Amino acid dipepetide frequency for Aeromicrobium sp. A1-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.582AlaAla: 17.582 ± 0.198	0.936AlaCys: 0.936 ± 0.036	8.114AlaAsp: 8.114 ± 0.104	7.684AlaGlu: 7.684 ± 0.118	3.64AlaPhe: 3.64 ± 0.059	11.325AlaGly: 11.325 ± 0.132	2.437AlaHis: 2.437 ± 0.053	5.777AlaIle: 5.777 ± 0.07	3.119AlaLys: 3.119 ± 0.065	12.656AlaLeu: 12.656 ± 0.143	2.938AlaMet: 2.938 ± 0.05	2.3AlaAsn: 2.3 ± 0.046	5.358AlaPro: 5.358 ± 0.079	3.679AlaGln: 3.679 ± 0.064	8.283AlaArg: 8.283 ± 0.108	6.769AlaSer: 6.769 ± 0.084	7.344AlaThr: 7.344 ± 0.105	10.747AlaVal: 10.747 ± 0.111	1.714AlaTrp: 1.714 ± 0.044	2.588AlaTyr: 2.588 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.85CysAla: 0.85 ± 0.033	0.078CysCys: 0.078 ± 0.009	0.436CysAsp: 0.436 ± 0.021	0.392CysGlu: 0.392 ± 0.017	0.219CysPhe: 0.219 ± 0.017	0.772CysGly: 0.772 ± 0.028	0.198CysHis: 0.198 ± 0.012	0.23CysIle: 0.23 ± 0.014	0.121CysLys: 0.121 ± 0.011	0.615CysLeu: 0.615 ± 0.024	0.127CysMet: 0.127 ± 0.011	0.155CysAsn: 0.155 ± 0.01	0.428CysPro: 0.428 ± 0.021	0.189CysGln: 0.189 ± 0.014	0.51CysArg: 0.51 ± 0.02	0.432CysSer: 0.432 ± 0.022	0.41CysThr: 0.41 ± 0.019	0.584CysVal: 0.584 ± 0.023	0.077CysTrp: 0.077 ± 0.008	0.119CysTyr: 0.119 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.666AspAla: 7.666 ± 0.099	0.378AspCys: 0.378 ± 0.019	4.545AspAsp: 4.545 ± 0.078	4.27AspGlu: 4.27 ± 0.07	1.828AspPhe: 1.828 ± 0.044	6.165AspGly: 6.165 ± 0.082	1.526AspHis: 1.526 ± 0.032	2.702AspIle: 2.702 ± 0.051	1.497AspLys: 1.497 ± 0.049	6.996AspLeu: 6.996 ± 0.098	0.966AspMet: 0.966 ± 0.033	1.234AspAsn: 1.234 ± 0.04	4.136AspPro: 4.136 ± 0.067	1.951AspGln: 1.951 ± 0.041	4.758AspArg: 4.758 ± 0.067	3.134AspSer: 3.134 ± 0.058	3.099AspThr: 3.099 ± 0.061	5.853AspVal: 5.853 ± 0.083	0.925AspTrp: 0.925 ± 0.031	1.219AspTyr: 1.219 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.767GluAla: 6.767 ± 0.089	0.326GluCys: 0.326 ± 0.017	2.821GluAsp: 2.821 ± 0.06	2.729GluGlu: 2.729 ± 0.055	1.679GluPhe: 1.679 ± 0.045	4.036GluGly: 4.036 ± 0.069	1.549GluHis: 1.549 ± 0.039	3.076GluIle: 3.076 ± 0.064	1.351GluLys: 1.351 ± 0.043	6.275GluLeu: 6.275 ± 0.086	1.085GluMet: 1.085 ± 0.033	0.98GluAsn: 0.98 ± 0.03	2.994GluPro: 2.994 ± 0.055	2.365GluGln: 2.365 ± 0.059	4.637GluArg: 4.637 ± 0.076	3.161GluSer: 3.161 ± 0.059	2.983GluThr: 2.983 ± 0.059	4.803GluVal: 4.803 ± 0.079	0.746GluTrp: 0.746 ± 0.029	1.007GluTyr: 1.007 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.985PheAla: 3.985 ± 0.066	0.286PheCys: 0.286 ± 0.017	2.319PheAsp: 2.319 ± 0.046	1.617PheGlu: 1.617 ± 0.036	1.02PhePhe: 1.02 ± 0.034	3.394PheGly: 3.394 ± 0.068	0.627PheHis: 0.627 ± 0.028	1.078PheIle: 1.078 ± 0.035	0.626PheLys: 0.626 ± 0.024	2.679PheLeu: 2.679 ± 0.056	0.556PheMet: 0.556 ± 0.023	0.707PheAsn: 0.707 ± 0.027	1.342PhePro: 1.342 ± 0.038	0.71PheGln: 0.71 ± 0.023	1.674PheArg: 1.674 ± 0.042	1.732PheSer: 1.732 ± 0.044	2.051PheThr: 2.051 ± 0.042	2.819PheVal: 2.819 ± 0.057	0.413PheTrp: 0.413 ± 0.022	0.691PheTyr: 0.691 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.947GlyAla: 9.947 ± 0.108	0.69GlyCys: 0.69 ± 0.026	5.328GlyAsp: 5.328 ± 0.076	4.574GlyGlu: 4.574 ± 0.069	3.135GlyPhe: 3.135 ± 0.055	7.846GlyGly: 7.846 ± 0.11	2.046GlyHis: 2.046 ± 0.05	4.373GlyIle: 4.373 ± 0.071	2.545GlyLys: 2.545 ± 0.056	9.302GlyLeu: 9.302 ± 0.117	1.989GlyMet: 1.989 ± 0.047	1.832GlyAsn: 1.832 ± 0.049	3.919GlyPro: 3.919 ± 0.061	2.721GlyGln: 2.721 ± 0.051	6.517GlyArg: 6.517 ± 0.089	5.903GlySer: 5.903 ± 0.083	5.537GlyThr: 5.537 ± 0.072	7.784GlyVal: 7.784 ± 0.098	1.574GlyTrp: 1.574 ± 0.042	2.045GlyTyr: 2.045 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.403HisAla: 2.403 ± 0.052	0.156HisCys: 0.156 ± 0.012	1.582HisAsp: 1.582 ± 0.038	1.3HisGlu: 1.3 ± 0.037	0.598HisPhe: 0.598 ± 0.026	2.185HisGly: 2.185 ± 0.049	0.665HisHis: 0.665 ± 0.03	0.771HisIle: 0.771 ± 0.028	0.405HisLys: 0.405 ± 0.02	2.278HisLeu: 2.278 ± 0.054	0.367HisMet: 0.367 ± 0.021	0.384HisAsn: 0.384 ± 0.022	1.469HisPro: 1.469 ± 0.042	0.65HisGln: 0.65 ± 0.025	1.793HisArg: 1.793 ± 0.05	1.034HisSer: 1.034 ± 0.029	1.199HisThr: 1.199 ± 0.032	2.009HisVal: 2.009 ± 0.043	0.298HisTrp: 0.298 ± 0.018	0.427HisTyr: 0.427 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.685IleAla: 6.685 ± 0.078	0.359IleCys: 0.359 ± 0.02	3.667IleAsp: 3.667 ± 0.067	2.999IleGlu: 2.999 ± 0.055	1.168IlePhe: 1.168 ± 0.037	4.891IleGly: 4.891 ± 0.081	0.822IleHis: 0.822 ± 0.029	1.806IleIle: 1.806 ± 0.054	1.04IleLys: 1.04 ± 0.032	3.547IleLeu: 3.547 ± 0.064	0.704IleMet: 0.704 ± 0.028	1.04IleAsn: 1.04 ± 0.03	2.202IlePro: 2.202 ± 0.048	1.067IleGln: 1.067 ± 0.035	2.641IleArg: 2.641 ± 0.053	2.512IleSer: 2.512 ± 0.051	2.77IleThr: 2.77 ± 0.049	4.534IleVal: 4.534 ± 0.063	0.52IleTrp: 0.52 ± 0.023	0.769IleTyr: 0.769 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.048LysAla: 3.048 ± 0.066	0.108LysCys: 0.108 ± 0.011	1.518LysAsp: 1.518 ± 0.05	1.11LysGlu: 1.11 ± 0.035	0.693LysPhe: 0.693 ± 0.027	1.904LysGly: 1.904 ± 0.056	0.527LysHis: 0.527 ± 0.023	1.213LysIle: 1.213 ± 0.039	1.023LysLys: 1.023 ± 0.043	2.076LysLeu: 2.076 ± 0.052	0.509LysMet: 0.509 ± 0.024	0.585LysAsn: 0.585 ± 0.027	1.408LysPro: 1.408 ± 0.04	0.872LysGln: 0.872 ± 0.033	1.664LysArg: 1.664 ± 0.041	1.465LysSer: 1.465 ± 0.036	1.467LysThr: 1.467 ± 0.051	2.148LysVal: 2.148 ± 0.055	0.259LysTrp: 0.259 ± 0.018	0.528LysTyr: 0.528 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.887LeuAla: 13.887 ± 0.151	0.615LeuCys: 0.615 ± 0.026	7.074LeuAsp: 7.074 ± 0.098	5.198LeuGlu: 5.198 ± 0.085	2.623LeuPhe: 2.623 ± 0.052	9.284LeuGly: 9.284 ± 0.109	2.011LeuHis: 2.011 ± 0.042	4.147LeuIle: 4.147 ± 0.064	2.125LeuLys: 2.125 ± 0.051	10.046LeuLeu: 10.046 ± 0.128	1.789LeuMet: 1.789 ± 0.045	1.854LeuAsn: 1.854 ± 0.046	5.29LeuPro: 5.29 ± 0.076	2.468LeuGln: 2.468 ± 0.051	7.113LeuArg: 7.113 ± 0.087	5.816LeuSer: 5.816 ± 0.08	6.425LeuThr: 6.425 ± 0.079	9.449LeuVal: 9.449 ± 0.115	1.115LeuTrp: 1.115 ± 0.035	1.514LeuTyr: 1.514 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.438MetAla: 2.438 ± 0.047	0.141MetCys: 0.141 ± 0.013	0.99MetAsp: 0.99 ± 0.032	0.749MetGlu: 0.749 ± 0.028	0.616MetPhe: 0.616 ± 0.021	1.475MetGly: 1.475 ± 0.034	0.435MetHis: 0.435 ± 0.02	1.007MetIle: 1.007 ± 0.031	0.535MetLys: 0.535 ± 0.026	2.024MetLeu: 2.024 ± 0.052	0.36MetMet: 0.36 ± 0.022	0.478MetAsn: 0.478 ± 0.024	1.159MetPro: 1.159 ± 0.035	0.576MetGln: 0.576 ± 0.022	1.572MetArg: 1.572 ± 0.037	1.668MetSer: 1.668 ± 0.043	1.91MetThr: 1.91 ± 0.043	1.523MetVal: 1.523 ± 0.037	0.234MetTrp: 0.234 ± 0.016	0.353MetTyr: 0.353 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.373AsnAla: 2.373 ± 0.053	0.16AsnCys: 0.16 ± 0.014	1.265AsnAsp: 1.265 ± 0.041	0.951AsnGlu: 0.951 ± 0.033	0.587AsnPhe: 0.587 ± 0.026	1.861AsnGly: 1.861 ± 0.043	0.414AsnHis: 0.414 ± 0.018	0.901AsnIle: 0.901 ± 0.031	0.513AsnLys: 0.513 ± 0.025	2.051AsnLeu: 2.051 ± 0.048	0.314AsnMet: 0.314 ± 0.015	0.516AsnAsn: 0.516 ± 0.028	1.398AsnPro: 1.398 ± 0.04	0.647AsnGln: 0.647 ± 0.026	1.43AsnArg: 1.43 ± 0.042	1.049AsnSer: 1.049 ± 0.031	1.195AsnThr: 1.195 ± 0.041	1.685AsnVal: 1.685 ± 0.048	0.285AsnTrp: 0.285 ± 0.017	0.447AsnTyr: 0.447 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.154ProAla: 6.154 ± 0.09	0.254ProCys: 0.254 ± 0.017	4.059ProAsp: 4.059 ± 0.071	3.532ProGlu: 3.532 ± 0.061	1.573ProPhe: 1.573 ± 0.041	4.889ProGly: 4.889 ± 0.081	1.221ProHis: 1.221 ± 0.034	2.087ProIle: 2.087 ± 0.048	1.204ProLys: 1.204 ± 0.035	4.537ProLeu: 4.537 ± 0.066	1.096ProMet: 1.096 ± 0.031	0.951ProAsn: 0.951 ± 0.029	2.371ProPro: 2.371 ± 0.065	1.388ProGln: 1.388 ± 0.038	3.306ProArg: 3.306 ± 0.057	3.106ProSer: 3.106 ± 0.058	3.396ProThr: 3.396 ± 0.065	4.506ProVal: 4.506 ± 0.069	0.813ProTrp: 0.813 ± 0.033	1.097ProTyr: 1.097 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.66GlnAla: 3.66 ± 0.066	0.164GlnCys: 0.164 ± 0.013	1.398GlnAsp: 1.398 ± 0.044	1.235GlnGlu: 1.235 ± 0.04	0.868GlnPhe: 0.868 ± 0.025	2.159GlnGly: 2.159 ± 0.036	0.741GlnHis: 0.741 ± 0.026	1.682GlnIle: 1.682 ± 0.037	0.741GlnLys: 0.741 ± 0.031	3.071GlnLeu: 3.071 ± 0.059	0.682GlnMet: 0.682 ± 0.029	0.559GlnAsn: 0.559 ± 0.026	1.502GlnPro: 1.502 ± 0.045	1.168GlnGln: 1.168 ± 0.033	2.459GlnArg: 2.459 ± 0.053	1.586GlnSer: 1.586 ± 0.032	1.659GlnThr: 1.659 ± 0.041	2.768GlnVal: 2.768 ± 0.051	0.472GlnTrp: 0.472 ± 0.023	0.519GlnTyr: 0.519 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.787ArgAla: 7.787 ± 0.115	0.466ArgCys: 0.466 ± 0.024	4.103ArgAsp: 4.103 ± 0.057	4.002ArgGlu: 4.002 ± 0.074	2.3ArgPhe: 2.3 ± 0.052	5.194ArgGly: 5.194 ± 0.079	1.828ArgHis: 1.828 ± 0.046	3.537ArgIle: 3.537 ± 0.051	1.661ArgLys: 1.661 ± 0.042	7.524ArgLeu: 7.524 ± 0.11	1.686ArgMet: 1.686 ± 0.037	1.466ArgAsn: 1.466 ± 0.042	3.666ArgPro: 3.666 ± 0.068	2.246ArgGln: 2.246 ± 0.048	6.237ArgArg: 6.237 ± 0.096	4.522ArgSer: 4.522 ± 0.077	4.557ArgThr: 4.557 ± 0.061	5.62ArgVal: 5.62 ± 0.078	1.194ArgTrp: 1.194 ± 0.029	1.417ArgTyr: 1.417 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.032SerAla: 7.032 ± 0.083	0.42SerCys: 0.42 ± 0.026	3.5SerAsp: 3.5 ± 0.058	2.801SerGlu: 2.801 ± 0.061	1.892SerPhe: 1.892 ± 0.041	5.969SerGly: 5.969 ± 0.088	1.169SerHis: 1.169 ± 0.035	2.779SerIle: 2.779 ± 0.057	1.384SerLys: 1.384 ± 0.046	5.632SerLeu: 5.632 ± 0.083	1.536SerMet: 1.536 ± 0.04	1.209SerAsn: 1.209 ± 0.039	3.068SerPro: 3.068 ± 0.062	1.573SerGln: 1.573 ± 0.038	3.962SerArg: 3.962 ± 0.068	3.941SerSer: 3.941 ± 0.078	3.946SerThr: 3.946 ± 0.082	4.81SerVal: 4.81 ± 0.068	0.934SerTrp: 0.934 ± 0.029	1.299SerTyr: 1.299 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	7.359ThrAla: 7.359 ± 0.108	0.451ThrCys: 0.451 ± 0.023	3.723ThrAsp: 3.723 ± 0.067	3.158ThrGlu: 3.158 ± 0.057	2.065ThrPhe: 2.065 ± 0.045	5.827ThrGly: 5.827 ± 0.08	1.218ThrHis: 1.218 ± 0.029	3.18ThrIle: 3.18 ± 0.067	1.505ThrLys: 1.505 ± 0.039	5.78ThrLeu: 5.78 ± 0.07	1.256ThrMet: 1.256 ± 0.029	1.24ThrAsn: 1.24 ± 0.043	3.657ThrPro: 3.657 ± 0.065	1.563ThrGln: 1.563 ± 0.037	3.689ThrArg: 3.689 ± 0.062	3.877ThrSer: 3.877 ± 0.065	4.174ThrThr: 4.174 ± 0.081	5.693ThrVal: 5.693 ± 0.099	0.982ThrTrp: 0.982 ± 0.033	1.583ThrTyr: 1.583 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	11.247ValAla: 11.247 ± 0.117	0.674ValCys: 0.674 ± 0.027	6.077ValAsp: 6.077 ± 0.097	5.353ValGlu: 5.353 ± 0.078	2.577ValPhe: 2.577 ± 0.052	7.51ValGly: 7.51 ± 0.09	1.864ValHis: 1.864 ± 0.047	4.032ValIle: 4.032 ± 0.074	1.964ValLys: 1.964 ± 0.057	9.166ValLeu: 9.166 ± 0.115	1.735ValMet: 1.735 ± 0.044	1.848ValAsn: 1.848 ± 0.041	4.526ValPro: 4.526 ± 0.072	2.18ValGln: 2.18 ± 0.043	6.172ValArg: 6.172 ± 0.08	5.05ValSer: 5.05 ± 0.074	5.897ValThr: 5.897 ± 0.09	9.062ValVal: 9.062 ± 0.114	1.135ValTrp: 1.135 ± 0.034	1.375ValTyr: 1.375 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.488TrpAla: 1.488 ± 0.042	0.139TrpCys: 0.139 ± 0.012	0.806TrpAsp: 0.806 ± 0.03	0.604TrpGlu: 0.604 ± 0.022	0.531TrpPhe: 0.531 ± 0.024	0.984TrpGly: 0.984 ± 0.033	0.36TrpHis: 0.36 ± 0.018	0.738TrpIle: 0.738 ± 0.025	0.35TrpLys: 0.35 ± 0.019	1.575TrpLeu: 1.575 ± 0.047	0.315TrpMet: 0.315 ± 0.019	0.343TrpAsn: 0.343 ± 0.019	0.71TrpPro: 0.71 ± 0.029	0.541TrpGln: 0.541 ± 0.022	1.138TrpArg: 1.138 ± 0.036	1.038TrpSer: 1.038 ± 0.033	0.964TrpThr: 0.964 ± 0.033	1.076TrpVal: 1.076 ± 0.035	0.34TrpTrp: 0.34 ± 0.02	0.282TrpTyr: 0.282 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.632TyrAla: 2.632 ± 0.048	0.138TyrCys: 0.138 ± 0.01	1.526TyrAsp: 1.526 ± 0.039	1.114TyrGlu: 1.114 ± 0.036	0.716TyrPhe: 0.716 ± 0.026	1.937TyrGly: 1.937 ± 0.047	0.316TyrHis: 0.316 ± 0.019	0.628TyrIle: 0.628 ± 0.022	0.415TyrLys: 0.415 ± 0.021	2.012TyrLeu: 2.012 ± 0.042	0.232TyrMet: 0.232 ± 0.017	0.362TyrAsn: 0.362 ± 0.022	0.934TyrPro: 0.934 ± 0.028	0.539TyrGln: 0.539 ± 0.022	1.457TyrArg: 1.457 ± 0.037	1.058TyrSer: 1.058 ± 0.034	0.993TyrThr: 0.993 ± 0.035	1.975TyrVal: 1.975 ± 0.043	0.294TyrTrp: 0.294 ± 0.018	0.429TyrTyr: 0.429 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3244 proteins (1042278 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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