Amino acid dipepetide frequency for Schistosoma mansoni (Blood fluke)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.248AlaAla: 3.248 ± 0.04	1.017AlaCys: 1.017 ± 0.012	2.203AlaAsp: 2.203 ± 0.023	2.583AlaGlu: 2.583 ± 0.039	1.841AlaPhe: 1.841 ± 0.017	2.075AlaGly: 2.075 ± 0.023	1.066AlaHis: 1.066 ± 0.015	2.827AlaIle: 2.827 ± 0.02	2.449AlaLys: 2.449 ± 0.019	4.386AlaLeu: 4.386 ± 0.034	0.922AlaMet: 0.922 ± 0.013	2.53AlaAsn: 2.53 ± 0.019	1.728AlaPro: 1.728 ± 0.024	1.684AlaGln: 1.684 ± 0.019	2.147AlaArg: 2.147 ± 0.021	4.172AlaSer: 4.172 ± 0.03	2.818AlaThr: 2.818 ± 0.022	2.943AlaVal: 2.943 ± 0.029	0.449AlaTrp: 0.449 ± 0.007	1.59AlaTyr: 1.59 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	0.874CysAla: 0.874 ± 0.012	0.549CysCys: 0.549 ± 0.012	1.177CysAsp: 1.177 ± 0.016	1.13CysGlu: 1.13 ± 0.014	0.861CysPhe: 0.861 ± 0.01	1.087CysGly: 1.087 ± 0.014	0.662CysHis: 0.662 ± 0.011	1.496CysIle: 1.496 ± 0.017	1.073CysLys: 1.073 ± 0.015	2.443CysLeu: 2.443 ± 0.022	0.374CysMet: 0.374 ± 0.006	1.227CysAsn: 1.227 ± 0.015	1.06CysPro: 1.06 ± 0.015	0.946CysGln: 0.946 ± 0.015	1.09CysArg: 1.09 ± 0.016	2.16CysSer: 2.16 ± 0.022	1.238CysThr: 1.238 ± 0.013	1.076CysVal: 1.076 ± 0.013	0.231CysTrp: 0.231 ± 0.005	0.664CysTyr: 0.664 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	2.187AspAla: 2.187 ± 0.024	1.078AspCys: 1.078 ± 0.014	3.904AspAsp: 3.904 ± 0.04	3.753AspGlu: 3.753 ± 0.024	2.067AspPhe: 2.067 ± 0.017	2.524AspGly: 2.524 ± 0.028	1.516AspHis: 1.516 ± 0.017	3.528AspIle: 3.528 ± 0.023	2.921AspLys: 2.921 ± 0.022	4.995AspLeu: 4.995 ± 0.031	0.982AspMet: 0.982 ± 0.012	3.784AspAsn: 3.784 ± 0.029	2.264AspPro: 2.264 ± 0.02	2.111AspGln: 2.111 ± 0.017	2.345AspArg: 2.345 ± 0.019	4.863AspSer: 4.863 ± 0.027	2.698AspThr: 2.698 ± 0.02	2.951AspVal: 2.951 ± 0.049	0.576AspTrp: 0.576 ± 0.009	1.924AspTyr: 1.924 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	2.887GluAla: 2.887 ± 0.042	1.158GluCys: 1.158 ± 0.017	2.945GluAsp: 2.945 ± 0.025	3.953GluGlu: 3.953 ± 0.039	2.203GluPhe: 2.203 ± 0.02	1.847GluGly: 1.847 ± 0.025	1.402GluHis: 1.402 ± 0.015	3.802GluIle: 3.802 ± 0.027	3.738GluLys: 3.738 ± 0.035	5.884GluLeu: 5.884 ± 0.045	1.266GluMet: 1.266 ± 0.015	4.041GluAsn: 4.041 ± 0.024	1.829GluPro: 1.829 ± 0.021	2.585GluGln: 2.585 ± 0.021	2.785GluArg: 2.785 ± 0.037	4.857GluSer: 4.857 ± 0.039	3.28GluThr: 3.28 ± 0.031	2.917GluVal: 2.917 ± 0.034	0.552GluTrp: 0.552 ± 0.008	1.879GluTyr: 1.879 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	1.652PheAla: 1.652 ± 0.019	0.882PheCys: 0.882 ± 0.011	2.126PheAsp: 2.126 ± 0.019	1.975PheGlu: 1.975 ± 0.018	1.308PhePhe: 1.308 ± 0.014	2.011PheGly: 2.011 ± 0.021	1.171PheHis: 1.171 ± 0.015	2.872PheIle: 2.872 ± 0.025	1.939PheLys: 1.939 ± 0.018	3.588PheLeu: 3.588 ± 0.028	0.817PheMet: 0.817 ± 0.011	2.595PheAsn: 2.595 ± 0.023	1.71PhePro: 1.71 ± 0.016	1.529PheGln: 1.529 ± 0.014	1.816PheArg: 1.816 ± 0.017	3.607PheSer: 3.607 ± 0.026	2.498PheThr: 2.498 ± 0.021	2.124PheVal: 2.124 ± 0.018	0.431PheTrp: 0.431 ± 0.008	1.381PheTyr: 1.381 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	1.933GlyAla: 1.933 ± 0.021	0.991GlyCys: 0.991 ± 0.012	2.289GlyAsp: 2.289 ± 0.028	2.291GlyGlu: 2.291 ± 0.048	1.918GlyPhe: 1.918 ± 0.019	2.664GlyGly: 2.664 ± 0.036	1.21GlyHis: 1.21 ± 0.013	2.967GlyIle: 2.967 ± 0.026	2.342GlyLys: 2.342 ± 0.026	4.432GlyLeu: 4.432 ± 0.034	0.827GlyMet: 0.827 ± 0.011	2.534GlyAsn: 2.534 ± 0.019	1.814GlyPro: 1.814 ± 0.039	1.763GlyGln: 1.763 ± 0.019	2.398GlyArg: 2.398 ± 0.025	4.243GlySer: 4.243 ± 0.032	2.48GlyThr: 2.48 ± 0.018	2.634GlyVal: 2.634 ± 0.024	0.507GlyTrp: 0.507 ± 0.01	1.648GlyTyr: 1.648 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.016HisAla: 1.016 ± 0.012	0.7HisCys: 0.7 ± 0.01	1.308HisAsp: 1.308 ± 0.014	1.471HisGlu: 1.471 ± 0.016	1.151HisPhe: 1.151 ± 0.013	1.212HisGly: 1.212 ± 0.013	1.596HisHis: 1.596 ± 0.056	1.815HisIle: 1.815 ± 0.016	1.425HisLys: 1.425 ± 0.015	3.093HisLeu: 3.093 ± 0.022	0.512HisMet: 0.512 ± 0.007	1.872HisAsn: 1.872 ± 0.02	1.417HisPro: 1.417 ± 0.015	1.502HisGln: 1.502 ± 0.018	1.503HisArg: 1.503 ± 0.017	3.059HisSer: 3.059 ± 0.025	1.559HisThr: 1.559 ± 0.014	1.404HisVal: 1.404 ± 0.013	0.318HisTrp: 0.318 ± 0.008	1.028HisTyr: 1.028 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	2.751IleAla: 2.751 ± 0.02	1.503IleCys: 1.503 ± 0.014	3.734IleAsp: 3.734 ± 0.025	3.635IleGlu: 3.635 ± 0.027	2.434IlePhe: 2.434 ± 0.022	2.899IleGly: 2.899 ± 0.026	2.141IleHis: 2.141 ± 0.021	4.526IleIle: 4.526 ± 0.034	3.739IleLys: 3.739 ± 0.034	5.887IleLeu: 5.887 ± 0.037	1.27IleMet: 1.27 ± 0.013	5.017IleAsn: 5.017 ± 0.041	3.489IlePro: 3.489 ± 0.025	3.166IleGln: 3.166 ± 0.023	3.09IleArg: 3.09 ± 0.023	6.478IleSer: 6.478 ± 0.029	4.292IleThr: 4.292 ± 0.031	3.242IleVal: 3.242 ± 0.026	0.674IleTrp: 0.674 ± 0.01	2.214IleTyr: 2.214 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.452LysAla: 2.452 ± 0.023	1.261LysCys: 1.261 ± 0.015	2.562LysAsp: 2.562 ± 0.021	3.399LysGlu: 3.399 ± 0.034	2.093LysPhe: 2.093 ± 0.023	1.79LysGly: 1.79 ± 0.029	1.723LysHis: 1.723 ± 0.015	3.449LysIle: 3.449 ± 0.026	3.536LysLys: 3.536 ± 0.033	6.055LysLeu: 6.055 ± 0.037	1.211LysMet: 1.211 ± 0.014	3.417LysAsn: 3.417 ± 0.026	2.657LysPro: 2.657 ± 0.032	2.988LysGln: 2.988 ± 0.027	3.292LysArg: 3.292 ± 0.022	5.926LysSer: 5.926 ± 0.039	3.362LysThr: 3.362 ± 0.023	2.662LysVal: 2.662 ± 0.031	0.583LysTrp: 0.583 ± 0.009	2.015LysTyr: 2.015 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	4.774LeuAla: 4.774 ± 0.032	2.18LeuCys: 2.18 ± 0.02	4.884LeuAsp: 4.884 ± 0.028	5.119LeuGlu: 5.119 ± 0.04	3.904LeuPhe: 3.904 ± 0.028	3.838LeuGly: 3.838 ± 0.026	2.709LeuHis: 2.709 ± 0.02	6.495LeuIle: 6.495 ± 0.041	5.881LeuLys: 5.881 ± 0.041	9.944LeuLeu: 9.944 ± 0.056	1.906LeuMet: 1.906 ± 0.015	6.705LeuAsn: 6.705 ± 0.042	5.064LeuPro: 5.064 ± 0.033	4.112LeuGln: 4.112 ± 0.027	4.891LeuArg: 4.891 ± 0.038	9.931LeuSer: 9.931 ± 0.047	6.035LeuThr: 6.035 ± 0.028	4.769LeuVal: 4.769 ± 0.032	0.963LeuTrp: 0.963 ± 0.013	2.868LeuTyr: 2.868 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	1.012MetAla: 1.012 ± 0.013	0.36MetCys: 0.36 ± 0.007	1.195MetAsp: 1.195 ± 0.011	1.224MetGlu: 1.224 ± 0.016	0.729MetPhe: 0.729 ± 0.009	0.803MetGly: 0.803 ± 0.011	0.504MetHis: 0.504 ± 0.009	1.291MetIle: 1.291 ± 0.014	1.517MetLys: 1.517 ± 0.015	1.68MetLeu: 1.68 ± 0.016	0.459MetMet: 0.459 ± 0.008	1.886MetAsn: 1.886 ± 0.019	0.812MetPro: 0.812 ± 0.013	0.692MetGln: 0.692 ± 0.009	0.873MetArg: 0.873 ± 0.01	1.75MetSer: 1.75 ± 0.016	1.192MetThr: 1.192 ± 0.014	0.951MetVal: 0.951 ± 0.011	0.163MetTrp: 0.163 ± 0.004	0.563MetTyr: 0.563 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.529AsnAla: 2.529 ± 0.019	1.363AsnCys: 1.363 ± 0.015	4.305AsnAsp: 4.305 ± 0.039	4.389AsnGlu: 4.389 ± 0.033	2.27AsnPhe: 2.27 ± 0.02	3.001AsnGly: 3.001 ± 0.024	2.378AsnHis: 2.378 ± 0.026	4.586AsnIle: 4.586 ± 0.035	4.008AsnLys: 4.008 ± 0.031	6.189AsnLeu: 6.189 ± 0.035	1.259AsnMet: 1.259 ± 0.012	8.244AsnAsn: 8.244 ± 0.092	2.979AsnPro: 2.979 ± 0.025	3.382AsnGln: 3.382 ± 0.033	2.888AsnArg: 2.888 ± 0.022	7.542AsnSer: 7.542 ± 0.056	4.522AsnThr: 4.522 ± 0.039	3.424AsnVal: 3.424 ± 0.021	0.602AsnTrp: 0.602 ± 0.01	2.42AsnTyr: 2.42 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	1.782ProAla: 1.782 ± 0.023	0.847ProCys: 0.847 ± 0.014	2.332ProAsp: 2.332 ± 0.028	2.46ProGlu: 2.46 ± 0.024	1.723ProPhe: 1.723 ± 0.018	2.293ProGly: 2.293 ± 0.05	1.123ProHis: 1.123 ± 0.012	3.295ProIle: 3.295 ± 0.021	2.383ProLys: 2.383 ± 0.027	4.082ProLeu: 4.082 ± 0.03	0.849ProMet: 0.849 ± 0.011	3.114ProAsn: 3.114 ± 0.022	3.106ProPro: 3.106 ± 0.041	1.682ProGln: 1.682 ± 0.016	1.915ProArg: 1.915 ± 0.017	5.123ProSer: 5.123 ± 0.043	3.319ProThr: 3.319 ± 0.034	3.131ProVal: 3.131 ± 0.046	0.408ProTrp: 0.408 ± 0.007	1.483ProTyr: 1.483 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	1.84GlnAla: 1.84 ± 0.019	0.931GlnCys: 0.931 ± 0.015	1.575GlnAsp: 1.575 ± 0.014	1.989GlnGlu: 1.989 ± 0.019	1.742GlnPhe: 1.742 ± 0.017	1.263GlnGly: 1.263 ± 0.017	1.33GlnHis: 1.33 ± 0.016	2.965GlnIle: 2.965 ± 0.024	2.381GlnLys: 2.381 ± 0.021	5.121GlnLeu: 5.121 ± 0.039	1.002GlnMet: 1.002 ± 0.013	2.828GlnAsn: 2.828 ± 0.023	2.099GlnPro: 2.099 ± 0.03	3.016GlnGln: 3.016 ± 0.043	2.17GlnArg: 2.17 ± 0.018	4.674GlnSer: 4.674 ± 0.035	2.792GlnThr: 2.792 ± 0.031	1.907GlnVal: 1.907 ± 0.024	0.441GlnTrp: 0.441 ± 0.007	1.495GlnTyr: 1.495 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	2.143ArgAla: 2.143 ± 0.019	1.06ArgCys: 1.06 ± 0.018	2.117ArgAsp: 2.117 ± 0.019	2.493ArgGlu: 2.493 ± 0.026	1.98ArgPhe: 1.98 ± 0.017	1.965ArgGly: 1.965 ± 0.023	1.435ArgHis: 1.435 ± 0.016	3.306ArgIle: 3.306 ± 0.021	3.103ArgLys: 3.103 ± 0.029	5.536ArgLeu: 5.536 ± 0.035	0.96ArgMet: 0.96 ± 0.011	2.871ArgAsn: 2.871 ± 0.02	2.115ArgPro: 2.115 ± 0.02	2.237ArgGln: 2.237 ± 0.02	3.566ArgArg: 3.566 ± 0.033	4.377ArgSer: 4.377 ± 0.032	2.571ArgThr: 2.571 ± 0.028	2.421ArgVal: 2.421 ± 0.026	0.517ArgTrp: 0.517 ± 0.009	1.624ArgTyr: 1.624 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	4.084SerAla: 4.084 ± 0.031	1.991SerCys: 1.991 ± 0.02	5.349SerAsp: 5.349 ± 0.031	5.13SerGlu: 5.13 ± 0.036	3.573SerPhe: 3.573 ± 0.024	4.842SerGly: 4.842 ± 0.037	2.651SerHis: 2.651 ± 0.021	6.475SerIle: 6.475 ± 0.037	5.376SerLys: 5.376 ± 0.031	9.196SerLeu: 9.196 ± 0.046	1.947SerMet: 1.947 ± 0.016	7.952SerAsn: 7.952 ± 0.058	4.721SerPro: 4.721 ± 0.037	4.006SerGln: 4.006 ± 0.032	4.412SerArg: 4.412 ± 0.028	14.559SerSer: 14.559 ± 0.114	7.607SerThr: 7.607 ± 0.085	5.856SerVal: 5.856 ± 0.029	0.859SerTrp: 0.859 ± 0.012	2.79SerTyr: 2.79 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	2.938ThrAla: 2.938 ± 0.027	1.298ThrCys: 1.298 ± 0.018	3.512ThrAsp: 3.512 ± 0.023	3.44ThrGlu: 3.44 ± 0.025	2.183ThrPhe: 2.183 ± 0.019	3.121ThrGly: 3.121 ± 0.025	1.449ThrHis: 1.449 ± 0.013	4.235ThrIle: 4.235 ± 0.028	3.302ThrLys: 3.302 ± 0.026	5.259ThrLeu: 5.259 ± 0.028	1.247ThrMet: 1.247 ± 0.015	5.158ThrAsn: 5.158 ± 0.045	3.093ThrPro: 3.093 ± 0.034	2.212ThrGln: 2.212 ± 0.046	2.496ThrArg: 2.496 ± 0.023	7.134ThrSer: 7.134 ± 0.048	6.737ThrThr: 6.737 ± 0.117	3.764ThrVal: 3.764 ± 0.026	0.504ThrTrp: 0.504 ± 0.008	1.84ThrTyr: 1.84 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	2.712ValAla: 2.712 ± 0.024	1.258ValCys: 1.258 ± 0.015	3.168ValAsp: 3.168 ± 0.032	3.02ValGlu: 3.02 ± 0.049	2.06ValPhe: 2.06 ± 0.03	2.613ValGly: 2.613 ± 0.027	1.521ValHis: 1.521 ± 0.017	3.425ValIle: 3.425 ± 0.025	3.044ValLys: 3.044 ± 0.028	4.645ValLeu: 4.645 ± 0.034	0.996ValMet: 0.996 ± 0.011	3.793ValAsn: 3.793 ± 0.022	2.469ValPro: 2.469 ± 0.043	2.16ValGln: 2.16 ± 0.017	2.439ValArg: 2.439 ± 0.023	4.911ValSer: 4.911 ± 0.038	3.474ValThr: 3.474 ± 0.031	3.158ValVal: 3.158 ± 0.033	0.551ValTrp: 0.551 ± 0.009	1.847ValTyr: 1.847 ± 0.013	0.0ValXaa: 0.0 ± 0.0
Trp	0.412TrpAla: 0.412 ± 0.008	0.237TrpCys: 0.237 ± 0.006	0.538TrpAsp: 0.538 ± 0.009	0.473TrpGlu: 0.473 ± 0.009	0.496TrpPhe: 0.496 ± 0.008	0.354TrpGly: 0.354 ± 0.007	0.243TrpHis: 0.243 ± 0.006	0.797TrpIle: 0.797 ± 0.011	0.618TrpLys: 0.618 ± 0.009	1.14TrpLeu: 1.14 ± 0.014	0.213TrpMet: 0.213 ± 0.005	0.667TrpAsn: 0.667 ± 0.007	0.44TrpPro: 0.44 ± 0.007	0.34TrpGln: 0.34 ± 0.007	0.563TrpArg: 0.563 ± 0.008	0.929TrpSer: 0.929 ± 0.014	0.539TrpThr: 0.539 ± 0.009	0.376TrpVal: 0.376 ± 0.007	0.136TrpTrp: 0.136 ± 0.004	0.331TrpTyr: 0.331 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.453TyrAla: 1.453 ± 0.015	0.754TyrCys: 0.754 ± 0.01	1.746TyrAsp: 1.746 ± 0.016	1.885TyrGlu: 1.885 ± 0.018	1.496TyrPhe: 1.496 ± 0.017	1.683TyrGly: 1.683 ± 0.018	1.135TyrHis: 1.135 ± 0.014	2.032TyrIle: 2.032 ± 0.019	1.656TyrLys: 1.656 ± 0.017	3.416TyrLeu: 3.416 ± 0.03	0.633TyrMet: 0.633 ± 0.008	2.048TyrAsn: 2.048 ± 0.026	1.581TyrPro: 1.581 ± 0.015	1.448TyrGln: 1.448 ± 0.016	1.719TyrArg: 1.719 ± 0.017	3.08TyrSer: 3.08 ± 0.021	1.909TyrThr: 1.909 ± 0.016	1.553TyrVal: 1.553 ± 0.013	0.378TyrTrp: 0.378 ± 0.008	1.31TyrTyr: 1.31 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 14182 proteins (8463562 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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