Amino acid dipepetide frequency for Thermomonas hydrothermalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.285AlaAla: 18.285 ± 0.241	1.375AlaCys: 1.375 ± 0.052	6.905AlaAsp: 6.905 ± 0.113	7.004AlaGlu: 7.004 ± 0.101	4.053AlaPhe: 4.053 ± 0.084	10.99AlaGly: 10.99 ± 0.148	2.981AlaHis: 2.981 ± 0.069	5.423AlaIle: 5.423 ± 0.093	3.146AlaLys: 3.146 ± 0.082	17.629AlaLeu: 17.629 ± 0.215	3.315AlaMet: 3.315 ± 0.074	2.712AlaAsn: 2.712 ± 0.076	6.431AlaPro: 6.431 ± 0.123	6.084AlaGln: 6.084 ± 0.106	11.295AlaArg: 11.295 ± 0.163	5.938AlaSer: 5.938 ± 0.113	5.947AlaThr: 5.947 ± 0.106	8.649AlaVal: 8.649 ± 0.112	2.038AlaTrp: 2.038 ± 0.057	2.442AlaTyr: 2.442 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	1.121CysAla: 1.121 ± 0.043	0.103CysCys: 0.103 ± 0.012	0.54CysAsp: 0.54 ± 0.032	0.448CysGlu: 0.448 ± 0.026	0.267CysPhe: 0.267 ± 0.017	0.97CysGly: 0.97 ± 0.042	0.275CysHis: 0.275 ± 0.019	0.37CysIle: 0.37 ± 0.024	0.209CysLys: 0.209 ± 0.018	0.889CysLeu: 0.889 ± 0.037	0.181CysMet: 0.181 ± 0.016	0.204CysAsn: 0.204 ± 0.018	0.551CysPro: 0.551 ± 0.029	0.333CysGln: 0.333 ± 0.022	0.641CysArg: 0.641 ± 0.031	0.373CysSer: 0.373 ± 0.025	0.469CysThr: 0.469 ± 0.024	0.673CysVal: 0.673 ± 0.028	0.111CysTrp: 0.111 ± 0.014	0.181CysTyr: 0.181 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.447AspAla: 8.447 ± 0.135	0.453AspCys: 0.453 ± 0.029	3.09AspAsp: 3.09 ± 0.077	3.087AspGlu: 3.087 ± 0.077	1.851AspPhe: 1.851 ± 0.051	5.333AspGly: 5.333 ± 0.085	1.173AspHis: 1.173 ± 0.04	2.447AspIle: 2.447 ± 0.056	1.401AspLys: 1.401 ± 0.049	5.601AspLeu: 5.601 ± 0.097	1.09AspMet: 1.09 ± 0.043	1.193AspAsn: 1.193 ± 0.055	3.806AspPro: 3.806 ± 0.092	1.684AspGln: 1.684 ± 0.051	3.932AspArg: 3.932 ± 0.072	2.143AspSer: 2.143 ± 0.051	2.828AspThr: 2.828 ± 0.054	4.185AspVal: 4.185 ± 0.091	1.169AspTrp: 1.169 ± 0.042	1.534AspTyr: 1.534 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.373GluAla: 7.373 ± 0.117	0.378GluCys: 0.378 ± 0.023	2.513GluAsp: 2.513 ± 0.058	2.438GluGlu: 2.438 ± 0.065	1.682GluPhe: 1.682 ± 0.041	3.669GluGly: 3.669 ± 0.072	1.43GluHis: 1.43 ± 0.047	2.465GluIle: 2.465 ± 0.057	1.581GluLys: 1.581 ± 0.055	5.65GluLeu: 5.65 ± 0.088	1.062GluMet: 1.062 ± 0.036	1.023GluAsn: 1.023 ± 0.041	2.384GluPro: 2.384 ± 0.063	2.632GluGln: 2.632 ± 0.065	5.015GluArg: 5.015 ± 0.101	2.066GluSer: 2.066 ± 0.053	2.51GluThr: 2.51 ± 0.056	3.819GluVal: 3.819 ± 0.081	0.613GluTrp: 0.613 ± 0.031	1.18GluTyr: 1.18 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.949PheAla: 3.949 ± 0.072	0.326PheCys: 0.326 ± 0.022	2.526PheAsp: 2.526 ± 0.065	1.924PheGlu: 1.924 ± 0.061	1.129PhePhe: 1.129 ± 0.041	2.996PheGly: 2.996 ± 0.073	0.758PheHis: 0.758 ± 0.031	1.306PheIle: 1.306 ± 0.047	0.911PheLys: 0.911 ± 0.04	3.062PheLeu: 3.062 ± 0.072	0.624PheMet: 0.624 ± 0.032	0.957PheAsn: 0.957 ± 0.036	1.393PhePro: 1.393 ± 0.049	0.979PheGln: 0.979 ± 0.04	2.107PheArg: 2.107 ± 0.057	1.743PheSer: 1.743 ± 0.059	1.635PheThr: 1.635 ± 0.056	2.363PheVal: 2.363 ± 0.064	0.489PheTrp: 0.489 ± 0.028	0.815PheTyr: 0.815 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	8.244GlyAla: 8.244 ± 0.125	0.905GlyCys: 0.905 ± 0.037	4.38GlyAsp: 4.38 ± 0.085	4.408GlyGlu: 4.408 ± 0.078	3.103GlyPhe: 3.103 ± 0.07	6.576GlyGly: 6.576 ± 0.13	2.132GlyHis: 2.132 ± 0.056	4.112GlyIle: 4.112 ± 0.092	3.035GlyLys: 3.035 ± 0.081	9.257GlyLeu: 9.257 ± 0.136	2.248GlyMet: 2.248 ± 0.063	2.139GlyAsn: 2.139 ± 0.073	3.208GlyPro: 3.208 ± 0.061	3.531GlyGln: 3.531 ± 0.072	6.132GlyArg: 6.132 ± 0.09	4.058GlySer: 4.058 ± 0.086	4.075GlyThr: 4.075 ± 0.09	6.5GlyVal: 6.5 ± 0.105	1.679GlyTrp: 1.679 ± 0.057	2.333GlyTyr: 2.333 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	3.354HisAla: 3.354 ± 0.082	0.323HisCys: 0.323 ± 0.022	1.305HisAsp: 1.305 ± 0.046	1.038HisGlu: 1.038 ± 0.04	0.877HisPhe: 0.877 ± 0.036	2.403HisGly: 2.403 ± 0.062	0.716HisHis: 0.716 ± 0.033	0.856HisIle: 0.856 ± 0.033	0.535HisLys: 0.535 ± 0.029	2.496HisLeu: 2.496 ± 0.066	0.43HisMet: 0.43 ± 0.024	0.472HisAsn: 0.472 ± 0.023	1.788HisPro: 1.788 ± 0.053	0.734HisGln: 0.734 ± 0.031	1.711HisArg: 1.711 ± 0.05	0.912HisSer: 0.912 ± 0.039	1.184HisThr: 1.184 ± 0.042	1.71HisVal: 1.71 ± 0.051	0.528HisTrp: 0.528 ± 0.027	0.672HisTyr: 0.672 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.256IleAla: 6.256 ± 0.104	0.365IleCys: 0.365 ± 0.024	3.24IleAsp: 3.24 ± 0.068	3.009IleGlu: 3.009 ± 0.076	1.021IlePhe: 1.021 ± 0.044	4.059IleGly: 4.059 ± 0.077	0.943IleHis: 0.943 ± 0.037	1.371IleIle: 1.371 ± 0.048	1.122IleLys: 1.122 ± 0.045	3.409IleLeu: 3.409 ± 0.074	0.526IleMet: 0.526 ± 0.029	1.224IleAsn: 1.224 ± 0.048	2.296IlePro: 2.296 ± 0.046	1.219IleGln: 1.219 ± 0.042	3.091IleArg: 3.091 ± 0.072	1.961IleSer: 1.961 ± 0.058	2.274IleThr: 2.274 ± 0.066	3.106IleVal: 3.106 ± 0.07	0.433IleTrp: 0.433 ± 0.026	0.823IleTyr: 0.823 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.542LysAla: 3.542 ± 0.097	0.172LysCys: 0.172 ± 0.019	1.446LysAsp: 1.446 ± 0.057	1.132LysGlu: 1.132 ± 0.048	0.681LysPhe: 0.681 ± 0.033	1.961LysGly: 1.961 ± 0.06	0.593LysHis: 0.593 ± 0.027	1.181LysIle: 1.181 ± 0.037	1.066LysLys: 1.066 ± 0.062	2.8LysLeu: 2.8 ± 0.059	0.559LysMet: 0.559 ± 0.031	0.671LysAsn: 0.671 ± 0.037	1.853LysPro: 1.853 ± 0.059	1.128LysGln: 1.128 ± 0.043	2.155LysArg: 2.155 ± 0.054	1.23LysSer: 1.23 ± 0.042	1.729LysThr: 1.729 ± 0.061	2.182LysVal: 2.182 ± 0.062	0.284LysTrp: 0.284 ± 0.02	0.583LysTyr: 0.583 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	17.066LeuAla: 17.066 ± 0.197	1.022LeuCys: 1.022 ± 0.043	7.102LeuAsp: 7.102 ± 0.104	5.658LeuGlu: 5.658 ± 0.096	3.275LeuPhe: 3.275 ± 0.071	8.875LeuGly: 8.875 ± 0.118	2.842LeuHis: 2.842 ± 0.065	4.034LeuIle: 4.034 ± 0.076	3.09LeuLys: 3.09 ± 0.077	13.496LeuLeu: 13.496 ± 0.232	2.083LeuMet: 2.083 ± 0.063	2.278LeuAsn: 2.278 ± 0.061	7.359LeuPro: 7.359 ± 0.117	4.482LeuGln: 4.482 ± 0.091	9.867LeuArg: 9.867 ± 0.143	5.238LeuSer: 5.238 ± 0.085	5.823LeuThr: 5.823 ± 0.096	7.853LeuVal: 7.853 ± 0.133	1.608LeuTrp: 1.608 ± 0.056	2.274LeuTyr: 2.274 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.646MetAla: 2.646 ± 0.066	0.122MetCys: 0.122 ± 0.013	0.971MetAsp: 0.971 ± 0.039	0.838MetGlu: 0.838 ± 0.029	0.539MetPhe: 0.539 ± 0.026	1.511MetGly: 1.511 ± 0.055	0.48MetHis: 0.48 ± 0.023	0.786MetIle: 0.786 ± 0.035	0.693MetLys: 0.693 ± 0.031	2.429MetLeu: 2.429 ± 0.064	0.441MetMet: 0.441 ± 0.026	0.628MetAsn: 0.628 ± 0.027	1.428MetPro: 1.428 ± 0.045	1.051MetGln: 1.051 ± 0.037	1.863MetArg: 1.863 ± 0.052	1.341MetSer: 1.341 ± 0.039	1.446MetThr: 1.446 ± 0.041	1.357MetVal: 1.357 ± 0.041	0.202MetTrp: 0.202 ± 0.017	0.355MetTyr: 0.355 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.213AsnAla: 3.213 ± 0.075	0.176AsnCys: 0.176 ± 0.015	1.222AsnAsp: 1.222 ± 0.047	1.014AsnGlu: 1.014 ± 0.036	0.762AsnPhe: 0.762 ± 0.038	2.156AsnGly: 2.156 ± 0.089	0.449AsnHis: 0.449 ± 0.026	0.932AsnIle: 0.932 ± 0.045	0.586AsnLys: 0.586 ± 0.035	2.421AsnLeu: 2.421 ± 0.056	0.347AsnMet: 0.347 ± 0.023	0.573AsnAsn: 0.573 ± 0.041	1.805AsnPro: 1.805 ± 0.053	0.747AsnGln: 0.747 ± 0.034	1.694AsnArg: 1.694 ± 0.05	0.955AsnSer: 0.955 ± 0.066	1.263AsnThr: 1.263 ± 0.048	1.674AsnVal: 1.674 ± 0.062	0.331AsnTrp: 0.331 ± 0.02	0.51AsnTyr: 0.51 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	8.109ProAla: 8.109 ± 0.144	0.369ProCys: 0.369 ± 0.027	3.961ProAsp: 3.961 ± 0.068	3.375ProGlu: 3.375 ± 0.08	1.688ProPhe: 1.688 ± 0.048	5.108ProGly: 5.108 ± 0.09	1.336ProHis: 1.336 ± 0.043	1.982ProIle: 1.982 ± 0.057	1.499ProLys: 1.499 ± 0.049	6.016ProLeu: 6.016 ± 0.107	1.281ProMet: 1.281 ± 0.041	1.133ProAsn: 1.133 ± 0.038	3.599ProPro: 3.599 ± 0.093	2.357ProGln: 2.357 ± 0.062	3.698ProArg: 3.698 ± 0.079	2.504ProSer: 2.504 ± 0.056	2.646ProThr: 2.646 ± 0.062	4.582ProVal: 4.582 ± 0.08	0.972ProTrp: 0.972 ± 0.042	1.211ProTyr: 1.211 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	6.901GlnAla: 6.901 ± 0.118	0.264GlnCys: 0.264 ± 0.021	1.712GlnAsp: 1.712 ± 0.043	1.501GlnGlu: 1.501 ± 0.052	1.132GlnPhe: 1.132 ± 0.037	2.993GlnGly: 2.993 ± 0.065	0.943GlnHis: 0.943 ± 0.037	1.801GlnIle: 1.801 ± 0.048	0.925GlnLys: 0.925 ± 0.039	4.334GlnLeu: 4.334 ± 0.081	0.815GlnMet: 0.815 ± 0.035	0.676GlnAsn: 0.676 ± 0.031	2.569GlnPro: 2.569 ± 0.064	1.997GlnGln: 1.997 ± 0.069	4.073GlnArg: 4.073 ± 0.09	1.46GlnSer: 1.46 ± 0.045	2.022GlnThr: 2.022 ± 0.053	3.363GlnVal: 3.363 ± 0.067	0.597GlnTrp: 0.597 ± 0.025	0.799GlnTyr: 0.799 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	9.364ArgAla: 9.364 ± 0.14	0.61ArgCys: 0.61 ± 0.031	4.449ArgAsp: 4.449 ± 0.074	4.541ArgGlu: 4.541 ± 0.091	3.005ArgPhe: 3.005 ± 0.071	5.151ArgGly: 5.151 ± 0.083	2.261ArgHis: 2.261 ± 0.061	4.181ArgIle: 4.181 ± 0.082	2.207ArgLys: 2.207 ± 0.061	9.911ArgLeu: 9.911 ± 0.14	1.999ArgMet: 1.999 ± 0.049	1.893ArgAsn: 1.893 ± 0.054	3.973ArgPro: 3.973 ± 0.092	3.768ArgGln: 3.768 ± 0.084	6.521ArgArg: 6.521 ± 0.127	3.204ArgSer: 3.204 ± 0.06	3.501ArgThr: 3.501 ± 0.07	5.431ArgVal: 5.431 ± 0.096	1.644ArgTrp: 1.644 ± 0.055	2.269ArgTyr: 2.269 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	5.483SerAla: 5.483 ± 0.1	0.39SerCys: 0.39 ± 0.022	2.404SerAsp: 2.404 ± 0.056	2.227SerGlu: 2.227 ± 0.053	1.541SerPhe: 1.541 ± 0.046	4.557SerGly: 4.557 ± 0.121	1.004SerHis: 1.004 ± 0.035	1.942SerIle: 1.942 ± 0.056	1.216SerLys: 1.216 ± 0.045	4.921SerLeu: 4.921 ± 0.09	0.904SerMet: 0.904 ± 0.03	1.215SerAsn: 1.215 ± 0.054	2.73SerPro: 2.73 ± 0.063	1.624SerGln: 1.624 ± 0.047	3.264SerArg: 3.264 ± 0.068	2.26SerSer: 2.26 ± 0.065	2.301SerThr: 2.301 ± 0.068	3.208SerVal: 3.208 ± 0.071	0.618SerTrp: 0.618 ± 0.031	1.124SerTyr: 1.124 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.908ThrAla: 5.908 ± 0.109	0.441ThrCys: 0.441 ± 0.027	2.587ThrAsp: 2.587 ± 0.06	2.03ThrGlu: 2.03 ± 0.065	1.462ThrPhe: 1.462 ± 0.046	4.688ThrGly: 4.688 ± 0.097	1.191ThrHis: 1.191 ± 0.035	1.91ThrIle: 1.91 ± 0.055	0.876ThrLys: 0.876 ± 0.04	6.893ThrLeu: 6.893 ± 0.105	0.845ThrMet: 0.845 ± 0.038	0.971ThrAsn: 0.971 ± 0.048	4.086ThrPro: 4.086 ± 0.078	1.769ThrGln: 1.769 ± 0.051	3.652ThrArg: 3.652 ± 0.08	2.132ThrSer: 2.132 ± 0.065	2.584ThrThr: 2.584 ± 0.077	4.034ThrVal: 4.034 ± 0.061	0.662ThrTrp: 0.662 ± 0.031	1.011ThrTyr: 1.011 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	9.119ValAla: 9.119 ± 0.124	0.744ValCys: 0.744 ± 0.031	4.132ValAsp: 4.132 ± 0.082	4.243ValGlu: 4.243 ± 0.088	2.541ValPhe: 2.541 ± 0.061	5.113ValGly: 5.113 ± 0.097	1.652ValHis: 1.652 ± 0.048	3.319ValIle: 3.319 ± 0.069	1.903ValLys: 1.903 ± 0.071	8.891ValLeu: 8.891 ± 0.113	1.607ValMet: 1.607 ± 0.047	1.861ValAsn: 1.861 ± 0.063	4.085ValPro: 4.085 ± 0.075	2.856ValGln: 2.856 ± 0.068	5.556ValArg: 5.556 ± 0.085	3.67ValSer: 3.67 ± 0.067	3.61ValThr: 3.61 ± 0.078	6.012ValVal: 6.012 ± 0.102	1.038ValTrp: 1.038 ± 0.037	1.416ValTyr: 1.416 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.431TrpAla: 1.431 ± 0.048	0.181TrpCys: 0.181 ± 0.015	0.668TrpAsp: 0.668 ± 0.034	0.55TrpGlu: 0.55 ± 0.029	0.54TrpPhe: 0.54 ± 0.029	0.894TrpGly: 0.894 ± 0.04	0.397TrpHis: 0.397 ± 0.024	0.634TrpIle: 0.634 ± 0.027	0.397TrpLys: 0.397 ± 0.024	2.658TrpLeu: 2.658 ± 0.08	0.406TrpMet: 0.406 ± 0.023	0.426TrpAsn: 0.426 ± 0.023	0.869TrpPro: 0.869 ± 0.037	1.03TrpGln: 1.03 ± 0.035	1.455TrpArg: 1.455 ± 0.049	0.697TrpSer: 0.697 ± 0.032	0.73TrpThr: 0.73 ± 0.038	1.031TrpVal: 1.031 ± 0.037	0.345TrpTrp: 0.345 ± 0.024	0.392TrpTyr: 0.392 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.831TyrAla: 2.831 ± 0.072	0.19TyrCys: 0.19 ± 0.015	1.297TyrAsp: 1.297 ± 0.053	1.019TyrGlu: 1.019 ± 0.035	0.845TyrPhe: 0.845 ± 0.036	2.053TyrGly: 2.053 ± 0.074	0.488TyrHis: 0.488 ± 0.025	0.696TyrIle: 0.696 ± 0.034	0.547TyrLys: 0.547 ± 0.033	2.561TyrLeu: 2.561 ± 0.065	0.363TyrMet: 0.363 ± 0.023	0.578TyrAsn: 0.578 ± 0.032	1.212TyrPro: 1.212 ± 0.045	0.873TyrGln: 0.873 ± 0.03	2.164TyrArg: 2.164 ± 0.052	1.05TyrSer: 1.05 ± 0.054	1.153TyrThr: 1.153 ± 0.048	1.636TyrVal: 1.636 ± 0.053	0.367TyrTrp: 0.367 ± 0.024	0.575TyrTyr: 0.575 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2296 proteins (745712 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---