Amino acid dipepetide frequency for Micromonas pusilla virus 12T

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.005AlaAla: 4.005 ± 0.382
0.906AlaCys: 0.906 ± 0.121
2.638AlaAsp: 2.638 ± 0.215
2.622AlaGlu: 2.622 ± 0.228
2.225AlaPhe: 2.225 ± 0.212
3.814AlaGly: 3.814 ± 0.462
0.954AlaHis: 0.954 ± 0.129
3.496AlaIle: 3.496 ± 0.221
3.878AlaLys: 3.878 ± 0.417
4.625AlaLeu: 4.625 ± 0.273
1.685AlaMet: 1.685 ± 0.184
2.845AlaAsn: 2.845 ± 0.292
1.939AlaPro: 1.939 ± 0.222
1.748AlaGln: 1.748 ± 0.169
2.304AlaArg: 2.304 ± 0.225
4.259AlaSer: 4.259 ± 0.381
3.751AlaThr: 3.751 ± 0.376
3.385AlaVal: 3.385 ± 0.252
0.461AlaTrp: 0.461 ± 0.119
2.304AlaTyr: 2.304 ± 0.271
0.0AlaXaa: 0.0 ± 0.0
Cys
0.699CysAla: 0.699 ± 0.099
0.286CysCys: 0.286 ± 0.072
0.954CysAsp: 0.954 ± 0.113
0.954CysGlu: 0.954 ± 0.145
0.683CysPhe: 0.683 ± 0.098
1.128CysGly: 1.128 ± 0.159
0.222CysHis: 0.222 ± 0.053
0.954CysIle: 0.954 ± 0.159
1.192CysLys: 1.192 ± 0.19
0.906CysLeu: 0.906 ± 0.125
0.572CysMet: 0.572 ± 0.098
0.842CysAsn: 0.842 ± 0.117
0.89CysPro: 0.89 ± 0.148
0.445CysGln: 0.445 ± 0.083
0.811CysArg: 0.811 ± 0.121
0.795CysSer: 0.795 ± 0.136
0.922CysThr: 0.922 ± 0.138
1.097CysVal: 1.097 ± 0.151
0.095CysTrp: 0.095 ± 0.035
0.667CysTyr: 0.667 ± 0.111
0.0CysXaa: 0.0 ± 0.0
Asp
3.671AspAla: 3.671 ± 0.275
0.731AspCys: 0.731 ± 0.109
4.148AspAsp: 4.148 ± 0.437
4.72AspGlu: 4.72 ± 0.354
2.591AspPhe: 2.591 ± 0.165
4.402AspGly: 4.402 ± 0.381
1.335AspHis: 1.335 ± 0.182
4.657AspIle: 4.657 ± 0.335
3.624AspLys: 3.624 ± 0.255
4.641AspLeu: 4.641 ± 0.321
1.669AspMet: 1.669 ± 0.176
3.067AspAsn: 3.067 ± 0.223
2.304AspPro: 2.304 ± 0.224
1.605AspGln: 1.605 ± 0.161
2.416AspArg: 2.416 ± 0.205
3.306AspSer: 3.306 ± 0.244
4.498AspThr: 4.498 ± 0.312
3.703AspVal: 3.703 ± 0.246
0.636AspTrp: 0.636 ± 0.106
2.877AspTyr: 2.877 ± 0.228
0.0AspXaa: 0.0 ± 0.0
Glu
3.353GluAla: 3.353 ± 0.344
0.842GluCys: 0.842 ± 0.128
3.989GluAsp: 3.989 ± 0.323
4.736GluGlu: 4.736 ± 0.582
2.94GluPhe: 2.94 ± 0.225
2.781GluGly: 2.781 ± 0.206
1.319GluHis: 1.319 ± 0.166
4.434GluIle: 4.434 ± 0.3
4.672GluLys: 4.672 ± 0.503
5.372GluLeu: 5.372 ± 0.287
1.478GluMet: 1.478 ± 0.164
3.862GluAsn: 3.862 ± 0.349
2.384GluPro: 2.384 ± 0.231
1.748GluGln: 1.748 ± 0.185
3.115GluArg: 3.115 ± 0.455
3.036GluSer: 3.036 ± 0.249
3.401GluThr: 3.401 ± 0.24
3.624GluVal: 3.624 ± 0.243
0.842GluTrp: 0.842 ± 0.121
2.575GluTyr: 2.575 ± 0.225
0.0GluXaa: 0.0 ± 0.0
Phe
2.177PheAla: 2.177 ± 0.252
0.826PheCys: 0.826 ± 0.125
2.972PheAsp: 2.972 ± 0.247
2.352PheGlu: 2.352 ± 0.22
1.875PhePhe: 1.875 ± 0.233
2.4PheGly: 2.4 ± 0.234
0.826PheHis: 0.826 ± 0.118
2.988PheIle: 2.988 ± 0.225
2.908PheLys: 2.908 ± 0.235
3.036PheLeu: 3.036 ± 0.257
1.557PheMet: 1.557 ± 0.191
2.924PheAsn: 2.924 ± 0.23
1.478PhePro: 1.478 ± 0.155
1.065PheGln: 1.065 ± 0.133
1.859PheArg: 1.859 ± 0.175
3.036PheSer: 3.036 ± 0.254
3.147PheThr: 3.147 ± 0.308
3.163PheVal: 3.163 ± 0.256
0.366PheTrp: 0.366 ± 0.071
1.573PheTyr: 1.573 ± 0.157
0.0PheXaa: 0.0 ± 0.0
Gly
4.164GlyAla: 4.164 ± 0.66
0.731GlyCys: 0.731 ± 0.121
3.719GlyAsp: 3.719 ± 0.318
3.242GlyGlu: 3.242 ± 0.259
2.654GlyPhe: 2.654 ± 0.206
7.549GlyGly: 7.549 ± 1.535
1.192GlyHis: 1.192 ± 0.147
4.307GlyIle: 4.307 ± 0.247
4.1GlyLys: 4.1 ± 0.317
4.752GlyLeu: 4.752 ± 0.303
1.732GlyMet: 1.732 ± 0.155
4.005GlyAsn: 4.005 ± 0.425
2.225GlyPro: 2.225 ± 0.223
1.987GlyGln: 1.987 ± 0.211
3.067GlyArg: 3.067 ± 0.296
5.308GlySer: 5.308 ± 0.539
5.753GlyThr: 5.753 ± 0.799
4.18GlyVal: 4.18 ± 0.252
0.604GlyTrp: 0.604 ± 0.102
2.829GlyTyr: 2.829 ± 0.237
0.0GlyXaa: 0.0 ± 0.0
His
1.081HisAla: 1.081 ± 0.126
0.493HisCys: 0.493 ± 0.081
1.081HisAsp: 1.081 ± 0.121
1.192HisGlu: 1.192 ± 0.146
0.811HisPhe: 0.811 ± 0.12
1.51HisGly: 1.51 ± 0.137
0.524HisHis: 0.524 ± 0.068
1.669HisIle: 1.669 ± 0.164
1.303HisLys: 1.303 ± 0.139
1.637HisLeu: 1.637 ± 0.202
0.493HisMet: 0.493 ± 0.07
1.065HisAsn: 1.065 ± 0.13
1.081HisPro: 1.081 ± 0.118
0.62HisGln: 0.62 ± 0.096
1.017HisArg: 1.017 ± 0.12
1.049HisSer: 1.049 ± 0.141
1.478HisThr: 1.478 ± 0.214
1.446HisVal: 1.446 ± 0.165
0.35HisTrp: 0.35 ± 0.066
0.842HisTyr: 0.842 ± 0.123
0.0HisXaa: 0.0 ± 0.0
Ile
3.242IleAla: 3.242 ± 0.269
1.128IleCys: 1.128 ± 0.135
5.499IleAsp: 5.499 ± 0.377
4.386IleGlu: 4.386 ± 0.312
2.527IlePhe: 2.527 ± 0.189
3.608IleGly: 3.608 ± 0.269
1.859IleHis: 1.859 ± 0.228
3.989IleIle: 3.989 ± 0.315
5.102IleLys: 5.102 ± 0.307
4.911IleLeu: 4.911 ± 0.367
1.669IleMet: 1.669 ± 0.174
3.767IleAsn: 3.767 ± 0.305
3.417IlePro: 3.417 ± 0.236
2.797IleGln: 2.797 ± 0.243
3.115IleArg: 3.115 ± 0.206
4.514IleSer: 4.514 ± 0.248
4.1IleThr: 4.1 ± 0.33
4.021IleVal: 4.021 ± 0.354
0.62IleTrp: 0.62 ± 0.098
2.781IleTyr: 2.781 ± 0.228
0.0IleXaa: 0.0 ± 0.0
Lys
3.29LysAla: 3.29 ± 0.406
1.081LysCys: 1.081 ± 0.149
4.164LysAsp: 4.164 ± 0.31
5.07LysGlu: 5.07 ± 0.596
3.147LysPhe: 3.147 ± 0.256
2.988LysGly: 2.988 ± 0.245
1.414LysHis: 1.414 ± 0.164
5.197LysIle: 5.197 ± 0.309
7.756LysLys: 7.756 ± 0.778
5.801LysLeu: 5.801 ± 0.343
2.511LysMet: 2.511 ± 0.225
4.895LysAsn: 4.895 ± 0.366
2.845LysPro: 2.845 ± 0.27
2.606LysGln: 2.606 ± 0.311
4.084LysArg: 4.084 ± 0.362
4.355LysSer: 4.355 ± 0.283
4.609LysThr: 4.609 ± 0.439
4.434LysVal: 4.434 ± 0.315
0.715LysTrp: 0.715 ± 0.123
2.734LysTyr: 2.734 ± 0.23
0.0LysXaa: 0.0 ± 0.0
Leu
3.703LeuAla: 3.703 ± 0.287
1.24LeuCys: 1.24 ± 0.167
4.752LeuAsp: 4.752 ± 0.253
4.529LeuGlu: 4.529 ± 0.285
2.988LeuPhe: 2.988 ± 0.263
4.45LeuGly: 4.45 ± 0.3
1.732LeuHis: 1.732 ± 0.152
5.197LeuIle: 5.197 ± 0.356
6.23LeuLys: 6.23 ± 0.422
5.864LeuLeu: 5.864 ± 0.413
1.748LeuMet: 1.748 ± 0.159
4.8LeuAsn: 4.8 ± 0.283
3.369LeuPro: 3.369 ± 0.265
2.702LeuGln: 2.702 ± 0.178
4.005LeuArg: 4.005 ± 0.32
5.292LeuSer: 5.292 ± 0.304
5.276LeuThr: 5.276 ± 0.414
4.688LeuVal: 4.688 ± 0.244
0.874LeuTrp: 0.874 ± 0.121
3.353LeuTyr: 3.353 ± 0.249
0.0LeuXaa: 0.0 ± 0.0
Met
1.208MetAla: 1.208 ± 0.157
0.509MetCys: 0.509 ± 0.103
1.383MetAsp: 1.383 ± 0.158
1.446MetGlu: 1.446 ± 0.154
1.081MetPhe: 1.081 ± 0.124
1.653MetGly: 1.653 ± 0.151
0.54MetHis: 0.54 ± 0.103
1.828MetIle: 1.828 ± 0.189
2.479MetLys: 2.479 ± 0.207
1.796MetLeu: 1.796 ± 0.19
0.906MetMet: 0.906 ± 0.143
1.844MetAsn: 1.844 ± 0.182
0.985MetPro: 0.985 ± 0.127
0.715MetGln: 0.715 ± 0.12
1.081MetArg: 1.081 ± 0.148
2.638MetSer: 2.638 ± 0.253
1.748MetThr: 1.748 ± 0.169
1.653MetVal: 1.653 ± 0.153
0.302MetTrp: 0.302 ± 0.065
1.43MetTyr: 1.43 ± 0.171
0.0MetXaa: 0.0 ± 0.0
Asn
3.274AsnAla: 3.274 ± 0.286
0.604AsnCys: 0.604 ± 0.108
3.099AsnAsp: 3.099 ± 0.223
3.274AsnGlu: 3.274 ± 0.337
2.877AsnPhe: 2.877 ± 0.239
4.466AsnGly: 4.466 ± 0.374
1.144AsnHis: 1.144 ± 0.115
4.243AsnIle: 4.243 ± 0.27
3.83AsnLys: 3.83 ± 0.387
4.784AsnLeu: 4.784 ± 0.38
1.526AsnMet: 1.526 ± 0.164
4.132AsnAsn: 4.132 ± 0.47
2.67AsnPro: 2.67 ± 0.247
1.812AsnGln: 1.812 ± 0.186
2.686AsnArg: 2.686 ± 0.237
4.18AsnSer: 4.18 ± 0.308
3.989AsnThr: 3.989 ± 0.288
5.117AsnVal: 5.117 ± 0.577
0.667AsnTrp: 0.667 ± 0.117
2.177AsnTyr: 2.177 ± 0.174
0.0AsnXaa: 0.0 ± 0.0
Pro
1.796ProAla: 1.796 ± 0.176
0.604ProCys: 0.604 ± 0.104
2.749ProAsp: 2.749 ± 0.236
2.924ProGlu: 2.924 ± 0.296
1.78ProPhe: 1.78 ± 0.186
2.845ProGly: 2.845 ± 0.276
0.985ProHis: 0.985 ± 0.139
2.432ProIle: 2.432 ± 0.198
2.829ProLys: 2.829 ± 0.307
2.749ProLeu: 2.749 ± 0.225
1.351ProMet: 1.351 ± 0.168
1.828ProAsn: 1.828 ± 0.177
2.289ProPro: 2.289 ± 0.29
1.669ProGln: 1.669 ± 0.158
1.828ProArg: 1.828 ± 0.17
2.813ProSer: 2.813 ± 0.222
3.115ProThr: 3.115 ± 0.248
2.924ProVal: 2.924 ± 0.264
0.302ProTrp: 0.302 ± 0.076
1.621ProTyr: 1.621 ± 0.144
0.0ProXaa: 0.0 ± 0.0
Gln
1.812GlnAla: 1.812 ± 0.173
0.524GlnCys: 0.524 ± 0.094
1.51GlnAsp: 1.51 ± 0.164
1.844GlnGlu: 1.844 ± 0.185
1.351GlnPhe: 1.351 ± 0.148
1.732GlnGly: 1.732 ± 0.17
0.572GlnHis: 0.572 ± 0.081
1.844GlnIle: 1.844 ± 0.195
2.304GlnLys: 2.304 ± 0.242
3.226GlnLeu: 3.226 ± 0.22
0.874GlnMet: 0.874 ± 0.139
1.796GlnAsn: 1.796 ± 0.179
1.399GlnPro: 1.399 ± 0.162
0.954GlnGln: 0.954 ± 0.113
1.685GlnArg: 1.685 ± 0.201
2.034GlnSer: 2.034 ± 0.151
1.875GlnThr: 1.875 ± 0.172
2.082GlnVal: 2.082 ± 0.213
0.366GlnTrp: 0.366 ± 0.059
1.16GlnTyr: 1.16 ± 0.13
0.0GlnXaa: 0.0 ± 0.0
Arg
2.336ArgAla: 2.336 ± 0.254
0.811ArgCys: 0.811 ± 0.136
2.432ArgAsp: 2.432 ± 0.214
2.94ArgGlu: 2.94 ± 0.369
1.828ArgPhe: 1.828 ± 0.191
2.892ArgGly: 2.892 ± 0.272
1.017ArgHis: 1.017 ± 0.15
3.083ArgIle: 3.083 ± 0.234
3.973ArgLys: 3.973 ± 0.573
4.116ArgLeu: 4.116 ± 0.274
1.303ArgMet: 1.303 ± 0.153
2.447ArgAsn: 2.447 ± 0.232
1.748ArgPro: 1.748 ± 0.186
1.335ArgGln: 1.335 ± 0.14
2.734ArgArg: 2.734 ± 0.268
2.877ArgSer: 2.877 ± 0.241
2.559ArgThr: 2.559 ± 0.216
3.369ArgVal: 3.369 ± 0.268
0.588ArgTrp: 0.588 ± 0.099
1.716ArgTyr: 1.716 ± 0.155
0.0ArgXaa: 0.0 ± 0.0
Ser
3.544SerAla: 3.544 ± 0.283
1.033SerCys: 1.033 ± 0.149
4.243SerAsp: 4.243 ± 0.316
3.703SerGlu: 3.703 ± 0.264
3.194SerPhe: 3.194 ± 0.28
6.087SerGly: 6.087 ± 0.618
1.16SerHis: 1.16 ± 0.119
4.514SerIle: 4.514 ± 0.309
4.243SerLys: 4.243 ± 0.3
4.911SerLeu: 4.911 ± 0.326
1.399SerMet: 1.399 ± 0.167
5.197SerAsn: 5.197 ± 0.514
2.527SerPro: 2.527 ± 0.209
2.177SerGln: 2.177 ± 0.194
3.02SerArg: 3.02 ± 0.251
5.276SerSer: 5.276 ± 0.485
4.514SerThr: 4.514 ± 0.348
4.561SerVal: 4.561 ± 0.313
0.699SerTrp: 0.699 ± 0.125
2.734SerTyr: 2.734 ± 0.226
0.0SerXaa: 0.0 ± 0.0
Thr
4.037ThrAla: 4.037 ± 0.346
0.985ThrCys: 0.985 ± 0.146
3.925ThrAsp: 3.925 ± 0.264
3.465ThrGlu: 3.465 ± 0.273
3.21ThrPhe: 3.21 ± 0.233
6.087ThrGly: 6.087 ± 0.691
1.43ThrHis: 1.43 ± 0.144
4.339ThrIle: 4.339 ± 0.392
4.355ThrLys: 4.355 ± 0.262
4.72ThrLeu: 4.72 ± 0.365
1.605ThrMet: 1.605 ± 0.182
4.148ThrAsn: 4.148 ± 0.338
3.274ThrPro: 3.274 ± 0.294
1.796ThrGln: 1.796 ± 0.17
2.479ThrArg: 2.479 ± 0.216
5.404ThrSer: 5.404 ± 0.577
5.864ThrThr: 5.864 ± 0.625
4.529ThrVal: 4.529 ± 0.467
0.747ThrTrp: 0.747 ± 0.129
2.813ThrTyr: 2.813 ± 0.28
0.0ThrXaa: 0.0 ± 0.0
Val
3.973ValAla: 3.973 ± 0.286
1.033ValCys: 1.033 ± 0.149
4.196ValAsp: 4.196 ± 0.237
4.053ValGlu: 4.053 ± 0.275
2.591ValPhe: 2.591 ± 0.196
4.355ValGly: 4.355 ± 0.453
1.271ValHis: 1.271 ± 0.148
3.814ValIle: 3.814 ± 0.302
5.102ValLys: 5.102 ± 0.354
4.815ValLeu: 4.815 ± 0.301
1.573ValMet: 1.573 ± 0.158
3.814ValAsn: 3.814 ± 0.284
2.813ValPro: 2.813 ± 0.243
1.923ValGln: 1.923 ± 0.167
2.845ValArg: 2.845 ± 0.224
4.847ValSer: 4.847 ± 0.375
4.927ValThr: 4.927 ± 0.607
4.37ValVal: 4.37 ± 0.324
0.667ValTrp: 0.667 ± 0.109
2.495ValTyr: 2.495 ± 0.238
0.0ValXaa: 0.0 ± 0.0
Trp
0.429TrpAla: 0.429 ± 0.073
0.27TrpCys: 0.27 ± 0.066
0.747TrpAsp: 0.747 ± 0.136
0.683TrpGlu: 0.683 ± 0.117
0.509TrpPhe: 0.509 ± 0.093
0.54TrpGly: 0.54 ± 0.103
0.191TrpHis: 0.191 ± 0.068
0.779TrpIle: 0.779 ± 0.135
0.747TrpLys: 0.747 ± 0.123
0.922TrpLeu: 0.922 ± 0.135
0.159TrpMet: 0.159 ± 0.048
0.667TrpAsn: 0.667 ± 0.089
0.397TrpPro: 0.397 ± 0.083
0.175TrpGln: 0.175 ± 0.045
0.381TrpArg: 0.381 ± 0.093
0.811TrpSer: 0.811 ± 0.121
0.699TrpThr: 0.699 ± 0.113
0.731TrpVal: 0.731 ± 0.116
0.222TrpTrp: 0.222 ± 0.056
0.477TrpTyr: 0.477 ± 0.09
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.05TyrAla: 2.05 ± 0.198
0.477TyrCys: 0.477 ± 0.098
2.4TyrAsp: 2.4 ± 0.227
2.368TyrGlu: 2.368 ± 0.214
1.669TyrPhe: 1.669 ± 0.176
2.813TyrGly: 2.813 ± 0.235
1.049TyrHis: 1.049 ± 0.133
3.29TyrIle: 3.29 ± 0.27
3.067TyrLys: 3.067 ± 0.241
3.21TyrLeu: 3.21 ± 0.244
1.399TyrMet: 1.399 ± 0.163
2.606TyrAsn: 2.606 ± 0.24
1.399TyrPro: 1.399 ± 0.166
1.065TyrGln: 1.065 ± 0.144
1.573TyrArg: 1.573 ± 0.161
2.924TyrSer: 2.924 ± 0.247
2.988TyrThr: 2.988 ± 0.298
2.4TyrVal: 2.4 ± 0.218
0.413TyrTrp: 0.413 ± 0.093
1.653TyrTyr: 1.653 ± 0.212
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 253 proteins (62923 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski