Amino acid dipepetide frequency for Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.189AlaAla: 3.189 ± 0.067
0.516AlaCys: 0.516 ± 0.021
2.682AlaAsp: 2.682 ± 0.053
3.783AlaGlu: 3.783 ± 0.055
2.777AlaPhe: 2.777 ± 0.053
3.771AlaGly: 3.771 ± 0.072
0.902AlaHis: 0.902 ± 0.028
4.62AlaIle: 4.62 ± 0.071
4.92AlaLys: 4.92 ± 0.08
5.64AlaLeu: 5.64 ± 0.066
1.44AlaMet: 1.44 ± 0.038
2.775AlaAsn: 2.775 ± 0.055
1.729AlaPro: 1.729 ± 0.041
1.46AlaGln: 1.46 ± 0.038
2.075AlaArg: 2.075 ± 0.044
3.925AlaSer: 3.925 ± 0.066
2.81AlaThr: 2.81 ± 0.056
3.469AlaVal: 3.469 ± 0.068
0.481AlaTrp: 0.481 ± 0.023
1.956AlaTyr: 1.956 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.435CysAla: 0.435 ± 0.018
0.068CysCys: 0.068 ± 0.008
0.412CysAsp: 0.412 ± 0.019
0.463CysGlu: 0.463 ± 0.017
0.535CysPhe: 0.535 ± 0.021
0.581CysGly: 0.581 ± 0.024
0.232CysHis: 0.232 ± 0.016
0.62CysIle: 0.62 ± 0.022
0.49CysLys: 0.49 ± 0.023
0.877CysLeu: 0.877 ± 0.031
0.18CysMet: 0.18 ± 0.013
0.353CysAsn: 0.353 ± 0.018
0.379CysPro: 0.379 ± 0.02
0.29CysGln: 0.29 ± 0.015
0.281CysArg: 0.281 ± 0.015
0.586CysSer: 0.586 ± 0.023
0.381CysThr: 0.381 ± 0.019
0.446CysVal: 0.446 ± 0.02
0.053CysTrp: 0.053 ± 0.006
0.306CysTyr: 0.306 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
2.729AspAla: 2.729 ± 0.063
0.386AspCys: 0.386 ± 0.018
2.054AspAsp: 2.054 ± 0.048
3.211AspGlu: 3.211 ± 0.054
2.943AspPhe: 2.943 ± 0.05
3.279AspGly: 3.279 ± 0.054
1.039AspHis: 1.039 ± 0.03
3.254AspIle: 3.254 ± 0.056
3.039AspLys: 3.039 ± 0.054
5.569AspLeu: 5.569 ± 0.068
0.926AspMet: 0.926 ± 0.025
1.511AspAsn: 1.511 ± 0.034
2.662AspPro: 2.662 ± 0.044
1.665AspGln: 1.665 ± 0.033
2.218AspArg: 2.218 ± 0.04
3.527AspSer: 3.527 ± 0.057
2.406AspThr: 2.406 ± 0.044
2.713AspVal: 2.713 ± 0.045
0.74AspTrp: 0.74 ± 0.027
1.858AspTyr: 1.858 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
3.835GluAla: 3.835 ± 0.069
0.402GluCys: 0.402 ± 0.018
3.344GluAsp: 3.344 ± 0.054
5.959GluGlu: 5.959 ± 0.1
3.538GluPhe: 3.538 ± 0.059
3.845GluGly: 3.845 ± 0.065
1.044GluHis: 1.044 ± 0.03
6.211GluIle: 6.211 ± 0.084
6.314GluLys: 6.314 ± 0.088
6.49GluLeu: 6.49 ± 0.074
1.711GluMet: 1.711 ± 0.04
3.687GluAsn: 3.687 ± 0.055
1.976GluPro: 1.976 ± 0.048
1.763GluGln: 1.763 ± 0.039
3.212GluArg: 3.212 ± 0.062
5.351GluSer: 5.351 ± 0.079
4.413GluThr: 4.413 ± 0.062
4.096GluVal: 4.096 ± 0.059
0.943GluTrp: 0.943 ± 0.029
2.389GluTyr: 2.389 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.145PheAla: 3.145 ± 0.055
0.587PheCys: 0.587 ± 0.021
2.657PheAsp: 2.657 ± 0.04
3.143PheGlu: 3.143 ± 0.059
3.959PhePhe: 3.959 ± 0.085
4.084PheGly: 4.084 ± 0.075
1.395PheHis: 1.395 ± 0.033
3.39PheIle: 3.39 ± 0.054
2.708PheLys: 2.708 ± 0.051
7.339PheLeu: 7.339 ± 0.117
0.975PheMet: 0.975 ± 0.028
1.813PheAsn: 1.813 ± 0.043
2.774PhePro: 2.774 ± 0.057
2.824PheGln: 2.824 ± 0.052
2.567PheArg: 2.567 ± 0.049
4.753PheSer: 4.753 ± 0.068
2.84PheThr: 2.84 ± 0.053
3.706PheVal: 3.706 ± 0.052
0.709PheTrp: 0.709 ± 0.027
2.428PheTyr: 2.428 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
3.539GlyAla: 3.539 ± 0.079
0.527GlyCys: 0.527 ± 0.023
3.044GlyAsp: 3.044 ± 0.059
4.053GlyGlu: 4.053 ± 0.057
3.978GlyPhe: 3.978 ± 0.061
4.438GlyGly: 4.438 ± 0.079
1.164GlyHis: 1.164 ± 0.031
5.948GlyIle: 5.948 ± 0.071
5.925GlyLys: 5.925 ± 0.083
6.007GlyLeu: 6.007 ± 0.089
1.756GlyMet: 1.756 ± 0.037
3.29GlyAsn: 3.29 ± 0.059
1.7GlyPro: 1.7 ± 0.04
1.635GlyGln: 1.635 ± 0.038
2.375GlyArg: 2.375 ± 0.048
4.379GlySer: 4.379 ± 0.069
3.618GlyThr: 3.618 ± 0.075
4.031GlyVal: 4.031 ± 0.059
0.694GlyTrp: 0.694 ± 0.025
2.712GlyTyr: 2.712 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
0.925HisAla: 0.925 ± 0.031
0.252HisCys: 0.252 ± 0.014
0.692HisAsp: 0.692 ± 0.026
0.926HisGlu: 0.926 ± 0.028
1.337HisPhe: 1.337 ± 0.036
1.172HisGly: 1.172 ± 0.031
0.532HisHis: 0.532 ± 0.02
1.324HisIle: 1.324 ± 0.033
1.182HisLys: 1.182 ± 0.034
2.319HisLeu: 2.319 ± 0.053
0.349HisMet: 0.349 ± 0.016
0.716HisAsn: 0.716 ± 0.023
1.192HisPro: 1.192 ± 0.032
0.651HisGln: 0.651 ± 0.022
0.88HisArg: 0.88 ± 0.03
1.594HisSer: 1.594 ± 0.041
0.99HisThr: 0.99 ± 0.027
0.949HisVal: 0.949 ± 0.028
0.319HisTrp: 0.319 ± 0.015
0.766HisTyr: 0.766 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
4.483IleAla: 4.483 ± 0.061
0.665IleCys: 0.665 ± 0.022
3.481IleAsp: 3.481 ± 0.055
4.922IleGlu: 4.922 ± 0.075
3.907IlePhe: 3.907 ± 0.065
5.073IleGly: 5.073 ± 0.079
1.825IleHis: 1.825 ± 0.042
4.619IleIle: 4.619 ± 0.072
4.467IleLys: 4.467 ± 0.072
9.325IleLeu: 9.325 ± 0.088
1.117IleMet: 1.117 ± 0.034
2.813IleAsn: 2.813 ± 0.053
4.108IlePro: 4.108 ± 0.056
4.032IleGln: 4.032 ± 0.06
3.709IleArg: 3.709 ± 0.056
5.83IleSer: 5.83 ± 0.08
3.971IleThr: 3.971 ± 0.058
4.487IleVal: 4.487 ± 0.065
0.814IleTrp: 0.814 ± 0.026
2.557IleTyr: 2.557 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
3.898LysAla: 3.898 ± 0.065
0.308LysCys: 0.308 ± 0.014
4.115LysAsp: 4.115 ± 0.058
7.703LysGlu: 7.703 ± 0.106
3.017LysPhe: 3.017 ± 0.052
4.132LysGly: 4.132 ± 0.07
1.285LysHis: 1.285 ± 0.034
5.893LysIle: 5.893 ± 0.075
6.892LysLys: 6.892 ± 0.108
6.529LysLeu: 6.529 ± 0.089
1.747LysMet: 1.747 ± 0.041
4.198LysAsn: 4.198 ± 0.061
2.813LysPro: 2.813 ± 0.048
3.134LysGln: 3.134 ± 0.057
3.344LysArg: 3.344 ± 0.056
5.117LysSer: 5.117 ± 0.068
4.36LysThr: 4.36 ± 0.056
4.097LysVal: 4.097 ± 0.065
0.752LysTrp: 0.752 ± 0.029
2.21LysTyr: 2.21 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
6.051LeuAla: 6.051 ± 0.087
0.867LeuCys: 0.867 ± 0.026
5.128LeuAsp: 5.128 ± 0.069
7.297LeuGlu: 7.297 ± 0.092
6.507LeuPhe: 6.507 ± 0.096
7.192LeuGly: 7.192 ± 0.08
1.848LeuHis: 1.848 ± 0.045
7.032LeuIle: 7.032 ± 0.092
7.442LeuLys: 7.442 ± 0.073
10.364LeuLeu: 10.364 ± 0.129
1.91LeuMet: 1.91 ± 0.041
4.788LeuAsn: 4.788 ± 0.064
4.643LeuPro: 4.643 ± 0.059
3.304LeuGln: 3.304 ± 0.06
4.146LeuArg: 4.146 ± 0.053
8.573LeuSer: 8.573 ± 0.094
5.474LeuThr: 5.474 ± 0.07
6.852LeuVal: 6.852 ± 0.082
1.044LeuTrp: 1.044 ± 0.032
3.724LeuTyr: 3.724 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
1.574MetAla: 1.574 ± 0.039
0.115MetCys: 0.115 ± 0.011
1.286MetAsp: 1.286 ± 0.028
1.901MetGlu: 1.901 ± 0.034
0.952MetPhe: 0.952 ± 0.025
1.631MetGly: 1.631 ± 0.04
0.271MetHis: 0.271 ± 0.015
1.648MetIle: 1.648 ± 0.037
1.939MetLys: 1.939 ± 0.04
1.645MetLeu: 1.645 ± 0.037
0.58MetMet: 0.58 ± 0.023
1.254MetAsn: 1.254 ± 0.032
0.718MetPro: 0.718 ± 0.021
0.552MetGln: 0.552 ± 0.022
0.845MetArg: 0.845 ± 0.028
1.337MetSer: 1.337 ± 0.036
1.096MetThr: 1.096 ± 0.031
1.526MetVal: 1.526 ± 0.033
0.152MetTrp: 0.152 ± 0.012
0.579MetTyr: 0.579 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
2.7AsnAla: 2.7 ± 0.056
0.467AsnCys: 0.467 ± 0.023
2.121AsnAsp: 2.121 ± 0.042
3.141AsnGlu: 3.141 ± 0.05
2.605AsnPhe: 2.605 ± 0.053
3.152AsnGly: 3.152 ± 0.065
1.233AsnHis: 1.233 ± 0.03
3.045AsnIle: 3.045 ± 0.056
2.609AsnLys: 2.609 ± 0.054
5.799AsnLeu: 5.799 ± 0.071
0.851AsnMet: 0.851 ± 0.025
1.637AsnAsn: 1.637 ± 0.046
2.947AsnPro: 2.947 ± 0.053
2.708AsnGln: 2.708 ± 0.048
2.396AsnArg: 2.396 ± 0.045
3.229AsnSer: 3.229 ± 0.054
2.318AsnThr: 2.318 ± 0.05
2.544AsnVal: 2.544 ± 0.048
0.628AsnTrp: 0.628 ± 0.027
1.673AsnTyr: 1.673 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
1.732ProAla: 1.732 ± 0.043
0.242ProCys: 0.242 ± 0.016
2.065ProAsp: 2.065 ± 0.042
3.311ProGlu: 3.311 ± 0.049
2.449ProPhe: 2.449 ± 0.048
2.584ProGly: 2.584 ± 0.05
0.705ProHis: 0.705 ± 0.025
3.554ProIle: 3.554 ± 0.055
3.644ProLys: 3.644 ± 0.058
3.388ProLeu: 3.388 ± 0.061
0.966ProMet: 0.966 ± 0.027
2.935ProAsn: 2.935 ± 0.055
1.277ProPro: 1.277 ± 0.038
1.002ProGln: 1.002 ± 0.027
1.233ProArg: 1.233 ± 0.031
3.024ProSer: 3.024 ± 0.044
2.204ProThr: 2.204 ± 0.049
2.465ProVal: 2.465 ± 0.049
0.468ProTrp: 0.468 ± 0.021
1.502ProTyr: 1.502 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
1.696GlnAla: 1.696 ± 0.036
0.272GlnCys: 0.272 ± 0.014
1.283GlnAsp: 1.283 ± 0.032
2.013GlnGlu: 2.013 ± 0.043
2.019GlnPhe: 2.019 ± 0.039
1.885GlnGly: 1.885 ± 0.047
0.412GlnHis: 0.412 ± 0.017
3.477GlnIle: 3.477 ± 0.049
3.432GlnLys: 3.432 ± 0.056
2.997GlnLeu: 2.997 ± 0.049
0.978GlnMet: 0.978 ± 0.029
2.493GlnAsn: 2.493 ± 0.048
0.88GlnPro: 0.88 ± 0.025
0.651GlnGln: 0.651 ± 0.024
1.218GlnArg: 1.218 ± 0.037
2.682GlnSer: 2.682 ± 0.046
2.461GlnThr: 2.461 ± 0.044
2.058GlnVal: 2.058 ± 0.041
0.447GlnTrp: 0.447 ± 0.02
1.126GlnTyr: 1.126 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
2.056ArgAla: 2.056 ± 0.044
0.235ArgCys: 0.235 ± 0.014
2.041ArgAsp: 2.041 ± 0.041
3.122ArgGlu: 3.122 ± 0.055
2.528ArgPhe: 2.528 ± 0.044
2.138ArgGly: 2.138 ± 0.043
0.678ArgHis: 0.678 ± 0.025
3.635ArgIle: 3.635 ± 0.059
3.423ArgLys: 3.423 ± 0.052
4.076ArgLeu: 4.076 ± 0.058
1.252ArgMet: 1.252 ± 0.033
2.344ArgAsn: 2.344 ± 0.042
1.314ArgPro: 1.314 ± 0.034
1.081ArgGln: 1.081 ± 0.03
1.606ArgArg: 1.606 ± 0.037
2.799ArgSer: 2.799 ± 0.048
2.15ArgThr: 2.15 ± 0.041
2.483ArgVal: 2.483 ± 0.045
0.482ArgTrp: 0.482 ± 0.023
1.719ArgTyr: 1.719 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
3.943SerAla: 3.943 ± 0.068
0.637SerCys: 0.637 ± 0.026
3.513SerAsp: 3.513 ± 0.055
5.077SerGlu: 5.077 ± 0.064
5.124SerPhe: 5.124 ± 0.074
5.113SerGly: 5.113 ± 0.067
1.458SerHis: 1.458 ± 0.033
6.082SerIle: 6.082 ± 0.067
5.379SerLys: 5.379 ± 0.083
8.517SerLeu: 8.517 ± 0.104
1.505SerMet: 1.505 ± 0.033
3.39SerAsn: 3.39 ± 0.066
2.964SerPro: 2.964 ± 0.058
2.453SerGln: 2.453 ± 0.05
2.52SerArg: 2.52 ± 0.044
4.878SerSer: 4.878 ± 0.082
3.225SerThr: 3.225 ± 0.059
4.577SerVal: 4.577 ± 0.064
0.687SerTrp: 0.687 ± 0.025
2.762SerTyr: 2.762 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
2.968ThrAla: 2.968 ± 0.055
0.417ThrCys: 0.417 ± 0.02
2.558ThrAsp: 2.558 ± 0.049
3.645ThrGlu: 3.645 ± 0.054
2.605ThrPhe: 2.605 ± 0.049
3.836ThrGly: 3.836 ± 0.059
1.003ThrHis: 1.003 ± 0.031
4.512ThrIle: 4.512 ± 0.063
4.537ThrLys: 4.537 ± 0.065
5.42ThrLeu: 5.42 ± 0.072
1.074ThrMet: 1.074 ± 0.031
3.0ThrAsn: 3.0 ± 0.06
2.283ThrPro: 2.283 ± 0.047
1.479ThrGln: 1.479 ± 0.035
1.803ThrArg: 1.803 ± 0.039
3.725ThrSer: 3.725 ± 0.068
2.841ThrThr: 2.841 ± 0.059
3.223ThrVal: 3.223 ± 0.061
0.538ThrTrp: 0.538 ± 0.021
1.95ThrTyr: 1.95 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
3.5ValAla: 3.5 ± 0.058
0.608ValCys: 0.608 ± 0.022
2.774ValAsp: 2.774 ± 0.045
3.568ValGlu: 3.568 ± 0.054
3.779ValPhe: 3.779 ± 0.056
4.024ValGly: 4.024 ± 0.06
1.029ValHis: 1.029 ± 0.031
4.157ValIle: 4.157 ± 0.068
3.781ValLys: 3.781 ± 0.052
6.452ValLeu: 6.452 ± 0.08
1.361ValMet: 1.361 ± 0.035
2.567ValAsn: 2.567 ± 0.054
2.427ValPro: 2.427 ± 0.046
1.802ValGln: 1.802 ± 0.035
2.584ValArg: 2.584 ± 0.037
5.225ValSer: 5.225 ± 0.067
3.511ValThr: 3.511 ± 0.065
4.157ValVal: 4.157 ± 0.079
0.805ValTrp: 0.805 ± 0.028
2.346ValTyr: 2.346 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.507TrpAla: 0.507 ± 0.021
0.077TrpCys: 0.077 ± 0.008
0.68TrpAsp: 0.68 ± 0.025
1.034TrpGlu: 1.034 ± 0.028
0.599TrpPhe: 0.599 ± 0.025
0.655TrpGly: 0.655 ± 0.024
0.177TrpHis: 0.177 ± 0.012
1.009TrpIle: 1.009 ± 0.034
1.277TrpLys: 1.277 ± 0.036
0.88TrpLeu: 0.88 ± 0.027
0.326TrpMet: 0.326 ± 0.017
0.863TrpAsn: 0.863 ± 0.03
0.275TrpPro: 0.275 ± 0.016
0.327TrpGln: 0.327 ± 0.016
0.382TrpArg: 0.382 ± 0.018
0.619TrpSer: 0.619 ± 0.024
0.554TrpThr: 0.554 ± 0.024
0.664TrpVal: 0.664 ± 0.026
0.119TrpTrp: 0.119 ± 0.01
0.326TrpTyr: 0.326 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.015TyrAla: 2.015 ± 0.034
0.32TyrCys: 0.32 ± 0.018
1.798TyrAsp: 1.798 ± 0.045
2.252TyrGlu: 2.252 ± 0.047
2.637TyrPhe: 2.637 ± 0.043
2.228TyrGly: 2.228 ± 0.04
0.836TyrHis: 0.836 ± 0.027
2.175TyrIle: 2.175 ± 0.041
2.146TyrLys: 2.146 ± 0.042
4.554TyrLeu: 4.554 ± 0.076
0.597TyrMet: 0.597 ± 0.021
1.378TyrAsn: 1.378 ± 0.037
1.687TyrPro: 1.687 ± 0.035
1.664TyrGln: 1.664 ± 0.035
1.767TyrArg: 1.767 ± 0.045
2.65TyrSer: 2.65 ± 0.048
1.795TyrThr: 1.795 ± 0.038
1.912TyrVal: 1.912 ± 0.043
0.475TyrTrp: 0.475 ± 0.021
1.54TyrTyr: 1.54 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3723 proteins (1222038 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski