Amino acid dipepetide frequency for Rhodonellum psychrophilum GCM71 = DSM 17998

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.734AlaAla: 4.734 ± 0.078	0.536AlaCys: 0.536 ± 0.021	3.291AlaAsp: 3.291 ± 0.045	4.098AlaGlu: 4.098 ± 0.061	3.804AlaPhe: 3.804 ± 0.057	4.793AlaGly: 4.793 ± 0.083	1.16AlaHis: 1.16 ± 0.026	4.977AlaIle: 4.977 ± 0.066	4.366AlaLys: 4.366 ± 0.062	6.467AlaLeu: 6.467 ± 0.077	1.721AlaMet: 1.721 ± 0.039	3.229AlaAsn: 3.229 ± 0.048	2.106AlaPro: 2.106 ± 0.044	2.432AlaGln: 2.432 ± 0.041	2.23AlaArg: 2.23 ± 0.042	4.196AlaSer: 4.196 ± 0.063	3.056AlaThr: 3.056 ± 0.053	4.169AlaVal: 4.169 ± 0.062	0.719AlaTrp: 0.719 ± 0.026	2.336AlaTyr: 2.336 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.411CysAla: 0.411 ± 0.02	0.083CysCys: 0.083 ± 0.006	0.345CysAsp: 0.345 ± 0.016	0.381CysGlu: 0.381 ± 0.017	0.44CysPhe: 0.44 ± 0.017	0.586CysGly: 0.586 ± 0.025	0.206CysHis: 0.206 ± 0.014	0.468CysIle: 0.468 ± 0.019	0.385CysLys: 0.385 ± 0.017	0.654CysLeu: 0.654 ± 0.02	0.146CysMet: 0.146 ± 0.009	0.287CysAsn: 0.287 ± 0.013	0.309CysPro: 0.309 ± 0.018	0.281CysGln: 0.281 ± 0.016	0.236CysArg: 0.236 ± 0.013	0.462CysSer: 0.462 ± 0.018	0.357CysThr: 0.357 ± 0.017	0.363CysVal: 0.363 ± 0.015	0.074CysTrp: 0.074 ± 0.007	0.223CysTyr: 0.223 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.297AspAla: 3.297 ± 0.044	0.367AspCys: 0.367 ± 0.015	2.163AspAsp: 2.163 ± 0.042	3.169AspGlu: 3.169 ± 0.047	3.901AspPhe: 3.901 ± 0.055	3.759AspGly: 3.759 ± 0.069	1.053AspHis: 1.053 ± 0.028	3.824AspIle: 3.824 ± 0.055	3.411AspLys: 3.411 ± 0.051	5.822AspLeu: 5.822 ± 0.072	1.169AspMet: 1.169 ± 0.025	2.434AspAsn: 2.434 ± 0.042	2.468AspPro: 2.468 ± 0.048	2.176AspGln: 2.176 ± 0.039	2.29AspArg: 2.29 ± 0.04	2.798AspSer: 2.798 ± 0.048	2.084AspThr: 2.084 ± 0.039	2.874AspVal: 2.874 ± 0.045	0.86AspTrp: 0.86 ± 0.024	2.302AspTyr: 2.302 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	4.405GluAla: 4.405 ± 0.064	0.271GluCys: 0.271 ± 0.014	3.404GluAsp: 3.404 ± 0.056	5.185GluGlu: 5.185 ± 0.077	3.195GluPhe: 3.195 ± 0.052	4.352GluGly: 4.352 ± 0.053	0.972GluHis: 0.972 ± 0.026	5.97GluIle: 5.97 ± 0.07	6.269GluLys: 6.269 ± 0.089	6.106GluLeu: 6.106 ± 0.075	2.011GluMet: 2.011 ± 0.043	4.546GluAsn: 4.546 ± 0.06	1.67GluPro: 1.67 ± 0.028	2.069GluGln: 2.069 ± 0.038	2.762GluArg: 2.762 ± 0.051	3.728GluSer: 3.728 ± 0.044	3.212GluThr: 3.212 ± 0.047	4.328GluVal: 4.328 ± 0.054	0.764GluTrp: 0.764 ± 0.026	2.11GluTyr: 2.11 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.233PheAla: 3.233 ± 0.049	0.453PheCys: 0.453 ± 0.02	3.356PheAsp: 3.356 ± 0.047	3.756PheGlu: 3.756 ± 0.054	3.359PhePhe: 3.359 ± 0.056	4.281PheGly: 4.281 ± 0.056	1.088PheHis: 1.088 ± 0.029	3.64PheIle: 3.64 ± 0.055	3.313PheLys: 3.313 ± 0.049	5.746PheLeu: 5.746 ± 0.078	1.331PheMet: 1.331 ± 0.033	2.941PheAsn: 2.941 ± 0.059	2.214PhePro: 2.214 ± 0.039	2.115PheGln: 2.115 ± 0.038	2.248PheArg: 2.248 ± 0.043	4.558PheSer: 4.558 ± 0.06	2.887PheThr: 2.887 ± 0.047	3.211PheVal: 3.211 ± 0.054	0.76PheTrp: 0.76 ± 0.024	2.174PheTyr: 2.174 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.432GlyAla: 4.432 ± 0.076	0.53GlyCys: 0.53 ± 0.023	3.501GlyAsp: 3.501 ± 0.057	4.334GlyGlu: 4.334 ± 0.051	4.482GlyPhe: 4.482 ± 0.057	5.205GlyGly: 5.205 ± 0.149	1.223GlyHis: 1.223 ± 0.03	5.977GlyIle: 5.977 ± 0.072	5.402GlyLys: 5.402 ± 0.055	7.003GlyLeu: 7.003 ± 0.068	2.022GlyMet: 2.022 ± 0.037	3.898GlyAsn: 3.898 ± 0.071	1.812GlyPro: 1.812 ± 0.039	2.432GlyGln: 2.432 ± 0.044	2.722GlyArg: 2.722 ± 0.052	4.348GlySer: 4.348 ± 0.067	3.877GlyThr: 3.877 ± 0.098	4.525GlyVal: 4.525 ± 0.064	0.923GlyTrp: 0.923 ± 0.027	2.785GlyTyr: 2.785 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.092HisAla: 1.092 ± 0.027	0.167HisCys: 0.167 ± 0.011	0.854HisAsp: 0.854 ± 0.025	1.057HisGlu: 1.057 ± 0.029	1.261HisPhe: 1.261 ± 0.027	1.227HisGly: 1.227 ± 0.033	0.546HisHis: 0.546 ± 0.02	1.169HisIle: 1.169 ± 0.031	1.008HisLys: 1.008 ± 0.029	2.109HisLeu: 2.109 ± 0.043	0.369HisMet: 0.369 ± 0.015	0.777HisAsn: 0.777 ± 0.023	1.093HisPro: 1.093 ± 0.029	0.892HisGln: 0.892 ± 0.025	0.742HisArg: 0.742 ± 0.021	1.181HisSer: 1.181 ± 0.027	0.832HisThr: 0.832 ± 0.023	1.016HisVal: 1.016 ± 0.029	0.263HisTrp: 0.263 ± 0.014	0.789HisTyr: 0.789 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.085IleAla: 5.085 ± 0.07	0.615IleCys: 0.615 ± 0.024	3.934IleAsp: 3.934 ± 0.053	4.693IleGlu: 4.693 ± 0.059	3.929IlePhe: 3.929 ± 0.058	5.459IleGly: 5.459 ± 0.067	1.627IleHis: 1.627 ± 0.036	4.946IleIle: 4.946 ± 0.079	5.069IleLys: 5.069 ± 0.063	7.572IleLeu: 7.572 ± 0.085	1.511IleMet: 1.511 ± 0.029	3.948IleAsn: 3.948 ± 0.06	3.643IlePro: 3.643 ± 0.052	3.123IleGln: 3.123 ± 0.05	3.131IleArg: 3.131 ± 0.047	5.8IleSer: 5.8 ± 0.068	3.86IleThr: 3.86 ± 0.061	4.185IleVal: 4.185 ± 0.057	0.85IleTrp: 0.85 ± 0.026	2.473IleTyr: 2.473 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.573LysAla: 4.573 ± 0.065	0.323LysCys: 0.323 ± 0.015	3.807LysAsp: 3.807 ± 0.051	5.572LysGlu: 5.572 ± 0.081	2.987LysPhe: 2.987 ± 0.051	4.731LysGly: 4.731 ± 0.054	1.153LysHis: 1.153 ± 0.028	6.084LysIle: 6.084 ± 0.064	5.864LysLys: 5.864 ± 0.073	5.997LysLeu: 5.997 ± 0.074	2.098LysMet: 2.098 ± 0.036	4.476LysAsn: 4.476 ± 0.064	2.579LysPro: 2.579 ± 0.043	2.005LysGln: 2.005 ± 0.04	2.684LysArg: 2.684 ± 0.046	4.801LysSer: 4.801 ± 0.065	3.94LysThr: 3.94 ± 0.05	4.332LysVal: 4.332 ± 0.05	0.802LysTrp: 0.802 ± 0.023	2.417LysTyr: 2.417 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	6.539LeuAla: 6.539 ± 0.076	0.62LeuCys: 0.62 ± 0.022	5.45LeuAsp: 5.45 ± 0.064	6.971LeuGlu: 6.971 ± 0.078	5.307LeuPhe: 5.307 ± 0.075	6.848LeuGly: 6.848 ± 0.078	1.667LeuHis: 1.667 ± 0.033	7.265LeuIle: 7.265 ± 0.086	7.293LeuLys: 7.293 ± 0.09	9.466LeuLeu: 9.466 ± 0.115	2.432LeuMet: 2.432 ± 0.04	5.101LeuAsn: 5.101 ± 0.065	4.166LeuPro: 4.166 ± 0.053	3.283LeuGln: 3.283 ± 0.05	3.713LeuArg: 3.713 ± 0.049	6.913LeuSer: 6.913 ± 0.077	4.982LeuThr: 4.982 ± 0.06	6.174LeuVal: 6.174 ± 0.074	1.025LeuTrp: 1.025 ± 0.028	2.941LeuTyr: 2.941 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.969MetAla: 1.969 ± 0.039	0.113MetCys: 0.113 ± 0.009	1.581MetAsp: 1.581 ± 0.033	2.045MetGlu: 2.045 ± 0.037	0.885MetPhe: 0.885 ± 0.027	2.035MetGly: 2.035 ± 0.04	0.43MetHis: 0.43 ± 0.018	1.744MetIle: 1.744 ± 0.037	2.197MetLys: 2.197 ± 0.041	2.186MetLeu: 2.186 ± 0.036	0.738MetMet: 0.738 ± 0.022	1.321MetAsn: 1.321 ± 0.033	0.997MetPro: 0.997 ± 0.03	0.794MetGln: 0.794 ± 0.024	1.0MetArg: 1.0 ± 0.025	1.366MetSer: 1.366 ± 0.03	1.222MetThr: 1.222 ± 0.034	1.853MetVal: 1.853 ± 0.033	0.181MetTrp: 0.181 ± 0.01	0.608MetTyr: 0.608 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.404AsnAla: 3.404 ± 0.058	0.375AsnCys: 0.375 ± 0.019	2.412AsnAsp: 2.412 ± 0.046	3.048AsnGlu: 3.048 ± 0.047	3.013AsnPhe: 3.013 ± 0.052	3.813AsnGly: 3.813 ± 0.081	1.051AsnHis: 1.051 ± 0.028	3.911AsnIle: 3.911 ± 0.065	3.282AsnLys: 3.282 ± 0.054	5.576AsnLeu: 5.576 ± 0.078	1.248AsnMet: 1.248 ± 0.028	2.73AsnAsn: 2.73 ± 0.063	3.167AsnPro: 3.167 ± 0.059	2.446AsnGln: 2.446 ± 0.048	2.379AsnArg: 2.379 ± 0.045	3.455AsnSer: 3.455 ± 0.06	2.828AsnThr: 2.828 ± 0.049	2.919AsnVal: 2.919 ± 0.045	0.784AsnTrp: 0.784 ± 0.022	2.114AsnTyr: 2.114 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	2.41ProAla: 2.41 ± 0.048	0.181ProCys: 0.181 ± 0.011	2.418ProAsp: 2.418 ± 0.047	3.469ProGlu: 3.469 ± 0.053	2.298ProPhe: 2.298 ± 0.041	2.638ProGly: 2.638 ± 0.052	0.682ProHis: 0.682 ± 0.023	2.977ProIle: 2.977 ± 0.041	2.707ProLys: 2.707 ± 0.048	3.577ProLeu: 3.577 ± 0.049	1.004ProMet: 1.004 ± 0.029	2.209ProAsn: 2.209 ± 0.045	0.954ProPro: 0.954 ± 0.029	1.252ProGln: 1.252 ± 0.026	1.238ProArg: 1.238 ± 0.027	2.504ProSer: 2.504 ± 0.042	1.943ProThr: 1.943 ± 0.046	2.592ProVal: 2.592 ± 0.045	0.452ProTrp: 0.452 ± 0.02	1.419ProTyr: 1.419 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.302GlnAla: 2.302 ± 0.042	0.156GlnCys: 0.156 ± 0.01	1.743GlnAsp: 1.743 ± 0.032	2.716GlnGlu: 2.716 ± 0.048	1.768GlnPhe: 1.768 ± 0.033	2.256GlnGly: 2.256 ± 0.042	0.612GlnHis: 0.612 ± 0.021	2.787GlnIle: 2.787 ± 0.044	2.98GlnLys: 2.98 ± 0.051	3.419GlnLeu: 3.419 ± 0.053	1.036GlnMet: 1.036 ± 0.028	2.194GlnAsn: 2.194 ± 0.043	1.259GlnPro: 1.259 ± 0.031	1.301GlnGln: 1.301 ± 0.031	1.425GlnArg: 1.425 ± 0.033	2.18GlnSer: 2.18 ± 0.042	1.869GlnThr: 1.869 ± 0.038	2.319GlnVal: 2.319 ± 0.037	0.407GlnTrp: 0.407 ± 0.015	1.276GlnTyr: 1.276 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.238ArgAla: 2.238 ± 0.04	0.193ArgCys: 0.193 ± 0.011	2.063ArgAsp: 2.063 ± 0.041	2.856ArgGlu: 2.856 ± 0.054	2.321ArgPhe: 2.321 ± 0.046	2.348ArgGly: 2.348 ± 0.044	0.683ArgHis: 0.683 ± 0.021	3.277ArgIle: 3.277 ± 0.054	3.054ArgLys: 3.054 ± 0.046	3.764ArgLeu: 3.764 ± 0.054	1.174ArgMet: 1.174 ± 0.027	2.289ArgAsn: 2.289 ± 0.042	1.349ArgPro: 1.349 ± 0.03	1.381ArgGln: 1.381 ± 0.031	1.623ArgArg: 1.623 ± 0.038	2.252ArgSer: 2.252 ± 0.044	1.941ArgThr: 1.941 ± 0.041	2.398ArgVal: 2.398 ± 0.041	0.504ArgTrp: 0.504 ± 0.016	1.557ArgTyr: 1.557 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	3.913SerAla: 3.913 ± 0.058	0.555SerCys: 0.555 ± 0.02	3.231SerAsp: 3.231 ± 0.048	4.16SerGlu: 4.16 ± 0.056	3.953SerPhe: 3.953 ± 0.064	5.298SerGly: 5.298 ± 0.081	1.184SerHis: 1.184 ± 0.036	5.105SerIle: 5.105 ± 0.057	4.511SerLys: 4.511 ± 0.054	6.576SerLeu: 6.576 ± 0.075	1.57SerMet: 1.57 ± 0.033	3.299SerAsn: 3.299 ± 0.055	2.742SerPro: 2.742 ± 0.054	2.378SerGln: 2.378 ± 0.043	2.57SerArg: 2.57 ± 0.043	4.253SerSer: 4.253 ± 0.068	3.234SerThr: 3.234 ± 0.051	3.769SerVal: 3.769 ± 0.06	0.838SerTrp: 0.838 ± 0.026	2.308SerTyr: 2.308 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	3.454ThrAla: 3.454 ± 0.056	0.313ThrCys: 0.313 ± 0.017	2.747ThrAsp: 2.747 ± 0.046	3.037ThrGlu: 3.037 ± 0.051	2.856ThrPhe: 2.856 ± 0.053	4.196ThrGly: 4.196 ± 0.077	0.978ThrHis: 0.978 ± 0.029	3.763ThrIle: 3.763 ± 0.056	3.053ThrLys: 3.053 ± 0.05	5.029ThrLeu: 5.029 ± 0.059	0.978ThrMet: 0.978 ± 0.026	2.53ThrAsn: 2.53 ± 0.049	2.242ThrPro: 2.242 ± 0.044	1.739ThrGln: 1.739 ± 0.036	1.735ThrArg: 1.735 ± 0.035	3.189ThrSer: 3.189 ± 0.049	2.632ThrThr: 2.632 ± 0.057	3.284ThrVal: 3.284 ± 0.06	0.608ThrTrp: 0.608 ± 0.023	1.936ThrTyr: 1.936 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	3.952ValAla: 3.952 ± 0.062	0.486ValCys: 0.486 ± 0.022	3.317ValAsp: 3.317 ± 0.05	3.876ValGlu: 3.876 ± 0.065	3.818ValPhe: 3.818 ± 0.048	4.161ValGly: 4.161 ± 0.064	1.086ValHis: 1.086 ± 0.03	4.52ValIle: 4.52 ± 0.063	4.085ValLys: 4.085 ± 0.056	6.156ValLeu: 6.156 ± 0.068	1.559ValMet: 1.559 ± 0.034	3.305ValAsn: 3.305 ± 0.057	2.28ValPro: 2.28 ± 0.045	1.827ValGln: 1.827 ± 0.03	2.317ValArg: 2.317 ± 0.04	4.218ValSer: 4.218 ± 0.058	3.08ValThr: 3.08 ± 0.049	3.826ValVal: 3.826 ± 0.048	0.702ValTrp: 0.702 ± 0.021	2.174ValTyr: 2.174 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.76TrpAla: 0.76 ± 0.023	0.085TrpCys: 0.085 ± 0.006	0.719TrpAsp: 0.719 ± 0.022	0.864TrpGlu: 0.864 ± 0.025	0.604TrpPhe: 0.604 ± 0.023	0.836TrpGly: 0.836 ± 0.025	0.247TrpHis: 0.247 ± 0.014	0.91TrpIle: 0.91 ± 0.025	0.908TrpLys: 0.908 ± 0.025	1.087TrpLeu: 1.087 ± 0.031	0.414TrpMet: 0.414 ± 0.019	0.677TrpAsn: 0.677 ± 0.02	0.355TrpPro: 0.355 ± 0.016	0.454TrpGln: 0.454 ± 0.02	0.522TrpArg: 0.522 ± 0.02	0.697TrpSer: 0.697 ± 0.023	0.648TrpThr: 0.648 ± 0.023	0.799TrpVal: 0.799 ± 0.023	0.183TrpTrp: 0.183 ± 0.012	0.426TrpTyr: 0.426 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.212TyrAla: 2.212 ± 0.039	0.276TyrCys: 0.276 ± 0.014	1.886TyrAsp: 1.886 ± 0.038	2.04TyrGlu: 2.04 ± 0.041	2.486TyrPhe: 2.486 ± 0.043	2.61TyrGly: 2.61 ± 0.048	0.795TyrHis: 0.795 ± 0.027	2.138TyrIle: 2.138 ± 0.042	2.07TyrLys: 2.07 ± 0.039	3.844TyrLeu: 3.844 ± 0.053	0.736TyrMet: 0.736 ± 0.021	1.766TyrAsn: 1.766 ± 0.038	1.521TyrPro: 1.521 ± 0.028	1.625TyrGln: 1.625 ± 0.033	1.697TyrArg: 1.697 ± 0.036	2.55TyrSer: 2.55 ± 0.044	1.815TyrThr: 1.815 ± 0.038	1.809TyrVal: 1.809 ± 0.035	0.493TyrTrp: 0.493 ± 0.021	1.487TyrTyr: 1.487 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4904 proteins (1499400 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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