Amino acid dipepetide frequency for Miniimonas arenae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.233AlaAla: 23.233 ± 0.251	0.888AlaCys: 0.888 ± 0.03	9.42AlaAsp: 9.42 ± 0.119	8.327AlaGlu: 8.327 ± 0.104	3.613AlaPhe: 3.613 ± 0.072	14.085AlaGly: 14.085 ± 0.149	2.912AlaHis: 2.912 ± 0.065	4.432AlaIle: 4.432 ± 0.081	1.877AlaLys: 1.877 ± 0.054	15.644AlaLeu: 15.644 ± 0.174	2.603AlaMet: 2.603 ± 0.052	2.015AlaAsn: 2.015 ± 0.05	8.049AlaPro: 8.049 ± 0.124	4.273AlaGln: 4.273 ± 0.068	11.477AlaArg: 11.477 ± 0.156	7.639AlaSer: 7.639 ± 0.088	8.851AlaThr: 8.851 ± 0.112	14.192AlaVal: 14.192 ± 0.17	2.406AlaTrp: 2.406 ± 0.057	2.408AlaTyr: 2.408 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.718CysAla: 0.718 ± 0.03	0.052CysCys: 0.052 ± 0.008	0.315CysAsp: 0.315 ± 0.017	0.293CysGlu: 0.293 ± 0.017	0.142CysPhe: 0.142 ± 0.011	0.637CysGly: 0.637 ± 0.025	0.128CysHis: 0.128 ± 0.012	0.14CysIle: 0.14 ± 0.012	0.046CysLys: 0.046 ± 0.007	0.476CysLeu: 0.476 ± 0.027	0.08CysMet: 0.08 ± 0.008	0.077CysAsn: 0.077 ± 0.009	0.381CysPro: 0.381 ± 0.021	0.121CysGln: 0.121 ± 0.011	0.373CysArg: 0.373 ± 0.021	0.358CysSer: 0.358 ± 0.02	0.343CysThr: 0.343 ± 0.028	0.482CysVal: 0.482 ± 0.022	0.072CysTrp: 0.072 ± 0.01	0.108CysTyr: 0.108 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	10.08AspAla: 10.08 ± 0.119	0.24AspCys: 0.24 ± 0.017	3.913AspAsp: 3.913 ± 0.08	3.639AspGlu: 3.639 ± 0.062	1.309AspPhe: 1.309 ± 0.045	7.568AspGly: 7.568 ± 0.11	1.226AspHis: 1.226 ± 0.041	1.391AspIle: 1.391 ± 0.043	0.682AspLys: 0.682 ± 0.029	7.038AspLeu: 7.038 ± 0.09	0.654AspMet: 0.654 ± 0.027	0.625AspAsn: 0.625 ± 0.029	4.837AspPro: 4.837 ± 0.073	1.345AspGln: 1.345 ± 0.04	4.103AspArg: 4.103 ± 0.072	2.447AspSer: 2.447 ± 0.053	2.774AspThr: 2.774 ± 0.064	7.102AspVal: 7.102 ± 0.106	0.943AspTrp: 0.943 ± 0.029	1.064AspTyr: 1.064 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.626GluAla: 7.626 ± 0.107	0.231GluCys: 0.231 ± 0.016	2.954GluAsp: 2.954 ± 0.055	3.062GluGlu: 3.062 ± 0.057	1.141GluPhe: 1.141 ± 0.04	4.018GluGly: 4.018 ± 0.062	1.703GluHis: 1.703 ± 0.04	2.223GluIle: 2.223 ± 0.054	0.884GluLys: 0.884 ± 0.034	6.362GluLeu: 6.362 ± 0.087	0.767GluMet: 0.767 ± 0.029	0.911GluAsn: 0.911 ± 0.034	3.636GluPro: 3.636 ± 0.08	2.015GluGln: 2.015 ± 0.047	5.55GluArg: 5.55 ± 0.089	2.447GluSer: 2.447 ± 0.043	2.694GluThr: 2.694 ± 0.06	5.318GluVal: 5.318 ± 0.077	0.719GluTrp: 0.719 ± 0.026	0.902GluTyr: 0.902 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.616PheAla: 3.616 ± 0.067	0.162PheCys: 0.162 ± 0.011	1.82PheAsp: 1.82 ± 0.046	1.274PheGlu: 1.274 ± 0.043	0.792PhePhe: 0.792 ± 0.038	2.767PheGly: 2.767 ± 0.056	0.505PheHis: 0.505 ± 0.025	0.637PheIle: 0.637 ± 0.031	0.298PheLys: 0.298 ± 0.02	2.4PheLeu: 2.4 ± 0.063	0.316PheMet: 0.316 ± 0.019	0.402PheAsn: 0.402 ± 0.025	1.162PhePro: 1.162 ± 0.042	0.59PheGln: 0.59 ± 0.024	1.51PheArg: 1.51 ± 0.045	1.353PheSer: 1.353 ± 0.049	1.761PheThr: 1.761 ± 0.049	2.466PheVal: 2.466 ± 0.053	0.411PheTrp: 0.411 ± 0.024	0.505PheTyr: 0.505 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	12.802GlyAla: 12.802 ± 0.151	0.527GlyCys: 0.527 ± 0.026	5.407GlyAsp: 5.407 ± 0.094	5.987GlyGlu: 5.987 ± 0.091	2.575GlyPhe: 2.575 ± 0.057	8.806GlyGly: 8.806 ± 0.132	1.962GlyHis: 1.962 ± 0.049	3.25GlyIle: 3.25 ± 0.066	1.609GlyLys: 1.609 ± 0.047	9.071GlyLeu: 9.071 ± 0.107	1.784GlyMet: 1.784 ± 0.046	1.408GlyAsn: 1.408 ± 0.045	4.803GlyPro: 4.803 ± 0.07	2.365GlyGln: 2.365 ± 0.05	7.058GlyArg: 7.058 ± 0.119	5.662GlySer: 5.662 ± 0.095	6.381GlyThr: 6.381 ± 0.104	9.354GlyVal: 9.354 ± 0.116	1.727GlyTrp: 1.727 ± 0.049	2.081GlyTyr: 2.081 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.861HisAla: 2.861 ± 0.061	0.117HisCys: 0.117 ± 0.012	1.487HisAsp: 1.487 ± 0.042	1.235HisGlu: 1.235 ± 0.037	0.388HisPhe: 0.388 ± 0.02	2.134HisGly: 2.134 ± 0.049	0.642HisHis: 0.642 ± 0.031	0.451HisIle: 0.451 ± 0.017	0.215HisLys: 0.215 ± 0.014	2.385HisLeu: 2.385 ± 0.05	0.235HisMet: 0.235 ± 0.017	0.282HisAsn: 0.282 ± 0.018	1.586HisPro: 1.586 ± 0.043	0.499HisGln: 0.499 ± 0.022	1.807HisArg: 1.807 ± 0.041	0.758HisSer: 0.758 ± 0.032	1.063HisThr: 1.063 ± 0.035	2.012HisVal: 2.012 ± 0.048	0.264HisTrp: 0.264 ± 0.016	0.36HisTyr: 0.36 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.114IleAla: 5.114 ± 0.081	0.184IleCys: 0.184 ± 0.014	2.344IleAsp: 2.344 ± 0.055	1.929IleGlu: 1.929 ± 0.05	0.742IlePhe: 0.742 ± 0.031	3.406IleGly: 3.406 ± 0.079	0.448IleHis: 0.448 ± 0.022	0.856IleIle: 0.856 ± 0.04	0.505IleLys: 0.505 ± 0.027	2.518IleLeu: 2.518 ± 0.06	0.382IleMet: 0.382 ± 0.024	0.527IleAsn: 0.527 ± 0.025	1.638IlePro: 1.638 ± 0.044	0.608IleGln: 0.608 ± 0.027	1.806IleArg: 1.806 ± 0.05	1.469IleSer: 1.469 ± 0.051	1.981IleThr: 1.981 ± 0.049	3.16IleVal: 3.16 ± 0.07	0.36IleTrp: 0.36 ± 0.023	0.525IleTyr: 0.525 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	1.795LysAla: 1.795 ± 0.054	0.054LysCys: 0.054 ± 0.008	0.807LysAsp: 0.807 ± 0.033	0.723LysGlu: 0.723 ± 0.03	0.298LysPhe: 0.298 ± 0.017	1.129LysGly: 1.129 ± 0.033	0.283LysHis: 0.283 ± 0.02	0.549LysIle: 0.549 ± 0.032	0.418LysLys: 0.418 ± 0.028	1.064LysLeu: 1.064 ± 0.037	0.226LysMet: 0.226 ± 0.015	0.326LysAsn: 0.326 ± 0.021	0.756LysPro: 0.756 ± 0.03	0.409LysGln: 0.409 ± 0.021	0.986LysArg: 0.986 ± 0.039	0.682LysSer: 0.682 ± 0.027	0.834LysThr: 0.834 ± 0.028	1.362LysVal: 1.362 ± 0.04	0.143LysTrp: 0.143 ± 0.013	0.283LysTyr: 0.283 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	17.774LeuAla: 17.774 ± 0.186	0.467LeuCys: 0.467 ± 0.022	7.325LeuAsp: 7.325 ± 0.093	5.345LeuGlu: 5.345 ± 0.079	2.15LeuPhe: 2.15 ± 0.066	9.658LeuGly: 9.658 ± 0.111	1.888LeuHis: 1.888 ± 0.045	2.56LeuIle: 2.56 ± 0.07	1.103LeuLys: 1.103 ± 0.042	10.784LeuLeu: 10.784 ± 0.149	1.352LeuMet: 1.352 ± 0.043	1.304LeuAsn: 1.304 ± 0.038	6.061LeuPro: 6.061 ± 0.082	2.184LeuGln: 2.184 ± 0.047	8.083LeuArg: 8.083 ± 0.104	4.469LeuSer: 4.469 ± 0.07	6.96LeuThr: 6.96 ± 0.087	11.116LeuVal: 11.116 ± 0.16	1.172LeuTrp: 1.172 ± 0.032	1.403LeuTyr: 1.403 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.113MetAla: 2.113 ± 0.055	0.098MetCys: 0.098 ± 0.01	0.724MetAsp: 0.724 ± 0.031	0.472MetGlu: 0.472 ± 0.024	0.358MetPhe: 0.358 ± 0.022	1.092MetGly: 1.092 ± 0.038	0.262MetHis: 0.262 ± 0.015	0.567MetIle: 0.567 ± 0.027	0.252MetLys: 0.252 ± 0.019	1.68MetLeu: 1.68 ± 0.044	0.202MetMet: 0.202 ± 0.015	0.302MetAsn: 0.302 ± 0.017	0.999MetPro: 0.999 ± 0.032	0.35MetGln: 0.35 ± 0.019	1.315MetArg: 1.315 ± 0.039	1.2MetSer: 1.2 ± 0.037	1.525MetThr: 1.525 ± 0.042	1.212MetVal: 1.212 ± 0.038	0.196MetTrp: 0.196 ± 0.017	0.209MetTyr: 0.209 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.022AsnAla: 2.022 ± 0.05	0.08AsnCys: 0.08 ± 0.009	0.916AsnAsp: 0.916 ± 0.033	0.728AsnGlu: 0.728 ± 0.03	0.399AsnPhe: 0.399 ± 0.023	1.465AsnGly: 1.465 ± 0.047	0.345AsnHis: 0.345 ± 0.022	0.491AsnIle: 0.491 ± 0.025	0.214AsnLys: 0.214 ± 0.015	1.495AsnLeu: 1.495 ± 0.044	0.203AsnMet: 0.203 ± 0.016	0.274AsnAsn: 0.274 ± 0.018	1.26AsnPro: 1.26 ± 0.034	0.426AsnGln: 0.426 ± 0.024	0.988AsnArg: 0.988 ± 0.035	0.605AsnSer: 0.605 ± 0.029	0.837AsnThr: 0.837 ± 0.037	1.434AsnVal: 1.434 ± 0.042	0.188AsnTrp: 0.188 ± 0.012	0.332AsnTyr: 0.332 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.917ProAla: 8.917 ± 0.119	0.239ProCys: 0.239 ± 0.014	4.95ProAsp: 4.95 ± 0.083	4.034ProGlu: 4.034 ± 0.071	1.538ProPhe: 1.538 ± 0.04	6.312ProGly: 6.312 ± 0.098	1.254ProHis: 1.254 ± 0.033	1.474ProIle: 1.474 ± 0.042	0.635ProLys: 0.635 ± 0.031	5.076ProLeu: 5.076 ± 0.077	0.88ProMet: 0.88 ± 0.03	0.768ProAsn: 0.768 ± 0.027	3.288ProPro: 3.288 ± 0.08	1.534ProGln: 1.534 ± 0.042	4.08ProArg: 4.08 ± 0.08	3.483ProSer: 3.483 ± 0.078	4.337ProThr: 4.337 ± 0.093	5.551ProVal: 5.551 ± 0.086	1.03ProTrp: 1.03 ± 0.036	1.011ProTyr: 1.011 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.786GlnAla: 3.786 ± 0.069	0.132GlnCys: 0.132 ± 0.013	1.275GlnAsp: 1.275 ± 0.037	1.284GlnGlu: 1.284 ± 0.038	0.598GlnPhe: 0.598 ± 0.028	2.009GlnGly: 2.009 ± 0.049	0.625GlnHis: 0.625 ± 0.025	0.998GlnIle: 0.998 ± 0.036	0.36GlnLys: 0.36 ± 0.019	2.731GlnLeu: 2.731 ± 0.056	0.42GlnMet: 0.42 ± 0.021	0.402GlnAsn: 0.402 ± 0.022	1.577GlnPro: 1.577 ± 0.046	1.011GlnGln: 1.011 ± 0.039	2.313GlnArg: 2.313 ± 0.047	1.044GlnSer: 1.044 ± 0.034	1.317GlnThr: 1.317 ± 0.037	2.691GlnVal: 2.691 ± 0.052	0.434GlnTrp: 0.434 ± 0.022	0.5GlnTyr: 0.5 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	10.778ArgAla: 10.778 ± 0.121	0.43ArgCys: 0.43 ± 0.022	4.36ArgAsp: 4.36 ± 0.064	4.643ArgGlu: 4.643 ± 0.077	1.946ArgPhe: 1.946 ± 0.039	6.161ArgGly: 6.161 ± 0.092	1.746ArgHis: 1.746 ± 0.04	2.783ArgIle: 2.783 ± 0.067	0.978ArgLys: 0.978 ± 0.036	7.985ArgLeu: 7.985 ± 0.109	1.464ArgMet: 1.464 ± 0.036	1.078ArgAsn: 1.078 ± 0.036	4.537ArgPro: 4.537 ± 0.088	1.864ArgGln: 1.864 ± 0.042	7.877ArgArg: 7.877 ± 0.13	4.245ArgSer: 4.245 ± 0.078	5.294ArgThr: 5.294 ± 0.083	6.699ArgVal: 6.699 ± 0.102	1.418ArgTrp: 1.418 ± 0.038	1.589ArgTyr: 1.589 ± 0.038	0.001ArgXaa: 0.001 ± 0.001
Ser	7.246SerAla: 7.246 ± 0.103	0.307SerCys: 0.307 ± 0.021	3.077SerAsp: 3.077 ± 0.067	2.322SerGlu: 2.322 ± 0.048	1.509SerPhe: 1.509 ± 0.041	5.934SerGly: 5.934 ± 0.099	0.92SerHis: 0.92 ± 0.032	1.674SerIle: 1.674 ± 0.041	0.586SerLys: 0.586 ± 0.027	4.751SerLeu: 4.751 ± 0.071	0.92SerMet: 0.92 ± 0.033	0.764SerAsn: 0.764 ± 0.031	3.415SerPro: 3.415 ± 0.08	1.2SerGln: 1.2 ± 0.037	3.749SerArg: 3.749 ± 0.067	3.227SerSer: 3.227 ± 0.067	3.512SerThr: 3.512 ± 0.065	4.482SerVal: 4.482 ± 0.068	0.915SerTrp: 0.915 ± 0.033	1.059SerTyr: 1.059 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	8.889ThrAla: 8.889 ± 0.113	0.372ThrCys: 0.372 ± 0.023	3.759ThrAsp: 3.759 ± 0.07	2.863ThrGlu: 2.863 ± 0.066	1.948ThrPhe: 1.948 ± 0.049	6.181ThrGly: 6.181 ± 0.095	1.213ThrHis: 1.213 ± 0.037	2.2ThrIle: 2.2 ± 0.061	0.87ThrLys: 0.87 ± 0.036	6.294ThrLeu: 6.294 ± 0.091	0.922ThrMet: 0.922 ± 0.036	1.025ThrAsn: 1.025 ± 0.044	4.704ThrPro: 4.704 ± 0.085	1.555ThrGln: 1.555 ± 0.045	4.21ThrArg: 4.21 ± 0.065	3.876ThrSer: 3.876 ± 0.077	4.603ThrThr: 4.603 ± 0.086	5.839ThrVal: 5.839 ± 0.107	1.095ThrTrp: 1.095 ± 0.038	1.352ThrTyr: 1.352 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	14.859ValAla: 14.859 ± 0.167	0.524ValCys: 0.524 ± 0.025	5.977ValAsp: 5.977 ± 0.091	5.378ValGlu: 5.378 ± 0.08	2.248ValPhe: 2.248 ± 0.059	8.366ValGly: 8.366 ± 0.126	2.047ValHis: 2.047 ± 0.05	2.93ValIle: 2.93 ± 0.066	1.173ValLys: 1.173 ± 0.041	11.428ValLeu: 11.428 ± 0.145	1.327ValMet: 1.327 ± 0.044	1.54ValAsn: 1.54 ± 0.047	5.899ValPro: 5.899 ± 0.08	2.129ValGln: 2.129 ± 0.041	7.646ValArg: 7.646 ± 0.107	4.706ValSer: 4.706 ± 0.08	6.618ValThr: 6.618 ± 0.124	11.627ValVal: 11.627 ± 0.143	1.263ValTrp: 1.263 ± 0.04	1.357ValTyr: 1.357 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.759TrpAla: 1.759 ± 0.046	0.116TrpCys: 0.116 ± 0.01	0.909TrpAsp: 0.909 ± 0.032	0.661TrpGlu: 0.661 ± 0.026	0.533TrpPhe: 0.533 ± 0.026	1.122TrpGly: 1.122 ± 0.036	0.358TrpHis: 0.358 ± 0.021	0.531TrpIle: 0.531 ± 0.025	0.185TrpLys: 0.185 ± 0.013	1.844TrpLeu: 1.844 ± 0.051	0.227TrpMet: 0.227 ± 0.015	0.344TrpAsn: 0.344 ± 0.02	0.806TrpPro: 0.806 ± 0.03	0.516TrpGln: 0.516 ± 0.026	1.464TrpArg: 1.464 ± 0.038	0.982TrpSer: 0.982 ± 0.029	1.027TrpThr: 1.027 ± 0.037	1.341TrpVal: 1.341 ± 0.041	0.475TrpTrp: 0.475 ± 0.024	0.298TrpTyr: 0.298 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.358TyrAla: 2.358 ± 0.05	0.121TyrCys: 0.121 ± 0.012	1.241TyrAsp: 1.241 ± 0.04	0.965TyrGlu: 0.965 ± 0.036	0.521TyrPhe: 0.521 ± 0.026	1.767TyrGly: 1.767 ± 0.048	0.315TyrHis: 0.315 ± 0.019	0.361TyrIle: 0.361 ± 0.021	0.237TyrLys: 0.237 ± 0.016	2.13TyrLeu: 2.13 ± 0.041	0.163TyrMet: 0.163 ± 0.014	0.33TyrAsn: 0.33 ± 0.02	0.998TyrPro: 0.998 ± 0.038	0.512TyrGln: 0.512 ± 0.023	1.482TyrArg: 1.482 ± 0.044	0.916TyrSer: 0.916 ± 0.033	1.058TyrThr: 1.058 ± 0.043	1.603TyrVal: 1.603 ± 0.047	0.267TyrTrp: 0.267 ± 0.015	0.397TyrTyr: 0.397 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2846 proteins (974644 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---