Amino acid dipepetide frequency for Panaeolus cyanescens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.3AlaAla: 7.3 ± 0.055	0.95AlaCys: 0.95 ± 0.014	3.7AlaAsp: 3.7 ± 0.025	4.305AlaGlu: 4.305 ± 0.036	3.146AlaPhe: 3.146 ± 0.023	4.905AlaGly: 4.905 ± 0.03	1.897AlaHis: 1.897 ± 0.018	4.092AlaIle: 4.092 ± 0.026	3.733AlaLys: 3.733 ± 0.029	7.598AlaLeu: 7.598 ± 0.045	1.767AlaMet: 1.767 ± 0.016	2.987AlaAsn: 2.987 ± 0.021	4.844AlaPro: 4.844 ± 0.038	3.222AlaGln: 3.222 ± 0.026	4.355AlaArg: 4.355 ± 0.031	7.348AlaSer: 7.348 ± 0.044	4.949AlaThr: 4.949 ± 0.03	4.716AlaVal: 4.716 ± 0.031	0.992AlaTrp: 0.992 ± 0.012	2.113AlaTyr: 2.113 ± 0.019	0.001AlaXaa: 0.001 ± 0.0
Cys	0.864CysAla: 0.864 ± 0.014	0.225CysCys: 0.225 ± 0.007	0.622CysAsp: 0.622 ± 0.011	0.527CysGlu: 0.527 ± 0.009	0.5CysPhe: 0.5 ± 0.009	0.811CysGly: 0.811 ± 0.013	0.317CysHis: 0.317 ± 0.007	0.699CysIle: 0.699 ± 0.011	0.529CysLys: 0.529 ± 0.01	1.187CysLeu: 1.187 ± 0.017	0.249CysMet: 0.249 ± 0.005	0.475CysAsn: 0.475 ± 0.01	0.735CysPro: 0.735 ± 0.012	0.425CysGln: 0.425 ± 0.009	0.673CysArg: 0.673 ± 0.01	0.932CysSer: 0.932 ± 0.015	0.699CysThr: 0.699 ± 0.014	0.735CysVal: 0.735 ± 0.01	0.176CysTrp: 0.176 ± 0.005	0.329CysTyr: 0.329 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.452AspAla: 4.452 ± 0.03	0.59AspCys: 0.59 ± 0.01	4.568AspAsp: 4.568 ± 0.04	4.378AspGlu: 4.378 ± 0.037	2.155AspPhe: 2.155 ± 0.019	3.69AspGly: 3.69 ± 0.029	1.277AspHis: 1.277 ± 0.015	3.324AspIle: 3.324 ± 0.024	2.305AspLys: 2.305 ± 0.019	4.974AspLeu: 4.974 ± 0.033	1.257AspMet: 1.257 ± 0.014	2.121AspAsn: 2.121 ± 0.019	3.405AspPro: 3.405 ± 0.024	1.738AspGln: 1.738 ± 0.016	2.687AspArg: 2.687 ± 0.024	4.326AspSer: 4.326 ± 0.032	3.03AspThr: 3.03 ± 0.024	3.869AspVal: 3.869 ± 0.027	0.847AspTrp: 0.847 ± 0.012	1.493AspTyr: 1.493 ± 0.014	0.001AspXaa: 0.001 ± 0.0
Glu	4.591GluAla: 4.591 ± 0.033	0.613GluCys: 0.613 ± 0.01	4.108GluAsp: 4.108 ± 0.033	5.363GluGlu: 5.363 ± 0.051	1.9GluPhe: 1.9 ± 0.018	3.55GluGly: 3.55 ± 0.03	1.36GluHis: 1.36 ± 0.014	2.97GluIle: 2.97 ± 0.024	3.352GluLys: 3.352 ± 0.027	5.005GluLeu: 5.005 ± 0.032	1.353GluMet: 1.353 ± 0.017	2.145GluAsn: 2.145 ± 0.017	2.614GluPro: 2.614 ± 0.022	2.159GluGln: 2.159 ± 0.022	3.882GluArg: 3.882 ± 0.039	4.075GluSer: 4.075 ± 0.029	2.998GluThr: 2.998 ± 0.023	3.458GluVal: 3.458 ± 0.027	0.907GluTrp: 0.907 ± 0.013	1.55GluTyr: 1.55 ± 0.016	0.001GluXaa: 0.001 ± 0.0
