Amino acid dipepetide frequency for Chlorogloeopsis fritschii PCC 6912

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.672AlaAla: 7.672 ± 0.093	0.881AlaCys: 0.881 ± 0.021	3.908AlaAsp: 3.908 ± 0.046	5.262AlaGlu: 5.262 ± 0.056	3.072AlaPhe: 3.072 ± 0.046	5.373AlaGly: 5.373 ± 0.062	1.413AlaHis: 1.413 ± 0.027	7.073AlaIle: 7.073 ± 0.069	4.197AlaLys: 4.197 ± 0.052	8.818AlaLeu: 8.818 ± 0.084	1.748AlaMet: 1.748 ± 0.027	3.508AlaAsn: 3.508 ± 0.052	2.943AlaPro: 2.943 ± 0.036	4.343AlaGln: 4.343 ± 0.057	3.846AlaArg: 3.846 ± 0.048	4.757AlaSer: 4.757 ± 0.056	4.72AlaThr: 4.72 ± 0.055	5.669AlaVal: 5.669 ± 0.058	1.099AlaTrp: 1.099 ± 0.024	2.416AlaTyr: 2.416 ± 0.034	0.0AlaXaa: 0.0 ± 0.001
Cys	0.695CysAla: 0.695 ± 0.019	0.177CysCys: 0.177 ± 0.011	0.55CysAsp: 0.55 ± 0.018	0.568CysGlu: 0.568 ± 0.016	0.447CysPhe: 0.447 ± 0.014	0.817CysGly: 0.817 ± 0.021	0.297CysHis: 0.297 ± 0.013	0.631CysIle: 0.631 ± 0.018	0.381CysLys: 0.381 ± 0.015	1.189CysLeu: 1.189 ± 0.027	0.182CysMet: 0.182 ± 0.009	0.4CysAsn: 0.4 ± 0.014	0.551CysPro: 0.551 ± 0.018	0.611CysGln: 0.611 ± 0.02	0.546CysArg: 0.546 ± 0.018	0.643CysSer: 0.643 ± 0.015	0.478CysThr: 0.478 ± 0.016	0.615CysVal: 0.615 ± 0.02	0.166CysTrp: 0.166 ± 0.009	0.349CysTyr: 0.349 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.668AspAla: 3.668 ± 0.044	0.536AspCys: 0.536 ± 0.016	2.068AspAsp: 2.068 ± 0.038	3.073AspGlu: 3.073 ± 0.038	2.278AspPhe: 2.278 ± 0.032	3.164AspGly: 3.164 ± 0.044	0.593AspHis: 0.593 ± 0.019	3.366AspIle: 3.366 ± 0.042	2.227AspLys: 2.227 ± 0.041	5.232AspLeu: 5.232 ± 0.06	0.772AspMet: 0.772 ± 0.021	1.899AspAsn: 1.899 ± 0.029	2.223AspPro: 2.223 ± 0.036	1.379AspGln: 1.379 ± 0.027	3.303AspArg: 3.303 ± 0.045	2.659AspSer: 2.659 ± 0.043	2.447AspThr: 2.447 ± 0.04	3.113AspVal: 3.113 ± 0.039	0.882AspTrp: 0.882 ± 0.021	1.836AspTyr: 1.836 ± 0.04	0.001AspXaa: 0.001 ± 0.001
Glu	5.475GluAla: 5.475 ± 0.054	0.551GluCys: 0.551 ± 0.02	2.74GluAsp: 2.74 ± 0.038	4.289GluGlu: 4.289 ± 0.061	2.546GluPhe: 2.546 ± 0.041	3.237GluGly: 3.237 ± 0.046	1.091GluHis: 1.091 ± 0.027	4.98GluIle: 4.98 ± 0.054	3.663GluLys: 3.663 ± 0.041	7.073GluLeu: 7.073 ± 0.063	1.347GluMet: 1.347 ± 0.029	2.835GluAsn: 2.835 ± 0.041	2.517GluPro: 2.517 ± 0.036	3.817GluGln: 3.817 ± 0.046	3.605GluArg: 3.605 ± 0.046	3.278GluSer: 3.278 ± 0.042	3.401GluThr: 3.401 ± 0.044	4.504GluVal: 4.504 ± 0.052	0.832GluTrp: 0.832 ± 0.02	1.963GluTyr: 1.963 ± 0.03	0.001GluXaa: 0.001 ± 0.001
Phe	3.256PheAla: 3.256 ± 0.04	0.563PheCys: 0.563 ± 0.015	2.229PheAsp: 2.229 ± 0.033	2.358PheGlu: 2.358 ± 0.04	1.718PhePhe: 1.718 ± 0.03	2.96PheGly: 2.96 ± 0.041	0.791PheHis: 0.791 ± 0.021	2.446PheIle: 2.446 ± 0.038	1.603PheLys: 1.603 ± 0.028	4.211PheLeu: 4.211 ± 0.051	0.737PheMet: 0.737 ± 0.02	1.785PheAsn: 1.785 ± 0.029	1.843PhePro: 1.843 ± 0.031	1.872PheGln: 1.872 ± 0.031	1.876PheArg: 1.876 ± 0.031	2.914PheSer: 2.914 ± 0.043	2.375PheThr: 2.375 ± 0.033	2.579PheVal: 2.579 ± 0.039	0.732PheTrp: 0.732 ± 0.021	1.382PheTyr: 1.382 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	4.868GlyAla: 4.868 ± 0.062	0.816GlyCys: 0.816 ± 0.021	3.164GlyAsp: 3.164 ± 0.045	4.145GlyGlu: 4.145 ± 0.051	2.971GlyPhe: 2.971 ± 0.037	4.498GlyGly: 4.498 ± 0.061	1.17GlyHis: 1.17 ± 0.03	5.091GlyIle: 5.091 ± 0.06	4.074GlyLys: 4.074 ± 0.053	6.733GlyLeu: 6.733 ± 0.063	1.578GlyMet: 1.578 ± 0.026	2.882GlyAsn: 2.882 ± 0.046	1.237GlyPro: 1.237 ± 0.029	2.686GlyGln: 2.686 ± 0.035	3.217GlyArg: 3.217 ± 0.045	4.013GlySer: 4.013 ± 0.053	3.807GlyThr: 3.807 ± 0.048	4.83GlyVal: 4.83 ± 0.051	1.164GlyTrp: 1.164 ± 0.028	2.406GlyTyr: 2.406 ± 0.033	0.001GlyXaa: 0.001 ± 0.001
His	1.166HisAla: 1.166 ± 0.026	0.259HisCys: 0.259 ± 0.01	0.745HisAsp: 0.745 ± 0.023	0.999HisGlu: 0.999 ± 0.021	0.86HisPhe: 0.86 ± 0.022	1.155HisGly: 1.155 ± 0.024	0.621HisHis: 0.621 ± 0.021	1.218HisIle: 1.218 ± 0.025	0.844HisLys: 0.844 ± 0.022	2.293HisLeu: 2.293 ± 0.039	0.297HisMet: 0.297 ± 0.012	0.796HisAsn: 0.796 ± 0.02	1.371HisPro: 1.371 ± 0.029	1.116HisGln: 1.116 ± 0.023	1.103HisArg: 1.103 ± 0.024	1.201HisSer: 1.201 ± 0.027	0.982HisThr: 0.982 ± 0.025	0.817HisVal: 0.817 ± 0.024	0.347HisTrp: 0.347 ± 0.014	0.694HisTyr: 0.694 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.318IleAla: 7.318 ± 0.057	0.802IleCys: 0.802 ± 0.021	3.479IleAsp: 3.479 ± 0.046	4.324IleGlu: 4.324 ± 0.051	2.72IlePhe: 2.72 ± 0.035	4.536IleGly: 4.536 ± 0.054	1.328IleHis: 1.328 ± 0.027	3.795IleIle: 3.795 ± 0.049	3.131IleLys: 3.131 ± 0.042	7.053IleLeu: 7.053 ± 0.071	0.872IleMet: 0.872 ± 0.024	3.026IleAsn: 3.026 ± 0.042	3.602IlePro: 3.602 ± 0.038	3.03IleGln: 3.03 ± 0.044	3.211IleArg: 3.211 ± 0.037	4.362IleSer: 4.362 ± 0.049	3.67IleThr: 3.67 ± 0.042	4.491IleVal: 4.491 ± 0.054	0.938IleTrp: 0.938 ± 0.024	2.154IleTyr: 2.154 ± 0.036	0.001IleXaa: 0.001 ± 0.001
Lys	4.028LysAla: 4.028 ± 0.05	0.335LysCys: 0.335 ± 0.015	2.156LysAsp: 2.156 ± 0.039	3.027LysGlu: 3.027 ± 0.039	1.878LysPhe: 1.878 ± 0.032	2.699LysGly: 2.699 ± 0.036	0.897LysHis: 0.897 ± 0.024	3.554LysIle: 3.554 ± 0.051	2.384LysLys: 2.384 ± 0.042	5.538LysLeu: 5.538 ± 0.058	0.948LysMet: 0.948 ± 0.019	2.207LysAsn: 2.207 ± 0.033	2.554LysPro: 2.554 ± 0.037	2.867LysGln: 2.867 ± 0.041	2.492LysArg: 2.492 ± 0.037	2.963LysSer: 2.963 ± 0.045	2.854LysThr: 2.854 ± 0.041	3.381LysVal: 3.381 ± 0.046	0.524LysTrp: 0.524 ± 0.016	1.511LysTyr: 1.511 ± 0.031	0.002LysXaa: 0.002 ± 0.001
Leu	9.704LeuAla: 9.704 ± 0.073	1.06LeuCys: 1.06 ± 0.024	4.992LeuAsp: 4.992 ± 0.052	7.408LeuGlu: 7.408 ± 0.071	3.943LeuPhe: 3.943 ± 0.056	7.452LeuGly: 7.452 ± 0.068	1.988LeuHis: 1.988 ± 0.029	6.788LeuIle: 6.788 ± 0.07	5.42LeuLys: 5.42 ± 0.06	11.466LeuLeu: 11.466 ± 0.094	2.145LeuMet: 2.145 ± 0.036	4.527LeuAsn: 4.527 ± 0.051	5.713LeuPro: 5.713 ± 0.054	5.969LeuGln: 5.969 ± 0.061	5.772LeuArg: 5.772 ± 0.062	7.231LeuSer: 7.231 ± 0.071	6.119LeuThr: 6.119 ± 0.06	7.391LeuVal: 7.391 ± 0.068	1.479LeuTrp: 1.479 ± 0.032	2.722LeuTyr: 2.722 ± 0.037	0.001LeuXaa: 0.001 ± 0.001
Met	1.755MetAla: 1.755 ± 0.033	0.138MetCys: 0.138 ± 0.009	0.746MetAsp: 0.746 ± 0.021	1.028MetGlu: 1.028 ± 0.022	0.617MetPhe: 0.617 ± 0.019	1.352MetGly: 1.352 ± 0.029	0.358MetHis: 0.358 ± 0.014	1.096MetIle: 1.096 ± 0.024	0.964MetLys: 0.964 ± 0.02	2.006MetLeu: 2.006 ± 0.033	0.479MetMet: 0.479 ± 0.016	0.904MetAsn: 0.904 ± 0.023	1.013MetPro: 1.013 ± 0.024	1.024MetGln: 1.024 ± 0.022	1.037MetArg: 1.037 ± 0.024	1.33MetSer: 1.33 ± 0.027	1.27MetThr: 1.27 ± 0.024	1.293MetVal: 1.293 ± 0.026	0.17MetTrp: 0.17 ± 0.009	0.399MetTyr: 0.399 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.947AsnAla: 2.947 ± 0.042	0.509AsnCys: 0.509 ± 0.016	1.554AsnAsp: 1.554 ± 0.032	1.878AsnGlu: 1.878 ± 0.033	2.049AsnPhe: 2.049 ± 0.03	2.569AsnGly: 2.569 ± 0.044	0.939AsnHis: 0.939 ± 0.022	2.925AsnIle: 2.925 ± 0.039	1.786AsnLys: 1.786 ± 0.035	5.494AsnLeu: 5.494 ± 0.066	0.655AsnMet: 0.655 ± 0.017	1.999AsnAsn: 1.999 ± 0.044	2.808AsnPro: 2.808 ± 0.035	2.683AsnGln: 2.683 ± 0.041	2.357AsnArg: 2.357 ± 0.032	2.979AsnSer: 2.979 ± 0.043	2.373AsnThr: 2.373 ± 0.043	2.263AsnVal: 2.263 ± 0.037	0.776AsnTrp: 0.776 ± 0.02	1.609AsnTyr: 1.609 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	3.22ProAla: 3.22 ± 0.043	0.365ProCys: 0.365 ± 0.013	2.798ProAsp: 2.798 ± 0.037	3.859ProGlu: 3.859 ± 0.047	1.78ProPhe: 1.78 ± 0.028	3.036ProGly: 3.036 ± 0.044	0.945ProHis: 0.945 ± 0.019	3.119ProIle: 3.119 ± 0.039	2.258ProLys: 2.258 ± 0.032	4.613ProLeu: 4.613 ± 0.054	0.758ProMet: 0.758 ± 0.02	2.236ProAsn: 2.236 ± 0.037	2.276ProPro: 2.276 ± 0.041	2.697ProGln: 2.697 ± 0.04	1.789ProArg: 1.789 ± 0.031	2.898ProSer: 2.898 ± 0.041	2.875ProThr: 2.875 ± 0.04	3.297ProVal: 3.297 ± 0.048	0.599ProTrp: 0.599 ± 0.019	1.382ProTyr: 1.382 ± 0.027	0.001ProXaa: 0.001 ± 0.001
Gln	4.927GlnAla: 4.927 ± 0.059	0.349GlnCys: 0.349 ± 0.014	2.04GlnAsp: 2.04 ± 0.033	3.801GlnGlu: 3.801 ± 0.05	1.738GlnPhe: 1.738 ± 0.032	3.184GlnGly: 3.184 ± 0.042	0.889GlnHis: 0.889 ± 0.024	3.745GlnIle: 3.745 ± 0.046	2.967GlnLys: 2.967 ± 0.037	5.965GlnLeu: 5.965 ± 0.069	1.131GlnMet: 1.131 ± 0.022	2.156GlnAsn: 2.156 ± 0.035	2.619GlnPro: 2.619 ± 0.041	3.967GlnGln: 3.967 ± 0.065	2.945GlnArg: 2.945 ± 0.039	2.783GlnSer: 2.783 ± 0.039	2.952GlnThr: 2.952 ± 0.043	3.863GlnVal: 3.863 ± 0.049	0.646GlnTrp: 0.646 ± 0.018	1.29GlnTyr: 1.29 ± 0.025	0.0GlnXaa: 0.0 ± 0.001
Arg	3.575ArgAla: 3.575 ± 0.051	0.529ArgCys: 0.529 ± 0.016	2.479ArgAsp: 2.479 ± 0.037	3.404ArgGlu: 3.404 ± 0.044	2.239ArgPhe: 2.239 ± 0.036	2.995ArgGly: 2.995 ± 0.041	1.046ArgHis: 1.046 ± 0.024	3.424ArgIle: 3.424 ± 0.035	2.332ArgLys: 2.332 ± 0.036	6.068ArgLeu: 6.068 ± 0.062	1.101ArgMet: 1.101 ± 0.024	2.139ArgAsn: 2.139 ± 0.036	1.88ArgPro: 1.88 ± 0.033	3.339ArgGln: 3.339 ± 0.034	3.236ArgArg: 3.236 ± 0.05	3.18ArgSer: 3.18 ± 0.045	2.617ArgThr: 2.617 ± 0.035	3.612ArgVal: 3.612 ± 0.048	0.862ArgTrp: 0.862 ± 0.023	2.009ArgTyr: 2.009 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	4.355SerAla: 4.355 ± 0.043	0.625SerCys: 0.625 ± 0.019	3.034SerAsp: 3.034 ± 0.043	3.679SerGlu: 3.679 ± 0.046	2.549SerPhe: 2.549 ± 0.038	4.387SerGly: 4.387 ± 0.053	1.342SerHis: 1.342 ± 0.025	3.736SerIle: 3.736 ± 0.048	2.8SerLys: 2.8 ± 0.041	6.986SerLeu: 6.986 ± 0.062	1.182SerMet: 1.182 ± 0.026	2.651SerAsn: 2.651 ± 0.041	3.24SerPro: 3.24 ± 0.046	3.506SerGln: 3.506 ± 0.044	3.122SerArg: 3.122 ± 0.041	4.311SerSer: 4.311 ± 0.06	3.478SerThr: 3.478 ± 0.043	4.032SerVal: 4.032 ± 0.049	0.891SerTrp: 0.891 ± 0.021	1.853SerTyr: 1.853 ± 0.032	0.001SerXaa: 0.001 ± 0.001
Thr	4.75ThrAla: 4.75 ± 0.057	0.491ThrCys: 0.491 ± 0.017	2.599ThrAsp: 2.599 ± 0.04	3.359ThrGlu: 3.359 ± 0.041	2.124ThrPhe: 2.124 ± 0.033	4.154ThrGly: 4.154 ± 0.053	1.032ThrHis: 1.032 ± 0.021	3.699ThrIle: 3.699 ± 0.046	2.393ThrLys: 2.393 ± 0.037	6.07ThrLeu: 6.07 ± 0.065	0.823ThrMet: 0.823 ± 0.022	2.347ThrAsn: 2.347 ± 0.033	3.482ThrPro: 3.482 ± 0.05	2.898ThrGln: 2.898 ± 0.044	2.435ThrArg: 2.435 ± 0.035	3.463ThrSer: 3.463 ± 0.042	3.444ThrThr: 3.444 ± 0.054	4.106ThrVal: 4.106 ± 0.045	0.712ThrTrp: 0.712 ± 0.019	1.648ThrTyr: 1.648 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	6.124ValAla: 6.124 ± 0.059	0.714ValCys: 0.714 ± 0.02	3.365ValAsp: 3.365 ± 0.044	4.591ValGlu: 4.591 ± 0.05	2.672ValPhe: 2.672 ± 0.038	4.708ValGly: 4.708 ± 0.05	1.079ValHis: 1.079 ± 0.026	4.428ValIle: 4.428 ± 0.051	3.386ValLys: 3.386 ± 0.039	6.885ValLeu: 6.885 ± 0.061	1.436ValMet: 1.436 ± 0.03	2.975ValAsn: 2.975 ± 0.042	2.988ValPro: 2.988 ± 0.045	2.936ValGln: 2.936 ± 0.038	3.368ValArg: 3.368 ± 0.046	4.151ValSer: 4.151 ± 0.05	3.931ValThr: 3.931 ± 0.05	5.067ValVal: 5.067 ± 0.055	0.893ValTrp: 0.893 ± 0.021	1.919ValTyr: 1.919 ± 0.03	0.001ValXaa: 0.001 ± 0.001
Trp	0.969TrpAla: 0.969 ± 0.022	0.163TrpCys: 0.163 ± 0.009	0.651TrpAsp: 0.651 ± 0.019	0.908TrpGlu: 0.908 ± 0.022	0.625TrpPhe: 0.625 ± 0.021	0.983TrpGly: 0.983 ± 0.023	0.382TrpHis: 0.382 ± 0.013	0.907TrpIle: 0.907 ± 0.023	0.619TrpLys: 0.619 ± 0.018	1.935TrpLeu: 1.935 ± 0.033	0.339TrpMet: 0.339 ± 0.014	0.641TrpAsn: 0.641 ± 0.02	0.275TrpPro: 0.275 ± 0.012	1.234TrpGln: 1.234 ± 0.029	0.869TrpArg: 0.869 ± 0.02	0.753TrpSer: 0.753 ± 0.02	0.61TrpThr: 0.61 ± 0.018	0.975TrpVal: 0.975 ± 0.022	0.249TrpTrp: 0.249 ± 0.012	0.438TrpTyr: 0.438 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.242TyrAla: 2.242 ± 0.037	0.43TyrCys: 0.43 ± 0.016	1.423TyrAsp: 1.423 ± 0.031	1.786TyrGlu: 1.786 ± 0.032	1.402TyrPhe: 1.402 ± 0.027	2.09TyrGly: 2.09 ± 0.033	0.684TyrHis: 0.684 ± 0.017	1.822TyrIle: 1.822 ± 0.031	1.371TyrLys: 1.371 ± 0.028	3.66TyrLeu: 3.66 ± 0.043	0.45TyrMet: 0.45 ± 0.015	1.24TyrAsn: 1.24 ± 0.03	1.664TyrPro: 1.664 ± 0.028	1.984TyrGln: 1.984 ± 0.033	1.935TyrArg: 1.935 ± 0.033	1.888TyrSer: 1.888 ± 0.034	1.626TyrThr: 1.626 ± 0.027	1.721TyrVal: 1.721 ± 0.031	0.562TyrTrp: 0.562 ± 0.016	1.128TyrTyr: 1.128 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.001	0.107XaaXaa: 0.107 ± 0.048

Statistics based on 6594 proteins (2055004 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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