Amino acid dipepetide frequency for Isoptericola sp. CG 20/1183

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.763AlaAla: 22.763 ± 0.221
0.784AlaCys: 0.784 ± 0.028
9.614AlaAsp: 9.614 ± 0.102
8.949AlaGlu: 8.949 ± 0.096
3.352AlaPhe: 3.352 ± 0.061
14.22AlaGly: 14.22 ± 0.12
2.707AlaHis: 2.707 ± 0.045
3.464AlaIle: 3.464 ± 0.056
1.848AlaLys: 1.848 ± 0.049
14.194AlaLeu: 14.194 ± 0.132
2.563AlaMet: 2.563 ± 0.053
1.703AlaAsn: 1.703 ± 0.042
7.336AlaPro: 7.336 ± 0.092
3.776AlaGln: 3.776 ± 0.058
11.028AlaArg: 11.028 ± 0.109
6.302AlaSer: 6.302 ± 0.074
8.385AlaThr: 8.385 ± 0.1
13.883AlaVal: 13.883 ± 0.13
2.186AlaTrp: 2.186 ± 0.05
2.344AlaTyr: 2.344 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.749CysAla: 0.749 ± 0.032
0.066CysCys: 0.066 ± 0.006
0.33CysAsp: 0.33 ± 0.018
0.298CysGlu: 0.298 ± 0.016
0.153CysPhe: 0.153 ± 0.011
0.651CysGly: 0.651 ± 0.027
0.132CysHis: 0.132 ± 0.01
0.103CysIle: 0.103 ± 0.009
0.042CysLys: 0.042 ± 0.007
0.489CysLeu: 0.489 ± 0.02
0.077CysMet: 0.077 ± 0.009
0.073CysAsn: 0.073 ± 0.008
0.337CysPro: 0.337 ± 0.016
0.118CysGln: 0.118 ± 0.01
0.409CysArg: 0.409 ± 0.021
0.336CysSer: 0.336 ± 0.017
0.397CysThr: 0.397 ± 0.023
0.496CysVal: 0.496 ± 0.02
0.084CysTrp: 0.084 ± 0.008
0.104CysTyr: 0.104 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
9.765AspAla: 9.765 ± 0.087
0.264AspCys: 0.264 ± 0.014
5.553AspAsp: 5.553 ± 0.093
4.39AspGlu: 4.39 ± 0.063
1.376AspPhe: 1.376 ± 0.036
8.016AspGly: 8.016 ± 0.122
1.497AspHis: 1.497 ± 0.041
1.406AspIle: 1.406 ± 0.042
0.774AspLys: 0.774 ± 0.034
6.99AspLeu: 6.99 ± 0.083
0.77AspMet: 0.77 ± 0.025
0.755AspAsn: 0.755 ± 0.03
4.949AspPro: 4.949 ± 0.083
1.614AspGln: 1.614 ± 0.039
4.869AspArg: 4.869 ± 0.066
2.208AspSer: 2.208 ± 0.046
2.997AspThr: 2.997 ± 0.045
7.478AspVal: 7.478 ± 0.087
0.949AspTrp: 0.949 ± 0.028
1.143AspTyr: 1.143 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
7.494GluAla: 7.494 ± 0.084
0.258GluCys: 0.258 ± 0.016
3.003GluAsp: 3.003 ± 0.052
2.937GluGlu: 2.937 ± 0.061
1.278GluPhe: 1.278 ± 0.037
4.109GluGly: 4.109 ± 0.066
1.825GluHis: 1.825 ± 0.042
2.423GluIle: 2.423 ± 0.042
0.963GluLys: 0.963 ± 0.034
6.625GluLeu: 6.625 ± 0.076
0.866GluMet: 0.866 ± 0.024
0.965GluAsn: 0.965 ± 0.027
3.808GluPro: 3.808 ± 0.072
2.176GluGln: 2.176 ± 0.045
5.428GluArg: 5.428 ± 0.082
2.652GluSer: 2.652 ± 0.056
2.88GluThr: 2.88 ± 0.06
5.609GluVal: 5.609 ± 0.069
0.761GluTrp: 0.761 ± 0.025
0.97GluTyr: 0.97 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.533PheAla: 3.533 ± 0.046
0.185PheCys: 0.185 ± 0.014
2.055PheAsp: 2.055 ± 0.051
1.418PheGlu: 1.418 ± 0.032
0.796PhePhe: 0.796 ± 0.028
2.743PheGly: 2.743 ± 0.053
0.512PheHis: 0.512 ± 0.019
0.56PheIle: 0.56 ± 0.027
0.304PheLys: 0.304 ± 0.016
2.51PheLeu: 2.51 ± 0.052
0.335PheMet: 0.335 ± 0.017
0.446PheAsn: 0.446 ± 0.021
1.184PhePro: 1.184 ± 0.033
0.607PheGln: 0.607 ± 0.025
1.598PheArg: 1.598 ± 0.041
1.376PheSer: 1.376 ± 0.036
1.718PheThr: 1.718 ± 0.04
2.648PheVal: 2.648 ± 0.054
0.484PheTrp: 0.484 ± 0.024
0.536PheTyr: 0.536 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
12.339GlyAla: 12.339 ± 0.125
0.552GlyCys: 0.552 ± 0.021
5.703GlyAsp: 5.703 ± 0.081
5.282GlyGlu: 5.282 ± 0.074
2.711GlyPhe: 2.711 ± 0.05
8.622GlyGly: 8.622 ± 0.111
2.076GlyHis: 2.076 ± 0.036
3.273GlyIle: 3.273 ± 0.054
1.699GlyLys: 1.699 ± 0.045
9.333GlyLeu: 9.333 ± 0.105
1.952GlyMet: 1.952 ± 0.045
1.453GlyAsn: 1.453 ± 0.043
5.15GlyPro: 5.15 ± 0.085
2.419GlyGln: 2.419 ± 0.051
7.387GlyArg: 7.387 ± 0.095
5.441GlySer: 5.441 ± 0.076
6.848GlyThr: 6.848 ± 0.092
8.592GlyVal: 8.592 ± 0.095
1.739GlyTrp: 1.739 ± 0.041
2.167GlyTyr: 2.167 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.802HisAla: 2.802 ± 0.055
0.119HisCys: 0.119 ± 0.011
1.655HisAsp: 1.655 ± 0.038
1.211HisGlu: 1.211 ± 0.033
0.488HisPhe: 0.488 ± 0.02
2.296HisGly: 2.296 ± 0.042
0.639HisHis: 0.639 ± 0.022
0.395HisIle: 0.395 ± 0.019
0.208HisLys: 0.208 ± 0.014
2.424HisLeu: 2.424 ± 0.051
0.246HisMet: 0.246 ± 0.014
0.318HisAsn: 0.318 ± 0.017
1.64HisPro: 1.64 ± 0.039
0.559HisGln: 0.559 ± 0.022
1.922HisArg: 1.922 ± 0.043
0.817HisSer: 0.817 ± 0.026
1.035HisThr: 1.035 ± 0.03
2.203HisVal: 2.203 ± 0.04
0.291HisTrp: 0.291 ± 0.018
0.39HisTyr: 0.39 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
4.095IleAla: 4.095 ± 0.063
0.183IleCys: 0.183 ± 0.015
2.322IleAsp: 2.322 ± 0.051
1.908IleGlu: 1.908 ± 0.044
0.73IlePhe: 0.73 ± 0.027
2.916IleGly: 2.916 ± 0.056
0.457IleHis: 0.457 ± 0.023
0.84IleIle: 0.84 ± 0.03
0.484IleLys: 0.484 ± 0.023
2.32IleLeu: 2.32 ± 0.048
0.396IleMet: 0.396 ± 0.019
0.553IleAsn: 0.553 ± 0.022
1.489IlePro: 1.489 ± 0.041
0.581IleGln: 0.581 ± 0.026
1.603IleArg: 1.603 ± 0.037
1.429IleSer: 1.429 ± 0.035
1.929IleThr: 1.929 ± 0.043
2.933IleVal: 2.933 ± 0.054
0.337IleTrp: 0.337 ± 0.017
0.463IleTyr: 0.463 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
1.69LysAla: 1.69 ± 0.051
0.057LysCys: 0.057 ± 0.007
0.813LysAsp: 0.813 ± 0.028
0.725LysGlu: 0.725 ± 0.031
0.325LysPhe: 0.325 ± 0.016
1.131LysGly: 1.131 ± 0.04
0.385LysHis: 0.385 ± 0.022
0.651LysIle: 0.651 ± 0.026
0.556LysLys: 0.556 ± 0.031
1.158LysLeu: 1.158 ± 0.035
0.285LysMet: 0.285 ± 0.017
0.365LysAsn: 0.365 ± 0.018
0.849LysPro: 0.849 ± 0.032
0.459LysGln: 0.459 ± 0.023
1.036LysArg: 1.036 ± 0.033
0.794LysSer: 0.794 ± 0.027
0.85LysThr: 0.85 ± 0.028
1.438LysVal: 1.438 ± 0.044
0.154LysTrp: 0.154 ± 0.011
0.304LysTyr: 0.304 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
16.069LeuAla: 16.069 ± 0.152
0.571LeuCys: 0.571 ± 0.021
7.511LeuAsp: 7.511 ± 0.09
5.252LeuGlu: 5.252 ± 0.071
2.275LeuPhe: 2.275 ± 0.044
9.489LeuGly: 9.489 ± 0.111
2.02LeuHis: 2.02 ± 0.041
2.109LeuIle: 2.109 ± 0.049
1.154LeuLys: 1.154 ± 0.042
10.489LeuLeu: 10.489 ± 0.135
1.433LeuMet: 1.433 ± 0.04
1.257LeuAsn: 1.257 ± 0.039
5.783LeuPro: 5.783 ± 0.076
2.216LeuGln: 2.216 ± 0.044
8.198LeuArg: 8.198 ± 0.093
4.664LeuSer: 4.664 ± 0.069
6.513LeuThr: 6.513 ± 0.079
10.906LeuVal: 10.906 ± 0.117
1.282LeuTrp: 1.282 ± 0.035
1.49LeuTyr: 1.49 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
1.982MetAla: 1.982 ± 0.037
0.099MetCys: 0.099 ± 0.008
0.807MetAsp: 0.807 ± 0.026
0.635MetGlu: 0.635 ± 0.025
0.442MetPhe: 0.442 ± 0.021
1.125MetGly: 1.125 ± 0.034
0.327MetHis: 0.327 ± 0.017
0.619MetIle: 0.619 ± 0.022
0.273MetLys: 0.273 ± 0.014
1.73MetLeu: 1.73 ± 0.043
0.238MetMet: 0.238 ± 0.015
0.351MetAsn: 0.351 ± 0.019
1.053MetPro: 1.053 ± 0.03
0.411MetGln: 0.411 ± 0.018
1.231MetArg: 1.231 ± 0.035
1.304MetSer: 1.304 ± 0.035
1.691MetThr: 1.691 ± 0.033
1.376MetVal: 1.376 ± 0.037
0.182MetTrp: 0.182 ± 0.013
0.234MetTyr: 0.234 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
1.828AsnAla: 1.828 ± 0.041
0.078AsnCys: 0.078 ± 0.01
0.92AsnAsp: 0.92 ± 0.027
0.712AsnGlu: 0.712 ± 0.026
0.409AsnPhe: 0.409 ± 0.019
1.427AsnGly: 1.427 ± 0.044
0.342AsnHis: 0.342 ± 0.017
0.514AsnIle: 0.514 ± 0.023
0.254AsnLys: 0.254 ± 0.017
1.547AsnLeu: 1.547 ± 0.039
0.242AsnMet: 0.242 ± 0.013
0.341AsnAsn: 0.341 ± 0.019
1.208AsnPro: 1.208 ± 0.031
0.456AsnGln: 0.456 ± 0.02
0.938AsnArg: 0.938 ± 0.031
0.647AsnSer: 0.647 ± 0.027
0.954AsnThr: 0.954 ± 0.032
1.424AsnVal: 1.424 ± 0.036
0.201AsnTrp: 0.201 ± 0.013
0.38AsnTyr: 0.38 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
8.683ProAla: 8.683 ± 0.109
0.221ProCys: 0.221 ± 0.014
5.046ProAsp: 5.046 ± 0.083
4.197ProGlu: 4.197 ± 0.066
1.546ProPhe: 1.546 ± 0.04
6.34ProGly: 6.34 ± 0.078
1.265ProHis: 1.265 ± 0.032
1.195ProIle: 1.195 ± 0.036
0.664ProLys: 0.664 ± 0.03
4.918ProLeu: 4.918 ± 0.072
0.858ProMet: 0.858 ± 0.028
0.721ProAsn: 0.721 ± 0.027
3.072ProPro: 3.072 ± 0.074
1.557ProGln: 1.557 ± 0.038
3.892ProArg: 3.892 ± 0.072
3.183ProSer: 3.183 ± 0.058
3.659ProThr: 3.659 ± 0.065
5.806ProVal: 5.806 ± 0.076
1.016ProTrp: 1.016 ± 0.031
1.046ProTyr: 1.046 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.376GlnAla: 3.376 ± 0.051
0.123GlnCys: 0.123 ± 0.009
1.481GlnAsp: 1.481 ± 0.035
1.37GlnGlu: 1.37 ± 0.035
0.632GlnPhe: 0.632 ± 0.025
2.1GlnGly: 2.1 ± 0.045
0.704GlnHis: 0.704 ± 0.027
0.98GlnIle: 0.98 ± 0.027
0.404GlnLys: 0.404 ± 0.019
2.574GlnLeu: 2.574 ± 0.058
0.455GlnMet: 0.455 ± 0.02
0.439GlnAsn: 0.439 ± 0.019
1.49GlnPro: 1.49 ± 0.037
1.091GlnGln: 1.091 ± 0.041
2.289GlnArg: 2.289 ± 0.054
1.123GlnSer: 1.123 ± 0.03
1.293GlnThr: 1.293 ± 0.035
3.085GlnVal: 3.085 ± 0.056
0.46GlnTrp: 0.46 ± 0.022
0.57GlnTyr: 0.57 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
10.23ArgAla: 10.23 ± 0.132
0.4ArgCys: 0.4 ± 0.02
4.667ArgAsp: 4.667 ± 0.065
4.393ArgGlu: 4.393 ± 0.074
2.126ArgPhe: 2.126 ± 0.039
6.008ArgGly: 6.008 ± 0.084
1.869ArgHis: 1.869 ± 0.044
2.549ArgIle: 2.549 ± 0.054
1.114ArgLys: 1.114 ± 0.039
8.112ArgLeu: 8.112 ± 0.09
1.584ArgMet: 1.584 ± 0.039
1.068ArgAsn: 1.068 ± 0.03
4.532ArgPro: 4.532 ± 0.072
2.019ArgGln: 2.019 ± 0.042
8.209ArgArg: 8.209 ± 0.125
4.441ArgSer: 4.441 ± 0.063
5.3ArgThr: 5.3 ± 0.074
6.538ArgVal: 6.538 ± 0.083
1.577ArgTrp: 1.577 ± 0.04
1.682ArgTyr: 1.682 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.604SerAla: 6.604 ± 0.068
0.298SerCys: 0.298 ± 0.018
2.935SerAsp: 2.935 ± 0.057
2.339SerGlu: 2.339 ± 0.047
1.538SerPhe: 1.538 ± 0.04
5.592SerGly: 5.592 ± 0.078
0.925SerHis: 0.925 ± 0.028
1.508SerIle: 1.508 ± 0.037
0.71SerLys: 0.71 ± 0.026
4.562SerLeu: 4.562 ± 0.062
1.008SerMet: 1.008 ± 0.031
0.817SerAsn: 0.817 ± 0.03
3.031SerPro: 3.031 ± 0.05
1.221SerGln: 1.221 ± 0.033
3.664SerArg: 3.664 ± 0.062
3.045SerSer: 3.045 ± 0.059
3.581SerThr: 3.581 ± 0.07
4.565SerVal: 4.565 ± 0.07
0.957SerTrp: 0.957 ± 0.029
1.003SerTyr: 1.003 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
8.692ThrAla: 8.692 ± 0.099
0.347ThrCys: 0.347 ± 0.021
4.104ThrAsp: 4.104 ± 0.066
3.357ThrGlu: 3.357 ± 0.068
1.948ThrPhe: 1.948 ± 0.046
6.381ThrGly: 6.381 ± 0.087
1.165ThrHis: 1.165 ± 0.032
1.956ThrIle: 1.956 ± 0.048
0.895ThrLys: 0.895 ± 0.032
5.911ThrLeu: 5.911 ± 0.081
0.927ThrMet: 0.927 ± 0.029
1.021ThrAsn: 1.021 ± 0.033
4.061ThrPro: 4.061 ± 0.066
1.434ThrGln: 1.434 ± 0.035
3.928ThrArg: 3.928 ± 0.048
3.606ThrSer: 3.606 ± 0.052
4.689ThrThr: 4.689 ± 0.073
6.746ThrVal: 6.746 ± 0.092
1.131ThrTrp: 1.131 ± 0.037
1.359ThrTyr: 1.359 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
14.563ValAla: 14.563 ± 0.134
0.594ValCys: 0.594 ± 0.021
6.881ValAsp: 6.881 ± 0.086
5.814ValGlu: 5.814 ± 0.075
2.273ValPhe: 2.273 ± 0.053
8.598ValGly: 8.598 ± 0.092
2.108ValHis: 2.108 ± 0.05
2.539ValIle: 2.539 ± 0.058
1.23ValLys: 1.23 ± 0.037
11.044ValLeu: 11.044 ± 0.123
1.37ValMet: 1.37 ± 0.037
1.445ValAsn: 1.445 ± 0.038
6.119ValPro: 6.119 ± 0.08
2.264ValGln: 2.264 ± 0.043
7.821ValArg: 7.821 ± 0.091
4.592ValSer: 4.592 ± 0.065
6.663ValThr: 6.663 ± 0.084
12.703ValVal: 12.703 ± 0.136
1.324ValTrp: 1.324 ± 0.031
1.558ValTyr: 1.558 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.738TrpAla: 1.738 ± 0.045
0.125TrpCys: 0.125 ± 0.01
0.976TrpAsp: 0.976 ± 0.03
0.78TrpGlu: 0.78 ± 0.026
0.592TrpPhe: 0.592 ± 0.023
1.142TrpGly: 1.142 ± 0.034
0.358TrpHis: 0.358 ± 0.017
0.511TrpIle: 0.511 ± 0.019
0.216TrpLys: 0.216 ± 0.014
1.741TrpLeu: 1.741 ± 0.046
0.295TrpMet: 0.295 ± 0.017
0.402TrpAsn: 0.402 ± 0.021
0.783TrpPro: 0.783 ± 0.025
0.571TrpGln: 0.571 ± 0.021
1.38TrpArg: 1.38 ± 0.038
1.04TrpSer: 1.04 ± 0.029
1.128TrpThr: 1.128 ± 0.034
1.332TrpVal: 1.332 ± 0.044
0.452TrpTrp: 0.452 ± 0.022
0.333TrpTyr: 0.333 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.403TyrAla: 2.403 ± 0.053
0.12TyrCys: 0.12 ± 0.011
1.387TyrAsp: 1.387 ± 0.042
1.064TyrGlu: 1.064 ± 0.029
0.558TyrPhe: 0.558 ± 0.023
1.83TyrGly: 1.83 ± 0.039
0.345TyrHis: 0.345 ± 0.017
0.373TyrIle: 0.373 ± 0.018
0.233TyrLys: 0.233 ± 0.013
2.013TyrLeu: 2.013 ± 0.04
0.21TyrMet: 0.21 ± 0.014
0.327TyrAsn: 0.327 ± 0.016
1.012TyrPro: 1.012 ± 0.031
0.493TyrGln: 0.493 ± 0.02
1.586TyrArg: 1.586 ± 0.039
0.904TyrSer: 0.904 ± 0.027
1.147TyrThr: 1.147 ± 0.034
1.743TyrVal: 1.743 ± 0.036
0.328TyrTrp: 0.328 ± 0.017
0.435TyrTyr: 0.435 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3485 proteins (1184991 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski