Amino acid dipepetide frequency for Acidovorax anthurii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.431AlaAla: 20.431 ± 0.176
1.471AlaCys: 1.471 ± 0.033
6.54AlaAsp: 6.54 ± 0.072
6.823AlaGlu: 6.823 ± 0.082
4.174AlaPhe: 4.174 ± 0.051
12.454AlaGly: 12.454 ± 0.12
3.029AlaHis: 3.029 ± 0.047
5.072AlaIle: 5.072 ± 0.069
3.049AlaLys: 3.049 ± 0.062
16.337AlaLeu: 16.337 ± 0.157
3.469AlaMet: 3.469 ± 0.046
2.562AlaAsn: 2.562 ± 0.043
8.028AlaPro: 8.028 ± 0.102
6.438AlaGln: 6.438 ± 0.08
11.077AlaArg: 11.077 ± 0.103
7.196AlaSer: 7.196 ± 0.085
6.549AlaThr: 6.549 ± 0.082
9.678AlaVal: 9.678 ± 0.091
2.249AlaTrp: 2.249 ± 0.038
2.503AlaTyr: 2.503 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.303CysAla: 1.303 ± 0.032
0.112CysCys: 0.112 ± 0.009
0.536CysAsp: 0.536 ± 0.016
0.514CysGlu: 0.514 ± 0.016
0.279CysPhe: 0.279 ± 0.012
0.962CysGly: 0.962 ± 0.027
0.249CysHis: 0.249 ± 0.013
0.379CysIle: 0.379 ± 0.018
0.169CysLys: 0.169 ± 0.011
0.865CysLeu: 0.865 ± 0.025
0.202CysMet: 0.202 ± 0.012
0.197CysAsn: 0.197 ± 0.012
0.473CysPro: 0.473 ± 0.021
0.274CysGln: 0.274 ± 0.014
0.604CysArg: 0.604 ± 0.022
0.466CysSer: 0.466 ± 0.02
0.505CysThr: 0.505 ± 0.02
0.725CysVal: 0.725 ± 0.024
0.13CysTrp: 0.13 ± 0.012
0.201CysTyr: 0.201 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.859AspAla: 7.859 ± 0.086
0.439AspCys: 0.439 ± 0.019
2.46AspAsp: 2.46 ± 0.05
2.71AspGlu: 2.71 ± 0.046
1.942AspPhe: 1.942 ± 0.036
4.895AspGly: 4.895 ± 0.075
1.13AspHis: 1.13 ± 0.027
2.204AspIle: 2.204 ± 0.04
1.41AspLys: 1.41 ± 0.033
5.27AspLeu: 5.27 ± 0.063
1.162AspMet: 1.162 ± 0.025
1.078AspAsn: 1.078 ± 0.027
3.052AspPro: 3.052 ± 0.044
1.498AspGln: 1.498 ± 0.032
3.462AspArg: 3.462 ± 0.05
2.15AspSer: 2.15 ± 0.041
2.616AspThr: 2.616 ± 0.04
3.853AspVal: 3.853 ± 0.063
0.967AspTrp: 0.967 ± 0.026
1.287AspTyr: 1.287 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
7.18GluAla: 7.18 ± 0.084
0.394GluCys: 0.394 ± 0.017
2.226GluAsp: 2.226 ± 0.043
2.46GluGlu: 2.46 ± 0.047
1.588GluPhe: 1.588 ± 0.033
4.162GluGly: 4.162 ± 0.059
1.289GluHis: 1.289 ± 0.031
2.423GluIle: 2.423 ± 0.045
1.549GluLys: 1.549 ± 0.041
5.172GluLeu: 5.172 ± 0.06
1.135GluMet: 1.135 ± 0.026
1.133GluAsn: 1.133 ± 0.029
2.724GluPro: 2.724 ± 0.045
2.477GluGln: 2.477 ± 0.047
4.953GluArg: 4.953 ± 0.071
2.575GluSer: 2.575 ± 0.043
2.385GluThr: 2.385 ± 0.042
3.847GluVal: 3.847 ± 0.05
0.727GluTrp: 0.727 ± 0.023
0.941GluTyr: 0.941 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.168PheAla: 4.168 ± 0.061
0.369PheCys: 0.369 ± 0.015
2.261PheAsp: 2.261 ± 0.038
1.841PheGlu: 1.841 ± 0.034
1.223PhePhe: 1.223 ± 0.032
3.14PheGly: 3.14 ± 0.043
0.781PheHis: 0.781 ± 0.022
1.314PheIle: 1.314 ± 0.031
0.999PheLys: 0.999 ± 0.025
2.821PheLeu: 2.821 ± 0.046
0.723PheMet: 0.723 ± 0.023
0.947PheAsn: 0.947 ± 0.028
1.453PhePro: 1.453 ± 0.031
1.097PheGln: 1.097 ± 0.028
1.815PheArg: 1.815 ± 0.036
2.059PheSer: 2.059 ± 0.039
1.829PheThr: 1.829 ± 0.034
2.545PheVal: 2.545 ± 0.041
0.497PheTrp: 0.497 ± 0.02
0.745PheTyr: 0.745 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
10.854GlyAla: 10.854 ± 0.103
0.88GlyCys: 0.88 ± 0.024
4.202GlyAsp: 4.202 ± 0.06
4.516GlyGlu: 4.516 ± 0.06
3.137GlyPhe: 3.137 ± 0.048
7.839GlyGly: 7.839 ± 0.106
2.141GlyHis: 2.141 ± 0.04
3.816GlyIle: 3.816 ± 0.061
2.695GlyLys: 2.695 ± 0.05
9.192GlyLeu: 9.192 ± 0.083
2.401GlyMet: 2.401 ± 0.044
2.182GlyAsn: 2.182 ± 0.056
3.735GlyPro: 3.735 ± 0.057
3.552GlyGln: 3.552 ± 0.054
6.53GlyArg: 6.53 ± 0.079
4.646GlySer: 4.646 ± 0.068
5.119GlyThr: 5.119 ± 0.086
6.613GlyVal: 6.613 ± 0.076
1.52GlyTrp: 1.52 ± 0.034
2.225GlyTyr: 2.225 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
3.415HisAla: 3.415 ± 0.053
0.278HisCys: 0.278 ± 0.013
1.164HisAsp: 1.164 ± 0.032
1.149HisGlu: 1.149 ± 0.029
0.826HisPhe: 0.826 ± 0.026
2.343HisGly: 2.343 ± 0.043
0.641HisHis: 0.641 ± 0.019
0.901HisIle: 0.901 ± 0.025
0.473HisLys: 0.473 ± 0.017
2.312HisLeu: 2.312 ± 0.039
0.502HisMet: 0.502 ± 0.02
0.442HisAsn: 0.442 ± 0.016
1.673HisPro: 1.673 ± 0.036
0.808HisGln: 0.808 ± 0.024
1.688HisArg: 1.688 ± 0.036
1.002HisSer: 1.002 ± 0.023
1.07HisThr: 1.07 ± 0.027
1.627HisVal: 1.627 ± 0.03
0.442HisTrp: 0.442 ± 0.018
0.615HisTyr: 0.615 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.264IleAla: 6.264 ± 0.068
0.326IleCys: 0.326 ± 0.014
2.948IleAsp: 2.948 ± 0.049
2.681IleGlu: 2.681 ± 0.053
1.042IlePhe: 1.042 ± 0.033
3.751IleGly: 3.751 ± 0.056
0.869IleHis: 0.869 ± 0.023
1.19IleIle: 1.19 ± 0.032
1.156IleLys: 1.156 ± 0.03
2.992IleLeu: 2.992 ± 0.05
0.602IleMet: 0.602 ± 0.021
1.136IleAsn: 1.136 ± 0.029
1.876IlePro: 1.876 ± 0.035
1.298IleGln: 1.298 ± 0.031
2.459IleArg: 2.459 ± 0.046
1.95IleSer: 1.95 ± 0.042
2.193IleThr: 2.193 ± 0.043
3.148IleVal: 3.148 ± 0.054
0.399IleTrp: 0.399 ± 0.016
0.839IleTyr: 0.839 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
3.42LysAla: 3.42 ± 0.062
0.143LysCys: 0.143 ± 0.01
1.446LysAsp: 1.446 ± 0.039
1.274LysGlu: 1.274 ± 0.04
0.755LysPhe: 0.755 ± 0.025
2.099LysGly: 2.099 ± 0.042
0.487LysHis: 0.487 ± 0.017
1.189LysIle: 1.189 ± 0.032
1.117LysLys: 1.117 ± 0.044
2.636LysLeu: 2.636 ± 0.048
0.566LysMet: 0.566 ± 0.021
0.739LysAsn: 0.739 ± 0.026
1.685LysPro: 1.685 ± 0.039
0.934LysGln: 0.934 ± 0.023
1.755LysArg: 1.755 ± 0.035
1.455LysSer: 1.455 ± 0.036
1.64LysThr: 1.64 ± 0.036
2.094LysVal: 2.094 ± 0.044
0.282LysTrp: 0.282 ± 0.012
0.525LysTyr: 0.525 ± 0.02
0.001LysXaa: 0.001 ± 0.001
Leu
15.667LeuAla: 15.667 ± 0.148
1.087LeuCys: 1.087 ± 0.03
5.683LeuAsp: 5.683 ± 0.066
5.197LeuGlu: 5.197 ± 0.062
3.074LeuPhe: 3.074 ± 0.048
8.925LeuGly: 8.925 ± 0.088
2.463LeuHis: 2.463 ± 0.047
3.702LeuIle: 3.702 ± 0.059
2.839LeuLys: 2.839 ± 0.052
11.128LeuLeu: 11.128 ± 0.125
2.211LeuMet: 2.211 ± 0.039
2.334LeuAsn: 2.334 ± 0.043
6.504LeuPro: 6.504 ± 0.07
4.687LeuGln: 4.687 ± 0.066
8.765LeuArg: 8.765 ± 0.085
5.934LeuSer: 5.934 ± 0.067
4.812LeuThr: 4.812 ± 0.059
7.553LeuVal: 7.553 ± 0.073
1.433LeuTrp: 1.433 ± 0.033
1.992LeuTyr: 1.992 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
3.21MetAla: 3.21 ± 0.049
0.133MetCys: 0.133 ± 0.009
1.142MetAsp: 1.142 ± 0.027
1.133MetGlu: 1.133 ± 0.027
0.615MetPhe: 0.615 ± 0.022
1.889MetGly: 1.889 ± 0.037
0.549MetHis: 0.549 ± 0.019
0.688MetIle: 0.688 ± 0.022
0.795MetLys: 0.795 ± 0.027
2.38MetLeu: 2.38 ± 0.039
0.472MetMet: 0.472 ± 0.017
0.683MetAsn: 0.683 ± 0.02
1.569MetPro: 1.569 ± 0.033
1.034MetGln: 1.034 ± 0.024
1.618MetArg: 1.618 ± 0.034
1.308MetSer: 1.308 ± 0.031
1.353MetThr: 1.353 ± 0.03
1.686MetVal: 1.686 ± 0.035
0.188MetTrp: 0.188 ± 0.01
0.33MetTyr: 0.33 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.145AsnAla: 3.145 ± 0.049
0.217AsnCys: 0.217 ± 0.012
1.163AsnAsp: 1.163 ± 0.033
0.972AsnGlu: 0.972 ± 0.03
0.782AsnPhe: 0.782 ± 0.024
2.017AsnGly: 2.017 ± 0.047
0.498AsnHis: 0.498 ± 0.019
1.024AsnIle: 1.024 ± 0.026
0.581AsnLys: 0.581 ± 0.022
2.296AsnLeu: 2.296 ± 0.043
0.462AsnMet: 0.462 ± 0.018
0.626AsnAsn: 0.626 ± 0.02
1.686AsnPro: 1.686 ± 0.037
0.843AsnGln: 0.843 ± 0.021
1.531AsnArg: 1.531 ± 0.032
0.993AsnSer: 0.993 ± 0.027
1.291AsnThr: 1.291 ± 0.03
1.73AsnVal: 1.73 ± 0.037
0.333AsnTrp: 0.333 ± 0.014
0.572AsnTyr: 0.572 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
8.89ProAla: 8.89 ± 0.098
0.424ProCys: 0.424 ± 0.017
3.218ProAsp: 3.218 ± 0.051
3.451ProGlu: 3.451 ± 0.053
1.785ProPhe: 1.785 ± 0.036
5.638ProGly: 5.638 ± 0.069
1.342ProHis: 1.342 ± 0.033
1.739ProIle: 1.739 ± 0.036
1.144ProLys: 1.144 ± 0.035
5.76ProLeu: 5.76 ± 0.078
1.286ProMet: 1.286 ± 0.026
1.059ProAsn: 1.059 ± 0.026
3.727ProPro: 3.727 ± 0.072
2.362ProGln: 2.362 ± 0.039
3.858ProArg: 3.858 ± 0.058
3.185ProSer: 3.185 ± 0.05
2.535ProThr: 2.535 ± 0.039
4.414ProVal: 4.414 ± 0.057
0.91ProTrp: 0.91 ± 0.026
1.105ProTyr: 1.105 ± 0.025
0.001ProXaa: 0.001 ± 0.001
Gln
6.322GlnAla: 6.322 ± 0.081
0.32GlnCys: 0.32 ± 0.014
1.869GlnAsp: 1.869 ± 0.033
1.927GlnGlu: 1.927 ± 0.038
1.223GlnPhe: 1.223 ± 0.026
3.582GlnGly: 3.582 ± 0.046
0.869GlnHis: 0.869 ± 0.024
1.679GlnIle: 1.679 ± 0.032
1.069GlnLys: 1.069 ± 0.031
4.02GlnLeu: 4.02 ± 0.049
0.924GlnMet: 0.924 ± 0.023
0.869GlnAsn: 0.869 ± 0.028
2.483GlnPro: 2.483 ± 0.042
1.932GlnGln: 1.932 ± 0.04
3.656GlnArg: 3.656 ± 0.058
2.073GlnSer: 2.073 ± 0.038
1.766GlnThr: 1.766 ± 0.037
3.014GlnVal: 3.014 ± 0.046
0.772GlnTrp: 0.772 ± 0.022
0.82GlnTyr: 0.82 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
9.376ArgAla: 9.376 ± 0.093
0.645ArgCys: 0.645 ± 0.025
3.693ArgAsp: 3.693 ± 0.052
4.313ArgGlu: 4.313 ± 0.063
2.761ArgPhe: 2.761 ± 0.043
5.426ArgGly: 5.426 ± 0.064
2.232ArgHis: 2.232 ± 0.037
3.533ArgIle: 3.533 ± 0.043
1.971ArgLys: 1.971 ± 0.039
8.587ArgLeu: 8.587 ± 0.089
2.05ArgMet: 2.05 ± 0.034
1.698ArgAsn: 1.698 ± 0.034
3.955ArgPro: 3.955 ± 0.055
3.411ArgGln: 3.411 ± 0.055
5.929ArgArg: 5.929 ± 0.068
3.727ArgSer: 3.727 ± 0.053
3.646ArgThr: 3.646 ± 0.051
5.277ArgVal: 5.277 ± 0.063
1.406ArgTrp: 1.406 ± 0.035
1.875ArgTyr: 1.875 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
6.828SerAla: 6.828 ± 0.079
0.438SerCys: 0.438 ± 0.02
2.555SerAsp: 2.555 ± 0.038
2.336SerGlu: 2.336 ± 0.039
1.851SerPhe: 1.851 ± 0.036
5.395SerGly: 5.395 ± 0.067
1.187SerHis: 1.187 ± 0.026
2.182SerIle: 2.182 ± 0.045
1.182SerLys: 1.182 ± 0.028
5.481SerLeu: 5.481 ± 0.06
1.231SerMet: 1.231 ± 0.033
1.188SerAsn: 1.188 ± 0.03
3.194SerPro: 3.194 ± 0.047
1.838SerGln: 1.838 ± 0.035
3.595SerArg: 3.595 ± 0.047
3.057SerSer: 3.057 ± 0.061
2.882SerThr: 2.882 ± 0.053
3.94SerVal: 3.94 ± 0.057
0.646SerTrp: 0.646 ± 0.021
1.171SerTyr: 1.171 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
6.542ThrAla: 6.542 ± 0.074
0.381ThrCys: 0.381 ± 0.019
2.509ThrAsp: 2.509 ± 0.047
2.27ThrGlu: 2.27 ± 0.039
1.609ThrPhe: 1.609 ± 0.034
4.804ThrGly: 4.804 ± 0.083
1.118ThrHis: 1.118 ± 0.03
1.873ThrIle: 1.873 ± 0.039
1.047ThrLys: 1.047 ± 0.029
6.119ThrLeu: 6.119 ± 0.067
0.949ThrMet: 0.949 ± 0.026
1.093ThrAsn: 1.093 ± 0.026
3.692ThrPro: 3.692 ± 0.046
2.01ThrGln: 2.01 ± 0.037
3.298ThrArg: 3.298 ± 0.054
2.52ThrSer: 2.52 ± 0.05
2.767ThrThr: 2.767 ± 0.058
4.237ThrVal: 4.237 ± 0.055
0.659ThrTrp: 0.659 ± 0.023
1.114ThrTyr: 1.114 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
10.033ValAla: 10.033 ± 0.098
0.691ValCys: 0.691 ± 0.02
3.852ValAsp: 3.852 ± 0.047
4.085ValGlu: 4.085 ± 0.057
2.621ValPhe: 2.621 ± 0.039
5.503ValGly: 5.503 ± 0.068
1.675ValHis: 1.675 ± 0.036
2.897ValIle: 2.897 ± 0.053
1.971ValLys: 1.971 ± 0.046
8.298ValLeu: 8.298 ± 0.082
1.636ValMet: 1.636 ± 0.036
1.879ValAsn: 1.879 ± 0.035
4.476ValPro: 4.476 ± 0.058
3.09ValGln: 3.09 ± 0.05
5.746ValArg: 5.746 ± 0.066
3.936ValSer: 3.936 ± 0.056
3.743ValThr: 3.743 ± 0.067
6.156ValVal: 6.156 ± 0.075
0.929ValTrp: 0.929 ± 0.024
1.466ValTyr: 1.466 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.538TrpAla: 1.538 ± 0.036
0.172TrpCys: 0.172 ± 0.01
0.657TrpAsp: 0.657 ± 0.021
0.576TrpGlu: 0.576 ± 0.019
0.528TrpPhe: 0.528 ± 0.021
1.064TrpGly: 1.064 ± 0.032
0.397TrpHis: 0.397 ± 0.017
0.645TrpIle: 0.645 ± 0.023
0.468TrpLys: 0.468 ± 0.018
2.105TrpLeu: 2.105 ± 0.038
0.437TrpMet: 0.437 ± 0.017
0.404TrpAsn: 0.404 ± 0.017
0.755TrpPro: 0.755 ± 0.026
0.765TrpGln: 0.765 ± 0.021
1.408TrpArg: 1.408 ± 0.031
0.889TrpSer: 0.889 ± 0.026
0.751TrpThr: 0.751 ± 0.023
1.025TrpVal: 1.025 ± 0.027
0.292TrpTrp: 0.292 ± 0.014
0.259TrpTyr: 0.259 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.682TyrAla: 2.682 ± 0.044
0.226TyrCys: 0.226 ± 0.013
1.321TyrAsp: 1.321 ± 0.081
1.113TyrGlu: 1.113 ± 0.027
0.811TyrPhe: 0.811 ± 0.022
1.907TyrGly: 1.907 ± 0.04
0.425TyrHis: 0.425 ± 0.018
0.668TyrIle: 0.668 ± 0.02
0.559TyrLys: 0.559 ± 0.02
2.217TyrLeu: 2.217 ± 0.041
0.354TyrMet: 0.354 ± 0.014
0.511TyrAsn: 0.511 ± 0.021
1.091TyrPro: 1.091 ± 0.029
0.844TyrGln: 0.844 ± 0.026
1.762TyrArg: 1.762 ± 0.039
1.058TyrSer: 1.058 ± 0.025
1.161TyrThr: 1.161 ± 0.031
1.519TyrVal: 1.519 ± 0.033
0.352TyrTrp: 0.352 ± 0.016
0.534TyrTyr: 0.534 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.001
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.003
Statistics based on 4779 proteins (1605248 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski