3.438GluThr: 3.438 ± 0.733
1.637GluVal: 1.637 ± 0.168
0.164GluTrp: 0.164 ± 0.131
2.455GluTyr: 2.455 ± 0.99
0.0GluXaa: 0.0 ± 0.0
Phe
2.455PheAla: 2.455 ± 0.489
1.31PheCys: 1.31 ± 0.255
3.438PheAsp: 3.438 ± 1.067
2.619PheGlu: 2.619 ± 0.439
0.164PhePhe: 0.164 ± 0.117
2.619PheGly: 2.619 ± 0.488
0.818PheHis: 0.818 ± 0.418
3.765PheIle: 3.765 ± 1.33
2.292PheLys: 2.292 ± 0.741
3.11PheLeu: 3.11 ± 0.336
0.982PheMet: 0.982 ± 0.287
2.455PheAsn: 2.455 ± 0.796
0.982PhePro: 0.982 ± 0.101
0.818PheGln: 0.818 ± 0.254
1.31PheArg: 1.31 ± 0.794
2.292PheSer: 2.292 ± 0.604
3.11PheThr: 3.11 ± 0.991
2.783PheVal: 2.783 ± 0.524
0.327PheTrp: 0.327 ± 0.234
1.473PheTyr: 1.473 ± 0.231
0.0PheXaa: 0.0 ± 0.0
Gly
0.982GlyAla: 0.982 ± 0.101
0.327GlyCys: 0.327 ± 0.096
2.128GlyAsp: 2.128 ± 0.071
1.801GlyGlu: 1.801 ± 0.488
1.964GlyPhe: 1.964 ± 0.426
1.146GlyGly: 1.146 ± 0.486
0.655GlyHis: 0.655 ± 0.273
1.637GlyIle: 1.637 ± 0.584
3.274GlyLys: 3.274 ± 0.943
2.455GlyLeu: 2.455 ± 0.675
0.491GlyMet: 0.491 ± 0.198
1.637GlyAsn: 1.637 ± 0.162
1.31GlyPro: 1.31 ± 0.547
0.164GlyGln: 0.164 ± 0.117
1.31GlyArg: 1.31 ± 0.101
2.128GlySer: 2.128 ± 0.162
2.128GlyThr: 2.128 ± 0.425
1.146GlyVal: 1.146 ± 0.257
0.491GlyTrp: 0.491 ± 0.285
1.801GlyTyr: 1.801 ± 0.334
0.0GlyXaa: 0.0 ± 0.0
His
2.455HisAla: 2.455 ± 0.402
0.982HisCys: 0.982 ± 0.396
1.31HisAsp: 1.31 ± 0.383
1.473HisGlu: 1.473 ± 0.414
1.801HisPhe: 1.801 ± 0.488
0.982HisGly: 0.982 ± 0.101
1.146HisHis: 1.146 ± 0.65
2.619HisIle: 2.619 ± 0.201
2.619HisLys: 2.619 ± 0.623
3.274HisLeu: 3.274 ± 0.327
0.327HisMet: 0.327 ± 0.096
3.11HisAsn: 3.11 ± 0.593
2.455HisPro: 2.455 ± 0.192
1.964HisGln: 1.964 ± 0.697
0.491HisArg: 0.491 ± 0.198
1.801HisSer: 1.801 ± 0.81
3.274HisThr: 3.274 ± 0.849
1.801HisVal: 1.801 ± 0.52
0.327HisTrp: 0.327 ± 0.263
1.801HisTyr: 1.801 ± 0.486
0.0HisXaa: 0.0 ± 0.0
Ile
4.42IleAla: 4.42 ± 1.713
1.801IleCys: 1.801 ± 0.141
4.747IleAsp: 4.747 ± 0.472
2.128IleGlu: 2.128 ± 0.162
2.128IlePhe: 2.128 ± 0.486
2.292IleGly: 2.292 ± 0.301
2.292IleHis: 2.292 ± 0.514
5.402IleIle: 5.402 ± 0.294
4.747IleLys: 4.747 ± 0.469
7.53IleLeu: 7.53 ± 1.49
2.783IleMet: 2.783 ± 0.195
8.348IleAsn: 8.348 ± 2.428
4.42IlePro: 4.42 ± 0.733
2.619IleGln: 2.619 ± 0.645
3.929IleArg: 3.929 ± 0.93
4.583IleSer: 4.583 ± 0.802
5.566IleThr: 5.566 ± 0.886
3.929IleVal: 3.929 ± 0.453
0.655IleTrp: 0.655 ± 0.191
3.274IleTyr: 3.274 ± 0.645
0.0IleXaa: 0.0 ± 0.0
Lys
4.42LysAla: 4.42 ± 0.341
0.818LysCys: 0.818 ± 0.233
4.747LysAsp: 4.747 ± 1.378
3.11LysGlu: 3.11 ± 0.811
2.128LysPhe: 2.128 ± 0.62
1.637LysGly: 1.637 ± 0.605
2.619LysHis: 2.619 ± 0.762
3.765LysIle: 3.765 ± 1.343
1.146LysLys: 1.146 ± 0.439
6.057LysLeu: 6.057 ± 0.224
1.146LysMet: 1.146 ± 0.254
2.946LysAsn: 2.946 ± 0.641
3.929LysPro: 3.929 ± 1.264
2.783LysGln: 2.783 ± 1.383
3.274LysArg: 3.274 ± 0.042
4.256LysSer: 4.256 ± 0.737
4.583LysThr: 4.583 ± 1.208
2.946LysVal: 2.946 ± 0.432
0.491LysTrp: 0.491 ± 0.175
3.765LysTyr: 3.765 ± 0.168
0.0LysXaa: 0.0 ± 0.0
Leu
5.238LeuAla: 5.238 ± 0.696
1.637LeuCys: 1.637 ± 0.716
5.074LeuAsp: 5.074 ± 1.783
4.911LeuGlu: 4.911 ± 0.384
3.929LeuPhe: 3.929 ± 0.184
1.801LeuGly: 1.801 ± 0.184
3.274LeuHis: 3.274 ± 1.066
8.021LeuIle: 8.021 ± 0.427
7.694LeuLys: 7.694 ± 0.406
9.167LeuLeu: 9.167 ± 0.114
2.455LeuMet: 2.455 ± 0.98
8.185LeuAsn: 8.185 ± 0.561
3.438LeuPro: 3.438 ± 0.154
5.566LeuGln: 5.566 ± 0.926
4.747LeuArg: 4.747 ± 0.556
7.039LeuSer: 7.039 ± 0.218
7.366LeuThr: 7.366 ± 0.449
4.092LeuVal: 4.092 ± 0.405
0.818LeuTrp: 0.818 ± 0.254
6.548LeuTyr: 6.548 ± 1.47
0.0LeuXaa: 0.0 ± 0.0
Met
0.982MetAla: 0.982 ± 0.287
0.327MetCys: 0.327 ± 0.096
1.146MetAsp: 1.146 ± 0.372
0.982MetGlu: 0.982 ± 0.138
0.655MetPhe: 0.655 ± 0.169
0.491MetGly: 0.491 ± 0.198
0.818MetHis: 0.818 ± 0.714
1.473MetIle: 1.473 ± 0.597
0.982MetLys: 0.982 ± 0.138
2.455MetLeu: 2.455 ± 0.413
0.0MetMet: 0.0 ± 0.0
1.31MetAsn: 1.31 ± 0.315
1.146MetPro: 1.146 ± 0.324
1.31MetGln: 1.31 ± 0.101
0.818MetArg: 0.818 ± 0.282
0.982MetSer: 0.982 ± 0.138
0.982MetThr: 0.982 ± 0.396
0.982MetVal: 0.982 ± 0.327
0.0MetTrp: 0.0 ± 0.0
0.655MetTyr: 0.655 ± 0.174
0.0MetXaa: 0.0 ± 0.0
Asn
4.092AsnAla: 4.092 ± 0.951
1.801AsnCys: 1.801 ± 0.556
3.274AsnAsp: 3.274 ± 0.271
2.455AsnGlu: 2.455 ± 1.14
3.11AsnPhe: 3.11 ± 0.724
1.801AsnGly: 1.801 ± 0.555
1.473AsnHis: 1.473 ± 0.464
6.548AsnIle: 6.548 ± 0.147
4.42AsnLys: 4.42 ± 0.315
8.676AsnLeu: 8.676 ± 0.538
1.473AsnMet: 1.473 ± 0.293
6.057AsnAsn: 6.057 ± 1.623
3.601AsnPro: 3.601 ± 0.422
3.438AsnGln: 3.438 ± 0.321
1.637AsnArg: 1.637 ± 0.162
4.747AsnSer: 4.747 ± 1.166
5.893AsnThr: 5.893 ± 0.576
3.11AsnVal: 3.11 ± 0.548
0.655AsnTrp: 0.655 ± 0.191
4.42AsnTyr: 4.42 ± 1.29
0.0AsnXaa: 0.0 ± 0.0
Pro
3.11ProAla: 3.11 ± 0.975
0.491ProCys: 0.491 ± 0.292
2.292ProAsp: 2.292 ± 0.346
2.455ProGlu: 2.455 ± 0.506
0.491ProPhe: 0.491 ± 0.497
1.31ProGly: 1.31 ± 0.612
1.637ProHis: 1.637 ± 0.227
4.092ProIle: 4.092 ± 1.092
2.455ProLys: 2.455 ± 0.984
5.729ProLeu: 5.729 ± 0.567
0.655ProMet: 0.655 ± 0.444
2.783ProAsn: 2.783 ± 0.315
1.964ProPro: 1.964 ± 0.402
1.801ProGln: 1.801 ± 0.557
2.128ProArg: 2.128 ± 0.391
4.256ProSer: 4.256 ± 0.965
4.747ProThr: 4.747 ± 0.695
2.292ProVal: 2.292 ± 0.32
0.491ProTrp: 0.491 ± 0.168
2.292ProTyr: 2.292 ± 0.32
0.0ProXaa: 0.0 ± 0.0
Gln
1.801GlnAla: 1.801 ± 0.81
0.818GlnCys: 0.818 ± 0.247
1.964GlnAsp: 1.964 ± 0.688
1.473GlnGlu: 1.473 ± 0.43
0.655GlnPhe: 0.655 ± 0.191
1.31GlnGly: 1.31 ± 0.612
2.783GlnHis: 2.783 ± 0.932
2.455GlnIle: 2.455 ± 0.092
2.292GlnLys: 2.292 ± 0.32
4.583GlnLeu: 4.583 ± 0.799
0.164GlnMet: 0.164 ± 0.131
3.11GlnAsn: 3.11 ± 1.065
2.946GlnPro: 2.946 ± 0.87
1.964GlnGln: 1.964 ± 1.339
1.801GlnArg: 1.801 ± 0.579
3.438GlnSer: 3.438 ± 1.89
3.11GlnThr: 3.11 ± 0.397
1.964GlnVal: 1.964 ± 0.426
0.164GlnTrp: 0.164 ± 0.117
1.964GlnTyr: 1.964 ± 0.481
0.0GlnXaa: 0.0 ± 0.0
Arg
0.818ArgAla: 0.818 ± 0.254
0.818ArgCys: 0.818 ± 0.247
2.128ArgAsp: 2.128 ± 0.299
2.455ArgGlu: 2.455 ± 0.192
2.292ArgPhe: 2.292 ± 0.346
0.327ArgGly: 0.327 ± 0.096
1.473ArgHis: 1.473 ± 0.578
3.765ArgIle: 3.765 ± 0.703
3.438ArgLys: 3.438 ± 0.688
2.619ArgLeu: 2.619 ± 0.324
0.491ArgMet: 0.491 ± 0.198
2.946ArgAsn: 2.946 ± 0.587
1.801ArgPro: 1.801 ± 0.211
1.473ArgGln: 1.473 ± 0.293
2.128ArgArg: 2.128 ± 0.306
2.619ArgSer: 2.619 ± 0.901
2.946ArgThr: 2.946 ± 1.132
1.801ArgVal: 1.801 ± 0.334
0.327ArgTrp: 0.327 ± 0.244
3.765ArgTyr: 3.765 ± 1.084
0.0ArgXaa: 0.0 ± 0.0
Ser
4.092SerAla: 4.092 ± 0.437
1.146SerCys: 1.146 ± 0.203
4.583SerAsp: 4.583 ± 0.355
6.22SerGlu: 6.22 ± 1.344
2.619SerPhe: 2.619 ± 0.564
1.801SerGly: 1.801 ± 0.353
2.455SerHis: 2.455 ± 0.869
4.092SerIle: 4.092 ± 1.385
5.238SerLys: 5.238 ± 0.243
5.402SerLeu: 5.402 ± 2.175
0.982SerMet: 0.982 ± 0.413
3.438SerAsn: 3.438 ± 0.99
1.964SerPro: 1.964 ± 0.502
2.455SerGln: 2.455 ± 0.803
1.801SerArg: 1.801 ± 0.488
4.42SerSer: 4.42 ± 2.885
4.583SerThr: 4.583 ± 0.578
3.438SerVal: 3.438 ± 1.317
0.0SerTrp: 0.0 ± 0.0
5.566SerTyr: 5.566 ± 1.628
0.0SerXaa: 0.0 ± 0.0
Thr
3.438ThrAla: 3.438 ± 0.542
2.128ThrCys: 2.128 ± 0.306
2.292ThrAsp: 2.292 ± 0.429
2.946ThrGlu: 2.946 ± 0.753
2.292ThrPhe: 2.292 ± 0.6
2.783ThrGly: 2.783 ± 0.257
2.619ThrHis: 2.619 ± 0.488
6.057ThrIle: 6.057 ± 0.785
3.929ThrLys: 3.929 ± 0.691
8.021ThrLeu: 8.021 ± 0.55
1.473ThrMet: 1.473 ± 0.566
4.092ThrAsn: 4.092 ± 0.951
5.566ThrPro: 5.566 ± 0.953
3.274ThrGln: 3.274 ± 0.324
4.092ThrArg: 4.092 ± 1.13
6.875ThrSer: 6.875 ± 0.904
7.53ThrThr: 7.53 ± 1.942
5.074ThrVal: 5.074 ± 0.519
0.491ThrTrp: 0.491 ± 0.285
4.583ThrTyr: 4.583 ± 1.011
0.0ThrXaa: 0.0 ± 0.0
Val
2.946ValAla: 2.946 ± 1.062
1.473ValCys: 1.473 ± 0.414
2.292ValAsp: 2.292 ± 0.914
2.128ValGlu: 2.128 ± 1.311
2.292ValPhe: 2.292 ± 0.397
1.146ValGly: 1.146 ± 0.432
2.292ValHis: 2.292 ± 0.301
3.274ValIle: 3.274 ± 0.271
3.438ValLys: 3.438 ± 1.177
5.566ValLeu: 5.566 ± 0.676
0.655ValMet: 0.655 ± 0.191
3.438ValAsn: 3.438 ± 0.4
2.128ValPro: 2.128 ± 0.425
1.964ValGln: 1.964 ± 0.373
1.801ValArg: 1.801 ± 0.211
3.438ValSer: 3.438 ± 2.183
3.601ValThr: 3.601 ± 0.235
2.619ValVal: 2.619 ± 1.085
0.164ValTrp: 0.164 ± 0.117
2.619ValTyr: 2.619 ± 0.647
0.0ValXaa: 0.0 ± 0.0
Trp
0.327TrpAla: 0.327 ± 0.244
0.0TrpCys: 0.0 ± 0.0
0.818TrpAsp: 0.818 ± 0.514
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.164TrpGly: 0.164 ± 0.131
0.327TrpHis: 0.327 ± 0.263
0.491TrpIle: 0.491 ± 0.198
0.164TrpLys: 0.164 ± 0.117
0.982TrpLeu: 0.982 ± 0.327
0.164TrpMet: 0.164 ± 0.131
0.491TrpAsn: 0.491 ± 0.394
0.164TrpPro: 0.164 ± 0.27
0.164TrpGln: 0.164 ± 0.131
0.327TrpArg: 0.327 ± 0.234
0.0TrpSer: 0.0 ± 0.0
0.655TrpThr: 0.655 ± 0.273
0.327TrpVal: 0.327 ± 0.234
0.0TrpTrp: 0.0 ± 0.0
0.982TrpTyr: 0.982 ± 0.413
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.274TyrAla: 3.274 ± 0.188
1.146TyrCys: 1.146 ± 0.324
2.619TyrAsp: 2.619 ± 0.631
2.783TyrGlu: 2.783 ± 0.501
1.801TyrPhe: 1.801 ± 0.391
2.128TyrGly: 2.128 ± 0.306
2.455TyrHis: 2.455 ± 0.402
5.729TyrIle: 5.729 ± 0.372
2.619TyrLys: 2.619 ± 0.623
6.384TyrLeu: 6.384 ± 0.062
1.146TyrMet: 1.146 ± 0.372
5.402TyrAsn: 5.402 ± 1.442
1.801TyrPro: 1.801 ± 0.353
2.292TyrGln: 2.292 ± 0.619
2.783TyrArg: 2.783 ± 0.591
3.601TyrSer: 3.601 ± 0.902
4.911TyrThr: 4.911 ± 0.565
3.274TyrVal: 3.274 ± 0.719
0.327TyrTrp: 0.327 ± 0.539
3.274TyrTyr: 3.274 ± 0.946
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (6110 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski