Amino acid dipepetide frequency for Helicobacter bilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.384AlaAla: 3.384 ± 0.09
1.162AlaCys: 1.162 ± 0.061
3.057AlaAsp: 3.057 ± 0.065
3.104AlaGlu: 3.104 ± 0.082
3.465AlaPhe: 3.465 ± 0.089
3.557AlaGly: 3.557 ± 0.099
1.419AlaHis: 1.419 ± 0.049
5.862AlaIle: 5.862 ± 0.115
6.59AlaLys: 6.59 ± 0.106
8.025AlaLeu: 8.025 ± 0.117
2.206AlaMet: 2.206 ± 0.062
4.352AlaAsn: 4.352 ± 0.095
1.768AlaPro: 1.768 ± 0.063
3.147AlaGln: 3.147 ± 0.08
2.491AlaArg: 2.491 ± 0.068
3.87AlaSer: 3.87 ± 0.086
3.486AlaThr: 3.486 ± 0.075
3.155AlaVal: 3.155 ± 0.101
0.528AlaTrp: 0.528 ± 0.03
2.739AlaTyr: 2.739 ± 0.083
0.0AlaXaa: 0.0 ± 0.0
Cys
0.922CysAla: 0.922 ± 0.042
0.165CysCys: 0.165 ± 0.017
0.821CysAsp: 0.821 ± 0.038
0.848CysGlu: 0.848 ± 0.042
0.763CysPhe: 0.763 ± 0.035
0.955CysGly: 0.955 ± 0.04
0.347CysHis: 0.347 ± 0.023
1.149CysIle: 1.149 ± 0.051
1.075CysLys: 1.075 ± 0.047
1.16CysLeu: 1.16 ± 0.043
0.373CysMet: 0.373 ± 0.023
0.75CysAsn: 0.75 ± 0.04
0.342CysPro: 0.342 ± 0.021
0.245CysGln: 0.245 ± 0.019
0.354CysArg: 0.354 ± 0.022
0.816CysSer: 0.816 ± 0.036
0.397CysThr: 0.397 ± 0.027
1.184CysVal: 1.184 ± 0.046
0.067CysTrp: 0.067 ± 0.01
0.574CysTyr: 0.574 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
2.157AspAla: 2.157 ± 0.065
0.747AspCys: 0.747 ± 0.037
2.414AspAsp: 2.414 ± 0.07
3.449AspGlu: 3.449 ± 0.08
3.712AspPhe: 3.712 ± 0.078
2.571AspGly: 2.571 ± 0.072
0.461AspHis: 0.461 ± 0.03
5.521AspIle: 5.521 ± 0.101
4.556AspLys: 4.556 ± 0.089
4.649AspLeu: 4.649 ± 0.091
1.809AspMet: 1.809 ± 0.058
2.873AspAsn: 2.873 ± 0.072
1.098AspPro: 1.098 ± 0.042
0.597AspGln: 0.597 ± 0.033
1.744AspArg: 1.744 ± 0.055
6.963AspSer: 6.963 ± 0.139
3.203AspThr: 3.203 ± 0.097
2.286AspVal: 2.286 ± 0.068
0.331AspTrp: 0.331 ± 0.025
2.381AspTyr: 2.381 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
4.331GluAla: 4.331 ± 0.094
0.904GluCys: 0.904 ± 0.046
2.369GluAsp: 2.369 ± 0.064
3.593GluGlu: 3.593 ± 0.089
2.803GluPhe: 2.803 ± 0.075
2.702GluGly: 2.702 ± 0.078
1.203GluHis: 1.203 ± 0.044
6.128GluIle: 6.128 ± 0.103
5.328GluLys: 5.328 ± 0.121
5.63GluLeu: 5.63 ± 0.099
1.673GluMet: 1.673 ± 0.059
4.28GluAsn: 4.28 ± 0.098
1.182GluPro: 1.182 ± 0.048
2.245GluGln: 2.245 ± 0.058
2.661GluArg: 2.661 ± 0.071
6.233GluSer: 6.233 ± 0.146
2.744GluThr: 2.744 ± 0.077
3.915GluVal: 3.915 ± 0.085
0.587GluTrp: 0.587 ± 0.03
2.686GluTyr: 2.686 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
3.494PheAla: 3.494 ± 0.095
0.922PheCys: 0.922 ± 0.042
2.697PheAsp: 2.697 ± 0.072
2.734PheGlu: 2.734 ± 0.068
2.659PhePhe: 2.659 ± 0.08
3.4PheGly: 3.4 ± 0.092
1.03PheHis: 1.03 ± 0.044
4.272PheIle: 4.272 ± 0.11
3.214PheLys: 3.214 ± 0.077
4.908PheLeu: 4.908 ± 0.108
1.55PheMet: 1.55 ± 0.056
2.733PheAsn: 2.733 ± 0.068
1.106PhePro: 1.106 ± 0.046
1.259PheGln: 1.259 ± 0.039
1.406PheArg: 1.406 ± 0.049
4.078PheSer: 4.078 ± 0.089
2.275PheThr: 2.275 ± 0.064
3.089PheVal: 3.089 ± 0.076
0.419PheTrp: 0.419 ± 0.028
2.502PheTyr: 2.502 ± 0.07
0.0PheXaa: 0.0 ± 0.0
Gly
3.958GlyAla: 3.958 ± 0.11
0.698GlyCys: 0.698 ± 0.041
2.912GlyAsp: 2.912 ± 0.076
3.286GlyGlu: 3.286 ± 0.084
3.585GlyPhe: 3.585 ± 0.079
4.454GlyGly: 4.454 ± 0.128
1.04GlyHis: 1.04 ± 0.04
5.457GlyIle: 5.457 ± 0.109
4.224GlyLys: 4.224 ± 0.092
5.494GlyLeu: 5.494 ± 0.106
1.681GlyMet: 1.681 ± 0.053
2.87GlyAsn: 2.87 ± 0.093
0.698GlyPro: 0.698 ± 0.036
1.517GlyGln: 1.517 ± 0.059
2.049GlyArg: 2.049 ± 0.066
3.472GlySer: 3.472 ± 0.079
2.211GlyThr: 2.211 ± 0.068
4.395GlyVal: 4.395 ± 0.109
0.426GlyTrp: 0.426 ± 0.027
2.665GlyTyr: 2.665 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.56HisAla: 1.56 ± 0.05
0.336HisCys: 0.336 ± 0.025
1.035HisAsp: 1.035 ± 0.047
1.17HisGlu: 1.17 ± 0.047
1.31HisPhe: 1.31 ± 0.052
1.123HisGly: 1.123 ± 0.051
0.411HisHis: 0.411 ± 0.029
2.409HisIle: 2.409 ± 0.063
1.806HisLys: 1.806 ± 0.059
1.902HisLeu: 1.902 ± 0.056
0.262HisMet: 0.262 ± 0.019
1.621HisAsn: 1.621 ± 0.054
0.662HisPro: 0.662 ± 0.038
0.427HisGln: 0.427 ± 0.028
0.733HisArg: 0.733 ± 0.038
1.401HisSer: 1.401 ± 0.053
1.542HisThr: 1.542 ± 0.061
0.914HisVal: 0.914 ± 0.045
0.139HisTrp: 0.139 ± 0.014
0.984HisTyr: 0.984 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
7.19IleAla: 7.19 ± 0.143
1.16IleCys: 1.16 ± 0.04
4.934IleAsp: 4.934 ± 0.084
5.864IleGlu: 5.864 ± 0.103
3.961IlePhe: 3.961 ± 0.084
4.985IleGly: 4.985 ± 0.112
1.731IleHis: 1.731 ± 0.059
6.073IleIle: 6.073 ± 0.105
6.276IleLys: 6.276 ± 0.127
8.676IleLeu: 8.676 ± 0.13
1.989IleMet: 1.989 ± 0.056
4.348IleAsn: 4.348 ± 0.095
2.995IlePro: 2.995 ± 0.061
3.013IleGln: 3.013 ± 0.082
2.456IleArg: 2.456 ± 0.068
5.185IleSer: 5.185 ± 0.088
4.777IleThr: 4.777 ± 0.099
4.643IleVal: 4.643 ± 0.092
0.509IleTrp: 0.509 ± 0.03
3.227IleTyr: 3.227 ± 0.082
0.0IleXaa: 0.0 ± 0.0
Lys
5.872LysAla: 5.872 ± 0.115
0.589LysCys: 0.589 ± 0.028
6.28LysAsp: 6.28 ± 0.119
7.22LysGlu: 7.22 ± 0.125
2.304LysPhe: 2.304 ± 0.063
4.278LysGly: 4.278 ± 0.097
2.062LysHis: 2.062 ± 0.063
6.567LysIle: 6.567 ± 0.105
6.364LysLys: 6.364 ± 0.126
6.481LysLeu: 6.481 ± 0.095
1.958LysMet: 1.958 ± 0.054
5.262LysAsn: 5.262 ± 0.089
2.526LysPro: 2.526 ± 0.061
3.88LysGln: 3.88 ± 0.099
3.126LysArg: 3.126 ± 0.077
4.923LysSer: 4.923 ± 0.089
4.092LysThr: 4.092 ± 0.079
3.75LysVal: 3.75 ± 0.08
0.534LysTrp: 0.534 ± 0.03
2.619LysTyr: 2.619 ± 0.074
0.0LysXaa: 0.0 ± 0.0
Leu
6.91LeuAla: 6.91 ± 0.129
1.776LeuCys: 1.776 ± 0.061
6.02LeuAsp: 6.02 ± 0.105
7.367LeuGlu: 7.367 ± 0.127
4.747LeuPhe: 4.747 ± 0.118
5.892LeuGly: 5.892 ± 0.115
2.696LeuHis: 2.696 ± 0.077
6.236LeuIle: 6.236 ± 0.111
7.759LeuLys: 7.759 ± 0.114
9.201LeuLeu: 9.201 ± 0.137
2.147LeuMet: 2.147 ± 0.065
5.433LeuAsn: 5.433 ± 0.106
3.377LeuPro: 3.377 ± 0.075
5.361LeuGln: 5.361 ± 0.118
3.771LeuArg: 3.771 ± 0.085
7.267LeuSer: 7.267 ± 0.119
4.268LeuThr: 4.268 ± 0.084
4.536LeuVal: 4.536 ± 0.094
0.734LeuTrp: 0.734 ± 0.037
3.942LeuTyr: 3.942 ± 0.088
0.0LeuXaa: 0.0 ± 0.0
Met
1.806MetAla: 1.806 ± 0.058
0.296MetCys: 0.296 ± 0.023
1.152MetAsp: 1.152 ± 0.046
1.361MetGlu: 1.361 ± 0.048
1.054MetPhe: 1.054 ± 0.048
1.616MetGly: 1.616 ± 0.05
0.368MetHis: 0.368 ± 0.024
1.787MetIle: 1.787 ± 0.046
1.707MetLys: 1.707 ± 0.05
3.366MetLeu: 3.366 ± 0.078
0.507MetMet: 0.507 ± 0.029
1.158MetAsn: 1.158 ± 0.043
1.342MetPro: 1.342 ± 0.044
2.31MetGln: 2.31 ± 0.07
1.504MetArg: 1.504 ± 0.048
1.717MetSer: 1.717 ± 0.054
0.928MetThr: 0.928 ± 0.039
1.142MetVal: 1.142 ± 0.044
0.165MetTrp: 0.165 ± 0.017
0.698MetTyr: 0.698 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
5.017AsnAla: 5.017 ± 0.105
0.453AsnCys: 0.453 ± 0.029
3.07AsnAsp: 3.07 ± 0.069
3.987AsnGlu: 3.987 ± 0.083
2.411AsnPhe: 2.411 ± 0.062
3.377AsnGly: 3.377 ± 0.096
1.178AsnHis: 1.178 ± 0.044
5.353AsnIle: 5.353 ± 0.116
4.515AsnLys: 4.515 ± 0.099
6.308AsnLeu: 6.308 ± 0.115
1.579AsnMet: 1.579 ± 0.055
3.648AsnAsn: 3.648 ± 0.115
2.453AsnPro: 2.453 ± 0.07
1.52AsnGln: 1.52 ± 0.056
1.806AsnArg: 1.806 ± 0.048
2.949AsnSer: 2.949 ± 0.077
4.164AsnThr: 4.164 ± 0.102
3.131AsnVal: 3.131 ± 0.084
0.222AsnTrp: 0.222 ± 0.018
1.901AsnTyr: 1.901 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
1.435ProAla: 1.435 ± 0.054
0.376ProCys: 0.376 ± 0.025
1.21ProAsp: 1.21 ± 0.04
1.304ProGlu: 1.304 ± 0.054
1.8ProPhe: 1.8 ± 0.055
0.925ProGly: 0.925 ± 0.041
0.93ProHis: 0.93 ± 0.035
2.417ProIle: 2.417 ± 0.062
2.633ProLys: 2.633 ± 0.068
3.59ProLeu: 3.59 ± 0.081
0.698ProMet: 0.698 ± 0.034
2.022ProAsn: 2.022 ± 0.056
1.07ProPro: 1.07 ± 0.055
1.569ProGln: 1.569 ± 0.051
0.869ProArg: 0.869 ± 0.039
1.909ProSer: 1.909 ± 0.054
1.885ProThr: 1.885 ± 0.059
1.286ProVal: 1.286 ± 0.057
0.162ProTrp: 0.162 ± 0.017
1.579ProTyr: 1.579 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
2.885GlnAla: 2.885 ± 0.071
0.419GlnCys: 0.419 ± 0.024
2.707GlnAsp: 2.707 ± 0.086
3.059GlnGlu: 3.059 ± 0.082
1.163GlnPhe: 1.163 ± 0.043
2.109GlnGly: 2.109 ± 0.061
0.854GlnHis: 0.854 ± 0.034
3.097GlnIle: 3.097 ± 0.078
3.765GlnLys: 3.765 ± 0.089
2.31GlnLeu: 2.31 ± 0.063
0.861GlnMet: 0.861 ± 0.038
3.293GlnAsn: 3.293 ± 0.09
0.781GlnPro: 0.781 ± 0.04
1.616GlnGln: 1.616 ± 0.059
1.377GlnArg: 1.377 ± 0.05
2.896GlnSer: 2.896 ± 0.069
2.499GlnThr: 2.499 ± 0.079
1.889GlnVal: 1.889 ± 0.057
0.24GlnTrp: 0.24 ± 0.019
1.566GlnTyr: 1.566 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
2.27ArgAla: 2.27 ± 0.065
0.258ArgCys: 0.258 ± 0.023
2.353ArgAsp: 2.353 ± 0.06
2.771ArgGlu: 2.771 ± 0.082
2.205ArgPhe: 2.205 ± 0.064
1.949ArgGly: 1.949 ± 0.057
0.758ArgHis: 0.758 ± 0.042
3.392ArgIle: 3.392 ± 0.075
2.505ArgLys: 2.505 ± 0.067
3.64ArgLeu: 3.64 ± 0.094
0.906ArgMet: 0.906 ± 0.038
1.925ArgAsn: 1.925 ± 0.056
0.84ArgPro: 0.84 ± 0.032
1.242ArgGln: 1.242 ± 0.044
1.16ArgArg: 1.16 ± 0.048
1.736ArgSer: 1.736 ± 0.059
1.521ArgThr: 1.521 ± 0.048
2.28ArgVal: 2.28 ± 0.066
0.176ArgTrp: 0.176 ± 0.019
1.646ArgTyr: 1.646 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
3.872SerAla: 3.872 ± 0.087
0.827SerCys: 0.827 ± 0.041
2.976SerAsp: 2.976 ± 0.073
3.294SerGlu: 3.294 ± 0.082
3.953SerPhe: 3.953 ± 0.081
4.212SerGly: 4.212 ± 0.089
1.595SerHis: 1.595 ± 0.06
6.475SerIle: 6.475 ± 0.112
6.192SerLys: 6.192 ± 0.124
7.758SerLeu: 7.758 ± 0.124
2.113SerMet: 2.113 ± 0.062
4.227SerAsn: 4.227 ± 0.106
1.968SerPro: 1.968 ± 0.058
2.369SerGln: 2.369 ± 0.065
2.043SerArg: 2.043 ± 0.054
4.536SerSer: 4.536 ± 0.106
3.294SerThr: 3.294 ± 0.089
4.401SerVal: 4.401 ± 0.078
0.47SerTrp: 0.47 ± 0.029
2.99SerTyr: 2.99 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
2.509ThrAla: 2.509 ± 0.071
0.594ThrCys: 0.594 ± 0.033
2.347ThrAsp: 2.347 ± 0.058
2.616ThrGlu: 2.616 ± 0.068
2.307ThrPhe: 2.307 ± 0.069
2.161ThrGly: 2.161 ± 0.08
1.848ThrHis: 1.848 ± 0.064
3.926ThrIle: 3.926 ± 0.08
4.604ThrLys: 4.604 ± 0.086
6.376ThrLeu: 6.376 ± 0.102
1.07ThrMet: 1.07 ± 0.038
3.062ThrAsn: 3.062 ± 0.08
2.491ThrPro: 2.491 ± 0.07
3.897ThrGln: 3.897 ± 0.099
1.845ThrArg: 1.845 ± 0.056
3.099ThrSer: 3.099 ± 0.075
3.185ThrThr: 3.185 ± 0.096
0.555ThrVal: 0.555 ± 0.037
0.365ThrTrp: 0.365 ± 0.028
1.899ThrTyr: 1.899 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
4.28ValAla: 4.28 ± 0.098
0.973ValCys: 0.973 ± 0.043
2.472ValAsp: 2.472 ± 0.061
3.193ValGlu: 3.193 ± 0.085
3.019ValPhe: 3.019 ± 0.074
3.755ValGly: 3.755 ± 0.104
0.731ValHis: 0.731 ± 0.039
4.18ValIle: 4.18 ± 0.102
3.606ValLys: 3.606 ± 0.076
5.593ValLeu: 5.593 ± 0.111
1.47ValMet: 1.47 ± 0.049
2.342ValAsn: 2.342 ± 0.072
1.47ValPro: 1.47 ± 0.053
1.454ValGln: 1.454 ± 0.056
2.23ValArg: 2.23 ± 0.06
3.872ValSer: 3.872 ± 0.083
1.886ValThr: 1.886 ± 0.057
3.694ValVal: 3.694 ± 0.093
0.475ValTrp: 0.475 ± 0.029
1.837ValTyr: 1.837 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.387TrpAla: 0.387 ± 0.026
0.104TrpCys: 0.104 ± 0.013
0.414TrpAsp: 0.414 ± 0.024
0.443TrpGlu: 0.443 ± 0.026
0.325TrpPhe: 0.325 ± 0.026
0.55TrpGly: 0.55 ± 0.029
0.222TrpHis: 0.222 ± 0.02
0.563TrpIle: 0.563 ± 0.031
0.333TrpLys: 0.333 ± 0.023
0.875TrpLeu: 0.875 ± 0.037
0.125TrpMet: 0.125 ± 0.014
0.376TrpAsn: 0.376 ± 0.028
0.067TrpPro: 0.067 ± 0.011
0.416TrpGln: 0.416 ± 0.028
0.314TrpArg: 0.314 ± 0.023
0.392TrpSer: 0.392 ± 0.029
0.194TrpThr: 0.194 ± 0.018
0.398TrpVal: 0.398 ± 0.026
0.101TrpTrp: 0.101 ± 0.012
0.301TrpTyr: 0.301 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.129TyrAla: 3.129 ± 0.078
0.55TyrCys: 0.55 ± 0.034
2.281TyrAsp: 2.281 ± 0.068
2.533TyrGlu: 2.533 ± 0.058
2.201TyrPhe: 2.201 ± 0.066
2.52TyrGly: 2.52 ± 0.077
0.864TyrHis: 0.864 ± 0.044
3.126TyrIle: 3.126 ± 0.088
3.635TyrLys: 3.635 ± 0.081
3.499TyrLeu: 3.499 ± 0.073
1.005TyrMet: 1.005 ± 0.042
2.467TyrAsn: 2.467 ± 0.063
1.432TyrPro: 1.432 ± 0.053
1.302TyrGln: 1.302 ± 0.047
1.593TyrArg: 1.593 ± 0.062
2.254TyrSer: 2.254 ± 0.062
2.205TyrThr: 2.205 ± 0.062
1.889TyrVal: 1.889 ± 0.055
0.25TyrTrp: 0.25 ± 0.022
1.795TyrTyr: 1.795 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2030 proteins (625050 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski