Amino acid dipepetide frequency for Bibersteinia trehalosi USDA-ARS-USMARC-192

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.839AlaAla: 6.839 ± 0.138
1.131AlaCys: 1.131 ± 0.05
4.562AlaAsp: 4.562 ± 0.092
6.864AlaGlu: 6.864 ± 0.113
3.713AlaPhe: 3.713 ± 0.085
6.32AlaGly: 6.32 ± 0.17
1.512AlaHis: 1.512 ± 0.045
6.205AlaIle: 6.205 ± 0.1
6.255AlaLys: 6.255 ± 0.112
9.75AlaLeu: 9.75 ± 0.145
2.462AlaMet: 2.462 ± 0.065
4.369AlaAsn: 4.369 ± 0.151
2.612AlaPro: 2.612 ± 0.075
4.377AlaGln: 4.377 ± 0.089
3.671AlaArg: 3.671 ± 0.087
4.349AlaSer: 4.349 ± 0.106
4.788AlaThr: 4.788 ± 0.18
6.583AlaVal: 6.583 ± 0.132
0.919AlaTrp: 0.919 ± 0.039
2.449AlaTyr: 2.449 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.753CysAla: 0.753 ± 0.036
0.159CysCys: 0.159 ± 0.016
0.584CysAsp: 0.584 ± 0.03
0.628CysGlu: 0.628 ± 0.03
0.468CysPhe: 0.468 ± 0.025
0.902CysGly: 0.902 ± 0.048
0.302CysHis: 0.302 ± 0.027
0.581CysIle: 0.581 ± 0.031
0.5CysLys: 0.5 ± 0.03
1.042CysLeu: 1.042 ± 0.044
0.163CysMet: 0.163 ± 0.015
0.35CysAsn: 0.35 ± 0.021
0.417CysPro: 0.417 ± 0.023
0.473CysGln: 0.473 ± 0.028
0.419CysArg: 0.419 ± 0.026
0.584CysSer: 0.584 ± 0.031
0.431CysThr: 0.431 ± 0.024
0.63CysVal: 0.63 ± 0.038
0.114CysTrp: 0.114 ± 0.012
0.38CysTyr: 0.38 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
3.547AspAla: 3.547 ± 0.104
0.518AspCys: 0.518 ± 0.034
2.403AspAsp: 2.403 ± 0.068
3.569AspGlu: 3.569 ± 0.089
2.561AspPhe: 2.561 ± 0.07
3.461AspGly: 3.461 ± 0.135
0.836AspHis: 0.836 ± 0.037
3.533AspIle: 3.533 ± 0.075
3.122AspLys: 3.122 ± 0.07
5.025AspLeu: 5.025 ± 0.087
1.095AspMet: 1.095 ± 0.038
2.417AspAsn: 2.417 ± 0.081
1.977AspPro: 1.977 ± 0.055
1.557AspGln: 1.557 ± 0.048
2.033AspArg: 2.033 ± 0.057
2.605AspSer: 2.605 ± 0.063
2.145AspThr: 2.145 ± 0.055
3.179AspVal: 3.179 ± 0.074
0.701AspTrp: 0.701 ± 0.036
2.132AspTyr: 2.132 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
4.617GluAla: 4.617 ± 0.098
0.487GluCys: 0.487 ± 0.029
2.217GluAsp: 2.217 ± 0.065
3.552GluGlu: 3.552 ± 0.09
2.445GluPhe: 2.445 ± 0.058
3.505GluGly: 3.505 ± 0.11
1.37GluHis: 1.37 ± 0.051
4.951GluIle: 4.951 ± 0.091
4.993GluLys: 4.993 ± 0.104
6.618GluLeu: 6.618 ± 0.117
1.865GluMet: 1.865 ± 0.059
4.024GluAsn: 4.024 ± 0.084
2.037GluPro: 2.037 ± 0.069
4.478GluGln: 4.478 ± 0.114
3.347GluArg: 3.347 ± 0.082
3.049GluSer: 3.049 ± 0.065
3.186GluThr: 3.186 ± 0.069
3.903GluVal: 3.903 ± 0.1
0.839GluTrp: 0.839 ± 0.037
1.652GluTyr: 1.652 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
4.236PheAla: 4.236 ± 0.089
0.651PheCys: 0.651 ± 0.03
2.779PheAsp: 2.779 ± 0.068
2.653PheGlu: 2.653 ± 0.06
1.977PhePhe: 1.977 ± 0.079
3.477PheGly: 3.477 ± 0.087
0.862PheHis: 0.862 ± 0.035
3.065PheIle: 3.065 ± 0.081
2.068PheLys: 2.068 ± 0.056
3.89PheLeu: 3.89 ± 0.099
1.004PheMet: 1.004 ± 0.043
2.194PheAsn: 2.194 ± 0.056
1.572PhePro: 1.572 ± 0.054
1.487PheGln: 1.487 ± 0.05
1.574PheArg: 1.574 ± 0.048
3.415PheSer: 3.415 ± 0.083
2.214PheThr: 2.214 ± 0.055
2.848PheVal: 2.848 ± 0.073
0.557PheTrp: 0.557 ± 0.03
1.526PheTyr: 1.526 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
5.383GlyAla: 5.383 ± 0.123
0.764GlyCys: 0.764 ± 0.038
3.403GlyAsp: 3.403 ± 0.124
4.595GlyGlu: 4.595 ± 0.09
3.154GlyPhe: 3.154 ± 0.077
4.83GlyGly: 4.83 ± 0.107
1.252GlyHis: 1.252 ± 0.047
5.285GlyIle: 5.285 ± 0.1
5.275GlyLys: 5.275 ± 0.119
6.784GlyLeu: 6.784 ± 0.112
1.808GlyMet: 1.808 ± 0.057
3.251GlyAsn: 3.251 ± 0.206
0.959GlyPro: 0.959 ± 0.045
2.611GlyGln: 2.611 ± 0.064
2.833GlyArg: 2.833 ± 0.071
3.992GlySer: 3.992 ± 0.126
3.66GlyThr: 3.66 ± 0.17
5.323GlyVal: 5.323 ± 0.113
0.948GlyTrp: 0.948 ± 0.044
2.523GlyTyr: 2.523 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.451HisAla: 1.451 ± 0.046
0.335HisCys: 0.335 ± 0.021
0.903HisAsp: 0.903 ± 0.038
0.884HisGlu: 0.884 ± 0.034
1.259HisPhe: 1.259 ± 0.044
1.364HisGly: 1.364 ± 0.045
0.674HisHis: 0.674 ± 0.04
1.521HisIle: 1.521 ± 0.049
1.104HisLys: 1.104 ± 0.041
2.238HisLeu: 2.238 ± 0.061
0.342HisMet: 0.342 ± 0.023
1.05HisAsn: 1.05 ± 0.038
0.996HisPro: 0.996 ± 0.042
1.156HisGln: 1.156 ± 0.04
1.033HisArg: 1.033 ± 0.043
1.458HisSer: 1.458 ± 0.054
1.121HisThr: 1.121 ± 0.042
0.88HisVal: 0.88 ± 0.039
0.327HisTrp: 0.327 ± 0.02
0.936HisTyr: 0.936 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
7.121IleAla: 7.121 ± 0.111
0.801IleCys: 0.801 ± 0.036
3.637IleAsp: 3.637 ± 0.079
4.655IleGlu: 4.655 ± 0.093
2.724IlePhe: 2.724 ± 0.075
5.205IleGly: 5.205 ± 0.106
1.326IleHis: 1.326 ± 0.049
4.172IleIle: 4.172 ± 0.093
3.572IleLys: 3.572 ± 0.078
6.163IleLeu: 6.163 ± 0.14
1.245IleMet: 1.245 ± 0.052
3.184IleAsn: 3.184 ± 0.11
2.667IlePro: 2.667 ± 0.074
2.78IleGln: 2.78 ± 0.076
2.959IleArg: 2.959 ± 0.072
4.736IleSer: 4.736 ± 0.116
3.746IleThr: 3.746 ± 0.116
4.324IleVal: 4.324 ± 0.079
0.698IleTrp: 0.698 ± 0.038
2.046IleTyr: 2.046 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.785LysAla: 5.785 ± 0.122
0.376LysCys: 0.376 ± 0.025
2.671LysAsp: 2.671 ± 0.088
3.616LysGlu: 3.616 ± 0.089
2.121LysPhe: 2.121 ± 0.053
3.848LysGly: 3.848 ± 0.086
1.169LysHis: 1.169 ± 0.046
3.97LysIle: 3.97 ± 0.075
3.393LysLys: 3.393 ± 0.095
5.811LysLeu: 5.811 ± 0.108
1.868LysMet: 1.868 ± 0.053
3.119LysAsn: 3.119 ± 0.075
2.261LysPro: 2.261 ± 0.068
3.35LysGln: 3.35 ± 0.07
2.815LysArg: 2.815 ± 0.071
3.235LysSer: 3.235 ± 0.082
3.263LysThr: 3.263 ± 0.073
4.035LysVal: 4.035 ± 0.099
0.62LysTrp: 0.62 ± 0.035
1.607LysTyr: 1.607 ± 0.055
0.0LysXaa: 0.0 ± 0.0
Leu
10.507LeuAla: 10.507 ± 0.18
0.996LeuCys: 0.996 ± 0.04
5.292LeuAsp: 5.292 ± 0.1
5.915LeuGlu: 5.915 ± 0.104
4.687LeuPhe: 4.687 ± 0.116
7.134LeuGly: 7.134 ± 0.098
2.11LeuHis: 2.11 ± 0.053
6.546LeuIle: 6.546 ± 0.131
5.722LeuLys: 5.722 ± 0.099
10.402LeuLeu: 10.402 ± 0.223
2.323LeuMet: 2.323 ± 0.072
5.37LeuAsn: 5.37 ± 0.115
4.654LeuPro: 4.654 ± 0.111
4.55LeuGln: 4.55 ± 0.107
4.432LeuArg: 4.432 ± 0.106
7.357LeuSer: 7.357 ± 0.129
5.654LeuThr: 5.654 ± 0.101
6.314LeuVal: 6.314 ± 0.109
1.078LeuTrp: 1.078 ± 0.049
2.663LeuTyr: 2.663 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.335MetAla: 2.335 ± 0.063
0.161MetCys: 0.161 ± 0.016
0.948MetAsp: 0.948 ± 0.034
1.201MetGlu: 1.201 ± 0.049
0.902MetPhe: 0.902 ± 0.041
1.551MetGly: 1.551 ± 0.055
0.433MetHis: 0.433 ± 0.025
1.479MetIle: 1.479 ± 0.047
1.508MetLys: 1.508 ± 0.049
2.699MetLeu: 2.699 ± 0.09
0.684MetMet: 0.684 ± 0.035
1.088MetAsn: 1.088 ± 0.034
1.144MetPro: 1.144 ± 0.043
1.467MetGln: 1.467 ± 0.052
1.01MetArg: 1.01 ± 0.037
1.462MetSer: 1.462 ± 0.048
1.333MetThr: 1.333 ± 0.045
1.511MetVal: 1.511 ± 0.052
0.218MetTrp: 0.218 ± 0.02
0.461MetTyr: 0.461 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
4.824AsnAla: 4.824 ± 0.229
0.384AsnCys: 0.384 ± 0.024
2.208AsnAsp: 2.208 ± 0.057
2.71AsnGlu: 2.71 ± 0.059
1.896AsnPhe: 1.896 ± 0.063
4.084AsnGly: 4.084 ± 0.247
1.092AsnHis: 1.092 ± 0.045
3.301AsnIle: 3.301 ± 0.11
2.464AsnLys: 2.464 ± 0.075
4.93AsnLeu: 4.93 ± 0.099
0.951AsnMet: 0.951 ± 0.037
2.585AsnAsn: 2.585 ± 0.208
2.392AsnPro: 2.392 ± 0.075
2.411AsnGln: 2.411 ± 0.077
2.187AsnArg: 2.187 ± 0.064
3.048AsnSer: 3.048 ± 0.124
2.564AsnThr: 2.564 ± 0.134
3.635AsnVal: 3.635 ± 0.198
0.613AsnTrp: 0.613 ± 0.036
1.635AsnTyr: 1.635 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
2.998ProAla: 2.998 ± 0.087
0.289ProCys: 0.289 ± 0.023
1.822ProAsp: 1.822 ± 0.057
3.157ProGlu: 3.157 ± 0.093
1.92ProPhe: 1.92 ± 0.067
1.292ProGly: 1.292 ± 0.061
0.915ProHis: 0.915 ± 0.039
2.517ProIle: 2.517 ± 0.078
2.143ProLys: 2.143 ± 0.059
3.944ProLeu: 3.944 ± 0.085
0.98ProMet: 0.98 ± 0.042
2.282ProAsn: 2.282 ± 0.057
1.037ProPro: 1.037 ± 0.04
1.747ProGln: 1.747 ± 0.06
1.29ProArg: 1.29 ± 0.046
2.251ProSer: 2.251 ± 0.061
2.212ProThr: 2.212 ± 0.071
2.51ProVal: 2.51 ± 0.061
0.334ProTrp: 0.334 ± 0.022
1.292ProTyr: 1.292 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
5.303GlnAla: 5.303 ± 0.102
0.366GlnCys: 0.366 ± 0.025
2.026GlnAsp: 2.026 ± 0.065
2.531GlnGlu: 2.531 ± 0.069
2.139GlnPhe: 2.139 ± 0.061
3.209GlnGly: 3.209 ± 0.09
1.233GlnHis: 1.233 ± 0.046
3.467GlnIle: 3.467 ± 0.081
2.894GlnLys: 2.894 ± 0.071
5.175GlnLeu: 5.175 ± 0.107
1.037GlnMet: 1.037 ± 0.039
2.421GlnAsn: 2.421 ± 0.072
1.884GlnPro: 1.884 ± 0.076
3.382GlnGln: 3.382 ± 0.101
2.386GlnArg: 2.386 ± 0.071
2.53GlnSer: 2.53 ± 0.069
2.579GlnThr: 2.579 ± 0.066
2.776GlnVal: 2.776 ± 0.065
0.649GlnTrp: 0.649 ± 0.031
1.449GlnTyr: 1.449 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
3.292ArgAla: 3.292 ± 0.077
0.426ArgCys: 0.426 ± 0.025
2.053ArgAsp: 2.053 ± 0.06
2.996ArgGlu: 2.996 ± 0.076
2.356ArgPhe: 2.356 ± 0.062
2.544ArgGly: 2.544 ± 0.063
1.077ArgHis: 1.077 ± 0.047
2.988ArgIle: 2.988 ± 0.084
2.566ArgLys: 2.566 ± 0.07
5.056ArgLeu: 5.056 ± 0.123
1.005ArgMet: 1.005 ± 0.039
2.04ArgAsn: 2.04 ± 0.056
1.514ArgPro: 1.514 ± 0.054
2.421ArgGln: 2.421 ± 0.065
2.027ArgArg: 2.027 ± 0.061
2.266ArgSer: 2.266 ± 0.063
2.025ArgThr: 2.025 ± 0.052
2.822ArgVal: 2.822 ± 0.08
0.543ArgTrp: 0.543 ± 0.027
1.847ArgTyr: 1.847 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
5.402SerAla: 5.402 ± 0.109
0.528SerCys: 0.528 ± 0.03
2.908SerAsp: 2.908 ± 0.065
3.675SerGlu: 3.675 ± 0.084
2.632SerPhe: 2.632 ± 0.068
4.64SerGly: 4.64 ± 0.102
1.433SerHis: 1.433 ± 0.041
3.693SerIle: 3.693 ± 0.089
2.957SerLys: 2.957 ± 0.067
6.294SerLeu: 6.294 ± 0.119
1.283SerMet: 1.283 ± 0.045
2.654SerAsn: 2.654 ± 0.108
2.34SerPro: 2.34 ± 0.064
2.961SerGln: 2.961 ± 0.073
2.598SerArg: 2.598 ± 0.07
3.499SerSer: 3.499 ± 0.093
2.971SerThr: 2.971 ± 0.132
4.003SerVal: 4.003 ± 0.109
0.684SerTrp: 0.684 ± 0.028
1.959SerTyr: 1.959 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
5.175ThrAla: 5.175 ± 0.128
0.377ThrCys: 0.377 ± 0.024
2.59ThrAsp: 2.59 ± 0.098
3.114ThrGlu: 3.114 ± 0.066
2.226ThrPhe: 2.226 ± 0.053
3.755ThrGly: 3.755 ± 0.089
1.167ThrHis: 1.167 ± 0.043
3.489ThrIle: 3.489 ± 0.111
2.434ThrLys: 2.434 ± 0.06
6.131ThrLeu: 6.131 ± 0.116
1.084ThrMet: 1.084 ± 0.041
2.369ThrAsn: 2.369 ± 0.182
2.476ThrPro: 2.476 ± 0.065
2.404ThrGln: 2.404 ± 0.066
1.946ThrArg: 1.946 ± 0.059
2.741ThrSer: 2.741 ± 0.1
3.104ThrThr: 3.104 ± 0.185
3.844ThrVal: 3.844 ± 0.187
0.505ThrTrp: 0.505 ± 0.027
1.481ThrTyr: 1.481 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
6.456ValAla: 6.456 ± 0.151
0.634ValCys: 0.634 ± 0.033
3.418ValAsp: 3.418 ± 0.093
4.739ValGlu: 4.739 ± 0.09
2.672ValPhe: 2.672 ± 0.064
4.557ValGly: 4.557 ± 0.096
1.106ValHis: 1.106 ± 0.039
4.523ValIle: 4.523 ± 0.091
4.021ValLys: 4.021 ± 0.081
6.49ValLeu: 6.49 ± 0.127
1.669ValMet: 1.669 ± 0.058
3.332ValAsn: 3.332 ± 0.231
2.413ValPro: 2.413 ± 0.058
2.713ValGln: 2.713 ± 0.062
2.868ValArg: 2.868 ± 0.065
4.19ValSer: 4.19 ± 0.103
3.382ValThr: 3.382 ± 0.135
4.999ValVal: 4.999 ± 0.11
0.672ValTrp: 0.672 ± 0.034
1.768ValTyr: 1.768 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.915TrpAla: 0.915 ± 0.036
0.113TrpCys: 0.113 ± 0.014
0.535TrpAsp: 0.535 ± 0.028
0.57TrpGlu: 0.57 ± 0.031
0.56TrpPhe: 0.56 ± 0.03
0.79TrpGly: 0.79 ± 0.042
0.32TrpHis: 0.32 ± 0.024
0.667TrpIle: 0.667 ± 0.032
0.633TrpLys: 0.633 ± 0.029
1.755TrpLeu: 1.755 ± 0.059
0.195TrpMet: 0.195 ± 0.016
0.494TrpAsn: 0.494 ± 0.032
0.117TrpPro: 0.117 ± 0.013
1.113TrpGln: 1.113 ± 0.046
0.605TrpArg: 0.605 ± 0.032
0.486TrpSer: 0.486 ± 0.028
0.468TrpThr: 0.468 ± 0.026
0.772TrpVal: 0.772 ± 0.04
0.166TrpTrp: 0.166 ± 0.018
0.324TrpTyr: 0.324 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.793TyrAla: 2.793 ± 0.064
0.385TyrCys: 0.385 ± 0.027
1.458TyrAsp: 1.458 ± 0.041
1.514TyrGlu: 1.514 ± 0.055
1.636TyrPhe: 1.636 ± 0.057
2.166TyrGly: 2.166 ± 0.061
0.845TyrHis: 0.845 ± 0.035
1.811TyrIle: 1.811 ± 0.055
1.307TyrLys: 1.307 ± 0.052
3.505TyrLeu: 3.505 ± 0.093
0.526TyrMet: 0.526 ± 0.03
1.321TyrAsn: 1.321 ± 0.047
1.463TyrPro: 1.463 ± 0.051
1.997TyrGln: 1.997 ± 0.055
1.832TyrArg: 1.832 ± 0.061
1.863TyrSer: 1.863 ± 0.055
1.567TyrThr: 1.567 ± 0.052
1.73TyrVal: 1.73 ± 0.062
0.412TyrTrp: 0.412 ± 0.024
1.113TyrTyr: 1.113 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2244 proteins (716193 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski