Amino acid dipepetide frequency for Sulfolobus spindle-shaped virus 5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.0AlaCys: 0.0 ± 0.0
0.595AlaAsp: 0.595 ± 0.362
3.57AlaGlu: 3.57 ± 0.881
2.578AlaPhe: 2.578 ± 0.725
3.372AlaGly: 3.372 ± 1.121
0.595AlaHis: 0.595 ± 0.344
4.562AlaIle: 4.562 ± 1.058
5.355AlaLys: 5.355 ± 1.5
4.76AlaLeu: 4.76 ± 0.854
0.992AlaMet: 0.992 ± 0.375
3.372AlaAsn: 3.372 ± 0.971
1.388AlaPro: 1.388 ± 0.423
1.388AlaGln: 1.388 ± 0.518
1.388AlaArg: 1.388 ± 0.537
3.768AlaSer: 3.768 ± 1.162
3.57AlaThr: 3.57 ± 0.916
2.975AlaVal: 2.975 ± 0.673
0.992AlaTrp: 0.992 ± 0.421
2.38AlaTyr: 2.38 ± 0.696
0.0AlaXaa: 0.0 ± 0.0
Cys
0.198CysAla: 0.198 ± 0.229
0.0CysCys: 0.0 ± 0.0
0.397CysAsp: 0.397 ± 0.362
0.198CysGlu: 0.198 ± 0.204
0.198CysPhe: 0.198 ± 0.196
0.793CysGly: 0.793 ± 0.46
0.0CysHis: 0.0 ± 0.0
0.793CysIle: 0.793 ± 0.434
0.397CysLys: 0.397 ± 0.287
0.992CysLeu: 0.992 ± 0.474
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.19CysPro: 1.19 ± 0.691
0.397CysGln: 0.397 ± 0.396
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.595CysVal: 0.595 ± 0.323
0.198CysTrp: 0.198 ± 0.229
0.595CysTyr: 0.595 ± 0.373
0.0CysXaa: 0.0 ± 0.0
Asp
1.388AspAla: 1.388 ± 0.794
0.198AspCys: 0.198 ± 0.204
1.785AspAsp: 1.785 ± 0.779
2.38AspGlu: 2.38 ± 0.831
0.793AspPhe: 0.793 ± 0.425
2.777AspGly: 2.777 ± 0.819
0.793AspHis: 0.793 ± 0.421
4.165AspIle: 4.165 ± 1.077
2.975AspLys: 2.975 ± 1.089
3.173AspLeu: 3.173 ± 1.051
0.595AspMet: 0.595 ± 0.399
1.19AspAsn: 1.19 ± 0.547
0.595AspPro: 0.595 ± 0.406
1.19AspGln: 1.19 ± 0.596
0.992AspArg: 0.992 ± 0.455
1.785AspSer: 1.785 ± 0.669
1.388AspThr: 1.388 ± 0.465
2.38AspVal: 2.38 ± 0.691
0.397AspTrp: 0.397 ± 0.361
1.983AspTyr: 1.983 ± 0.811
0.0AspXaa: 0.0 ± 0.0
Glu
3.372GluAla: 3.372 ± 1.049
0.793GluCys: 0.793 ± 0.566
2.975GluAsp: 2.975 ± 1.055
6.545GluGlu: 6.545 ± 2.436
1.983GluPhe: 1.983 ± 0.745
1.587GluGly: 1.587 ± 0.728
0.992GluHis: 0.992 ± 0.545
4.165GluIle: 4.165 ± 1.007
6.148GluLys: 6.148 ± 1.706
9.322GluLeu: 9.322 ± 2.406
1.785GluMet: 1.785 ± 0.619
2.578GluAsn: 2.578 ± 0.931
1.785GluPro: 1.785 ± 0.618
0.992GluGln: 0.992 ± 0.373
1.587GluArg: 1.587 ± 0.94
2.578GluSer: 2.578 ± 0.754
1.785GluThr: 1.785 ± 0.76
3.57GluVal: 3.57 ± 1.088
0.595GluTrp: 0.595 ± 0.334
1.983GluTyr: 1.983 ± 0.633
0.0GluXaa: 0.0 ± 0.0
Phe
2.182PheAla: 2.182 ± 0.524
0.397PheCys: 0.397 ± 0.245
2.182PheAsp: 2.182 ± 0.538
1.587PheGlu: 1.587 ± 0.671
2.975PhePhe: 2.975 ± 0.835
2.38PheGly: 2.38 ± 0.519
0.595PheHis: 0.595 ± 0.441
1.983PheIle: 1.983 ± 0.82
2.38PheLys: 2.38 ± 0.644
4.363PheLeu: 4.363 ± 1.066
1.587PheMet: 1.587 ± 0.486
1.785PheAsn: 1.785 ± 0.639
0.992PhePro: 0.992 ± 0.406
1.19PheGln: 1.19 ± 0.48
1.785PheArg: 1.785 ± 0.693
4.562PheSer: 4.562 ± 1.251
4.76PheThr: 4.76 ± 0.826
4.958PheVal: 4.958 ± 0.896
0.793PheTrp: 0.793 ± 0.338
4.165PheTyr: 4.165 ± 0.888
0.0PheXaa: 0.0 ± 0.0
Gly
2.182GlyAla: 2.182 ± 0.573
0.0GlyCys: 0.0 ± 0.0
2.38GlyAsp: 2.38 ± 0.837
1.388GlyGlu: 1.388 ± 0.512
3.967GlyPhe: 3.967 ± 1.029
3.173GlyGly: 3.173 ± 1.021
0.397GlyHis: 0.397 ± 0.244
5.752GlyIle: 5.752 ± 1.017
4.958GlyLys: 4.958 ± 1.031
7.338GlyLeu: 7.338 ± 1.534
0.595GlyMet: 0.595 ± 0.318
1.785GlyAsn: 1.785 ± 0.641
3.768GlyPro: 3.768 ± 1.845
1.983GlyGln: 1.983 ± 0.924
2.38GlyArg: 2.38 ± 0.862
4.363GlySer: 4.363 ± 1.355
3.57GlyThr: 3.57 ± 1.289
4.562GlyVal: 4.562 ± 0.972
0.992GlyTrp: 0.992 ± 0.351
2.777GlyTyr: 2.777 ± 0.85
0.0GlyXaa: 0.0 ± 0.0
His
0.595HisAla: 0.595 ± 0.456
0.0HisCys: 0.0 ± 0.0
0.198HisAsp: 0.198 ± 0.202
0.793HisGlu: 0.793 ± 0.387
1.19HisPhe: 1.19 ± 0.441
0.397HisGly: 0.397 ± 0.295
0.0HisHis: 0.0 ± 0.0
0.793HisIle: 0.793 ± 0.495
0.793HisLys: 0.793 ± 0.46
0.992HisLeu: 0.992 ± 0.531
0.0HisMet: 0.0 ± 0.0
1.19HisAsn: 1.19 ± 0.629
0.397HisPro: 0.397 ± 0.242
0.397HisGln: 0.397 ± 0.263
0.793HisArg: 0.793 ± 0.449
0.793HisSer: 0.793 ± 0.414
0.793HisThr: 0.793 ± 0.392
1.19HisVal: 1.19 ± 0.543
0.0HisTrp: 0.0 ± 0.0
1.388HisTyr: 1.388 ± 0.575
0.0HisXaa: 0.0 ± 0.0
Ile
4.363IleAla: 4.363 ± 0.984
0.793IleCys: 0.793 ± 0.44
2.182IleAsp: 2.182 ± 0.546
3.967IleGlu: 3.967 ± 1.079
4.958IlePhe: 4.958 ± 0.917
5.157IleGly: 5.157 ± 1.023
1.388IleHis: 1.388 ± 0.642
6.942IleIle: 6.942 ± 1.342
3.768IleLys: 3.768 ± 1.182
8.33IleLeu: 8.33 ± 1.468
1.785IleMet: 1.785 ± 0.483
3.967IleAsn: 3.967 ± 1.086
4.562IlePro: 4.562 ± 1.04
1.785IleGln: 1.785 ± 0.734
5.157IleArg: 5.157 ± 1.166
5.553IleSer: 5.553 ± 1.21
4.562IleThr: 4.562 ± 1.166
5.752IleVal: 5.752 ± 1.503
0.595IleTrp: 0.595 ± 0.39
4.958IleTyr: 4.958 ± 0.924
0.0IleXaa: 0.0 ± 0.0
Lys
3.372LysAla: 3.372 ± 1.211
0.397LysCys: 0.397 ± 0.305
1.587LysAsp: 1.587 ± 0.695
5.355LysGlu: 5.355 ± 1.351
2.578LysPhe: 2.578 ± 0.629
3.57LysGly: 3.57 ± 0.865
1.19LysHis: 1.19 ± 0.528
6.148LysIle: 6.148 ± 1.648
8.132LysLys: 8.132 ± 2.296
9.718LysLeu: 9.718 ± 1.825
2.182LysMet: 2.182 ± 0.726
2.38LysAsn: 2.38 ± 0.735
1.785LysPro: 1.785 ± 0.661
2.777LysGln: 2.777 ± 0.681
2.975LysArg: 2.975 ± 0.865
3.768LysSer: 3.768 ± 1.5
4.562LysThr: 4.562 ± 0.913
4.363LysVal: 4.363 ± 1.056
1.388LysTrp: 1.388 ± 0.489
3.967LysTyr: 3.967 ± 1.158
0.0LysXaa: 0.0 ± 0.0
Leu
5.157LeuAla: 5.157 ± 0.865
0.595LeuCys: 0.595 ± 0.385
3.768LeuAsp: 3.768 ± 1.265
4.76LeuGlu: 4.76 ± 1.316
6.347LeuPhe: 6.347 ± 1.252
5.752LeuGly: 5.752 ± 0.957
0.793LeuHis: 0.793 ± 0.396
8.925LeuIle: 8.925 ± 1.392
5.157LeuLys: 5.157 ± 1.148
14.082LeuLeu: 14.082 ± 1.746
2.777LeuMet: 2.777 ± 0.746
7.338LeuAsn: 7.338 ± 1.177
5.553LeuPro: 5.553 ± 0.615
3.768LeuGln: 3.768 ± 0.92
6.148LeuArg: 6.148 ± 1.409
8.727LeuSer: 8.727 ± 1.457
8.33LeuThr: 8.33 ± 1.139
8.528LeuVal: 8.528 ± 1.519
1.587LeuTrp: 1.587 ± 0.677
5.553LeuTyr: 5.553 ± 1.06
0.0LeuXaa: 0.0 ± 0.0
Met
0.992MetAla: 0.992 ± 0.475
0.0MetCys: 0.0 ± 0.0
0.793MetAsp: 0.793 ± 0.508
1.785MetGlu: 1.785 ± 0.568
0.397MetPhe: 0.397 ± 0.33
1.587MetGly: 1.587 ± 0.537
0.198MetHis: 0.198 ± 0.229
1.587MetIle: 1.587 ± 0.609
2.182MetLys: 2.182 ± 0.743
2.777MetLeu: 2.777 ± 0.91
0.397MetMet: 0.397 ± 0.347
0.793MetAsn: 0.793 ± 0.349
0.595MetPro: 0.595 ± 0.275
0.397MetGln: 0.397 ± 0.292
1.19MetArg: 1.19 ± 0.514
1.388MetSer: 1.388 ± 0.534
1.983MetThr: 1.983 ± 0.549
0.793MetVal: 0.793 ± 0.384
0.397MetTrp: 0.397 ± 0.244
0.992MetTyr: 0.992 ± 0.525
0.0MetXaa: 0.0 ± 0.0
Asn
2.975AsnAla: 2.975 ± 0.643
0.397AsnCys: 0.397 ± 0.291
1.785AsnAsp: 1.785 ± 0.629
3.173AsnGlu: 3.173 ± 0.959
1.983AsnPhe: 1.983 ± 0.709
4.165AsnGly: 4.165 ± 1.238
0.397AsnHis: 0.397 ± 0.338
4.958AsnIle: 4.958 ± 1.105
2.38AsnLys: 2.38 ± 0.651
3.57AsnLeu: 3.57 ± 1.064
0.793AsnMet: 0.793 ± 0.388
5.157AsnAsn: 5.157 ± 0.956
2.777AsnPro: 2.777 ± 0.629
1.587AsnGln: 1.587 ± 0.647
1.388AsnArg: 1.388 ± 0.517
2.777AsnSer: 2.777 ± 0.862
3.967AsnThr: 3.967 ± 1.236
4.76AsnVal: 4.76 ± 1.359
0.793AsnTrp: 0.793 ± 0.343
4.165AsnTyr: 4.165 ± 1.091
0.0AsnXaa: 0.0 ± 0.0
Pro
2.777ProAla: 2.777 ± 0.721
0.198ProCys: 0.198 ± 0.204
1.388ProAsp: 1.388 ± 0.552
1.785ProGlu: 1.785 ± 0.562
2.777ProPhe: 2.777 ± 0.727
1.587ProGly: 1.587 ± 0.709
0.793ProHis: 0.793 ± 0.375
1.587ProIle: 1.587 ± 0.592
1.587ProLys: 1.587 ± 0.581
4.165ProLeu: 4.165 ± 0.886
0.397ProMet: 0.397 ± 0.285
1.785ProAsn: 1.785 ± 0.47
4.562ProPro: 4.562 ± 1.503
1.983ProGln: 1.983 ± 0.669
1.785ProArg: 1.785 ± 0.58
3.768ProSer: 3.768 ± 1.067
1.983ProThr: 1.983 ± 0.752
2.975ProVal: 2.975 ± 0.911
1.19ProTrp: 1.19 ± 0.493
3.372ProTyr: 3.372 ± 0.875
0.0ProXaa: 0.0 ± 0.0
Gln
0.595GlnAla: 0.595 ± 0.342
0.198GlnCys: 0.198 ± 0.22
1.388GlnAsp: 1.388 ± 0.733
0.992GlnGlu: 0.992 ± 0.481
1.587GlnPhe: 1.587 ± 0.708
1.785GlnGly: 1.785 ± 0.503
1.388GlnHis: 1.388 ± 0.716
3.57GlnIle: 3.57 ± 0.717
2.182GlnLys: 2.182 ± 0.777
3.768GlnLeu: 3.768 ± 0.893
0.397GlnMet: 0.397 ± 0.367
1.785GlnAsn: 1.785 ± 0.528
1.19GlnPro: 1.19 ± 0.717
0.595GlnGln: 0.595 ± 0.262
0.595GlnArg: 0.595 ± 0.354
1.785GlnSer: 1.785 ± 0.746
2.38GlnThr: 2.38 ± 0.753
2.578GlnVal: 2.578 ± 0.659
0.992GlnTrp: 0.992 ± 0.373
0.992GlnTyr: 0.992 ± 0.458
0.0GlnXaa: 0.0 ± 0.0
Arg
1.19ArgAla: 1.19 ± 0.435
0.793ArgCys: 0.793 ± 0.447
1.785ArgAsp: 1.785 ± 0.745
3.768ArgGlu: 3.768 ± 1.01
1.19ArgPhe: 1.19 ± 0.502
1.785ArgGly: 1.785 ± 0.606
0.595ArgHis: 0.595 ± 0.367
2.182ArgIle: 2.182 ± 0.61
4.363ArgLys: 4.363 ± 0.996
2.975ArgLeu: 2.975 ± 1.018
1.388ArgMet: 1.388 ± 0.576
2.182ArgAsn: 2.182 ± 0.76
0.793ArgPro: 0.793 ± 0.397
1.785ArgGln: 1.785 ± 0.779
3.372ArgArg: 3.372 ± 1.062
1.587ArgSer: 1.587 ± 0.682
1.19ArgThr: 1.19 ± 0.457
4.363ArgVal: 4.363 ± 1.436
0.198ArgTrp: 0.198 ± 0.196
1.785ArgTyr: 1.785 ± 1.004
0.0ArgXaa: 0.0 ± 0.0
Ser
3.967SerAla: 3.967 ± 0.884
0.0SerCys: 0.0 ± 0.0
1.983SerAsp: 1.983 ± 0.586
3.967SerGlu: 3.967 ± 1.204
2.975SerPhe: 2.975 ± 0.557
6.545SerGly: 6.545 ± 1.014
0.595SerHis: 0.595 ± 0.324
6.347SerIle: 6.347 ± 1.763
6.347SerLys: 6.347 ± 1.63
7.14SerLeu: 7.14 ± 1.339
0.595SerMet: 0.595 ± 0.45
4.165SerAsn: 4.165 ± 0.934
2.578SerPro: 2.578 ± 0.66
2.182SerGln: 2.182 ± 0.638
2.182SerArg: 2.182 ± 0.692
5.95SerSer: 5.95 ± 2.074
4.165SerThr: 4.165 ± 1.213
5.355SerVal: 5.355 ± 1.486
0.595SerTrp: 0.595 ± 0.318
4.165SerTyr: 4.165 ± 1.125
0.0SerXaa: 0.0 ± 0.0
Thr
3.57ThrAla: 3.57 ± 0.964
0.198ThrCys: 0.198 ± 0.204
1.19ThrAsp: 1.19 ± 0.498
4.363ThrGlu: 4.363 ± 1.231
2.975ThrPhe: 2.975 ± 0.894
3.372ThrGly: 3.372 ± 1.146
0.595ThrHis: 0.595 ± 0.32
5.95ThrIle: 5.95 ± 1.399
4.76ThrLys: 4.76 ± 0.985
9.52ThrLeu: 9.52 ± 1.464
1.587ThrMet: 1.587 ± 0.615
3.173ThrAsn: 3.173 ± 0.842
2.777ThrPro: 2.777 ± 0.778
3.173ThrGln: 3.173 ± 0.92
1.19ThrArg: 1.19 ± 0.529
4.562ThrSer: 4.562 ± 1.034
5.157ThrThr: 5.157 ± 1.762
3.768ThrVal: 3.768 ± 1.185
0.793ThrTrp: 0.793 ± 0.371
2.777ThrTyr: 2.777 ± 0.866
0.0ThrXaa: 0.0 ± 0.0
Val
3.967ValAla: 3.967 ± 0.894
1.388ValCys: 1.388 ± 1.029
2.38ValAsp: 2.38 ± 0.789
4.76ValGlu: 4.76 ± 1.53
2.38ValPhe: 2.38 ± 0.764
4.165ValGly: 4.165 ± 0.81
0.595ValHis: 0.595 ± 0.33
4.562ValIle: 4.562 ± 0.989
3.967ValLys: 3.967 ± 0.864
6.942ValLeu: 6.942 ± 1.087
1.388ValMet: 1.388 ± 0.58
5.157ValAsn: 5.157 ± 0.91
2.182ValPro: 2.182 ± 0.744
1.388ValGln: 1.388 ± 0.597
2.182ValArg: 2.182 ± 0.822
8.925ValSer: 8.925 ± 1.332
6.148ValThr: 6.148 ± 1.238
5.752ValVal: 5.752 ± 1.298
1.19ValTrp: 1.19 ± 0.583
3.967ValTyr: 3.967 ± 0.959
0.0ValXaa: 0.0 ± 0.0
Trp
0.793TrpAla: 0.793 ± 0.438
0.198TrpCys: 0.198 ± 0.195
0.793TrpAsp: 0.793 ± 0.385
0.595TrpGlu: 0.595 ± 0.401
0.793TrpPhe: 0.793 ± 0.356
1.19TrpGly: 1.19 ± 0.539
0.0TrpHis: 0.0 ± 0.0
0.595TrpIle: 0.595 ± 0.387
1.19TrpLys: 1.19 ± 0.639
2.38TrpLeu: 2.38 ± 0.658
0.198TrpMet: 0.198 ± 0.249
0.198TrpAsn: 0.198 ± 0.198
0.397TrpPro: 0.397 ± 0.333
0.397TrpGln: 0.397 ± 0.281
0.0TrpArg: 0.0 ± 0.0
1.19TrpSer: 1.19 ± 0.655
0.992TrpThr: 0.992 ± 0.517
0.992TrpVal: 0.992 ± 0.47
0.0TrpTrp: 0.0 ± 0.0
1.983TrpTyr: 1.983 ± 0.581
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.967TyrAla: 3.967 ± 1.131
0.397TyrCys: 0.397 ± 0.396
1.388TyrAsp: 1.388 ± 0.587
1.388TyrGlu: 1.388 ± 0.666
2.975TyrPhe: 2.975 ± 0.824
3.173TyrGly: 3.173 ± 0.948
0.793TyrHis: 0.793 ± 0.44
4.958TyrIle: 4.958 ± 0.919
3.372TyrLys: 3.372 ± 1.019
7.338TyrLeu: 7.338 ± 0.914
1.587TyrMet: 1.587 ± 0.636
3.967TyrAsn: 3.967 ± 1.276
2.578TyrPro: 2.578 ± 0.846
1.388TyrGln: 1.388 ± 0.505
2.182TyrArg: 2.182 ± 0.71
3.967TyrSer: 3.967 ± 0.858
4.165TyrThr: 4.165 ± 0.717
3.173TyrVal: 3.173 ± 0.818
1.19TyrTrp: 1.19 ± 0.377
3.372TyrTyr: 3.372 ± 0.796
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 34 proteins (5043 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski