Amino acid dipepetide frequency for Acidipropionibacterium jensenii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.26AlaAla: 16.26 ± 0.17	1.104AlaCys: 1.104 ± 0.034	7.976AlaAsp: 7.976 ± 0.108	7.141AlaGlu: 7.141 ± 0.109	2.96AlaPhe: 2.96 ± 0.061	11.965AlaGly: 11.965 ± 0.136	2.57AlaHis: 2.57 ± 0.058	4.918AlaIle: 4.918 ± 0.086	2.646AlaLys: 2.646 ± 0.064	11.553AlaLeu: 11.553 ± 0.146	2.964AlaMet: 2.964 ± 0.059	2.155AlaAsn: 2.155 ± 0.054	5.426AlaPro: 5.426 ± 0.084	3.91AlaGln: 3.91 ± 0.076	8.821AlaArg: 8.821 ± 0.109	6.845AlaSer: 6.845 ± 0.112	6.915AlaThr: 6.915 ± 0.097	10.635AlaVal: 10.635 ± 0.133	1.809AlaTrp: 1.809 ± 0.049	1.812AlaTyr: 1.812 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.995CysAla: 0.995 ± 0.032	0.153CysCys: 0.153 ± 0.014	0.555CysAsp: 0.555 ± 0.025	0.449CysGlu: 0.449 ± 0.02	0.279CysPhe: 0.279 ± 0.017	1.042CysGly: 1.042 ± 0.039	0.244CysHis: 0.244 ± 0.019	0.303CysIle: 0.303 ± 0.017	0.112CysLys: 0.112 ± 0.009	0.953CysLeu: 0.953 ± 0.029	0.136CysMet: 0.136 ± 0.013	0.151CysAsn: 0.151 ± 0.012	0.581CysPro: 0.581 ± 0.03	0.327CysGln: 0.327 ± 0.02	0.751CysArg: 0.751 ± 0.031	0.566CysSer: 0.566 ± 0.026	0.531CysThr: 0.531 ± 0.019	0.583CysVal: 0.583 ± 0.023	0.178CysTrp: 0.178 ± 0.013	0.217CysTyr: 0.217 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.975AspAla: 6.975 ± 0.087	0.423AspCys: 0.423 ± 0.02	3.875AspAsp: 3.875 ± 0.081	3.828AspGlu: 3.828 ± 0.079	1.465AspPhe: 1.465 ± 0.044	5.431AspGly: 5.431 ± 0.082	1.692AspHis: 1.692 ± 0.048	2.371AspIle: 2.371 ± 0.053	1.258AspLys: 1.258 ± 0.04	7.053AspLeu: 7.053 ± 0.104	1.058AspMet: 1.058 ± 0.033	1.049AspAsn: 1.049 ± 0.038	4.983AspPro: 4.983 ± 0.081	2.419AspGln: 2.419 ± 0.059	5.118AspArg: 5.118 ± 0.082	3.404AspSer: 3.404 ± 0.067	2.91AspThr: 2.91 ± 0.053	4.653AspVal: 4.653 ± 0.076	0.967AspTrp: 0.967 ± 0.039	1.18AspTyr: 1.18 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.078GluAla: 6.078 ± 0.09	0.387GluCys: 0.387 ± 0.021	2.766GluAsp: 2.766 ± 0.063	2.978GluGlu: 2.978 ± 0.068	1.438GluPhe: 1.438 ± 0.041	3.965GluGly: 3.965 ± 0.067	1.497GluHis: 1.497 ± 0.039	2.563GluIle: 2.563 ± 0.058	1.477GluLys: 1.477 ± 0.045	5.496GluLeu: 5.496 ± 0.082	1.238GluMet: 1.238 ± 0.037	1.059GluAsn: 1.059 ± 0.039	2.683GluPro: 2.683 ± 0.067	2.026GluGln: 2.026 ± 0.053	3.751GluArg: 3.751 ± 0.064	2.85GluSer: 2.85 ± 0.06	2.681GluThr: 2.681 ± 0.055	4.594GluVal: 4.594 ± 0.074	0.664GluTrp: 0.664 ± 0.027	0.953GluTyr: 0.953 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.097PheAla: 3.097 ± 0.057	0.319PheCys: 0.319 ± 0.018	1.955PheAsp: 1.955 ± 0.046	1.21PheGlu: 1.21 ± 0.039	0.898PhePhe: 0.898 ± 0.04	2.882PheGly: 2.882 ± 0.068	0.638PheHis: 0.638 ± 0.03	1.242PheIle: 1.242 ± 0.039	0.612PheLys: 0.612 ± 0.025	2.569PheLeu: 2.569 ± 0.06	0.558PheMet: 0.558 ± 0.024	0.703PheAsn: 0.703 ± 0.03	1.203PhePro: 1.203 ± 0.036	0.76PheGln: 0.76 ± 0.03	1.556PheArg: 1.556 ± 0.037	1.839PheSer: 1.839 ± 0.048	1.982PheThr: 1.982 ± 0.049	2.091PheVal: 2.091 ± 0.059	0.437PheTrp: 0.437 ± 0.024	0.533PheTyr: 0.533 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.435GlyAla: 9.435 ± 0.115	0.923GlyCys: 0.923 ± 0.037	4.72GlyAsp: 4.72 ± 0.075	4.178GlyGlu: 4.178 ± 0.076	2.829GlyPhe: 2.829 ± 0.064	7.029GlyGly: 7.029 ± 0.12	2.353GlyHis: 2.353 ± 0.053	4.316GlyIle: 4.316 ± 0.066	2.284GlyLys: 2.284 ± 0.06	9.368GlyLeu: 9.368 ± 0.129	2.166GlyMet: 2.166 ± 0.057	1.638GlyAsn: 1.638 ± 0.046	4.51GlyPro: 4.51 ± 0.088	3.245GlyGln: 3.245 ± 0.076	7.19GlyArg: 7.19 ± 0.115	6.265GlySer: 6.265 ± 0.109	5.698GlyThr: 5.698 ± 0.089	7.843GlyVal: 7.843 ± 0.087	1.872GlyTrp: 1.872 ± 0.06	2.195GlyTyr: 2.195 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	2.151HisAla: 2.151 ± 0.053	0.226HisCys: 0.226 ± 0.017	1.674HisAsp: 1.674 ± 0.049	1.119HisGlu: 1.119 ± 0.041	0.57HisPhe: 0.57 ± 0.028	2.1HisGly: 2.1 ± 0.047	0.84HisHis: 0.84 ± 0.03	0.868HisIle: 0.868 ± 0.029	0.398HisLys: 0.398 ± 0.02	2.437HisLeu: 2.437 ± 0.051	0.43HisMet: 0.43 ± 0.02	0.444HisAsn: 0.444 ± 0.023	1.883HisPro: 1.883 ± 0.044	0.929HisGln: 0.929 ± 0.033	2.199HisArg: 2.199 ± 0.052	1.289HisSer: 1.289 ± 0.041	1.347HisThr: 1.347 ± 0.037	1.645HisVal: 1.645 ± 0.045	0.392HisTrp: 0.392 ± 0.022	0.495HisTyr: 0.495 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.721IleAla: 5.721 ± 0.093	0.587IleCys: 0.587 ± 0.021	3.391IleAsp: 3.391 ± 0.062	2.279IleGlu: 2.279 ± 0.05	1.063IlePhe: 1.063 ± 0.042	4.773IleGly: 4.773 ± 0.091	0.893IleHis: 0.893 ± 0.03	1.942IleIle: 1.942 ± 0.048	0.921IleLys: 0.921 ± 0.034	3.891IleLeu: 3.891 ± 0.083	0.731IleMet: 0.731 ± 0.028	1.085IleAsn: 1.085 ± 0.036	2.399IlePro: 2.399 ± 0.047	1.063IleGln: 1.063 ± 0.031	2.802IleArg: 2.802 ± 0.061	2.793IleSer: 2.793 ± 0.058	2.846IleThr: 2.846 ± 0.06	3.895IleVal: 3.895 ± 0.073	0.615IleTrp: 0.615 ± 0.03	0.815IleTyr: 0.815 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.842LysAla: 2.842 ± 0.07	0.123LysCys: 0.123 ± 0.012	1.319LysAsp: 1.319 ± 0.043	1.104LysGlu: 1.104 ± 0.042	0.486LysPhe: 0.486 ± 0.024	1.868LysGly: 1.868 ± 0.052	0.462LysHis: 0.462 ± 0.021	1.111LysIle: 1.111 ± 0.036	0.995LysLys: 0.995 ± 0.042	1.93LysLeu: 1.93 ± 0.048	0.513LysMet: 0.513 ± 0.023	0.594LysAsn: 0.594 ± 0.026	1.124LysPro: 1.124 ± 0.039	0.725LysGln: 0.725 ± 0.032	1.346LysArg: 1.346 ± 0.044	1.27LysSer: 1.27 ± 0.047	1.372LysThr: 1.372 ± 0.044	2.175LysVal: 2.175 ± 0.057	0.247LysTrp: 0.247 ± 0.017	0.542LysTyr: 0.542 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.822LeuAla: 13.822 ± 0.146	0.876LeuCys: 0.876 ± 0.031	6.834LeuAsp: 6.834 ± 0.093	4.744LeuGlu: 4.744 ± 0.072	2.531LeuPhe: 2.531 ± 0.065	8.727LeuGly: 8.727 ± 0.115	2.034LeuHis: 2.034 ± 0.047	4.285LeuIle: 4.285 ± 0.087	1.923LeuLys: 1.923 ± 0.054	9.123LeuLeu: 9.123 ± 0.161	2.038LeuMet: 2.038 ± 0.05	1.98LeuAsn: 1.98 ± 0.047	5.276LeuPro: 5.276 ± 0.072	2.275LeuGln: 2.275 ± 0.054	6.818LeuArg: 6.818 ± 0.09	6.229LeuSer: 6.229 ± 0.087	6.436LeuThr: 6.436 ± 0.096	9.334LeuVal: 9.334 ± 0.136	1.249LeuTrp: 1.249 ± 0.049	1.417LeuTyr: 1.417 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.989MetAla: 2.989 ± 0.062	0.191MetCys: 0.191 ± 0.015	1.157MetAsp: 1.157 ± 0.038	0.829MetGlu: 0.829 ± 0.032	0.556MetPhe: 0.556 ± 0.027	1.799MetGly: 1.799 ± 0.049	0.366MetHis: 0.366 ± 0.021	1.097MetIle: 1.097 ± 0.031	0.502MetLys: 0.502 ± 0.025	1.929MetLeu: 1.929 ± 0.047	0.468MetMet: 0.468 ± 0.023	0.555MetAsn: 0.555 ± 0.025	1.275MetPro: 1.275 ± 0.037	0.473MetGln: 0.473 ± 0.024	1.541MetArg: 1.541 ± 0.04	1.944MetSer: 1.944 ± 0.047	1.931MetThr: 1.931 ± 0.05	2.009MetVal: 2.009 ± 0.044	0.286MetTrp: 0.286 ± 0.016	0.292MetTyr: 0.292 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.277AsnAla: 2.277 ± 0.05	0.179AsnCys: 0.179 ± 0.016	1.079AsnAsp: 1.079 ± 0.038	0.866AsnGlu: 0.866 ± 0.034	0.581AsnPhe: 0.581 ± 0.025	1.973AsnGly: 1.973 ± 0.049	0.547AsnHis: 0.547 ± 0.028	0.84AsnIle: 0.84 ± 0.028	0.483AsnLys: 0.483 ± 0.024	2.004AsnLeu: 2.004 ± 0.047	0.39AsnMet: 0.39 ± 0.019	0.446AsnAsn: 0.446 ± 0.024	1.656AsnPro: 1.656 ± 0.047	0.684AsnGln: 0.684 ± 0.022	1.523AsnArg: 1.523 ± 0.043	1.115AsnSer: 1.115 ± 0.038	1.137AsnThr: 1.137 ± 0.034	1.395AsnVal: 1.395 ± 0.044	0.338AsnTrp: 0.338 ± 0.019	0.507AsnTyr: 0.507 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.924ProAla: 6.924 ± 0.105	0.363ProCys: 0.363 ± 0.018	4.354ProAsp: 4.354 ± 0.081	3.585ProGlu: 3.585 ± 0.07	1.471ProPhe: 1.471 ± 0.04	5.666ProGly: 5.666 ± 0.078	1.281ProHis: 1.281 ± 0.044	1.956ProIle: 1.956 ± 0.044	1.133ProLys: 1.133 ± 0.042	4.502ProLeu: 4.502 ± 0.072	1.113ProMet: 1.113 ± 0.034	0.965ProAsn: 0.965 ± 0.031	2.178ProPro: 2.178 ± 0.062	1.918ProGln: 1.918 ± 0.054	3.791ProArg: 3.791 ± 0.065	3.576ProSer: 3.576 ± 0.07	3.406ProThr: 3.406 ± 0.066	5.303ProVal: 5.303 ± 0.079	0.923ProTrp: 0.923 ± 0.035	0.991ProTyr: 0.991 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.958GlnAla: 3.958 ± 0.07	0.177GlnCys: 0.177 ± 0.013	1.602GlnAsp: 1.602 ± 0.047	1.484GlnGlu: 1.484 ± 0.037	0.869GlnPhe: 0.869 ± 0.033	2.526GlnGly: 2.526 ± 0.067	0.709GlnHis: 0.709 ± 0.031	1.902GlnIle: 1.902 ± 0.044	0.781GlnLys: 0.781 ± 0.032	3.224GlnLeu: 3.224 ± 0.066	0.893GlnMet: 0.893 ± 0.03	0.671GlnAsn: 0.671 ± 0.028	1.712GlnPro: 1.712 ± 0.049	1.36GlnGln: 1.36 ± 0.045	2.453GlnArg: 2.453 ± 0.048	1.716GlnSer: 1.716 ± 0.052	1.894GlnThr: 1.894 ± 0.051	3.068GlnVal: 3.068 ± 0.057	0.531GlnTrp: 0.531 ± 0.021	0.624GlnTyr: 0.624 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.122ArgAla: 8.122 ± 0.098	0.694ArgCys: 0.694 ± 0.03	4.193ArgAsp: 4.193 ± 0.068	3.651ArgGlu: 3.651 ± 0.061	2.152ArgPhe: 2.152 ± 0.042	5.365ArgGly: 5.365 ± 0.086	2.068ArgHis: 2.068 ± 0.048	3.813ArgIle: 3.813 ± 0.067	1.646ArgLys: 1.646 ± 0.05	7.384ArgLeu: 7.384 ± 0.105	1.969ArgMet: 1.969 ± 0.043	1.48ArgAsn: 1.48 ± 0.039	4.442ArgPro: 4.442 ± 0.086	2.651ArgGln: 2.651 ± 0.054	7.591ArgArg: 7.591 ± 0.121	4.789ArgSer: 4.789 ± 0.074	4.787ArgThr: 4.787 ± 0.076	5.888ArgVal: 5.888 ± 0.088	1.369ArgTrp: 1.369 ± 0.035	1.62ArgTyr: 1.62 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	7.302SerAla: 7.302 ± 0.097	0.539SerCys: 0.539 ± 0.027	3.32SerAsp: 3.32 ± 0.067	2.816SerGlu: 2.816 ± 0.06	1.716SerPhe: 1.716 ± 0.042	6.75SerGly: 6.75 ± 0.103	1.434SerHis: 1.434 ± 0.037	2.416SerIle: 2.416 ± 0.058	1.267SerLys: 1.267 ± 0.037	5.648SerLeu: 5.648 ± 0.079	1.536SerMet: 1.536 ± 0.041	1.203SerAsn: 1.203 ± 0.037	3.631SerPro: 3.631 ± 0.068	2.205SerGln: 2.205 ± 0.06	4.897SerArg: 4.897 ± 0.071	4.454SerSer: 4.454 ± 0.093	4.259SerThr: 4.259 ± 0.083	4.706SerVal: 4.706 ± 0.07	1.257SerTrp: 1.257 ± 0.042	1.364SerTyr: 1.364 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	7.478ThrAla: 7.478 ± 0.09	0.507ThrCys: 0.507 ± 0.026	3.761ThrAsp: 3.761 ± 0.074	2.922ThrGlu: 2.922 ± 0.065	1.732ThrPhe: 1.732 ± 0.048	6.334ThrGly: 6.334 ± 0.092	1.148ThrHis: 1.148 ± 0.032	2.741ThrIle: 2.741 ± 0.051	1.163ThrLys: 1.163 ± 0.032	5.907ThrLeu: 5.907 ± 0.09	1.286ThrMet: 1.286 ± 0.041	1.2ThrAsn: 1.2 ± 0.039	4.057ThrPro: 4.057 ± 0.07	1.533ThrGln: 1.533 ± 0.048	4.335ThrArg: 4.335 ± 0.069	4.09ThrSer: 4.09 ± 0.072	4.285ThrThr: 4.285 ± 0.078	5.8ThrVal: 5.8 ± 0.086	0.969ThrTrp: 0.969 ± 0.033	1.04ThrTyr: 1.04 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.426ValAla: 10.426 ± 0.125	0.927ValCys: 0.927 ± 0.035	5.63ValAsp: 5.63 ± 0.097	4.58ValGlu: 4.58 ± 0.074	2.303ValPhe: 2.303 ± 0.056	6.976ValGly: 6.976 ± 0.098	1.884ValHis: 1.884 ± 0.043	4.44ValIle: 4.44 ± 0.076	1.805ValLys: 1.805 ± 0.052	8.993ValLeu: 8.993 ± 0.131	2.006ValMet: 2.006 ± 0.055	1.793ValAsn: 1.793 ± 0.045	4.562ValPro: 4.562 ± 0.066	2.169ValGln: 2.169 ± 0.048	5.92ValArg: 5.92 ± 0.08	5.441ValSer: 5.441 ± 0.087	5.789ValThr: 5.789 ± 0.084	8.622ValVal: 8.622 ± 0.137	1.273ValTrp: 1.273 ± 0.038	1.295ValTyr: 1.295 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.711TrpAla: 1.711 ± 0.046	0.212TrpCys: 0.212 ± 0.016	0.804TrpAsp: 0.804 ± 0.031	0.578TrpGlu: 0.578 ± 0.019	0.55TrpPhe: 0.55 ± 0.024	1.236TrpGly: 1.236 ± 0.039	0.358TrpHis: 0.358 ± 0.022	0.745TrpIle: 0.745 ± 0.029	0.341TrpLys: 0.341 ± 0.021	1.796TrpLeu: 1.796 ± 0.056	0.402TrpMet: 0.402 ± 0.021	0.4TrpAsn: 0.4 ± 0.022	0.761TrpPro: 0.761 ± 0.029	0.721TrpGln: 0.721 ± 0.031	1.477TrpArg: 1.477 ± 0.047	1.07TrpSer: 1.07 ± 0.036	1.077TrpThr: 1.077 ± 0.039	1.169TrpVal: 1.169 ± 0.038	0.441TrpTrp: 0.441 ± 0.025	0.299TrpTyr: 0.299 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.82TyrAla: 1.82 ± 0.047	0.198TyrCys: 0.198 ± 0.016	1.149TyrAsp: 1.149 ± 0.039	0.804TyrGlu: 0.804 ± 0.03	0.634TyrPhe: 0.634 ± 0.025	1.649TyrGly: 1.649 ± 0.046	0.416TyrHis: 0.416 ± 0.022	0.638TyrIle: 0.638 ± 0.026	0.399TyrLys: 0.399 ± 0.023	2.191TyrLeu: 2.191 ± 0.055	0.292TyrMet: 0.292 ± 0.018	0.449TyrAsn: 0.449 ± 0.024	1.056TyrPro: 1.056 ± 0.039	0.763TyrGln: 0.763 ± 0.027	1.795TyrArg: 1.795 ± 0.047	1.173TyrSer: 1.173 ± 0.033	1.004TyrThr: 1.004 ± 0.037	1.43TyrVal: 1.43 ± 0.041	0.332TyrTrp: 0.332 ± 0.022	0.457TyrTyr: 0.457 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2761 proteins (920567 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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