Phe	2.905PheAla: 2.905 ± 0.021	0.569PheCys: 0.569 ± 0.011	2.332PheAsp: 2.332 ± 0.019	2.071PheGlu: 2.071 ± 0.022	1.603PhePhe: 1.603 ± 0.019	2.623PheGly: 2.623 ± 0.024	0.992PheHis: 0.992 ± 0.013	2.049PheIle: 2.049 ± 0.019	1.717PheLys: 1.717 ± 0.017	3.459PheLeu: 3.459 ± 0.026	0.809PheMet: 0.809 ± 0.01	1.624PheAsn: 1.624 ± 0.016	2.175PhePro: 2.175 ± 0.021	1.422PheGln: 1.422 ± 0.014	1.936PheArg: 1.936 ± 0.018	3.321PheSer: 3.321 ± 0.023	2.28PheThr: 2.28 ± 0.018	2.402PheVal: 2.402 ± 0.019	0.575PheTrp: 0.575 ± 0.01	1.128PheTyr: 1.128 ± 0.013	0.001PheXaa: 0.001 ± 0.0
Gly	4.554GlyAla: 4.554 ± 0.034	0.757GlyCys: 0.757 ± 0.012	3.273GlyAsp: 3.273 ± 0.025	3.162GlyGlu: 3.162 ± 0.027	2.507GlyPhe: 2.507 ± 0.02	5.44GlyGly: 5.44 ± 0.065	1.629GlyHis: 1.629 ± 0.017	3.229GlyIle: 3.229 ± 0.023	3.234GlyLys: 3.234 ± 0.025	5.296GlyLeu: 5.296 ± 0.029	1.412GlyMet: 1.412 ± 0.019	2.47GlyAsn: 2.47 ± 0.024	3.26GlyPro: 3.26 ± 0.027	2.278GlyGln: 2.278 ± 0.024	3.629GlyArg: 3.629 ± 0.027	5.664GlySer: 5.664 ± 0.039	3.846GlyThr: 3.846 ± 0.028	4.175GlyVal: 4.175 ± 0.035	1.03GlyTrp: 1.03 ± 0.014	1.907GlyTyr: 1.907 ± 0.021	0.001GlyXaa: 0.001 ± 0.0
His	1.884HisAla: 1.884 ± 0.019	0.329HisCys: 0.329 ± 0.007	1.38HisAsp: 1.38 ± 0.016	1.268HisGlu: 1.268 ± 0.015	1.025HisPhe: 1.025 ± 0.011	1.575HisGly: 1.575 ± 0.018	1.022HisHis: 1.022 ± 0.018	1.471HisIle: 1.471 ± 0.017	0.997HisLys: 0.997 ± 0.012	2.635HisLeu: 2.635 ± 0.02	0.474HisMet: 0.474 ± 0.009	1.028HisAsn: 1.028 ± 0.012	1.998HisPro: 1.998 ± 0.022	1.028HisGln: 1.028 ± 0.013	1.553HisArg: 1.553 ± 0.017	2.276HisSer: 2.276 ± 0.024	1.467HisThr: 1.467 ± 0.016	1.571HisVal: 1.571 ± 0.015	0.324HisTrp: 0.324 ± 0.007	0.738HisTyr: 0.738 ± 0.011	0.001HisXaa: 0.001 ± 0.0
Ile	4.054IleAla: 4.054 ± 0.028	0.725IleCys: 0.725 ± 0.012	2.966IleAsp: 2.966 ± 0.022	2.768IleGlu: 2.768 ± 0.021	2.058IlePhe: 2.058 ± 0.018	2.919IleGly: 2.919 ± 0.026	1.424IleHis: 1.424 ± 0.014	2.747IleIle: 2.747 ± 0.023	2.336IleLys: 2.336 ± 0.019	4.701IleLeu: 4.701 ± 0.029	1.003IleMet: 1.003 ± 0.012	1.985IleAsn: 1.985 ± 0.019	3.685IlePro: 3.685 ± 0.023	2.107IleGln: 2.107 ± 0.019	2.941IleArg: 2.941 ± 0.022	4.38IleSer: 4.38 ± 0.028	3.186IleThr: 3.186 ± 0.022	3.238IleVal: 3.238 ± 0.023	0.74IleTrp: 0.74 ± 0.012	1.412IleTyr: 1.412 ± 0.014	0.001IleXaa: 0.001 ± 0.0
Lys	4.152LysAla: 4.152 ± 0.031	0.496LysCys: 0.496 ± 0.01	2.729LysAsp: 2.729 ± 0.022	3.345LysGlu: 3.345 ± 0.028	1.556LysPhe: 1.556 ± 0.014	2.956LysGly: 2.956 ± 0.021	1.186LysHis: 1.186 ± 0.014	2.27LysIle: 2.27 ± 0.018	3.399LysLys: 3.399 ± 0.037	4.118LysLeu: 4.118 ± 0.027	0.999LysMet: 0.999 ± 0.013	1.725LysAsn: 1.725 ± 0.017	2.782LysPro: 2.782 ± 0.025	1.774LysGln: 1.774 ± 0.015	3.514LysArg: 3.514 ± 0.025	3.658LysSer: 3.658 ± 0.026	2.827LysThr: 2.827 ± 0.022	2.762LysVal: 2.762 ± 0.02	0.708LysTrp: 0.708 ± 0.01	1.333LysTyr: 1.333 ± 0.015	0.001LysXaa: 0.001 ± 0.0
Leu	7.148LeuAla: 7.148 ± 0.036	1.158LeuCys: 1.158 ± 0.014	5.256LeuAsp: 5.256 ± 0.029	5.445LeuGlu: 5.445 ± 0.035	3.391LeuPhe: 3.391 ± 0.029	5.176LeuGly: 5.176 ± 0.031	2.476LeuHis: 2.476 ± 0.021	4.125LeuIle: 4.125 ± 0.031	4.572LeuLys: 4.572 ± 0.03	8.074LeuLeu: 8.074 ± 0.044	1.69LeuMet: 1.69 ± 0.018	3.503LeuAsn: 3.503 ± 0.024	6.163LeuPro: 6.163 ± 0.039	3.9LeuGln: 3.9 ± 0.031	5.529LeuArg: 5.529 ± 0.031	8.136LeuSer: 8.136 ± 0.045	5.245LeuThr: 5.245 ± 0.031	5.334LeuVal: 5.334 ± 0.031	1.147LeuTrp: 1.147 ± 0.013	2.401LeuTyr: 2.401 ± 0.02	0.002LeuXaa: 0.002 ± 0.001
Met	1.709MetAla: 1.709 ± 0.014	0.223MetCys: 0.223 ± 0.006	1.307MetAsp: 1.307 ± 0.018	1.235MetGlu: 1.235 ± 0.014	0.756MetPhe: 0.756 ± 0.011	1.367MetGly: 1.367 ± 0.019	0.518MetHis: 0.518 ± 0.01	0.977MetIle: 0.977 ± 0.013	1.076MetLys: 1.076 ± 0.013	1.709MetLeu: 1.709 ± 0.016	0.537MetMet: 0.537 ± 0.009	0.801MetAsn: 0.801 ± 0.012	1.268MetPro: 1.268 ± 0.017	0.817MetGln: 0.817 ± 0.012	1.216MetArg: 1.216 ± 0.013	1.952MetSer: 1.952 ± 0.019	1.253MetThr: 1.253 ± 0.015	1.183MetVal: 1.183 ± 0.015	0.291MetTrp: 0.291 ± 0.006	0.516MetTyr: 0.516 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	3.382AsnAla: 3.382 ± 0.026	0.438AsnCys: 0.438 ± 0.008	2.13AsnAsp: 2.13 ± 0.018	1.993AsnGlu: 1.993 ± 0.017	1.475AsnPhe: 1.475 ± 0.016	2.868AsnGly: 2.868 ± 0.028	1.004AsnHis: 1.004 ± 0.011	2.249AsnIle: 2.249 ± 0.021	1.59AsnLys: 1.59 ± 0.017	3.631AsnLeu: 3.631 ± 0.028	0.836AsnMet: 0.836 ± 0.012	1.737AsnAsn: 1.737 ± 0.02	2.886AsnPro: 2.886 ± 0.022	1.415AsnGln: 1.415 ± 0.017	1.957AsnArg: 1.957 ± 0.016	3.138AsnSer: 3.138 ± 0.025	2.599AsnThr: 2.599 ± 0.023	2.626AsnVal: 2.626 ± 0.022	0.535AsnTrp: 0.535 ± 0.009	1.023AsnTyr: 1.023 ± 0.013	0.001AsnXaa: 0.001 ± 0.0
Pro	5.121ProAla: 5.121 ± 0.041	0.533ProCys: 0.533 ± 0.009	3.148ProAsp: 3.148 ± 0.024	3.443ProGlu: 3.443 ± 0.024	2.335ProPhe: 2.335 ± 0.021	3.668ProGly: 3.668 ± 0.028	1.691ProHis: 1.691 ± 0.022	3.104ProIle: 3.104 ± 0.024	2.738ProLys: 2.738 ± 0.024	5.387ProLeu: 5.387 ± 0.031	1.105ProMet: 1.105 ± 0.014	2.72ProAsn: 2.72 ± 0.023	6.552ProPro: 6.552 ± 0.073	2.608ProGln: 2.608 ± 0.026	3.298ProArg: 3.298 ± 0.03	7.467ProSer: 7.467 ± 0.05	4.816ProThr: 4.816 ± 0.032	3.859ProVal: 3.859 ± 0.031	0.681ProTrp: 0.681 ± 0.01	1.665ProTyr: 1.665 ± 0.019	0.001ProXaa: 0.001 ± 0.0
Gln	3.194GlnAla: 3.194 ± 0.029	0.468GlnCys: 0.468 ± 0.009	2.041GlnAsp: 2.041 ± 0.018	2.253GlnGlu: 2.253 ± 0.019	1.294GlnPhe: 1.294 ± 0.013	2.163GlnGly: 2.163 ± 0.019	1.194GlnHis: 1.194 ± 0.014	1.881GlnIle: 1.881 ± 0.02	1.843GlnLys: 1.843 ± 0.019	3.526GlnLeu: 3.526 ± 0.028	0.795GlnMet: 0.795 ± 0.011	1.579GlnAsn: 1.579 ± 0.017	2.68GlnPro: 2.68 ± 0.028	2.265GlnGln: 2.265 ± 0.042	2.516GlnArg: 2.516 ± 0.021	3.292GlnSer: 3.292 ± 0.025	2.428GlnThr: 2.428 ± 0.02	2.14GlnVal: 2.14 ± 0.018	0.567GlnTrp: 0.567 ± 0.012	1.115GlnTyr: 1.115 ± 0.014	0.001GlnXaa: 0.001 ± 0.0
Arg	4.311ArgAla: 4.311 ± 0.027	0.686ArgCys: 0.686 ± 0.012	3.116ArgAsp: 3.116 ± 0.026	3.506ArgGlu: 3.506 ± 0.033	2.174ArgPhe: 2.174 ± 0.019	3.278ArgGly: 3.278 ± 0.026	1.569ArgHis: 1.569 ± 0.018	3.064ArgIle: 3.064 ± 0.024	3.301ArgLys: 3.301 ± 0.026	5.404ArgLeu: 5.404 ± 0.032	1.286ArgMet: 1.286 ± 0.013	2.295ArgAsn: 2.295 ± 0.019	3.332ArgPro: 3.332 ± 0.027	2.323ArgGln: 2.323 ± 0.022	4.744ArgArg: 4.744 ± 0.038	4.903ArgSer: 4.903 ± 0.038	3.262ArgThr: 3.262 ± 0.025	3.325ArgVal: 3.325 ± 0.021	0.878ArgTrp: 0.878 ± 0.012	1.657ArgTyr: 1.657 ± 0.015	0.001ArgXaa: 0.001 ± 0.0
Ser	6.804SerAla: 6.804 ± 0.039	0.895SerCys: 0.895 ± 0.013	4.496SerAsp: 4.496 ± 0.029	4.082SerGlu: 4.082 ± 0.026	3.401SerPhe: 3.401 ± 0.024	5.56SerGly: 5.56 ± 0.037	2.249SerHis: 2.249 ± 0.023	4.407SerIle: 4.407 ± 0.03	3.95SerLys: 3.95 ± 0.028	8.069SerLeu: 8.069 ± 0.048	1.786SerMet: 1.786 ± 0.019	3.675SerAsn: 3.675 ± 0.028	6.411SerPro: 6.411 ± 0.055	3.471SerGln: 3.471 ± 0.025	5.036SerArg: 5.036 ± 0.034	11.096SerSer: 11.096 ± 0.085	6.736SerThr: 6.736 ± 0.041	4.961SerVal: 4.961 ± 0.03	1.061SerTrp: 1.061 ± 0.013	2.126SerTyr: 2.126 ± 0.02	0.001SerXaa: 0.001 ± 0.0
Thr	4.764ThrAla: 4.764 ± 0.027	0.732ThrCys: 0.732 ± 0.011	2.832ThrAsp: 2.832 ± 0.023	2.8ThrGlu: 2.8 ± 0.022	2.577ThrPhe: 2.577 ± 0.023	3.863ThrGly: 3.863 ± 0.028	1.596ThrHis: 1.596 ± 0.015	3.327ThrIle: 3.327 ± 0.025	2.623ThrLys: 2.623 ± 0.021	5.814ThrLeu: 5.814 ± 0.035	1.208ThrMet: 1.208 ± 0.014	2.389ThrAsn: 2.389 ± 0.02	5.041ThrPro: 5.041 ± 0.041	2.291ThrGln: 2.291 ± 0.021	3.289ThrArg: 3.289 ± 0.024	6.355ThrSer: 6.355 ± 0.036	4.914ThrThr: 4.914 ± 0.039	3.795ThrVal: 3.795 ± 0.025	0.789ThrTrp: 0.789 ± 0.011	1.647ThrTyr: 1.647 ± 0.016	0.001ThrXaa: 0.001 ± 0.001
Val	4.773ValAla: 4.773 ± 0.03	0.773ValCys: 0.773 ± 0.013	3.846ValAsp: 3.846 ± 0.026	3.751ValGlu: 3.751 ± 0.028	2.452ValPhe: 2.452 ± 0.022	3.654ValGly: 3.654 ± 0.032	1.514ValHis: 1.514 ± 0.015	3.141ValIle: 3.141 ± 0.023	3.023ValLys: 3.023 ± 0.025	5.547ValLeu: 5.547 ± 0.034	1.246ValMet: 1.246 ± 0.013	2.425ValAsn: 2.425 ± 0.021	3.889ValPro: 3.889 ± 0.027	2.474ValGln: 2.474 ± 0.021	3.128ValArg: 3.128 ± 0.024	4.781ValSer: 4.781 ± 0.028	3.535ValThr: 3.535 ± 0.026	4.331ValVal: 4.331 ± 0.032	0.851ValTrp: 0.851 ± 0.011	1.768ValTyr: 1.768 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	0.965TrpAla: 0.965 ± 0.014	0.182TrpCys: 0.182 ± 0.005	0.909TrpAsp: 0.909 ± 0.012	0.799TrpGlu: 0.799 ± 0.01	0.543TrpPhe: 0.543 ± 0.01	0.863TrpGly: 0.863 ± 0.014	0.341TrpHis: 0.341 ± 0.007	0.756TrpIle: 0.756 ± 0.013	0.859TrpLys: 0.859 ± 0.012	1.17TrpLeu: 1.17 ± 0.014	0.328TrpMet: 0.328 ± 0.006	0.655TrpAsn: 0.655 ± 0.01	0.567TrpPro: 0.567 ± 0.01	0.443TrpGln: 0.443 ± 0.01	0.911TrpArg: 0.911 ± 0.012	1.069TrpSer: 1.069 ± 0.013	0.894TrpThr: 0.894 ± 0.013	0.819TrpVal: 0.819 ± 0.012	0.26TrpTrp: 0.26 ± 0.007	0.398TrpTyr: 0.398 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.99TyrAla: 1.99 ± 0.021	0.37TyrCys: 0.37 ± 0.008	1.727TyrAsp: 1.727 ± 0.017	1.464TyrGlu: 1.464 ± 0.016	1.146TyrPhe: 1.146 ± 0.014	1.819TyrGly: 1.819 ± 0.019	0.79TyrHis: 0.79 ± 0.01	1.49TyrIle: 1.49 ± 0.015	1.112TyrLys: 1.112 ± 0.013	2.565TyrLeu: 2.565 ± 0.02	0.568TyrMet: 0.568 ± 0.009	1.172TyrAsn: 1.172 ± 0.013	1.653TyrPro: 1.653 ± 0.019	1.075TyrGln: 1.075 ± 0.014	1.617TyrArg: 1.617 ± 0.016	2.104TyrSer: 2.104 ± 0.019	1.682TyrThr: 1.682 ± 0.016	1.601TyrVal: 1.601 ± 0.015	0.372TyrTrp: 0.372 ± 0.008	0.893TyrTyr: 0.893 ± 0.012	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.002XaaLeu: 0.002 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 13419 proteins (6793608 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---