Amino acid dipepetide frequency for Microcystis phage vB_MweS-yong1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.162AlaAla: 1.162 ± 0.371
0.332AlaCys: 0.332 ± 0.229
2.989AlaAsp: 2.989 ± 0.745
3.321AlaGlu: 3.321 ± 0.409
1.992AlaPhe: 1.992 ± 0.481
2.324AlaGly: 2.324 ± 0.616
1.494AlaHis: 1.494 ± 0.412
5.977AlaIle: 5.977 ± 1.054
5.479AlaLys: 5.479 ± 1.426
5.147AlaLeu: 5.147 ± 0.784
1.162AlaMet: 1.162 ± 0.505
1.826AlaAsn: 1.826 ± 0.505
1.494AlaPro: 1.494 ± 0.643
2.656AlaGln: 2.656 ± 0.961
2.324AlaArg: 2.324 ± 0.674
2.989AlaSer: 2.989 ± 0.778
2.656AlaThr: 2.656 ± 0.743
3.321AlaVal: 3.321 ± 1.134
0.498AlaTrp: 0.498 ± 0.297
2.158AlaTyr: 2.158 ± 0.495
0.0AlaXaa: 0.0 ± 0.0
Cys
0.498CysAla: 0.498 ± 0.216
0.0CysCys: 0.0 ± 0.0
0.83CysAsp: 0.83 ± 0.458
0.166CysGlu: 0.166 ± 0.169
0.166CysPhe: 0.166 ± 0.157
0.166CysGly: 0.166 ± 0.154
0.0CysHis: 0.0 ± 0.0
0.83CysIle: 0.83 ± 0.376
0.83CysLys: 0.83 ± 0.447
0.498CysLeu: 0.498 ± 0.227
0.0CysMet: 0.0 ± 0.0
0.996CysAsn: 0.996 ± 0.452
0.166CysPro: 0.166 ± 0.14
0.166CysGln: 0.166 ± 0.154
0.0CysArg: 0.0 ± 0.0
0.83CysSer: 0.83 ± 0.483
0.498CysThr: 0.498 ± 0.261
0.498CysVal: 0.498 ± 0.303
0.332CysTrp: 0.332 ± 0.196
0.498CysTyr: 0.498 ± 0.263
0.0CysXaa: 0.0 ± 0.0
Asp
2.823AspAla: 2.823 ± 0.402
0.498AspCys: 0.498 ± 0.287
3.321AspAsp: 3.321 ± 0.625
3.155AspGlu: 3.155 ± 0.714
4.151AspPhe: 4.151 ± 0.593
3.155AspGly: 3.155 ± 0.668
0.664AspHis: 0.664 ± 0.354
6.309AspIle: 6.309 ± 0.677
5.313AspLys: 5.313 ± 0.778
6.807AspLeu: 6.807 ± 1.29
0.498AspMet: 0.498 ± 0.292
3.487AspAsn: 3.487 ± 1.068
2.656AspPro: 2.656 ± 1.042
1.826AspGln: 1.826 ± 0.497
3.155AspArg: 3.155 ± 0.615
2.823AspSer: 2.823 ± 0.678
3.819AspThr: 3.819 ± 0.67
3.487AspVal: 3.487 ± 0.794
0.166AspTrp: 0.166 ± 0.169
2.989AspTyr: 2.989 ± 0.685
0.0AspXaa: 0.0 ± 0.0
Glu
4.981GluAla: 4.981 ± 0.826
0.664GluCys: 0.664 ± 0.35
5.313GluAsp: 5.313 ± 1.099
3.985GluGlu: 3.985 ± 0.978
3.487GluPhe: 3.487 ± 0.644
2.158GluGly: 2.158 ± 0.752
1.66GluHis: 1.66 ± 0.649
6.641GluIle: 6.641 ± 1.108
8.302GluLys: 8.302 ± 1.229
7.471GluLeu: 7.471 ± 1.64
1.494GluMet: 1.494 ± 0.617
4.649GluAsn: 4.649 ± 0.749
1.328GluPro: 1.328 ± 0.41
5.479GluGln: 5.479 ± 1.247
3.819GluArg: 3.819 ± 1.014
4.981GluSer: 4.981 ± 1.058
3.155GluThr: 3.155 ± 0.6
3.321GluVal: 3.321 ± 0.99
0.332GluTrp: 0.332 ± 0.216
5.313GluTyr: 5.313 ± 1.123
0.0GluXaa: 0.0 ± 0.0
Phe
2.989PheAla: 2.989 ± 0.872
0.166PheCys: 0.166 ± 0.154
2.656PheAsp: 2.656 ± 0.477
3.487PheGlu: 3.487 ± 0.531
2.324PhePhe: 2.324 ± 0.715
1.826PheGly: 1.826 ± 0.601
0.83PheHis: 0.83 ± 0.423
4.649PheIle: 4.649 ± 0.842
3.653PheLys: 3.653 ± 0.634
2.989PheLeu: 2.989 ± 0.581
1.162PheMet: 1.162 ± 0.358
2.656PheAsn: 2.656 ± 0.683
0.996PhePro: 0.996 ± 0.456
2.158PheGln: 2.158 ± 0.412
1.992PheArg: 1.992 ± 0.539
2.656PheSer: 2.656 ± 0.797
2.324PheThr: 2.324 ± 0.64
2.823PheVal: 2.823 ± 0.746
0.332PheTrp: 0.332 ± 0.217
1.162PheTyr: 1.162 ± 0.361
0.0PheXaa: 0.0 ± 0.0
Gly
1.826GlyAla: 1.826 ± 0.496
0.332GlyCys: 0.332 ± 0.307
2.158GlyAsp: 2.158 ± 0.571
2.823GlyGlu: 2.823 ± 0.708
1.66GlyPhe: 1.66 ± 0.453
2.324GlyGly: 2.324 ± 0.698
0.498GlyHis: 0.498 ± 0.336
4.317GlyIle: 4.317 ± 1.076
5.147GlyLys: 5.147 ± 0.861
3.653GlyLeu: 3.653 ± 0.696
1.162GlyMet: 1.162 ± 0.36
2.158GlyAsn: 2.158 ± 0.556
0.664GlyPro: 0.664 ± 0.234
2.324GlyGln: 2.324 ± 0.515
1.162GlyArg: 1.162 ± 0.379
3.321GlySer: 3.321 ± 0.558
2.49GlyThr: 2.49 ± 0.67
3.487GlyVal: 3.487 ± 0.677
0.332GlyTrp: 0.332 ± 0.224
2.158GlyTyr: 2.158 ± 0.567
0.0GlyXaa: 0.0 ± 0.0
His
0.498HisAla: 0.498 ± 0.421
0.0HisCys: 0.0 ± 0.0
0.83HisAsp: 0.83 ± 0.337
1.826HisGlu: 1.826 ± 0.731
0.664HisPhe: 0.664 ± 0.261
1.494HisGly: 1.494 ± 0.705
0.332HisHis: 0.332 ± 0.278
1.328HisIle: 1.328 ± 0.549
1.494HisLys: 1.494 ± 0.823
1.992HisLeu: 1.992 ± 0.907
0.166HisMet: 0.166 ± 0.169
1.494HisAsn: 1.494 ± 0.491
0.996HisPro: 0.996 ± 0.425
0.664HisGln: 0.664 ± 0.386
1.162HisArg: 1.162 ± 0.423
0.664HisSer: 0.664 ± 0.427
1.494HisThr: 1.494 ± 0.663
0.996HisVal: 0.996 ± 0.446
0.0HisTrp: 0.0 ± 0.0
1.328HisTyr: 1.328 ± 0.512
0.0HisXaa: 0.0 ± 0.0
Ile
4.649IleAla: 4.649 ± 0.899
0.996IleCys: 0.996 ± 0.382
8.8IleAsp: 8.8 ± 1.25
9.464IleGlu: 9.464 ± 1.33
3.321IlePhe: 3.321 ± 0.594
3.487IleGly: 3.487 ± 0.825
2.49IleHis: 2.49 ± 0.683
9.298IleIle: 9.298 ± 1.725
6.475IleLys: 6.475 ± 1.105
8.8IleLeu: 8.8 ± 1.026
1.494IleMet: 1.494 ± 0.718
6.641IleAsn: 6.641 ± 1.222
2.656IlePro: 2.656 ± 0.379
3.653IleGln: 3.653 ± 0.833
3.819IleArg: 3.819 ± 0.761
5.811IleSer: 5.811 ± 0.87
5.479IleThr: 5.479 ± 0.849
4.151IleVal: 4.151 ± 0.916
0.498IleTrp: 0.498 ± 0.338
2.656IleTyr: 2.656 ± 0.559
0.0IleXaa: 0.0 ± 0.0
Lys
5.811LysAla: 5.811 ± 1.162
0.664LysCys: 0.664 ± 0.384
5.479LysAsp: 5.479 ± 0.877
7.471LysGlu: 7.471 ± 1.607
2.324LysPhe: 2.324 ± 0.406
4.151LysGly: 4.151 ± 0.69
1.328LysHis: 1.328 ± 0.495
8.966LysIle: 8.966 ± 1.286
7.637LysLys: 7.637 ± 1.36
7.969LysLeu: 7.969 ± 1.157
2.158LysMet: 2.158 ± 0.654
5.977LysAsn: 5.977 ± 1.097
2.823LysPro: 2.823 ± 0.565
2.823LysGln: 2.823 ± 0.517
3.487LysArg: 3.487 ± 0.484
5.147LysSer: 5.147 ± 0.937
5.645LysThr: 5.645 ± 0.854
2.989LysVal: 2.989 ± 0.652
0.996LysTrp: 0.996 ± 0.276
4.483LysTyr: 4.483 ± 1.08
0.0LysXaa: 0.0 ± 0.0
Leu
4.483LeuAla: 4.483 ± 0.814
0.83LeuCys: 0.83 ± 0.446
4.815LeuAsp: 4.815 ± 0.837
7.471LeuGlu: 7.471 ± 1.303
3.819LeuPhe: 3.819 ± 0.736
3.155LeuGly: 3.155 ± 0.818
2.656LeuHis: 2.656 ± 0.803
8.135LeuIle: 8.135 ± 1.459
8.468LeuLys: 8.468 ± 0.949
5.313LeuLeu: 5.313 ± 0.932
2.158LeuMet: 2.158 ± 0.686
7.305LeuAsn: 7.305 ± 1.522
1.494LeuPro: 1.494 ± 0.461
4.815LeuGln: 4.815 ± 0.925
3.653LeuArg: 3.653 ± 0.868
5.645LeuSer: 5.645 ± 1.05
5.479LeuThr: 5.479 ± 0.698
6.475LeuVal: 6.475 ± 1.321
0.664LeuTrp: 0.664 ± 0.324
1.992LeuTyr: 1.992 ± 0.612
0.0LeuXaa: 0.0 ± 0.0
Met
1.826MetAla: 1.826 ± 0.498
0.166MetCys: 0.166 ± 0.154
1.162MetAsp: 1.162 ± 0.298
0.996MetGlu: 0.996 ± 0.446
0.83MetPhe: 0.83 ± 0.454
0.83MetGly: 0.83 ± 0.396
0.664MetHis: 0.664 ± 0.36
2.158MetIle: 2.158 ± 0.706
3.653MetLys: 3.653 ± 0.821
1.328MetLeu: 1.328 ± 0.457
0.664MetMet: 0.664 ± 0.31
1.162MetAsn: 1.162 ± 0.499
0.498MetPro: 0.498 ± 0.342
1.328MetGln: 1.328 ± 0.524
1.328MetArg: 1.328 ± 0.417
1.328MetSer: 1.328 ± 0.506
0.996MetThr: 0.996 ± 0.526
1.826MetVal: 1.826 ± 0.542
0.0MetTrp: 0.0 ± 0.0
0.83MetTyr: 0.83 ± 0.403
0.0MetXaa: 0.0 ± 0.0
Asn
1.66AsnAla: 1.66 ± 0.347
0.664AsnCys: 0.664 ± 0.352
2.823AsnAsp: 2.823 ± 0.782
3.321AsnGlu: 3.321 ± 0.691
2.989AsnPhe: 2.989 ± 0.77
2.989AsnGly: 2.989 ± 0.682
0.664AsnHis: 0.664 ± 0.385
6.475AsnIle: 6.475 ± 1.605
4.317AsnLys: 4.317 ± 0.84
6.807AsnLeu: 6.807 ± 1.201
1.66AsnMet: 1.66 ± 0.487
3.653AsnAsn: 3.653 ± 0.966
2.158AsnPro: 2.158 ± 0.396
4.317AsnGln: 4.317 ± 1.052
3.321AsnArg: 3.321 ± 0.757
3.819AsnSer: 3.819 ± 1.032
4.483AsnThr: 4.483 ± 0.673
2.656AsnVal: 2.656 ± 0.558
0.332AsnTrp: 0.332 ± 0.199
2.823AsnTyr: 2.823 ± 0.604
0.0AsnXaa: 0.0 ± 0.0
Pro
1.494ProAla: 1.494 ± 0.694
0.166ProCys: 0.166 ± 0.154
0.996ProAsp: 0.996 ± 0.397
3.653ProGlu: 3.653 ± 0.994
1.162ProPhe: 1.162 ± 0.417
1.328ProGly: 1.328 ± 0.413
0.332ProHis: 0.332 ± 0.249
1.66ProIle: 1.66 ± 0.501
2.989ProLys: 2.989 ± 0.766
1.992ProLeu: 1.992 ± 0.703
0.166ProMet: 0.166 ± 0.154
3.487ProAsn: 3.487 ± 0.963
0.83ProPro: 0.83 ± 0.306
1.328ProGln: 1.328 ± 0.457
0.83ProArg: 0.83 ± 0.382
1.992ProSer: 1.992 ± 0.689
1.494ProThr: 1.494 ± 0.389
1.992ProVal: 1.992 ± 0.539
0.166ProTrp: 0.166 ± 0.169
0.498ProTyr: 0.498 ± 0.261
0.0ProXaa: 0.0 ± 0.0
Gln
3.819GlnAla: 3.819 ± 0.893
0.332GlnCys: 0.332 ± 0.231
2.324GlnAsp: 2.324 ± 0.512
6.143GlnGlu: 6.143 ± 1.119
2.324GlnPhe: 2.324 ± 0.472
2.49GlnGly: 2.49 ± 0.654
0.83GlnHis: 0.83 ± 0.312
4.649GlnIle: 4.649 ± 0.666
4.483GlnLys: 4.483 ± 0.853
4.317GlnLeu: 4.317 ± 0.647
0.83GlnMet: 0.83 ± 0.33
2.324GlnAsn: 2.324 ± 0.897
1.328GlnPro: 1.328 ± 0.421
2.656GlnGln: 2.656 ± 1.24
1.826GlnArg: 1.826 ± 0.463
2.656GlnSer: 2.656 ± 0.867
1.494GlnThr: 1.494 ± 0.433
2.158GlnVal: 2.158 ± 0.575
0.332GlnTrp: 0.332 ± 0.252
1.494GlnTyr: 1.494 ± 0.563
0.0GlnXaa: 0.0 ± 0.0
Arg
2.823ArgAla: 2.823 ± 0.766
0.166ArgCys: 0.166 ± 0.154
2.158ArgAsp: 2.158 ± 0.536
4.151ArgGlu: 4.151 ± 0.752
1.162ArgPhe: 1.162 ± 0.415
1.494ArgGly: 1.494 ± 0.56
0.664ArgHis: 0.664 ± 0.431
3.653ArgIle: 3.653 ± 0.914
3.819ArgLys: 3.819 ± 0.944
3.155ArgLeu: 3.155 ± 0.666
1.992ArgMet: 1.992 ± 0.554
2.49ArgAsn: 2.49 ± 0.746
1.494ArgPro: 1.494 ± 0.51
2.158ArgGln: 2.158 ± 0.614
1.494ArgArg: 1.494 ± 0.779
2.49ArgSer: 2.49 ± 0.641
2.324ArgThr: 2.324 ± 0.548
2.656ArgVal: 2.656 ± 0.522
0.166ArgTrp: 0.166 ± 0.154
2.158ArgTyr: 2.158 ± 0.617
0.0ArgXaa: 0.0 ± 0.0
Ser
1.826SerAla: 1.826 ± 0.343
0.498SerCys: 0.498 ± 0.276
3.819SerAsp: 3.819 ± 0.813
5.811SerGlu: 5.811 ± 1.036
3.155SerPhe: 3.155 ± 0.756
3.487SerGly: 3.487 ± 0.652
0.996SerHis: 0.996 ± 0.423
6.973SerIle: 6.973 ± 1.63
4.151SerLys: 4.151 ± 1.011
4.815SerLeu: 4.815 ± 0.667
1.992SerMet: 1.992 ± 0.96
3.155SerAsn: 3.155 ± 0.669
0.83SerPro: 0.83 ± 0.425
2.989SerGln: 2.989 ± 0.536
2.158SerArg: 2.158 ± 0.335
2.989SerSer: 2.989 ± 0.87
4.981SerThr: 4.981 ± 0.771
2.49SerVal: 2.49 ± 0.646
0.332SerTrp: 0.332 ± 0.182
1.992SerTyr: 1.992 ± 0.553
0.0SerXaa: 0.0 ± 0.0
Thr
2.989ThrAla: 2.989 ± 0.65
0.166ThrCys: 0.166 ± 0.154
3.321ThrAsp: 3.321 ± 0.474
3.155ThrGlu: 3.155 ± 0.714
2.49ThrPhe: 2.49 ± 0.375
3.487ThrGly: 3.487 ± 0.566
0.996ThrHis: 0.996 ± 0.31
5.147ThrIle: 5.147 ± 1.268
4.151ThrLys: 4.151 ± 0.695
5.147ThrLeu: 5.147 ± 1.062
1.328ThrMet: 1.328 ± 0.414
3.487ThrAsn: 3.487 ± 0.752
2.656ThrPro: 2.656 ± 0.574
3.155ThrGln: 3.155 ± 0.577
3.321ThrArg: 3.321 ± 1.062
1.992ThrSer: 1.992 ± 0.731
3.487ThrThr: 3.487 ± 0.802
2.656ThrVal: 2.656 ± 0.557
0.996ThrTrp: 0.996 ± 0.346
2.324ThrTyr: 2.324 ± 0.619
0.0ThrXaa: 0.0 ± 0.0
Val
3.155ValAla: 3.155 ± 0.872
0.664ValCys: 0.664 ± 0.304
4.317ValAsp: 4.317 ± 1.035
3.819ValGlu: 3.819 ± 0.617
2.656ValPhe: 2.656 ± 0.658
2.158ValGly: 2.158 ± 0.712
0.996ValHis: 0.996 ± 0.348
4.483ValIle: 4.483 ± 0.814
4.317ValLys: 4.317 ± 0.556
4.815ValLeu: 4.815 ± 0.865
1.66ValMet: 1.66 ± 0.632
1.826ValAsn: 1.826 ± 0.554
1.826ValPro: 1.826 ± 0.675
2.49ValGln: 2.49 ± 0.559
1.826ValArg: 1.826 ± 0.574
4.815ValSer: 4.815 ± 0.764
2.656ValThr: 2.656 ± 0.526
2.656ValVal: 2.656 ± 0.471
0.0ValTrp: 0.0 ± 0.0
1.992ValTyr: 1.992 ± 0.633
0.0ValXaa: 0.0 ± 0.0
Trp
0.664TrpAla: 0.664 ± 0.391
0.166TrpCys: 0.166 ± 0.14
0.498TrpAsp: 0.498 ± 0.2
0.664TrpGlu: 0.664 ± 0.37
0.166TrpPhe: 0.166 ± 0.161
0.166TrpGly: 0.166 ± 0.169
0.332TrpHis: 0.332 ± 0.308
0.664TrpIle: 0.664 ± 0.294
0.498TrpLys: 0.498 ± 0.245
0.83TrpLeu: 0.83 ± 0.274
0.166TrpMet: 0.166 ± 0.189
0.166TrpAsn: 0.166 ± 0.154
0.0TrpPro: 0.0 ± 0.0
0.166TrpGln: 0.166 ± 0.14
0.332TrpArg: 0.332 ± 0.187
0.498TrpSer: 0.498 ± 0.333
0.332TrpThr: 0.332 ± 0.249
0.166TrpVal: 0.166 ± 0.154
0.0TrpTrp: 0.0 ± 0.0
0.166TrpTyr: 0.166 ± 0.169
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.328TyrAla: 1.328 ± 0.613
0.498TyrCys: 0.498 ± 0.286
2.49TyrAsp: 2.49 ± 0.558
3.653TyrGlu: 3.653 ± 0.68
2.989TyrPhe: 2.989 ± 0.82
1.328TyrGly: 1.328 ± 0.452
0.996TyrHis: 0.996 ± 0.569
2.324TyrIle: 2.324 ± 0.599
3.155TyrLys: 3.155 ± 0.749
5.147TyrLeu: 5.147 ± 0.583
1.494TyrMet: 1.494 ± 0.457
2.989TyrAsn: 2.989 ± 0.408
1.66TyrPro: 1.66 ± 0.387
1.66TyrGln: 1.66 ± 0.511
1.66TyrArg: 1.66 ± 0.502
1.992TyrSer: 1.992 ± 0.59
1.162TyrThr: 1.162 ± 0.444
2.324TyrVal: 2.324 ± 0.451
0.166TyrTrp: 0.166 ± 0.169
1.826TyrTyr: 1.826 ± 0.666
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 23 proteins (6024 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski