Amino acid dipepetide frequency for Streptococcus satellite phage Javan209

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.417AlaAla: 1.417 ± 0.919
0.472AlaCys: 0.472 ± 0.453
1.417AlaAsp: 1.417 ± 0.886
2.834AlaGlu: 2.834 ± 0.849
4.251AlaPhe: 4.251 ± 1.045
2.834AlaGly: 2.834 ± 1.073
0.472AlaHis: 0.472 ± 0.453
2.834AlaIle: 2.834 ± 1.084
10.864AlaLys: 10.864 ± 2.208
4.251AlaLeu: 4.251 ± 1.152
1.889AlaMet: 1.889 ± 0.906
3.307AlaAsn: 3.307 ± 1.027
1.889AlaPro: 1.889 ± 0.836
2.834AlaGln: 2.834 ± 1.178
0.945AlaArg: 0.945 ± 0.534
2.834AlaSer: 2.834 ± 1.187
4.251AlaThr: 4.251 ± 1.644
2.834AlaVal: 2.834 ± 1.193
0.0AlaTrp: 0.0 ± 0.0
1.889AlaTyr: 1.889 ± 0.924
0.0AlaXaa: 0.0 ± 0.0
Cys
0.472CysAla: 0.472 ± 0.439
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.472CysGly: 0.472 ± 0.428
0.0CysHis: 0.0 ± 0.0
0.472CysIle: 0.472 ± 0.428
0.945CysLys: 0.945 ± 0.491
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.472CysAsn: 0.472 ± 0.453
1.889CysPro: 1.889 ± 1.127
0.472CysGln: 0.472 ± 0.575
0.472CysArg: 0.472 ± 0.453
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.472CysTyr: 0.472 ± 0.405
0.0CysXaa: 0.0 ± 0.0
Asp
1.889AspAla: 1.889 ± 1.373
0.472AspCys: 0.472 ± 0.428
3.307AspAsp: 3.307 ± 1.169
3.779AspGlu: 3.779 ± 1.467
4.251AspPhe: 4.251 ± 1.442
2.834AspGly: 2.834 ± 1.13
0.0AspHis: 0.0 ± 0.0
6.141AspIle: 6.141 ± 1.741
4.724AspLys: 4.724 ± 1.23
4.251AspLeu: 4.251 ± 1.502
0.945AspMet: 0.945 ± 0.671
4.724AspAsn: 4.724 ± 1.828
0.0AspPro: 0.0 ± 0.0
0.0AspGln: 0.0 ± 0.0
0.945AspArg: 0.945 ± 0.633
3.779AspSer: 3.779 ± 1.09
2.834AspThr: 2.834 ± 0.936
2.834AspVal: 2.834 ± 1.53
0.472AspTrp: 0.472 ± 0.439
3.779AspTyr: 3.779 ± 1.264
0.0AspXaa: 0.0 ± 0.0
Glu
6.141GluAla: 6.141 ± 1.584
0.472GluCys: 0.472 ± 0.439
2.362GluAsp: 2.362 ± 1.08
8.03GluGlu: 8.03 ± 2.129
1.889GluPhe: 1.889 ± 0.985
3.307GluGly: 3.307 ± 1.682
1.417GluHis: 1.417 ± 0.809
8.03GluIle: 8.03 ± 1.818
11.337GluLys: 11.337 ± 2.17
13.226GluLeu: 13.226 ± 3.051
0.945GluMet: 0.945 ± 0.619
5.196GluAsn: 5.196 ± 1.172
2.834GluPro: 2.834 ± 1.394
3.307GluGln: 3.307 ± 0.98
2.834GluArg: 2.834 ± 1.464
3.307GluSer: 3.307 ± 2.272
4.251GluThr: 4.251 ± 1.494
3.779GluVal: 3.779 ± 0.844
0.472GluTrp: 0.472 ± 0.453
1.417GluTyr: 1.417 ± 0.886
0.0GluXaa: 0.0 ± 0.0
Phe
1.417PheAla: 1.417 ± 0.573
0.0PheCys: 0.0 ± 0.0
3.307PheAsp: 3.307 ± 0.91
2.362PheGlu: 2.362 ± 0.954
2.362PhePhe: 2.362 ± 0.99
3.307PheGly: 3.307 ± 0.84
1.889PheHis: 1.889 ± 1.156
4.724PheIle: 4.724 ± 1.594
3.307PheLys: 3.307 ± 1.237
4.251PheLeu: 4.251 ± 1.798
1.889PheMet: 1.889 ± 0.897
3.779PheAsn: 3.779 ± 0.86
0.945PhePro: 0.945 ± 0.809
1.417PheGln: 1.417 ± 0.792
0.945PheArg: 0.945 ± 0.508
2.362PheSer: 2.362 ± 0.848
3.307PheThr: 3.307 ± 1.047
1.417PheVal: 1.417 ± 0.771
0.472PheTrp: 0.472 ± 0.428
0.945PheTyr: 0.945 ± 0.714
0.0PheXaa: 0.0 ± 0.0
Gly
3.307GlyAla: 3.307 ± 0.901
0.945GlyCys: 0.945 ± 0.508
2.362GlyAsp: 2.362 ± 1.24
1.889GlyGlu: 1.889 ± 0.916
2.362GlyPhe: 2.362 ± 0.932
3.307GlyGly: 3.307 ± 1.782
0.945GlyHis: 0.945 ± 0.55
3.779GlyIle: 3.779 ± 1.57
2.834GlyLys: 2.834 ± 0.665
5.196GlyLeu: 5.196 ± 2.02
0.945GlyMet: 0.945 ± 0.656
2.362GlyAsn: 2.362 ± 0.933
0.0GlyPro: 0.0 ± 0.0
0.0GlyGln: 0.0 ± 0.0
1.889GlyArg: 1.889 ± 0.82
0.472GlySer: 0.472 ± 0.439
1.889GlyThr: 1.889 ± 0.827
4.251GlyVal: 4.251 ± 1.951
0.472GlyTrp: 0.472 ± 0.439
5.196GlyTyr: 5.196 ± 1.708
0.0GlyXaa: 0.0 ± 0.0
His
1.889HisAla: 1.889 ± 1.453
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
1.417HisGlu: 1.417 ± 0.905
0.472HisPhe: 0.472 ± 0.453
0.472HisGly: 0.472 ± 0.528
0.0HisHis: 0.0 ± 0.0
1.889HisIle: 1.889 ± 0.916
0.945HisLys: 0.945 ± 0.508
1.889HisLeu: 1.889 ± 0.955
0.0HisMet: 0.0 ± 0.0
1.417HisAsn: 1.417 ± 0.793
0.472HisPro: 0.472 ± 0.528
0.472HisGln: 0.472 ± 0.453
0.0HisArg: 0.0 ± 0.0
0.472HisSer: 0.472 ± 0.453
0.472HisThr: 0.472 ± 0.453
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.889HisTyr: 1.889 ± 1.116
0.0HisXaa: 0.0 ± 0.0
Ile
5.196IleAla: 5.196 ± 1.613
0.472IleCys: 0.472 ± 0.423
6.141IleAsp: 6.141 ± 1.619
5.196IleGlu: 5.196 ± 1.53
3.779IlePhe: 3.779 ± 1.266
1.889IleGly: 1.889 ± 0.897
0.472IleHis: 0.472 ± 0.423
5.668IleIle: 5.668 ± 2.306
7.085IleLys: 7.085 ± 2.064
8.503IleLeu: 8.503 ± 1.742
1.417IleMet: 1.417 ± 0.869
7.085IleAsn: 7.085 ± 1.344
2.362IlePro: 2.362 ± 0.907
2.362IleGln: 2.362 ± 0.806
2.362IleArg: 2.362 ± 0.935
4.724IleSer: 4.724 ± 1.367
3.307IleThr: 3.307 ± 1.372
4.251IleVal: 4.251 ± 1.008
0.0IleTrp: 0.0 ± 0.0
2.362IleTyr: 2.362 ± 0.988
0.0IleXaa: 0.0 ± 0.0
Lys
7.085LysAla: 7.085 ± 1.738
0.945LysCys: 0.945 ± 0.491
5.668LysAsp: 5.668 ± 1.463
13.699LysGlu: 13.699 ± 2.777
2.362LysPhe: 2.362 ± 0.945
4.251LysGly: 4.251 ± 1.669
1.417LysHis: 1.417 ± 0.843
7.085LysIle: 7.085 ± 1.936
14.171LysLys: 14.171 ± 2.604
8.503LysLeu: 8.503 ± 1.785
3.779LysMet: 3.779 ± 1.376
8.503LysAsn: 8.503 ± 1.387
3.307LysPro: 3.307 ± 1.13
5.668LysGln: 5.668 ± 1.907
7.558LysArg: 7.558 ± 2.586
5.196LysSer: 5.196 ± 1.84
8.503LysThr: 8.503 ± 1.376
6.141LysVal: 6.141 ± 1.564
0.472LysTrp: 0.472 ± 0.505
4.251LysTyr: 4.251 ± 1.256
0.0LysXaa: 0.0 ± 0.0
Leu
4.724LeuAla: 4.724 ± 1.347
0.0LeuCys: 0.0 ± 0.0
5.668LeuAsp: 5.668 ± 1.435
11.809LeuGlu: 11.809 ± 1.232
3.307LeuPhe: 3.307 ± 1.147
5.196LeuGly: 5.196 ± 2.594
0.945LeuHis: 0.945 ± 0.57
6.141LeuIle: 6.141 ± 1.534
16.533LeuLys: 16.533 ± 2.566
7.558LeuLeu: 7.558 ± 1.75
2.834LeuMet: 2.834 ± 1.064
4.251LeuAsn: 4.251 ± 1.323
2.834LeuPro: 2.834 ± 0.853
3.779LeuGln: 3.779 ± 1.145
0.472LeuArg: 0.472 ± 0.47
6.141LeuSer: 6.141 ± 1.65
4.724LeuThr: 4.724 ± 1.494
6.141LeuVal: 6.141 ± 2.122
0.472LeuTrp: 0.472 ± 0.453
2.834LeuTyr: 2.834 ± 0.631
0.0LeuXaa: 0.0 ± 0.0
Met
1.417MetAla: 1.417 ± 0.993
0.0MetCys: 0.0 ± 0.0
3.307MetAsp: 3.307 ± 1.184
2.834MetGlu: 2.834 ± 1.105
0.472MetPhe: 0.472 ± 0.505
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.945MetIle: 0.945 ± 0.644
2.362MetLys: 2.362 ± 1.18
1.889MetLeu: 1.889 ± 1.046
0.472MetMet: 0.472 ± 0.423
1.417MetAsn: 1.417 ± 0.897
0.0MetPro: 0.0 ± 0.0
1.889MetGln: 1.889 ± 1.424
0.472MetArg: 0.472 ± 0.428
1.417MetSer: 1.417 ± 0.835
3.307MetThr: 3.307 ± 1.073
0.472MetVal: 0.472 ± 0.439
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.834AsnAla: 2.834 ± 0.787
0.0AsnCys: 0.0 ± 0.0
2.362AsnAsp: 2.362 ± 1.274
4.724AsnGlu: 4.724 ± 1.738
3.779AsnPhe: 3.779 ± 0.877
5.668AsnGly: 5.668 ± 1.832
0.472AsnHis: 0.472 ± 0.528
5.668AsnIle: 5.668 ± 1.88
8.03AsnLys: 8.03 ± 2.146
3.307AsnLeu: 3.307 ± 1.155
1.889AsnMet: 1.889 ± 0.907
3.779AsnAsn: 3.779 ± 1.676
1.889AsnPro: 1.889 ± 0.927
1.417AsnGln: 1.417 ± 0.926
2.834AsnArg: 2.834 ± 1.378
3.779AsnSer: 3.779 ± 1.497
3.779AsnThr: 3.779 ± 2.644
5.668AsnVal: 5.668 ± 1.452
2.362AsnTrp: 2.362 ± 1.072
3.779AsnTyr: 3.779 ± 1.164
0.0AsnXaa: 0.0 ± 0.0
Pro
2.834ProAla: 2.834 ± 0.683
0.0ProCys: 0.0 ± 0.0
0.945ProAsp: 0.945 ± 0.539
1.889ProGlu: 1.889 ± 1.087
2.834ProPhe: 2.834 ± 0.77
0.472ProGly: 0.472 ± 0.423
0.0ProHis: 0.0 ± 0.0
0.945ProIle: 0.945 ± 0.625
3.307ProLys: 3.307 ± 1.336
1.889ProLeu: 1.889 ± 1.22
0.472ProMet: 0.472 ± 0.423
1.417ProAsn: 1.417 ± 0.694
0.472ProPro: 0.472 ± 0.618
0.472ProGln: 0.472 ± 0.453
1.889ProArg: 1.889 ± 0.712
0.945ProSer: 0.945 ± 0.55
1.417ProThr: 1.417 ± 1.081
0.945ProVal: 0.945 ± 0.685
0.0ProTrp: 0.0 ± 0.0
2.362ProTyr: 2.362 ± 0.734
0.0ProXaa: 0.0 ± 0.0
Gln
2.362GlnAla: 2.362 ± 0.856
0.472GlnCys: 0.472 ± 0.575
1.417GlnAsp: 1.417 ± 0.731
3.779GlnGlu: 3.779 ± 1.202
0.945GlnPhe: 0.945 ± 0.655
0.0GlnGly: 0.0 ± 0.0
0.472GlnHis: 0.472 ± 0.453
1.889GlnIle: 1.889 ± 0.862
6.613GlnLys: 6.613 ± 1.14
5.196GlnLeu: 5.196 ± 1.044
0.472GlnMet: 0.472 ± 0.453
2.362GlnAsn: 2.362 ± 1.1
0.472GlnPro: 0.472 ± 0.428
3.307GlnGln: 3.307 ± 0.952
2.362GlnArg: 2.362 ± 0.919
0.945GlnSer: 0.945 ± 0.856
1.889GlnThr: 1.889 ± 0.957
0.945GlnVal: 0.945 ± 0.716
0.0GlnTrp: 0.0 ± 0.0
3.307GlnTyr: 3.307 ± 1.688
0.0GlnXaa: 0.0 ± 0.0
Arg
1.889ArgAla: 1.889 ± 0.956
0.0ArgCys: 0.0 ± 0.0
0.945ArgAsp: 0.945 ± 0.563
1.889ArgGlu: 1.889 ± 0.83
0.945ArgPhe: 0.945 ± 0.491
1.417ArgGly: 1.417 ± 0.812
0.945ArgHis: 0.945 ± 0.906
1.889ArgIle: 1.889 ± 0.757
3.779ArgLys: 3.779 ± 1.214
5.196ArgLeu: 5.196 ± 1.032
0.0ArgMet: 0.0 ± 0.585
2.362ArgAsn: 2.362 ± 1.058
0.472ArgPro: 0.472 ± 0.476
3.307ArgGln: 3.307 ± 1.099
0.472ArgArg: 0.472 ± 0.428
1.889ArgSer: 1.889 ± 0.707
3.779ArgThr: 3.779 ± 1.626
2.362ArgVal: 2.362 ± 1.129
0.472ArgTrp: 0.472 ± 0.618
1.417ArgTyr: 1.417 ± 0.788
0.0ArgXaa: 0.0 ± 0.0
Ser
2.362SerAla: 2.362 ± 1.222
0.0SerCys: 0.0 ± 0.0
4.724SerAsp: 4.724 ± 1.201
6.613SerGlu: 6.613 ± 2.033
0.0SerPhe: 0.0 ± 0.0
1.889SerGly: 1.889 ± 0.932
1.889SerHis: 1.889 ± 1.305
4.724SerIle: 4.724 ± 1.088
4.251SerLys: 4.251 ± 1.34
4.251SerLeu: 4.251 ± 1.26
0.472SerMet: 0.472 ± 0.453
2.362SerAsn: 2.362 ± 1.158
1.417SerPro: 1.417 ± 1.27
2.834SerGln: 2.834 ± 1.034
1.889SerArg: 1.889 ± 0.82
1.417SerSer: 1.417 ± 0.852
2.362SerThr: 2.362 ± 0.832
3.779SerVal: 3.779 ± 1.002
0.0SerTrp: 0.0 ± 0.0
4.724SerTyr: 4.724 ± 1.726
0.0SerXaa: 0.0 ± 0.0
Thr
3.307ThrAla: 3.307 ± 1.105
0.472ThrCys: 0.472 ± 0.428
0.945ThrAsp: 0.945 ± 0.57
2.834ThrGlu: 2.834 ± 1.497
2.834ThrPhe: 2.834 ± 1.017
3.779ThrGly: 3.779 ± 1.394
0.945ThrHis: 0.945 ± 0.906
4.251ThrIle: 4.251 ± 1.476
6.613ThrLys: 6.613 ± 1.7
5.196ThrLeu: 5.196 ± 1.356
1.417ThrMet: 1.417 ± 0.488
3.779ThrAsn: 3.779 ± 0.781
3.307ThrPro: 3.307 ± 1.65
0.945ThrGln: 0.945 ± 0.749
2.362ThrArg: 2.362 ± 0.957
1.889ThrSer: 1.889 ± 0.978
1.417ThrThr: 1.417 ± 0.488
6.141ThrVal: 6.141 ± 2.292
0.945ThrTrp: 0.945 ± 0.644
1.417ThrTyr: 1.417 ± 0.698
0.0ThrXaa: 0.0 ± 0.0
Val
1.417ValAla: 1.417 ± 1.011
0.472ValCys: 0.472 ± 0.439
4.724ValAsp: 4.724 ± 1.373
4.724ValGlu: 4.724 ± 2.437
4.251ValPhe: 4.251 ± 1.5
1.889ValGly: 1.889 ± 1.258
1.417ValHis: 1.417 ± 0.977
4.724ValIle: 4.724 ± 1.197
6.141ValLys: 6.141 ± 1.724
4.724ValLeu: 4.724 ± 1.126
0.472ValMet: 0.472 ± 0.677
4.724ValAsn: 4.724 ± 0.931
0.0ValPro: 0.0 ± 0.0
0.945ValGln: 0.945 ± 0.579
1.889ValArg: 1.889 ± 1.182
6.613ValSer: 6.613 ± 1.471
2.362ValThr: 2.362 ± 0.98
3.779ValVal: 3.779 ± 1.078
0.0ValTrp: 0.0 ± 0.0
2.834ValTyr: 2.834 ± 0.945
0.0ValXaa: 0.0 ± 0.0
Trp
0.472TrpAla: 0.472 ± 0.428
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.417TrpGlu: 1.417 ± 0.788
0.945TrpPhe: 0.945 ± 0.644
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.472TrpIle: 0.472 ± 0.528
0.0TrpLys: 0.0 ± 0.0
1.889TrpLeu: 1.889 ± 0.958
0.0TrpMet: 0.0 ± 0.0
0.472TrpAsn: 0.472 ± 0.439
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.472TrpSer: 0.472 ± 0.453
0.0TrpThr: 0.0 ± 0.0
0.472TrpVal: 0.472 ± 0.453
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.889TyrAla: 1.889 ± 0.522
0.945TyrCys: 0.945 ± 0.563
2.362TyrAsp: 2.362 ± 0.894
2.834TyrGlu: 2.834 ± 1.436
2.362TyrPhe: 2.362 ± 0.765
1.417TyrGly: 1.417 ± 0.698
0.472TyrHis: 0.472 ± 0.529
2.362TyrIle: 2.362 ± 0.947
4.724TyrLys: 4.724 ± 1.636
5.196TyrLeu: 5.196 ± 1.822
1.889TyrMet: 1.889 ± 0.993
4.251TyrAsn: 4.251 ± 1.41
0.945TyrPro: 0.945 ± 0.625
3.779TyrGln: 3.779 ± 1.471
3.307TyrArg: 3.307 ± 0.554
3.307TyrSer: 3.307 ± 1.098
0.945TyrThr: 0.945 ± 0.743
1.889TyrVal: 1.889 ± 0.941
0.0TyrTrp: 0.0 ± 0.0
3.307TyrTyr: 3.307 ± 1.178
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (2118 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski