Amino acid dipepetide frequency for Oxynema sp. AP17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.273AlaAla: 8.273 ± 0.093	0.91AlaCys: 0.91 ± 0.022	4.733AlaAsp: 4.733 ± 0.066	5.814AlaGlu: 5.814 ± 0.074	2.952AlaPhe: 2.952 ± 0.042	5.621AlaGly: 5.621 ± 0.071	1.407AlaHis: 1.407 ± 0.032	10.252AlaIle: 10.252 ± 0.099	3.424AlaLys: 3.424 ± 0.06	9.131AlaLeu: 9.131 ± 0.099	1.456AlaMet: 1.456 ± 0.031	3.208AlaAsn: 3.208 ± 0.072	3.528AlaPro: 3.528 ± 0.053	4.096AlaGln: 4.096 ± 0.058	5.549AlaArg: 5.549 ± 0.068	5.197AlaSer: 5.197 ± 0.063	5.001AlaThr: 5.001 ± 0.061	5.696AlaVal: 5.696 ± 0.061	1.017AlaTrp: 1.017 ± 0.024	2.397AlaTyr: 2.397 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.71CysAla: 0.71 ± 0.021	0.171CysCys: 0.171 ± 0.012	0.746CysAsp: 0.746 ± 0.023	0.653CysGlu: 0.653 ± 0.02	0.408CysPhe: 0.408 ± 0.016	0.821CysGly: 0.821 ± 0.023	0.299CysHis: 0.299 ± 0.013	0.478CysIle: 0.478 ± 0.016	0.282CysLys: 0.282 ± 0.015	1.103CysLeu: 1.103 ± 0.026	0.124CysMet: 0.124 ± 0.009	0.317CysAsn: 0.317 ± 0.013	0.573CysPro: 0.573 ± 0.021	0.582CysGln: 0.582 ± 0.016	0.698CysArg: 0.698 ± 0.023	0.6CysSer: 0.6 ± 0.019	0.45CysThr: 0.45 ± 0.016	0.531CysVal: 0.531 ± 0.019	0.158CysTrp: 0.158 ± 0.01	0.372CysTyr: 0.372 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.218AspAla: 4.218 ± 0.065	0.605AspCys: 0.605 ± 0.018	2.839AspAsp: 2.839 ± 0.071	3.351AspGlu: 3.351 ± 0.048	2.264AspPhe: 2.264 ± 0.035	4.209AspGly: 4.209 ± 0.088	0.522AspHis: 0.522 ± 0.023	2.825AspIle: 2.825 ± 0.053	1.518AspLys: 1.518 ± 0.035	7.204AspLeu: 7.204 ± 0.074	0.666AspMet: 0.666 ± 0.024	1.877AspAsn: 1.877 ± 0.046	3.62AspPro: 3.62 ± 0.053	0.843AspGln: 0.843 ± 0.027	9.035AspArg: 9.035 ± 0.099	2.916AspSer: 2.916 ± 0.055	2.352AspThr: 2.352 ± 0.051	2.722AspVal: 2.722 ± 0.043	0.995AspTrp: 0.995 ± 0.025	1.821AspTyr: 1.821 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.03GluAla: 7.03 ± 0.083	0.546GluCys: 0.546 ± 0.019	3.148GluAsp: 3.148 ± 0.052	4.407GluGlu: 4.407 ± 0.075	2.545GluPhe: 2.545 ± 0.041	4.299GluGly: 4.299 ± 0.057	1.012GluHis: 1.012 ± 0.029	5.092GluIle: 5.092 ± 0.05	2.935GluLys: 2.935 ± 0.051	7.337GluLeu: 7.337 ± 0.088	1.336GluMet: 1.336 ± 0.03	2.811GluAsn: 2.811 ± 0.046	2.839GluPro: 2.839 ± 0.059	3.397GluGln: 3.397 ± 0.049	4.69GluArg: 4.69 ± 0.065	3.874GluSer: 3.874 ± 0.06	4.43GluThr: 4.43 ± 0.114	4.283GluVal: 4.283 ± 0.059	0.896GluTrp: 0.896 ± 0.023	1.694GluTyr: 1.694 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.216PheAla: 3.216 ± 0.049	0.517PheCys: 0.517 ± 0.017	2.545PheAsp: 2.545 ± 0.04	2.505PheGlu: 2.505 ± 0.045	1.655PhePhe: 1.655 ± 0.035	2.978PheGly: 2.978 ± 0.051	0.694PheHis: 0.694 ± 0.021	1.912PheIle: 1.912 ± 0.036	1.432PheLys: 1.432 ± 0.036	3.936PheLeu: 3.936 ± 0.047	0.602PheMet: 0.602 ± 0.021	1.499PheAsn: 1.499 ± 0.032	1.875PhePro: 1.875 ± 0.039	1.534PheGln: 1.534 ± 0.031	1.847PheArg: 1.847 ± 0.037	2.797PheSer: 2.797 ± 0.05	1.956PheThr: 1.956 ± 0.037	2.44PheVal: 2.44 ± 0.038	0.696PheTrp: 0.696 ± 0.021	1.33PheTyr: 1.33 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.729GlyAla: 5.729 ± 0.09	0.786GlyCys: 0.786 ± 0.023	5.09GlyAsp: 5.09 ± 0.08	5.175GlyGlu: 5.175 ± 0.069	2.867GlyPhe: 2.867 ± 0.045	5.377GlyGly: 5.377 ± 0.108	1.39GlyHis: 1.39 ± 0.036	4.713GlyIle: 4.713 ± 0.057	3.229GlyLys: 3.229 ± 0.05	6.866GlyLeu: 6.866 ± 0.076	1.484GlyMet: 1.484 ± 0.034	2.98GlyAsn: 2.98 ± 0.082	1.741GlyPro: 1.741 ± 0.037	3.087GlyGln: 3.087 ± 0.044	4.23GlyArg: 4.23 ± 0.055	4.706GlySer: 4.706 ± 0.076	4.179GlyThr: 4.179 ± 0.085	4.676GlyVal: 4.676 ± 0.056	1.228GlyTrp: 1.228 ± 0.027	2.278GlyTyr: 2.278 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.248HisAla: 1.248 ± 0.024	0.319HisCys: 0.319 ± 0.014	0.854HisAsp: 0.854 ± 0.026	1.045HisGlu: 1.045 ± 0.024	0.818HisPhe: 0.818 ± 0.024	1.249HisGly: 1.249 ± 0.032	0.559HisHis: 0.559 ± 0.025	0.721HisIle: 0.721 ± 0.021	0.553HisLys: 0.553 ± 0.022	2.43HisLeu: 2.43 ± 0.041	0.184HisMet: 0.184 ± 0.01	0.563HisAsn: 0.563 ± 0.018	1.445HisPro: 1.445 ± 0.031	0.988HisGln: 0.988 ± 0.026	1.304HisArg: 1.304 ± 0.033	1.081HisSer: 1.081 ± 0.027	0.801HisThr: 0.801 ± 0.02	0.818HisVal: 0.818 ± 0.022	0.404HisTrp: 0.404 ± 0.019	0.693HisTyr: 0.693 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	9.242IleAla: 9.242 ± 0.088	0.658IleCys: 0.658 ± 0.02	4.034IleAsp: 4.034 ± 0.053	4.762IleGlu: 4.762 ± 0.065	2.262IlePhe: 2.262 ± 0.043	4.438IleGly: 4.438 ± 0.051	1.146IleHis: 1.146 ± 0.032	2.092IleIle: 2.092 ± 0.047	1.819IleLys: 1.819 ± 0.037	6.037IleLeu: 6.037 ± 0.065	0.552IleMet: 0.552 ± 0.019	1.658IleAsn: 1.658 ± 0.033	3.256IlePro: 3.256 ± 0.052	2.184IleGln: 2.184 ± 0.038	3.225IleArg: 3.225 ± 0.048	3.455IleSer: 3.455 ± 0.058	2.41IleThr: 2.41 ± 0.052	4.654IleVal: 4.654 ± 0.061	0.83IleTrp: 0.83 ± 0.025	1.776IleTyr: 1.776 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.377LysAla: 3.377 ± 0.051	0.259LysCys: 0.259 ± 0.013	1.579LysAsp: 1.579 ± 0.035	2.088LysGlu: 2.088 ± 0.044	1.32LysPhe: 1.32 ± 0.03	2.293LysGly: 2.293 ± 0.043	0.693LysHis: 0.693 ± 0.023	2.796LysIle: 2.796 ± 0.045	1.645LysLys: 1.645 ± 0.041	4.134LysLeu: 4.134 ± 0.069	0.775LysMet: 0.775 ± 0.022	1.532LysAsn: 1.532 ± 0.031	1.975LysPro: 1.975 ± 0.038	2.1LysGln: 2.1 ± 0.04	2.225LysArg: 2.225 ± 0.042	2.175LysSer: 2.175 ± 0.037	2.512LysThr: 2.512 ± 0.048	2.358LysVal: 2.358 ± 0.043	0.403LysTrp: 0.403 ± 0.016	1.027LysTyr: 1.027 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	10.115LeuAla: 10.115 ± 0.085	1.042LeuCys: 1.042 ± 0.024	6.716LeuAsp: 6.716 ± 0.07	8.067LeuGlu: 8.067 ± 0.096	3.817LeuPhe: 3.817 ± 0.05	7.996LeuGly: 7.996 ± 0.081	1.963LeuHis: 1.963 ± 0.035	5.162LeuIle: 5.162 ± 0.058	4.955LeuLys: 4.955 ± 0.07	10.903LeuLeu: 10.903 ± 0.117	1.905LeuMet: 1.905 ± 0.037	4.14LeuAsn: 4.14 ± 0.047	5.579LeuPro: 5.579 ± 0.059	5.424LeuGln: 5.424 ± 0.067	5.991LeuArg: 5.991 ± 0.065	7.666LeuSer: 7.666 ± 0.081	6.135LeuThr: 6.135 ± 0.07	6.814LeuVal: 6.814 ± 0.068	1.62LeuTrp: 1.62 ± 0.04	2.782LeuTyr: 2.782 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	1.739MetAla: 1.739 ± 0.033	0.089MetCys: 0.089 ± 0.007	0.72MetAsp: 0.72 ± 0.021	0.972MetGlu: 0.972 ± 0.025	0.493MetPhe: 0.493 ± 0.018	1.332MetGly: 1.332 ± 0.028	0.269MetHis: 0.269 ± 0.014	0.592MetIle: 0.592 ± 0.02	0.798MetLys: 0.798 ± 0.023	1.686MetLeu: 1.686 ± 0.032	0.397MetMet: 0.397 ± 0.017	0.745MetAsn: 0.745 ± 0.02	0.841MetPro: 0.841 ± 0.023	0.752MetGln: 0.752 ± 0.022	0.946MetArg: 0.946 ± 0.024	1.332MetSer: 1.332 ± 0.024	1.176MetThr: 1.176 ± 0.027	1.153MetVal: 1.153 ± 0.028	0.146MetTrp: 0.146 ± 0.008	0.307MetTyr: 0.307 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.826AsnAla: 2.826 ± 0.05	0.402AsnCys: 0.402 ± 0.016	1.702AsnAsp: 1.702 ± 0.055	1.706AsnGlu: 1.706 ± 0.035	1.644AsnPhe: 1.644 ± 0.033	2.638AsnGly: 2.638 ± 0.061	0.654AsnHis: 0.654 ± 0.019	1.884AsnIle: 1.884 ± 0.037	0.991AsnLys: 0.991 ± 0.025	5.04AsnLeu: 5.04 ± 0.092	0.464AsnMet: 0.464 ± 0.016	1.446AsnAsn: 1.446 ± 0.047	2.886AsnPro: 2.886 ± 0.047	1.672AsnGln: 1.672 ± 0.031	2.575AsnArg: 2.575 ± 0.041	2.274AsnSer: 2.274 ± 0.043	1.695AsnThr: 1.695 ± 0.038	1.797AsnVal: 1.797 ± 0.035	0.654AsnTrp: 0.654 ± 0.022	1.16AsnTyr: 1.16 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	3.549ProAla: 3.549 ± 0.049	0.376ProCys: 0.376 ± 0.015	3.684ProAsp: 3.684 ± 0.05	4.781ProGlu: 4.781 ± 0.064	1.879ProPhe: 1.879 ± 0.033	3.551ProGly: 3.551 ± 0.051	0.994ProHis: 0.994 ± 0.026	2.975ProIle: 2.975 ± 0.041	1.868ProLys: 1.868 ± 0.035	4.968ProLeu: 4.968 ± 0.064	0.817ProMet: 0.817 ± 0.023	1.976ProAsn: 1.976 ± 0.034	3.161ProPro: 3.161 ± 0.069	2.719ProGln: 2.719 ± 0.043	2.292ProArg: 2.292 ± 0.044	3.44ProSer: 3.44 ± 0.055	3.02ProThr: 3.02 ± 0.059	3.453ProVal: 3.453 ± 0.046	0.692ProTrp: 0.692 ± 0.024	1.298ProTyr: 1.298 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.278GlnAla: 4.278 ± 0.066	0.373GlnCys: 0.373 ± 0.014	1.75GlnAsp: 1.75 ± 0.033	2.86GlnGlu: 2.86 ± 0.051	1.904GlnPhe: 1.904 ± 0.035	2.886GlnGly: 2.886 ± 0.049	0.777GlnHis: 0.777 ± 0.02	3.201GlnIle: 3.201 ± 0.039	2.035GlnLys: 2.035 ± 0.037	5.973GlnLeu: 5.973 ± 0.069	0.97GlnMet: 0.97 ± 0.026	1.645GlnAsn: 1.645 ± 0.036	2.253GlnPro: 2.253 ± 0.041	3.011GlnGln: 3.011 ± 0.06	2.644GlnArg: 2.644 ± 0.061	2.581GlnSer: 2.581 ± 0.047	2.812GlnThr: 2.812 ± 0.043	3.316GlnVal: 3.316 ± 0.049	0.832GlnTrp: 0.832 ± 0.026	1.106GlnTyr: 1.106 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.358ArgAla: 5.358 ± 0.074	0.67ArgCys: 0.67 ± 0.022	4.207ArgAsp: 4.207 ± 0.061	4.975ArgGlu: 4.975 ± 0.056	2.548ArgPhe: 2.548 ± 0.036	4.421ArgGly: 4.421 ± 0.06	1.458ArgHis: 1.458 ± 0.03	3.465ArgIle: 3.465 ± 0.046	2.104ArgLys: 2.104 ± 0.037	7.308ArgLeu: 7.308 ± 0.075	1.049ArgMet: 1.049 ± 0.027	1.919ArgAsn: 1.919 ± 0.037	3.075ArgPro: 3.075 ± 0.048	4.191ArgGln: 4.191 ± 0.068	4.521ArgArg: 4.521 ± 0.066	4.721ArgSer: 4.721 ± 0.062	2.997ArgThr: 2.997 ± 0.048	4.224ArgVal: 4.224 ± 0.057	1.093ArgTrp: 1.093 ± 0.029	2.075ArgTyr: 2.075 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.998SerAla: 4.998 ± 0.053	0.607SerCys: 0.607 ± 0.019	3.659SerAsp: 3.659 ± 0.062	4.288SerGlu: 4.288 ± 0.063	2.423SerPhe: 2.423 ± 0.046	5.073SerGly: 5.073 ± 0.075	1.27SerHis: 1.27 ± 0.022	3.423SerIle: 3.423 ± 0.05	2.02SerLys: 2.02 ± 0.039	6.981SerLeu: 6.981 ± 0.07	1.118SerMet: 1.118 ± 0.027	2.059SerAsn: 2.059 ± 0.041	4.044SerPro: 4.044 ± 0.056	3.231SerGln: 3.231 ± 0.056	3.794SerArg: 3.794 ± 0.043	4.146SerSer: 4.146 ± 0.062	3.073SerThr: 3.073 ± 0.063	3.707SerVal: 3.707 ± 0.044	0.929SerTrp: 0.929 ± 0.028	1.591SerTyr: 1.591 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	4.801ThrAla: 4.801 ± 0.067	0.518ThrCys: 0.518 ± 0.018	2.715ThrAsp: 2.715 ± 0.054	3.308ThrGlu: 3.308 ± 0.061	1.892ThrPhe: 1.892 ± 0.032	4.496ThrGly: 4.496 ± 0.087	0.981ThrHis: 0.981 ± 0.027	3.774ThrIle: 3.774 ± 0.058	1.393ThrLys: 1.393 ± 0.033	6.305ThrLeu: 6.305 ± 0.071	0.679ThrMet: 0.679 ± 0.021	1.528ThrAsn: 1.528 ± 0.033	3.785ThrPro: 3.785 ± 0.069	2.325ThrGln: 2.325 ± 0.042	2.846ThrArg: 2.846 ± 0.046	2.902ThrSer: 2.902 ± 0.057	3.023ThrThr: 3.023 ± 0.067	4.159ThrVal: 4.159 ± 0.078	0.76ThrTrp: 0.76 ± 0.022	1.493ThrTyr: 1.493 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	5.975ValAla: 5.975 ± 0.074	0.697ValCys: 0.697 ± 0.021	3.366ValAsp: 3.366 ± 0.05	5.115ValGlu: 5.115 ± 0.062	2.372ValPhe: 2.372 ± 0.039	5.004ValGly: 5.004 ± 0.063	1.017ValHis: 1.017 ± 0.026	2.84ValIle: 2.84 ± 0.049	2.751ValLys: 2.751 ± 0.044	6.239ValLeu: 6.239 ± 0.071	1.21ValMet: 1.21 ± 0.031	2.538ValAsn: 2.538 ± 0.045	2.972ValPro: 2.972 ± 0.041	2.326ValGln: 2.326 ± 0.055	4.381ValArg: 4.381 ± 0.06	4.063ValSer: 4.063 ± 0.054	3.652ValThr: 3.652 ± 0.054	4.604ValVal: 4.604 ± 0.069	0.873ValTrp: 0.873 ± 0.025	1.739ValTyr: 1.739 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.965TrpAla: 0.965 ± 0.027	0.153TrpCys: 0.153 ± 0.009	0.753TrpAsp: 0.753 ± 0.024	0.998TrpGlu: 0.998 ± 0.027	0.618TrpPhe: 0.618 ± 0.018	1.104TrpGly: 1.104 ± 0.027	0.346TrpHis: 0.346 ± 0.017	0.892TrpIle: 0.892 ± 0.027	0.586TrpLys: 0.586 ± 0.022	1.787TrpLeu: 1.787 ± 0.034	0.345TrpMet: 0.345 ± 0.016	0.633TrpAsn: 0.633 ± 0.022	0.506TrpPro: 0.506 ± 0.019	1.123TrpGln: 1.123 ± 0.029	1.032TrpArg: 1.032 ± 0.028	0.85TrpSer: 0.85 ± 0.025	0.66TrpThr: 0.66 ± 0.023	0.988TrpVal: 0.988 ± 0.029	0.267TrpTrp: 0.267 ± 0.014	0.416TrpTyr: 0.416 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.017TyrAla: 2.017 ± 0.03	0.378TyrCys: 0.378 ± 0.017	1.559TyrAsp: 1.559 ± 0.043	1.73TyrGlu: 1.73 ± 0.04	1.283TyrPhe: 1.283 ± 0.035	2.028TyrGly: 2.028 ± 0.036	0.627TyrHis: 0.627 ± 0.021	1.405TyrIle: 1.405 ± 0.033	0.928TyrLys: 0.928 ± 0.025	3.423TyrLeu: 3.423 ± 0.051	0.351TyrMet: 0.351 ± 0.015	1.034TyrAsn: 1.034 ± 0.028	1.537TyrPro: 1.537 ± 0.032	1.622TyrGln: 1.622 ± 0.032	2.555TyrArg: 2.555 ± 0.041	1.658TyrSer: 1.658 ± 0.034	1.346TyrThr: 1.346 ± 0.032	1.339TyrVal: 1.339 ± 0.025	0.533TyrTrp: 0.533 ± 0.019	0.959TyrTyr: 0.959 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4779 proteins (1694947 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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