Amino acid dipepetide frequency for Propionispora vibrioides

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.205AlaAla: 11.205 ± 0.127	1.086AlaCys: 1.086 ± 0.033	4.586AlaAsp: 4.586 ± 0.062	5.833AlaGlu: 5.833 ± 0.075	3.179AlaPhe: 3.179 ± 0.046	8.421AlaGly: 8.421 ± 0.109	1.423AlaHis: 1.423 ± 0.031	6.269AlaIle: 6.269 ± 0.081	4.954AlaLys: 4.954 ± 0.065	9.23AlaLeu: 9.23 ± 0.103	2.545AlaMet: 2.545 ± 0.05	3.123AlaAsn: 3.123 ± 0.06	2.603AlaPro: 2.603 ± 0.051	3.331AlaGln: 3.331 ± 0.058	4.068AlaArg: 4.068 ± 0.062	4.43AlaSer: 4.43 ± 0.062	4.476AlaThr: 4.476 ± 0.085	8.19AlaVal: 8.19 ± 0.086	0.821AlaTrp: 0.821 ± 0.029	2.67AlaTyr: 2.67 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.859CysAla: 0.859 ± 0.026	0.229CysCys: 0.229 ± 0.015	0.539CysAsp: 0.539 ± 0.02	0.601CysGlu: 0.601 ± 0.021	0.466CysPhe: 0.466 ± 0.02	1.148CysGly: 1.148 ± 0.034	0.268CysHis: 0.268 ± 0.015	0.729CysIle: 0.729 ± 0.023	0.506CysLys: 0.506 ± 0.02	1.236CysLeu: 1.236 ± 0.038	0.28CysMet: 0.28 ± 0.014	0.406CysAsn: 0.406 ± 0.021	0.605CysPro: 0.605 ± 0.03	0.491CysGln: 0.491 ± 0.021	0.73CysArg: 0.73 ± 0.025	0.691CysSer: 0.691 ± 0.023	0.562CysThr: 0.562 ± 0.025	0.728CysVal: 0.728 ± 0.026	0.125CysTrp: 0.125 ± 0.009	0.354CysTyr: 0.354 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.734AspAla: 3.734 ± 0.066	0.645AspCys: 0.645 ± 0.025	2.098AspAsp: 2.098 ± 0.051	3.212AspGlu: 3.212 ± 0.052	2.224AspPhe: 2.224 ± 0.042	3.487AspGly: 3.487 ± 0.059	0.9AspHis: 0.9 ± 0.028	4.135AspIle: 4.135 ± 0.064	3.056AspLys: 3.056 ± 0.055	4.537AspLeu: 4.537 ± 0.064	1.47AspMet: 1.47 ± 0.039	1.888AspAsn: 1.888 ± 0.047	1.787AspPro: 1.787 ± 0.04	1.627AspGln: 1.627 ± 0.036	2.571AspArg: 2.571 ± 0.048	2.711AspSer: 2.711 ± 0.044	2.651AspThr: 2.651 ± 0.052	3.415AspVal: 3.415 ± 0.057	0.571AspTrp: 0.571 ± 0.02	2.066AspTyr: 2.066 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.856GluAla: 5.856 ± 0.067	0.557GluCys: 0.557 ± 0.021	2.679GluAsp: 2.679 ± 0.047	4.835GluGlu: 4.835 ± 0.07	2.185GluPhe: 2.185 ± 0.045	3.529GluGly: 3.529 ± 0.057	1.221GluHis: 1.221 ± 0.033	4.579GluIle: 4.579 ± 0.069	4.462GluLys: 4.462 ± 0.063	6.877GluLeu: 6.877 ± 0.093	1.735GluMet: 1.735 ± 0.04	2.623GluAsn: 2.623 ± 0.045	1.997GluPro: 1.997 ± 0.045	3.42GluGln: 3.42 ± 0.06	3.606GluArg: 3.606 ± 0.062	2.549GluSer: 2.549 ± 0.047	3.314GluThr: 3.314 ± 0.056	4.427GluVal: 4.427 ± 0.058	0.588GluTrp: 0.588 ± 0.021	2.116GluTyr: 2.116 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.462PheAla: 3.462 ± 0.058	0.544PheCys: 0.544 ± 0.021	2.057PheAsp: 2.057 ± 0.043	1.847PheGlu: 1.847 ± 0.041	1.88PhePhe: 1.88 ± 0.044	3.149PheGly: 3.149 ± 0.05	0.721PheHis: 0.721 ± 0.024	2.842PheIle: 2.842 ± 0.048	1.771PheLys: 1.771 ± 0.04	3.99PheLeu: 3.99 ± 0.075	1.021PheMet: 1.021 ± 0.031	1.544PheAsn: 1.544 ± 0.033	1.438PhePro: 1.438 ± 0.031	1.256PheGln: 1.256 ± 0.031	1.621PheArg: 1.621 ± 0.036	2.886PheSer: 2.886 ± 0.046	2.347PheThr: 2.347 ± 0.051	2.683PheVal: 2.683 ± 0.048	0.422PheTrp: 0.422 ± 0.019	1.397PheTyr: 1.397 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.96GlyAla: 5.96 ± 0.099	1.053GlyCys: 1.053 ± 0.032	3.397GlyAsp: 3.397 ± 0.06	4.218GlyGlu: 4.218 ± 0.06	3.157GlyPhe: 3.157 ± 0.058	5.516GlyGly: 5.516 ± 0.092	1.542GlyHis: 1.542 ± 0.038	6.226GlyIle: 6.226 ± 0.079	4.819GlyLys: 4.819 ± 0.062	7.545GlyLeu: 7.545 ± 0.075	2.318GlyMet: 2.318 ± 0.044	2.742GlyAsn: 2.742 ± 0.066	1.969GlyPro: 1.969 ± 0.041	3.012GlyGln: 3.012 ± 0.052	3.635GlyArg: 3.635 ± 0.053	4.389GlySer: 4.389 ± 0.072	4.414GlyThr: 4.414 ± 0.075	5.736GlyVal: 5.736 ± 0.074	0.799GlyTrp: 0.799 ± 0.027	2.989GlyTyr: 2.989 ± 0.049	0.001GlyXaa: 0.001 ± 0.001
His	1.433HisAla: 1.433 ± 0.033	0.323HisCys: 0.323 ± 0.015	0.89HisAsp: 0.89 ± 0.024	0.992HisGlu: 0.992 ± 0.029	0.841HisPhe: 0.841 ± 0.026	1.433HisGly: 1.433 ± 0.034	0.515HisHis: 0.515 ± 0.025	1.531HisIle: 1.531 ± 0.037	0.871HisLys: 0.871 ± 0.026	1.892HisLeu: 1.892 ± 0.041	0.552HisMet: 0.552 ± 0.02	0.772HisAsn: 0.772 ± 0.024	0.969HisPro: 0.969 ± 0.026	0.689HisGln: 0.689 ± 0.021	0.99HisArg: 0.99 ± 0.029	1.158HisSer: 1.158 ± 0.03	1.143HisThr: 1.143 ± 0.032	1.212HisVal: 1.212 ± 0.03	0.232HisTrp: 0.232 ± 0.014	0.73HisTyr: 0.73 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.852IleAla: 6.852 ± 0.071	0.817IleCys: 0.817 ± 0.024	3.783IleAsp: 3.783 ± 0.06	4.071IleGlu: 4.071 ± 0.066	2.445IlePhe: 2.445 ± 0.051	5.574IleGly: 5.574 ± 0.069	1.436IleHis: 1.436 ± 0.034	4.938IleIle: 4.938 ± 0.076	3.84IleLys: 3.84 ± 0.064	6.518IleLeu: 6.518 ± 0.079	1.71IleMet: 1.71 ± 0.04	2.991IleAsn: 2.991 ± 0.045	3.231IlePro: 3.231 ± 0.053	2.335IleGln: 2.335 ± 0.044	3.449IleArg: 3.449 ± 0.055	4.328IleSer: 4.328 ± 0.055	4.251IleThr: 4.251 ± 0.073	5.244IleVal: 5.244 ± 0.068	0.597IleTrp: 0.597 ± 0.023	1.965IleTyr: 1.965 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.957LysAla: 4.957 ± 0.071	0.388LysCys: 0.388 ± 0.018	2.712LysAsp: 2.712 ± 0.048	4.327LysGlu: 4.327 ± 0.066	1.595LysPhe: 1.595 ± 0.04	3.241LysGly: 3.241 ± 0.055	0.966LysHis: 0.966 ± 0.027	4.003LysIle: 4.003 ± 0.065	3.763LysLys: 3.763 ± 0.065	5.447LysLeu: 5.447 ± 0.062	1.56LysMet: 1.56 ± 0.036	2.506LysAsn: 2.506 ± 0.042	2.165LysPro: 2.165 ± 0.04	2.65LysGln: 2.65 ± 0.044	2.731LysArg: 2.731 ± 0.052	2.699LysSer: 2.699 ± 0.053	3.143LysThr: 3.143 ± 0.053	4.095LysVal: 4.095 ± 0.057	0.456LysTrp: 0.456 ± 0.019	1.794LysTyr: 1.794 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	10.783LeuAla: 10.783 ± 0.126	1.192LeuCys: 1.192 ± 0.035	4.951LeuAsp: 4.951 ± 0.07	6.162LeuGlu: 6.162 ± 0.087	4.093LeuPhe: 4.093 ± 0.074	7.307LeuGly: 7.307 ± 0.094	1.9LeuHis: 1.9 ± 0.039	6.208LeuIle: 6.208 ± 0.079	5.401LeuLys: 5.401 ± 0.062	11.524LeuLeu: 11.524 ± 0.145	2.322LeuMet: 2.322 ± 0.046	3.552LeuAsn: 3.552 ± 0.059	4.745LeuPro: 4.745 ± 0.07	4.404LeuGln: 4.404 ± 0.061	4.718LeuArg: 4.718 ± 0.066	6.524LeuSer: 6.524 ± 0.082	6.123LeuThr: 6.123 ± 0.07	7.068LeuVal: 7.068 ± 0.089	0.939LeuTrp: 0.939 ± 0.027	3.044LeuTyr: 3.044 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.634MetAla: 2.634 ± 0.043	0.202MetCys: 0.202 ± 0.013	1.365MetAsp: 1.365 ± 0.035	1.735MetGlu: 1.735 ± 0.036	0.913MetPhe: 0.913 ± 0.029	1.904MetGly: 1.904 ± 0.041	0.437MetHis: 0.437 ± 0.018	1.785MetIle: 1.785 ± 0.04	1.713MetLys: 1.713 ± 0.039	2.715MetLeu: 2.715 ± 0.055	0.702MetMet: 0.702 ± 0.027	1.116MetAsn: 1.116 ± 0.03	1.132MetPro: 1.132 ± 0.031	1.023MetGln: 1.023 ± 0.031	1.192MetArg: 1.192 ± 0.033	1.545MetSer: 1.545 ± 0.031	1.506MetThr: 1.506 ± 0.033	1.903MetVal: 1.903 ± 0.042	0.165MetTrp: 0.165 ± 0.011	0.67MetTyr: 0.67 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.696AsnAla: 2.696 ± 0.051	0.45AsnCys: 0.45 ± 0.021	1.731AsnAsp: 1.731 ± 0.045	2.103AsnGlu: 2.103 ± 0.044	1.444AsnPhe: 1.444 ± 0.037	2.788AsnGly: 2.788 ± 0.062	0.804AsnHis: 0.804 ± 0.024	3.083AsnIle: 3.083 ± 0.06	2.187AsnLys: 2.187 ± 0.046	3.758AsnLeu: 3.758 ± 0.065	1.096AsnMet: 1.096 ± 0.028	1.565AsnAsn: 1.565 ± 0.045	2.043AsnPro: 2.043 ± 0.044	1.606AsnGln: 1.606 ± 0.04	2.046AsnArg: 2.046 ± 0.046	2.187AsnSer: 2.187 ± 0.052	2.101AsnThr: 2.101 ± 0.05	2.473AsnVal: 2.473 ± 0.052	0.453AsnTrp: 0.453 ± 0.02	1.406AsnTyr: 1.406 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.906ProAla: 3.906 ± 0.064	0.422ProCys: 0.422 ± 0.02	2.367ProAsp: 2.367 ± 0.051	3.189ProGlu: 3.189 ± 0.059	1.639ProPhe: 1.639 ± 0.039	3.221ProGly: 3.221 ± 0.053	0.811ProHis: 0.811 ± 0.027	2.138ProIle: 2.138 ± 0.039	1.537ProLys: 1.537 ± 0.042	3.872ProLeu: 3.872 ± 0.06	0.846ProMet: 0.846 ± 0.029	1.23ProAsn: 1.23 ± 0.031	1.43ProPro: 1.43 ± 0.037	1.542ProGln: 1.542 ± 0.041	1.412ProArg: 1.412 ± 0.04	1.966ProSer: 1.966 ± 0.038	1.741ProThr: 1.741 ± 0.034	3.877ProVal: 3.877 ± 0.063	0.415ProTrp: 0.415 ± 0.018	1.359ProTyr: 1.359 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.496GlnAla: 4.496 ± 0.073	0.359GlnCys: 0.359 ± 0.018	1.952GlnAsp: 1.952 ± 0.036	3.094GlnGlu: 3.094 ± 0.053	1.343GlnPhe: 1.343 ± 0.032	2.87GlnGly: 2.87 ± 0.056	0.763GlnHis: 0.763 ± 0.021	2.622GlnIle: 2.622 ± 0.047	2.286GlnLys: 2.286 ± 0.047	4.002GlnLeu: 4.002 ± 0.067	1.061GlnMet: 1.061 ± 0.03	1.495GlnAsn: 1.495 ± 0.04	1.613GlnPro: 1.613 ± 0.042	2.206GlnGln: 2.206 ± 0.045	1.815GlnArg: 1.815 ± 0.042	2.076GlnSer: 2.076 ± 0.048	2.178GlnThr: 2.178 ± 0.051	3.186GlnVal: 3.186 ± 0.061	0.328GlnTrp: 0.328 ± 0.019	1.382GlnTyr: 1.382 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.241ArgAla: 3.241 ± 0.054	0.502ArgCys: 0.502 ± 0.021	2.366ArgAsp: 2.366 ± 0.042	3.775ArgGlu: 3.775 ± 0.069	1.947ArgPhe: 1.947 ± 0.045	2.834ArgGly: 2.834 ± 0.044	1.056ArgHis: 1.056 ± 0.034	3.392ArgIle: 3.392 ± 0.052	2.704ArgLys: 2.704 ± 0.044	5.503ArgLeu: 5.503 ± 0.071	1.372ArgMet: 1.372 ± 0.036	1.823ArgAsn: 1.823 ± 0.041	1.793ArgPro: 1.793 ± 0.046	2.877ArgGln: 2.877 ± 0.052	2.689ArgArg: 2.689 ± 0.052	2.478ArgSer: 2.478 ± 0.049	2.382ArgThr: 2.382 ± 0.043	3.133ArgVal: 3.133 ± 0.05	0.491ArgTrp: 0.491 ± 0.021	1.869ArgTyr: 1.869 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.493SerAla: 4.493 ± 0.078	0.65SerCys: 0.65 ± 0.023	2.493SerAsp: 2.493 ± 0.049	3.028SerGlu: 3.028 ± 0.052	2.552SerPhe: 2.552 ± 0.05	4.944SerGly: 4.944 ± 0.088	1.148SerHis: 1.148 ± 0.033	3.791SerIle: 3.791 ± 0.062	2.618SerLys: 2.618 ± 0.051	6.343SerLeu: 6.343 ± 0.077	1.512SerMet: 1.512 ± 0.036	1.931SerAsn: 1.931 ± 0.049	2.263SerPro: 2.263 ± 0.038	2.34SerGln: 2.34 ± 0.054	2.913SerArg: 2.913 ± 0.052	3.46SerSer: 3.46 ± 0.071	2.838SerThr: 2.838 ± 0.061	4.087SerVal: 4.087 ± 0.067	0.603SerTrp: 0.603 ± 0.024	2.008SerTyr: 2.008 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.729ThrAla: 5.729 ± 0.082	0.569ThrCys: 0.569 ± 0.021	2.701ThrAsp: 2.701 ± 0.05	3.168ThrGlu: 3.168 ± 0.056	2.01ThrPhe: 2.01 ± 0.041	5.467ThrGly: 5.467 ± 0.128	0.944ThrHis: 0.944 ± 0.027	3.823ThrIle: 3.823 ± 0.068	2.455ThrLys: 2.455 ± 0.051	5.521ThrLeu: 5.521 ± 0.071	1.31ThrMet: 1.31 ± 0.028	1.957ThrAsn: 1.957 ± 0.047	2.381ThrPro: 2.381 ± 0.047	1.73ThrGln: 1.73 ± 0.038	2.092ThrArg: 2.092 ± 0.047	2.786ThrSer: 2.786 ± 0.06	3.005ThrThr: 3.005 ± 0.066	5.138ThrVal: 5.138 ± 0.077	0.514ThrTrp: 0.514 ± 0.024	1.704ThrTyr: 1.704 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.02ValAla: 7.02 ± 0.074	0.959ValCys: 0.959 ± 0.029	3.884ValAsp: 3.884 ± 0.068	4.484ValGlu: 4.484 ± 0.062	3.037ValPhe: 3.037 ± 0.053	5.188ValGly: 5.188 ± 0.061	1.301ValHis: 1.301 ± 0.029	5.491ValIle: 5.491 ± 0.076	4.186ValLys: 4.186 ± 0.067	7.743ValLeu: 7.743 ± 0.077	1.959ValMet: 1.959 ± 0.047	2.998ValAsn: 2.998 ± 0.058	2.986ValPro: 2.986 ± 0.056	2.444ValGln: 2.444 ± 0.04	3.486ValArg: 3.486 ± 0.055	4.59ValSer: 4.59 ± 0.072	4.574ValThr: 4.574 ± 0.079	5.816ValVal: 5.816 ± 0.087	0.68ValTrp: 0.68 ± 0.027	2.316ValTyr: 2.316 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.637TrpAla: 0.637 ± 0.026	0.125TrpCys: 0.125 ± 0.009	0.5TrpAsp: 0.5 ± 0.024	0.601TrpGlu: 0.601 ± 0.021	0.404TrpPhe: 0.404 ± 0.021	0.766TrpGly: 0.766 ± 0.028	0.221TrpHis: 0.221 ± 0.014	0.574TrpIle: 0.574 ± 0.021	0.446TrpLys: 0.446 ± 0.022	1.25TrpLeu: 1.25 ± 0.038	0.256TrpMet: 0.256 ± 0.013	0.426TrpAsn: 0.426 ± 0.02	0.348TrpPro: 0.348 ± 0.018	0.617TrpGln: 0.617 ± 0.022	0.518TrpArg: 0.518 ± 0.023	0.548TrpSer: 0.548 ± 0.023	0.433TrpThr: 0.433 ± 0.021	0.585TrpVal: 0.585 ± 0.02	0.129TrpTrp: 0.129 ± 0.01	0.333TrpTyr: 0.333 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.491TyrAla: 2.491 ± 0.049	0.483TyrCys: 0.483 ± 0.019	1.735TyrAsp: 1.735 ± 0.042	1.878TyrGlu: 1.878 ± 0.045	1.523TyrPhe: 1.523 ± 0.037	2.652TyrGly: 2.652 ± 0.054	0.789TyrHis: 0.789 ± 0.024	2.215TyrIle: 2.215 ± 0.049	1.621TyrLys: 1.621 ± 0.036	3.456TyrLeu: 3.456 ± 0.056	0.731TyrMet: 0.731 ± 0.027	1.334TyrAsn: 1.334 ± 0.035	1.423TyrPro: 1.423 ± 0.038	1.527TyrGln: 1.527 ± 0.038	1.945TyrArg: 1.945 ± 0.042	2.013TyrSer: 2.013 ± 0.039	1.821TyrThr: 1.821 ± 0.043	2.148TyrVal: 2.148 ± 0.047	0.388TyrTrp: 0.388 ± 0.019	1.351TyrTyr: 1.351 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 4126 proteins (1252127 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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