Amino acid dipepetide frequency for Acidovorax delafieldii 2AN

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.952AlaAla: 17.952 ± 0.161
1.405AlaCys: 1.405 ± 0.035
6.216AlaAsp: 6.216 ± 0.07
6.449AlaGlu: 6.449 ± 0.079
3.977AlaPhe: 3.977 ± 0.055
10.793AlaGly: 10.793 ± 0.103
2.998AlaHis: 2.998 ± 0.052
5.162AlaIle: 5.162 ± 0.062
3.762AlaLys: 3.762 ± 0.069
15.6AlaLeu: 15.6 ± 0.127
3.614AlaMet: 3.614 ± 0.055
2.807AlaAsn: 2.807 ± 0.059
6.617AlaPro: 6.617 ± 0.087
6.738AlaGln: 6.738 ± 0.078
9.122AlaArg: 9.122 ± 0.096
6.925AlaSer: 6.925 ± 0.075
6.512AlaThr: 6.512 ± 0.081
9.442AlaVal: 9.442 ± 0.096
1.992AlaTrp: 1.992 ± 0.046
2.448AlaTyr: 2.448 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.312CysAla: 1.312 ± 0.031
0.147CysCys: 0.147 ± 0.012
0.524CysAsp: 0.524 ± 0.022
0.502CysGlu: 0.502 ± 0.017
0.319CysPhe: 0.319 ± 0.017
0.99CysGly: 0.99 ± 0.029
0.308CysHis: 0.308 ± 0.018
0.443CysIle: 0.443 ± 0.02
0.254CysLys: 0.254 ± 0.014
0.834CysLeu: 0.834 ± 0.026
0.264CysMet: 0.264 ± 0.015
0.26CysAsn: 0.26 ± 0.014
0.573CysPro: 0.573 ± 0.022
0.319CysGln: 0.319 ± 0.018
0.573CysArg: 0.573 ± 0.021
0.572CysSer: 0.572 ± 0.021
0.592CysThr: 0.592 ± 0.022
0.75CysVal: 0.75 ± 0.025
0.138CysTrp: 0.138 ± 0.01
0.221CysTyr: 0.221 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.934AspAla: 6.934 ± 0.08
0.455AspCys: 0.455 ± 0.021
2.465AspAsp: 2.465 ± 0.047
2.904AspGlu: 2.904 ± 0.053
1.913AspPhe: 1.913 ± 0.039
4.257AspGly: 4.257 ± 0.059
1.138AspHis: 1.138 ± 0.029
2.398AspIle: 2.398 ± 0.043
1.732AspLys: 1.732 ± 0.041
5.231AspLeu: 5.231 ± 0.075
1.284AspMet: 1.284 ± 0.031
1.163AspAsn: 1.163 ± 0.031
2.711AspPro: 2.711 ± 0.048
1.623AspGln: 1.623 ± 0.032
3.153AspArg: 3.153 ± 0.044
2.203AspSer: 2.203 ± 0.039
2.565AspThr: 2.565 ± 0.044
3.963AspVal: 3.963 ± 0.062
0.886AspTrp: 0.886 ± 0.026
1.346AspTyr: 1.346 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
6.559GluAla: 6.559 ± 0.086
0.408GluCys: 0.408 ± 0.017
2.185GluAsp: 2.185 ± 0.038
2.427GluGlu: 2.427 ± 0.048
1.732GluPhe: 1.732 ± 0.034
3.755GluGly: 3.755 ± 0.054
1.339GluHis: 1.339 ± 0.033
2.506GluIle: 2.506 ± 0.046
1.9GluLys: 1.9 ± 0.042
5.49GluLeu: 5.49 ± 0.073
1.222GluMet: 1.222 ± 0.028
1.227GluAsn: 1.227 ± 0.029
2.479GluPro: 2.479 ± 0.043
2.605GluGln: 2.605 ± 0.049
4.521GluArg: 4.521 ± 0.062
2.463GluSer: 2.463 ± 0.044
2.447GluThr: 2.447 ± 0.05
3.988GluVal: 3.988 ± 0.059
0.714GluTrp: 0.714 ± 0.023
1.01GluTyr: 1.01 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.23PheAla: 4.23 ± 0.055
0.413PheCys: 0.413 ± 0.018
2.361PheAsp: 2.361 ± 0.044
1.895PheGlu: 1.895 ± 0.044
1.367PhePhe: 1.367 ± 0.037
3.236PheGly: 3.236 ± 0.056
0.748PheHis: 0.748 ± 0.026
1.423PheIle: 1.423 ± 0.033
1.167PheLys: 1.167 ± 0.026
2.896PheLeu: 2.896 ± 0.044
0.809PheMet: 0.809 ± 0.024
1.071PheAsn: 1.071 ± 0.03
1.474PhePro: 1.474 ± 0.035
1.085PheGln: 1.085 ± 0.028
1.846PheArg: 1.846 ± 0.038
2.084PheSer: 2.084 ± 0.036
1.981PheThr: 1.981 ± 0.043
2.733PheVal: 2.733 ± 0.047
0.509PheTrp: 0.509 ± 0.021
0.834PheTyr: 0.834 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
9.617GlyAla: 9.617 ± 0.095
0.944GlyCys: 0.944 ± 0.025
3.85GlyAsp: 3.85 ± 0.052
4.184GlyGlu: 4.184 ± 0.062
3.21GlyPhe: 3.21 ± 0.046
7.01GlyGly: 7.01 ± 0.094
2.009GlyHis: 2.009 ± 0.035
3.892GlyIle: 3.892 ± 0.059
3.236GlyLys: 3.236 ± 0.055
8.834GlyLeu: 8.834 ± 0.094
2.433GlyMet: 2.433 ± 0.046
2.198GlyAsn: 2.198 ± 0.048
3.08GlyPro: 3.08 ± 0.052
3.638GlyGln: 3.638 ± 0.051
5.37GlyArg: 5.37 ± 0.065
4.578GlySer: 4.578 ± 0.059
4.718GlyThr: 4.718 ± 0.078
6.694GlyVal: 6.694 ± 0.076
1.441GlyTrp: 1.441 ± 0.034
2.284GlyTyr: 2.284 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
3.097HisAla: 3.097 ± 0.052
0.354HisCys: 0.354 ± 0.014
1.169HisAsp: 1.169 ± 0.03
1.195HisGlu: 1.195 ± 0.03
0.919HisPhe: 0.919 ± 0.023
2.213HisGly: 2.213 ± 0.042
0.717HisHis: 0.717 ± 0.026
1.066HisIle: 1.066 ± 0.029
0.586HisLys: 0.586 ± 0.024
2.429HisLeu: 2.429 ± 0.046
0.566HisMet: 0.566 ± 0.021
0.55HisAsn: 0.55 ± 0.021
1.629HisPro: 1.629 ± 0.036
0.884HisGln: 0.884 ± 0.023
1.557HisArg: 1.557 ± 0.032
1.149HisSer: 1.149 ± 0.026
1.22HisThr: 1.22 ± 0.032
1.626HisVal: 1.626 ± 0.032
0.434HisTrp: 0.434 ± 0.017
0.634HisTyr: 0.634 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.917IleAla: 5.917 ± 0.075
0.411IleCys: 0.411 ± 0.018
2.846IleAsp: 2.846 ± 0.043
2.863IleGlu: 2.863 ± 0.051
1.273IlePhe: 1.273 ± 0.036
3.716IleGly: 3.716 ± 0.053
0.92IleHis: 0.92 ± 0.027
1.5IleIle: 1.5 ± 0.036
1.461IleLys: 1.461 ± 0.035
3.207IleLeu: 3.207 ± 0.053
0.751IleMet: 0.751 ± 0.025
1.414IleAsn: 1.414 ± 0.034
2.043IlePro: 2.043 ± 0.035
1.345IleGln: 1.345 ± 0.032
2.457IleArg: 2.457 ± 0.047
2.282IleSer: 2.282 ± 0.039
2.589IleThr: 2.589 ± 0.045
3.396IleVal: 3.396 ± 0.052
0.441IleTrp: 0.441 ± 0.019
0.948IleTyr: 0.948 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
4.156LysAla: 4.156 ± 0.073
0.176LysCys: 0.176 ± 0.011
1.693LysAsp: 1.693 ± 0.041
1.54LysGlu: 1.54 ± 0.039
0.874LysPhe: 0.874 ± 0.026
2.479LysGly: 2.479 ± 0.046
0.642LysHis: 0.642 ± 0.021
1.52LysIle: 1.52 ± 0.045
1.417LysLys: 1.417 ± 0.043
3.333LysLeu: 3.333 ± 0.055
0.812LysMet: 0.812 ± 0.028
0.97LysAsn: 0.97 ± 0.029
1.949LysPro: 1.949 ± 0.036
1.172LysGln: 1.172 ± 0.034
1.995LysArg: 1.995 ± 0.039
1.713LysSer: 1.713 ± 0.044
1.902LysThr: 1.902 ± 0.042
2.587LysVal: 2.587 ± 0.051
0.355LysTrp: 0.355 ± 0.017
0.668LysTyr: 0.668 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
15.073LeuAla: 15.073 ± 0.147
1.131LeuCys: 1.131 ± 0.031
5.503LeuAsp: 5.503 ± 0.072
5.126LeuGlu: 5.126 ± 0.072
3.29LeuPhe: 3.29 ± 0.049
8.646LeuGly: 8.646 ± 0.082
2.55LeuHis: 2.55 ± 0.05
4.056LeuIle: 4.056 ± 0.061
3.392LeuLys: 3.392 ± 0.062
11.195LeuLeu: 11.195 ± 0.131
2.561LeuMet: 2.561 ± 0.044
2.634LeuAsn: 2.634 ± 0.046
6.089LeuPro: 6.089 ± 0.069
4.892LeuGln: 4.892 ± 0.065
7.783LeuArg: 7.783 ± 0.088
5.832LeuSer: 5.832 ± 0.066
5.317LeuThr: 5.317 ± 0.058
8.154LeuVal: 8.154 ± 0.1
1.409LeuTrp: 1.409 ± 0.035
2.03LeuTyr: 2.03 ± 0.042
0.001LeuXaa: 0.001 ± 0.001
Met
3.425MetAla: 3.425 ± 0.049
0.189MetCys: 0.189 ± 0.012
1.223MetAsp: 1.223 ± 0.029
1.14MetGlu: 1.14 ± 0.028
0.675MetPhe: 0.675 ± 0.024
2.093MetGly: 2.093 ± 0.044
0.642MetHis: 0.642 ± 0.021
0.831MetIle: 0.831 ± 0.028
0.986MetLys: 0.986 ± 0.023
2.63MetLeu: 2.63 ± 0.047
0.535MetMet: 0.535 ± 0.02
0.805MetAsn: 0.805 ± 0.024
1.532MetPro: 1.532 ± 0.032
1.173MetGln: 1.173 ± 0.03
1.722MetArg: 1.722 ± 0.036
1.48MetSer: 1.48 ± 0.035
1.507MetThr: 1.507 ± 0.032
1.968MetVal: 1.968 ± 0.035
0.22MetTrp: 0.22 ± 0.012
0.401MetTyr: 0.401 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.463AsnAla: 3.463 ± 0.056
0.259AsnCys: 0.259 ± 0.014
1.296AsnAsp: 1.296 ± 0.033
1.173AsnGlu: 1.173 ± 0.028
0.916AsnPhe: 0.916 ± 0.028
2.119AsnGly: 2.119 ± 0.047
0.551AsnHis: 0.551 ± 0.02
1.177AsnIle: 1.177 ± 0.028
0.81AsnLys: 0.81 ± 0.024
2.562AsnLeu: 2.562 ± 0.038
0.576AsnMet: 0.576 ± 0.021
0.751AsnAsn: 0.751 ± 0.029
1.82AsnPro: 1.82 ± 0.035
0.969AsnGln: 0.969 ± 0.03
1.591AsnArg: 1.591 ± 0.034
1.126AsnSer: 1.126 ± 0.031
1.487AsnThr: 1.487 ± 0.038
1.967AsnVal: 1.967 ± 0.041
0.372AsnTrp: 0.372 ± 0.016
0.642AsnTyr: 0.642 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
7.31ProAla: 7.31 ± 0.088
0.416ProCys: 0.416 ± 0.019
3.034ProAsp: 3.034 ± 0.044
3.256ProGlu: 3.256 ± 0.054
1.812ProPhe: 1.812 ± 0.037
4.874ProGly: 4.874 ± 0.074
1.266ProHis: 1.266 ± 0.027
1.82ProIle: 1.82 ± 0.041
1.404ProLys: 1.404 ± 0.037
5.522ProLeu: 5.522 ± 0.064
1.338ProMet: 1.338 ± 0.033
1.175ProAsn: 1.175 ± 0.029
2.855ProPro: 2.855 ± 0.051
2.379ProGln: 2.379 ± 0.043
3.065ProArg: 3.065 ± 0.049
2.901ProSer: 2.901 ± 0.046
2.649ProThr: 2.649 ± 0.047
4.353ProVal: 4.353 ± 0.055
0.822ProTrp: 0.822 ± 0.025
1.197ProTyr: 1.197 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
6.225GlnAla: 6.225 ± 0.088
0.354GlnCys: 0.354 ± 0.016
1.788GlnAsp: 1.788 ± 0.043
1.873GlnGlu: 1.873 ± 0.044
1.397GlnPhe: 1.397 ± 0.031
3.584GlnGly: 3.584 ± 0.053
1.097GlnHis: 1.097 ± 0.031
1.748GlnIle: 1.748 ± 0.034
1.231GlnLys: 1.231 ± 0.03
4.405GlnLeu: 4.405 ± 0.057
1.101GlnMet: 1.101 ± 0.029
0.953GlnAsn: 0.953 ± 0.028
2.531GlnPro: 2.531 ± 0.042
2.146GlnGln: 2.146 ± 0.042
3.722GlnArg: 3.722 ± 0.056
2.209GlnSer: 2.209 ± 0.041
2.008GlnThr: 2.008 ± 0.041
3.268GlnVal: 3.268 ± 0.044
0.805GlnTrp: 0.805 ± 0.023
0.82GlnTyr: 0.82 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
7.845ArgAla: 7.845 ± 0.085
0.64ArgCys: 0.64 ± 0.024
3.372ArgAsp: 3.372 ± 0.06
3.896ArgGlu: 3.896 ± 0.057
2.682ArgPhe: 2.682 ± 0.041
4.593ArgGly: 4.593 ± 0.059
1.904ArgHis: 1.904 ± 0.038
3.308ArgIle: 3.308 ± 0.052
2.192ArgLys: 2.192 ± 0.044
7.63ArgLeu: 7.63 ± 0.089
1.979ArgMet: 1.979 ± 0.033
1.886ArgAsn: 1.886 ± 0.037
3.259ArgPro: 3.259 ± 0.048
3.136ArgGln: 3.136 ± 0.055
4.936ArgArg: 4.936 ± 0.066
3.63ArgSer: 3.63 ± 0.051
3.465ArgThr: 3.465 ± 0.053
4.921ArgVal: 4.921 ± 0.061
1.254ArgTrp: 1.254 ± 0.034
1.751ArgTyr: 1.751 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
6.755SerAla: 6.755 ± 0.071
0.495SerCys: 0.495 ± 0.018
2.547SerAsp: 2.547 ± 0.045
2.401SerGlu: 2.401 ± 0.043
1.955SerPhe: 1.955 ± 0.04
5.044SerGly: 5.044 ± 0.073
1.291SerHis: 1.291 ± 0.032
2.287SerIle: 2.287 ± 0.048
1.5SerLys: 1.5 ± 0.034
5.441SerLeu: 5.441 ± 0.062
1.375SerMet: 1.375 ± 0.032
1.367SerAsn: 1.367 ± 0.032
2.945SerPro: 2.945 ± 0.05
1.916SerGln: 1.916 ± 0.042
3.362SerArg: 3.362 ± 0.052
3.053SerSer: 3.053 ± 0.054
3.101SerThr: 3.101 ± 0.05
4.124SerVal: 4.124 ± 0.059
0.673SerTrp: 0.673 ± 0.022
1.276SerTyr: 1.276 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.569ThrAla: 6.569 ± 0.076
0.459ThrCys: 0.459 ± 0.019
2.556ThrAsp: 2.556 ± 0.039
2.436ThrGlu: 2.436 ± 0.042
1.734ThrPhe: 1.734 ± 0.034
4.904ThrGly: 4.904 ± 0.067
1.256ThrHis: 1.256 ± 0.027
2.113ThrIle: 2.113 ± 0.04
1.324ThrLys: 1.324 ± 0.032
6.355ThrLeu: 6.355 ± 0.069
1.151ThrMet: 1.151 ± 0.032
1.229ThrAsn: 1.229 ± 0.034
3.717ThrPro: 3.717 ± 0.056
2.132ThrGln: 2.132 ± 0.045
3.253ThrArg: 3.253 ± 0.055
2.741ThrSer: 2.741 ± 0.048
3.071ThrThr: 3.071 ± 0.049
4.43ThrVal: 4.43 ± 0.062
0.681ThrTrp: 0.681 ± 0.02
1.086ThrTyr: 1.086 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.992ValAla: 9.992 ± 0.093
0.79ValCys: 0.79 ± 0.022
3.93ValAsp: 3.93 ± 0.05
4.006ValGlu: 4.006 ± 0.052
2.694ValPhe: 2.694 ± 0.04
5.877ValGly: 5.877 ± 0.073
1.758ValHis: 1.758 ± 0.035
3.134ValIle: 3.134 ± 0.05
2.437ValLys: 2.437 ± 0.05
8.646ValLeu: 8.646 ± 0.092
1.91ValMet: 1.91 ± 0.036
2.156ValAsn: 2.156 ± 0.043
4.221ValPro: 4.221 ± 0.061
3.471ValGln: 3.471 ± 0.052
5.41ValArg: 5.41 ± 0.069
3.973ValSer: 3.973 ± 0.054
4.109ValThr: 4.109 ± 0.065
6.781ValVal: 6.781 ± 0.082
1.01ValTrp: 1.01 ± 0.031
1.523ValTyr: 1.523 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.486TrpAla: 1.486 ± 0.032
0.185TrpCys: 0.185 ± 0.011
0.595TrpAsp: 0.595 ± 0.02
0.554TrpGlu: 0.554 ± 0.021
0.529TrpPhe: 0.529 ± 0.023
1.06TrpGly: 1.06 ± 0.032
0.414TrpHis: 0.414 ± 0.016
0.629TrpIle: 0.629 ± 0.022
0.465TrpLys: 0.465 ± 0.018
2.112TrpLeu: 2.112 ± 0.047
0.469TrpMet: 0.469 ± 0.02
0.41TrpAsn: 0.41 ± 0.017
0.748TrpPro: 0.748 ± 0.021
0.756TrpGln: 0.756 ± 0.022
1.193TrpArg: 1.193 ± 0.034
0.805TrpSer: 0.805 ± 0.026
0.741TrpThr: 0.741 ± 0.025
1.09TrpVal: 1.09 ± 0.03
0.286TrpTrp: 0.286 ± 0.015
0.276TrpTyr: 0.276 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.615TyrAla: 2.615 ± 0.044
0.262TyrCys: 0.262 ± 0.014
1.174TyrAsp: 1.174 ± 0.03
1.158TyrGlu: 1.158 ± 0.029
0.892TyrPhe: 0.892 ± 0.025
1.976TyrGly: 1.976 ± 0.034
0.445TyrHis: 0.445 ± 0.018
0.767TyrIle: 0.767 ± 0.025
0.698TyrLys: 0.698 ± 0.026
2.311TyrLeu: 2.311 ± 0.047
0.428TyrMet: 0.428 ± 0.017
0.601TyrAsn: 0.601 ± 0.022
1.179TyrPro: 1.179 ± 0.026
0.887TyrGln: 0.887 ± 0.026
1.646TyrArg: 1.646 ± 0.035
1.192TyrSer: 1.192 ± 0.029
1.212TyrThr: 1.212 ± 0.032
1.594TyrVal: 1.594 ± 0.034
0.36TyrTrp: 0.36 ± 0.017
0.563TyrTyr: 0.563 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.001
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4890 proteins (1405549 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski