Amino acid dipepetide frequency for Rhodovulum imhoffii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.657AlaAla: 16.657 ± 0.203	1.291AlaCys: 1.291 ± 0.039	6.476AlaAsp: 6.476 ± 0.084	8.137AlaGlu: 8.137 ± 0.099	4.248AlaPhe: 4.248 ± 0.075	11.426AlaGly: 11.426 ± 0.124	2.532AlaHis: 2.532 ± 0.055	5.415AlaIle: 5.415 ± 0.08	3.041AlaLys: 3.041 ± 0.068	14.777AlaLeu: 14.777 ± 0.191	3.649AlaMet: 3.649 ± 0.065	2.465AlaAsn: 2.465 ± 0.051	6.253AlaPro: 6.253 ± 0.087	4.623AlaGln: 4.623 ± 0.073	10.909AlaArg: 10.909 ± 0.134	5.004AlaSer: 5.004 ± 0.078	5.798AlaThr: 5.798 ± 0.089	8.604AlaVal: 8.604 ± 0.117	1.507AlaTrp: 1.507 ± 0.044	2.507AlaTyr: 2.507 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.2CysAla: 1.2 ± 0.04	0.121CysCys: 0.121 ± 0.013	0.597CysAsp: 0.597 ± 0.026	0.554CysGlu: 0.554 ± 0.024	0.365CysPhe: 0.365 ± 0.017	0.98CysGly: 0.98 ± 0.036	0.302CysHis: 0.302 ± 0.023	0.422CysIle: 0.422 ± 0.023	0.235CysLys: 0.235 ± 0.016	0.913CysLeu: 0.913 ± 0.03	0.186CysMet: 0.186 ± 0.015	0.241CysAsn: 0.241 ± 0.017	0.656CysPro: 0.656 ± 0.032	0.224CysGln: 0.224 ± 0.017	0.699CysArg: 0.699 ± 0.03	0.434CysSer: 0.434 ± 0.024	0.493CysThr: 0.493 ± 0.025	0.644CysVal: 0.644 ± 0.03	0.129CysTrp: 0.129 ± 0.013	0.215CysTyr: 0.215 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	6.551AspAla: 6.551 ± 0.096	0.468AspCys: 0.468 ± 0.025	2.936AspAsp: 2.936 ± 0.093	3.104AspGlu: 3.104 ± 0.073	2.159AspPhe: 2.159 ± 0.051	5.154AspGly: 5.154 ± 0.093	1.218AspHis: 1.218 ± 0.042	3.148AspIle: 3.148 ± 0.064	1.549AspLys: 1.549 ± 0.048	6.619AspLeu: 6.619 ± 0.099	1.643AspMet: 1.643 ± 0.048	1.113AspAsn: 1.113 ± 0.036	3.656AspPro: 3.656 ± 0.069	1.466AspGln: 1.466 ± 0.041	4.251AspArg: 4.251 ± 0.08	2.122AspSer: 2.122 ± 0.055	2.909AspThr: 2.909 ± 0.06	3.991AspVal: 3.991 ± 0.076	1.122AspTrp: 1.122 ± 0.034	1.507AspTyr: 1.507 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.02GluAla: 8.02 ± 0.131	0.383GluCys: 0.383 ± 0.022	3.506GluAsp: 3.506 ± 0.06	3.646GluGlu: 3.646 ± 0.103	1.782GluPhe: 1.782 ± 0.046	4.965GluGly: 4.965 ± 0.07	1.111GluHis: 1.111 ± 0.036	3.897GluIle: 3.897 ± 0.067	2.302GluLys: 2.302 ± 0.07	4.613GluLeu: 4.613 ± 0.078	1.834GluMet: 1.834 ± 0.041	1.814GluAsn: 1.814 ± 0.041	2.321GluPro: 2.321 ± 0.049	1.862GluGln: 1.862 ± 0.048	4.335GluArg: 4.335 ± 0.079	2.296GluSer: 2.296 ± 0.054	4.264GluThr: 4.264 ± 0.072	4.087GluVal: 4.087 ± 0.076	0.648GluTrp: 0.648 ± 0.026	1.013GluTyr: 1.013 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.371PheAla: 4.371 ± 0.075	0.462PheCys: 0.462 ± 0.022	2.731PheAsp: 2.731 ± 0.061	2.132PheGlu: 2.132 ± 0.054	1.464PhePhe: 1.464 ± 0.046	3.637PheGly: 3.637 ± 0.064	0.776PheHis: 0.776 ± 0.031	1.542PheIle: 1.542 ± 0.04	0.776PheLys: 0.776 ± 0.031	3.664PheLeu: 3.664 ± 0.08	0.82PheMet: 0.82 ± 0.029	1.01PheAsn: 1.01 ± 0.031	1.594PhePro: 1.594 ± 0.044	0.944PheGln: 0.944 ± 0.033	2.477PheArg: 2.477 ± 0.055	2.162PheSer: 2.162 ± 0.058	2.133PheThr: 2.133 ± 0.051	2.64PheVal: 2.64 ± 0.063	0.537PheTrp: 0.537 ± 0.025	0.984PheTyr: 0.984 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	10.779GlyAla: 10.779 ± 0.111	0.994GlyCys: 0.994 ± 0.036	4.463GlyAsp: 4.463 ± 0.081	4.839GlyGlu: 4.839 ± 0.078	3.725GlyPhe: 3.725 ± 0.062	7.861GlyGly: 7.861 ± 0.133	2.014GlyHis: 2.014 ± 0.057	4.305GlyIle: 4.305 ± 0.088	3.127GlyLys: 3.127 ± 0.069	9.772GlyLeu: 9.772 ± 0.116	2.665GlyMet: 2.665 ± 0.091	1.972GlyAsn: 1.972 ± 0.053	3.919GlyPro: 3.919 ± 0.073	3.286GlyGln: 3.286 ± 0.066	6.483GlyArg: 6.483 ± 0.108	3.814GlySer: 3.814 ± 0.07	4.855GlyThr: 4.855 ± 0.123	6.929GlyVal: 6.929 ± 0.093	1.582GlyTrp: 1.582 ± 0.05	2.305GlyTyr: 2.305 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.49HisAla: 2.49 ± 0.052	0.249HisCys: 0.249 ± 0.018	1.338HisAsp: 1.338 ± 0.034	1.02HisGlu: 1.02 ± 0.033	0.798HisPhe: 0.798 ± 0.03	1.972HisGly: 1.972 ± 0.052	0.5HisHis: 0.5 ± 0.023	1.002HisIle: 1.002 ± 0.036	0.524HisLys: 0.524 ± 0.024	2.19HisLeu: 2.19 ± 0.054	0.538HisMet: 0.538 ± 0.025	0.455HisAsn: 0.455 ± 0.021	1.483HisPro: 1.483 ± 0.038	0.514HisGln: 0.514 ± 0.023	1.573HisArg: 1.573 ± 0.051	0.841HisSer: 0.841 ± 0.03	0.865HisThr: 0.865 ± 0.037	1.593HisVal: 1.593 ± 0.043	0.323HisTrp: 0.323 ± 0.02	0.557HisTyr: 0.557 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.618IleAla: 6.618 ± 0.087	0.613IleCys: 0.613 ± 0.029	3.123IleAsp: 3.123 ± 0.055	3.081IleGlu: 3.081 ± 0.06	1.669IlePhe: 1.669 ± 0.044	4.657IleGly: 4.657 ± 0.079	0.924IleHis: 0.924 ± 0.035	1.81IleIle: 1.81 ± 0.055	1.087IleLys: 1.087 ± 0.042	4.806IleLeu: 4.806 ± 0.081	0.943IleMet: 0.943 ± 0.033	1.248IleAsn: 1.248 ± 0.036	2.37IlePro: 2.37 ± 0.054	1.084IleGln: 1.084 ± 0.04	3.542IleArg: 3.542 ± 0.063	2.818IleSer: 2.818 ± 0.067	2.56IleThr: 2.56 ± 0.053	3.886IleVal: 3.886 ± 0.073	0.7IleTrp: 0.7 ± 0.031	1.106IleTyr: 1.106 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.633LysAla: 3.633 ± 0.081	0.188LysCys: 0.188 ± 0.015	1.541LysAsp: 1.541 ± 0.048	1.437LysGlu: 1.437 ± 0.058	0.816LysPhe: 0.816 ± 0.033	2.523LysGly: 2.523 ± 0.058	0.559LysHis: 0.559 ± 0.025	1.481LysIle: 1.481 ± 0.04	1.024LysLys: 1.024 ± 0.035	2.756LysLeu: 2.756 ± 0.061	0.811LysMet: 0.811 ± 0.033	0.743LysAsn: 0.743 ± 0.027	1.693LysPro: 1.693 ± 0.049	0.705LysGln: 0.705 ± 0.031	2.135LysArg: 2.135 ± 0.053	1.611LysSer: 1.611 ± 0.046	1.999LysThr: 1.999 ± 0.049	2.202LysVal: 2.202 ± 0.06	0.346LysTrp: 0.346 ± 0.017	0.618LysTyr: 0.618 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	13.615LeuAla: 13.615 ± 0.167	1.111LeuCys: 1.111 ± 0.034	5.702LeuAsp: 5.702 ± 0.093	5.873LeuGlu: 5.873 ± 0.091	3.632LeuPhe: 3.632 ± 0.067	8.727LeuGly: 8.727 ± 0.117	2.093LeuHis: 2.093 ± 0.052	4.845LeuIle: 4.845 ± 0.085	3.154LeuLys: 3.154 ± 0.065	9.197LeuLeu: 9.197 ± 0.116	2.67LeuMet: 2.67 ± 0.057	2.65LeuAsn: 2.65 ± 0.048	6.0LeuPro: 6.0 ± 0.086	2.571LeuGln: 2.571 ± 0.059	8.247LeuArg: 8.247 ± 0.092	6.733LeuSer: 6.733 ± 0.101	6.101LeuThr: 6.101 ± 0.094	7.006LeuVal: 7.006 ± 0.103	1.33LeuTrp: 1.33 ± 0.043	2.011LeuTyr: 2.011 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.52MetAla: 3.52 ± 0.061	0.195MetCys: 0.195 ± 0.015	1.309MetAsp: 1.309 ± 0.035	1.421MetGlu: 1.421 ± 0.039	0.787MetPhe: 0.787 ± 0.03	2.413MetGly: 2.413 ± 0.065	0.459MetHis: 0.459 ± 0.022	1.424MetIle: 1.424 ± 0.041	1.019MetLys: 1.019 ± 0.036	2.439MetLeu: 2.439 ± 0.059	0.721MetMet: 0.721 ± 0.032	0.786MetAsn: 0.786 ± 0.03	1.504MetPro: 1.504 ± 0.041	0.864MetGln: 0.864 ± 0.034	1.932MetArg: 1.932 ± 0.047	1.605MetSer: 1.605 ± 0.057	2.037MetThr: 2.037 ± 0.046	1.787MetVal: 1.787 ± 0.043	0.229MetTrp: 0.229 ± 0.017	0.351MetTyr: 0.351 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.06AsnAla: 3.06 ± 0.063	0.277AsnCys: 0.277 ± 0.015	1.242AsnAsp: 1.242 ± 0.044	1.08AsnGlu: 1.08 ± 0.037	0.9AsnPhe: 0.9 ± 0.034	2.243AsnGly: 2.243 ± 0.057	0.464AsnHis: 0.464 ± 0.022	1.305AsnIle: 1.305 ± 0.039	0.571AsnLys: 0.571 ± 0.026	2.446AsnLeu: 2.446 ± 0.05	0.663AsnMet: 0.663 ± 0.026	0.553AsnAsn: 0.553 ± 0.028	1.845AsnPro: 1.845 ± 0.05	0.603AsnGln: 0.603 ± 0.024	1.791AsnArg: 1.791 ± 0.048	1.028AsnSer: 1.028 ± 0.047	1.213AsnThr: 1.213 ± 0.037	1.747AsnVal: 1.747 ± 0.051	0.413AsnTrp: 0.413 ± 0.02	0.593AsnTyr: 0.593 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	6.508ProAla: 6.508 ± 0.102	0.473ProCys: 0.473 ± 0.024	3.934ProAsp: 3.934 ± 0.07	4.414ProGlu: 4.414 ± 0.078	2.07ProPhe: 2.07 ± 0.047	5.198ProGly: 5.198 ± 0.09	1.184ProHis: 1.184 ± 0.037	1.997ProIle: 1.997 ± 0.045	1.455ProLys: 1.455 ± 0.038	4.907ProLeu: 4.907 ± 0.075	1.282ProMet: 1.282 ± 0.038	1.174ProAsn: 1.174 ± 0.039	2.774ProPro: 2.774 ± 0.07	1.792ProGln: 1.792 ± 0.048	3.394ProArg: 3.394 ± 0.075	2.235ProSer: 2.235 ± 0.05	2.297ProThr: 2.297 ± 0.055	4.786ProVal: 4.786 ± 0.092	0.684ProTrp: 0.684 ± 0.031	1.161ProTyr: 1.161 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.206GlnAla: 4.206 ± 0.068	0.186GlnCys: 0.186 ± 0.018	1.615GlnAsp: 1.615 ± 0.044	1.594GlnGlu: 1.594 ± 0.046	1.0GlnPhe: 1.0 ± 0.034	2.622GlnGly: 2.622 ± 0.055	0.512GlnHis: 0.512 ± 0.028	1.783GlnIle: 1.783 ± 0.04	1.072GlnLys: 1.072 ± 0.041	2.357GlnLeu: 2.357 ± 0.049	0.997GlnMet: 0.997 ± 0.033	0.821GlnAsn: 0.821 ± 0.03	1.625GlnPro: 1.625 ± 0.038	0.936GlnGln: 0.936 ± 0.035	2.139GlnArg: 2.139 ± 0.049	1.522GlnSer: 1.522 ± 0.044	1.817GlnThr: 1.817 ± 0.049	2.5GlnVal: 2.5 ± 0.053	0.37GlnTrp: 0.37 ± 0.023	0.525GlnTyr: 0.525 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.431ArgAla: 9.431 ± 0.121	0.534ArgCys: 0.534 ± 0.028	4.308ArgAsp: 4.308 ± 0.081	4.353ArgGlu: 4.353 ± 0.08	2.958ArgPhe: 2.958 ± 0.062	5.343ArgGly: 5.343 ± 0.083	1.781ArgHis: 1.781 ± 0.043	4.262ArgIle: 4.262 ± 0.07	2.523ArgLys: 2.523 ± 0.059	8.639ArgLeu: 8.639 ± 0.123	2.184ArgMet: 2.184 ± 0.048	1.972ArgAsn: 1.972 ± 0.056	4.138ArgPro: 4.138 ± 0.082	2.509ArgGln: 2.509 ± 0.054	6.125ArgArg: 6.125 ± 0.096	3.214ArgSer: 3.214 ± 0.064	3.434ArgThr: 3.434 ± 0.061	5.3ArgVal: 5.3 ± 0.093	1.013ArgTrp: 1.013 ± 0.04	1.564ArgTyr: 1.564 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.615SerAla: 5.615 ± 0.072	0.449SerCys: 0.449 ± 0.023	2.758SerAsp: 2.758 ± 0.057	2.63SerGlu: 2.63 ± 0.059	2.121SerPhe: 2.121 ± 0.052	5.481SerGly: 5.481 ± 0.107	1.016SerHis: 1.016 ± 0.031	2.062SerIle: 2.062 ± 0.044	1.187SerLys: 1.187 ± 0.037	4.794SerLeu: 4.794 ± 0.077	1.098SerMet: 1.098 ± 0.036	1.086SerAsn: 1.086 ± 0.03	2.635SerPro: 2.635 ± 0.064	1.389SerGln: 1.389 ± 0.039	3.523SerArg: 3.523 ± 0.068	2.331SerSer: 2.331 ± 0.073	2.309SerThr: 2.309 ± 0.052	3.635SerVal: 3.635 ± 0.068	0.643SerTrp: 0.643 ± 0.029	1.12SerTyr: 1.12 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.311ThrAla: 6.311 ± 0.095	0.545ThrCys: 0.545 ± 0.028	2.919ThrAsp: 2.919 ± 0.064	2.958ThrGlu: 2.958 ± 0.075	1.899ThrPhe: 1.899 ± 0.044	5.772ThrGly: 5.772 ± 0.114	1.161ThrHis: 1.161 ± 0.032	2.467ThrIle: 2.467 ± 0.056	1.189ThrLys: 1.189 ± 0.036	6.288ThrLeu: 6.288 ± 0.087	1.148ThrMet: 1.148 ± 0.034	1.159ThrAsn: 1.159 ± 0.037	3.701ThrPro: 3.701 ± 0.068	1.458ThrGln: 1.458 ± 0.037	4.138ThrArg: 4.138 ± 0.068	2.261ThrSer: 2.261 ± 0.049	2.706ThrThr: 2.706 ± 0.06	4.316ThrVal: 4.316 ± 0.075	0.645ThrTrp: 0.645 ± 0.029	1.201ThrTyr: 1.201 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	8.778ValAla: 8.778 ± 0.123	0.705ValCys: 0.705 ± 0.028	3.912ValAsp: 3.912 ± 0.074	4.522ValGlu: 4.522 ± 0.088	3.064ValPhe: 3.064 ± 0.07	5.532ValGly: 5.532 ± 0.079	1.369ValHis: 1.369 ± 0.042	3.848ValIle: 3.848 ± 0.066	1.996ValLys: 1.996 ± 0.058	8.248ValLeu: 8.248 ± 0.12	2.049ValMet: 2.049 ± 0.048	1.834ValAsn: 1.834 ± 0.051	3.762ValPro: 3.762 ± 0.074	2.155ValGln: 2.155 ± 0.052	5.041ValArg: 5.041 ± 0.073	4.108ValSer: 4.108 ± 0.074	4.533ValThr: 4.533 ± 0.112	5.766ValVal: 5.766 ± 0.095	0.973ValTrp: 0.973 ± 0.035	1.516ValTyr: 1.516 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.468TrpAla: 1.468 ± 0.053	0.128TrpCys: 0.128 ± 0.011	0.716TrpAsp: 0.716 ± 0.03	0.663TrpGlu: 0.663 ± 0.028	0.528TrpPhe: 0.528 ± 0.025	1.06TrpGly: 1.06 ± 0.038	0.325TrpHis: 0.325 ± 0.019	0.653TrpIle: 0.653 ± 0.028	0.435TrpLys: 0.435 ± 0.024	1.636TrpLeu: 1.636 ± 0.05	0.4TrpMet: 0.4 ± 0.021	0.393TrpAsn: 0.393 ± 0.021	0.743TrpPro: 0.743 ± 0.031	0.613TrpGln: 0.613 ± 0.028	1.191TrpArg: 1.191 ± 0.037	0.7TrpSer: 0.7 ± 0.027	0.705TrpThr: 0.705 ± 0.029	0.915TrpVal: 0.915 ± 0.03	0.217TrpTrp: 0.217 ± 0.016	0.255TrpTyr: 0.255 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.487TyrAla: 2.487 ± 0.056	0.238TyrCys: 0.238 ± 0.018	1.56TyrAsp: 1.56 ± 0.044	1.24TyrGlu: 1.24 ± 0.04	0.872TyrPhe: 0.872 ± 0.031	2.125TyrGly: 2.125 ± 0.052	0.526TyrHis: 0.526 ± 0.024	0.973TyrIle: 0.973 ± 0.03	0.557TyrLys: 0.557 ± 0.028	2.209TyrLeu: 2.209 ± 0.047	0.498TyrMet: 0.498 ± 0.022	0.55TyrAsn: 0.55 ± 0.025	1.048TyrPro: 1.048 ± 0.04	0.6TyrGln: 0.6 ± 0.027	1.661TyrArg: 1.661 ± 0.043	1.04TyrSer: 1.04 ± 0.033	1.215TyrThr: 1.215 ± 0.04	1.377TyrVal: 1.377 ± 0.044	0.332TyrTrp: 0.332 ± 0.017	0.564TyrTyr: 0.564 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2892 proteins (883240 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---