Amino acid dipepetide frequency for Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.722AlaAla: 7.722 ± 0.052
0.957AlaCys: 0.957 ± 0.014
3.622AlaAsp: 3.622 ± 0.023
4.53AlaGlu: 4.53 ± 0.034
3.075AlaPhe: 3.075 ± 0.03
5.073AlaGly: 5.073 ± 0.034
1.802AlaHis: 1.802 ± 0.017
3.991AlaIle: 3.991 ± 0.029
3.957AlaLys: 3.957 ± 0.033
7.965AlaLeu: 7.965 ± 0.047
1.74AlaMet: 1.74 ± 0.02
2.821AlaAsn: 2.821 ± 0.022
5.209AlaPro: 5.209 ± 0.048
3.183AlaGln: 3.183 ± 0.024
4.966AlaArg: 4.966 ± 0.033
7.557AlaSer: 7.557 ± 0.047
5.08AlaThr: 5.08 ± 0.03
4.931AlaVal: 4.931 ± 0.031
1.064AlaTrp: 1.064 ± 0.015
2.049AlaTyr: 2.049 ± 0.019
0.0AlaXaa: 0.0 ± 0.0
Cys
0.833CysAla: 0.833 ± 0.011
0.224CysCys: 0.224 ± 0.007
0.638CysAsp: 0.638 ± 0.012
0.562CysGlu: 0.562 ± 0.01
0.481CysPhe: 0.481 ± 0.01
0.831CysGly: 0.831 ± 0.015
0.325CysHis: 0.325 ± 0.008
0.653CysIle: 0.653 ± 0.013
0.48CysLys: 0.48 ± 0.009
1.163CysLeu: 1.163 ± 0.015
0.244CysMet: 0.244 ± 0.007
0.419CysAsn: 0.419 ± 0.008
0.766CysPro: 0.766 ± 0.014
0.404CysGln: 0.404 ± 0.01
0.759CysArg: 0.759 ± 0.012
0.906CysSer: 0.906 ± 0.014
0.71CysThr: 0.71 ± 0.012
0.737CysVal: 0.737 ± 0.012
0.188CysTrp: 0.188 ± 0.006
0.318CysTyr: 0.318 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
4.408AspAla: 4.408 ± 0.029
0.578AspCys: 0.578 ± 0.011
4.732AspAsp: 4.732 ± 0.04
4.579AspGlu: 4.579 ± 0.038
2.122AspPhe: 2.122 ± 0.021
4.085AspGly: 4.085 ± 0.031
1.255AspHis: 1.255 ± 0.017
2.919AspIle: 2.919 ± 0.023
2.206AspLys: 2.206 ± 0.02
5.095AspLeu: 5.095 ± 0.036
1.089AspMet: 1.089 ± 0.014
1.774AspAsn: 1.774 ± 0.019
3.642AspPro: 3.642 ± 0.03
1.638AspGln: 1.638 ± 0.02
3.007AspArg: 3.007 ± 0.033
4.321AspSer: 4.321 ± 0.032
2.791AspThr: 2.791 ± 0.025
3.828AspVal: 3.828 ± 0.029
0.896AspTrp: 0.896 ± 0.012
1.564AspTyr: 1.564 ± 0.016
0.0AspXaa: 0.0 ± 0.0
Glu
5.076GluAla: 5.076 ± 0.035
0.654GluCys: 0.654 ± 0.012
4.468GluAsp: 4.468 ± 0.033
6.222GluGlu: 6.222 ± 0.067
1.978GluPhe: 1.978 ± 0.017
4.281GluGly: 4.281 ± 0.033
1.35GluHis: 1.35 ± 0.015
2.887GluIle: 2.887 ± 0.023
3.459GluLys: 3.459 ± 0.033
5.323GluLeu: 5.323 ± 0.039
1.282GluMet: 1.282 ± 0.017
1.958GluAsn: 1.958 ± 0.019
2.977GluPro: 2.977 ± 0.028
2.223GluGln: 2.223 ± 0.021
4.386GluArg: 4.386 ± 0.04
4.173GluSer: 4.173 ± 0.027
3.133GluThr: 3.133 ± 0.027
3.774GluVal: 3.774 ± 0.025
0.969GluTrp: 0.969 ± 0.012
1.582GluTyr: 1.582 ± 0.018
0.0GluXaa: 0.0 ± 0.0
Phe
2.853PheAla: 2.853 ± 0.025
0.515PheCys: 0.515 ± 0.01
2.271PheAsp: 2.271 ± 0.018
2.112PheGlu: 2.112 ± 0.021
1.539PhePhe: 1.539 ± 0.02
2.608PheGly: 2.608 ± 0.027
0.968PheHis: 0.968 ± 0.012
1.785PheIle: 1.785 ± 0.019
1.619PheLys: 1.619 ± 0.019
3.403PheLeu: 3.403 ± 0.023
0.734PheMet: 0.734 ± 0.01
1.419PheAsn: 1.419 ± 0.015
2.188PhePro: 2.188 ± 0.023
1.299PheGln: 1.299 ± 0.015
2.014PheArg: 2.014 ± 0.021
3.016PheSer: 3.016 ± 0.025
2.17PheThr: 2.17 ± 0.023
2.416PheVal: 2.416 ± 0.022
0.548PheTrp: 0.548 ± 0.009
1.059PheTyr: 1.059 ± 0.013
0.0PheXaa: 0.0 ± 0.0
Gly
4.763GlyAla: 4.763 ± 0.033
0.844GlyCys: 0.844 ± 0.015
3.562GlyAsp: 3.562 ± 0.026
3.744GlyGlu: 3.744 ± 0.027
2.496GlyPhe: 2.496 ± 0.026
6.178GlyGly: 6.178 ± 0.069
1.751GlyHis: 1.751 ± 0.022
3.114GlyIle: 3.114 ± 0.026
3.47GlyLys: 3.47 ± 0.03
5.58GlyLeu: 5.58 ± 0.033
1.414GlyMet: 1.414 ± 0.02
2.434GlyAsn: 2.434 ± 0.024
3.551GlyPro: 3.551 ± 0.026
2.294GlyGln: 2.294 ± 0.022
4.22GlyArg: 4.22 ± 0.031
5.881GlySer: 5.881 ± 0.041
3.871GlyThr: 3.871 ± 0.031
4.267GlyVal: 4.267 ± 0.031
1.126GlyTrp: 1.126 ± 0.015
1.978GlyTyr: 1.978 ± 0.023
0.0GlyXaa: 0.0 ± 0.0
His
1.795HisAla: 1.795 ± 0.019
0.329HisCys: 0.329 ± 0.009
1.304HisAsp: 1.304 ± 0.017
1.236HisGlu: 1.236 ± 0.016
0.954HisPhe: 0.954 ± 0.012
1.667HisGly: 1.667 ± 0.019
0.984HisHis: 0.984 ± 0.02
1.227HisIle: 1.227 ± 0.014
0.89HisLys: 0.89 ± 0.013
2.537HisLeu: 2.537 ± 0.022
0.408HisMet: 0.408 ± 0.009
0.816HisAsn: 0.816 ± 0.012
2.058HisPro: 2.058 ± 0.024
0.999HisGln: 0.999 ± 0.016
1.726HisArg: 1.726 ± 0.016
2.07HisSer: 2.07 ± 0.022
1.35HisThr: 1.35 ± 0.015
1.497HisVal: 1.497 ± 0.017
0.37HisTrp: 0.37 ± 0.008
0.71HisTyr: 0.71 ± 0.011
0.0HisXaa: 0.0 ± 0.0
Ile
3.859IleAla: 3.859 ± 0.029
0.631IleCys: 0.631 ± 0.011
2.765IleAsp: 2.765 ± 0.024
2.712IleGlu: 2.712 ± 0.024
1.77IlePhe: 1.77 ± 0.019
2.765IleGly: 2.765 ± 0.026
1.264IleHis: 1.264 ± 0.015
2.235IleIle: 2.235 ± 0.024
1.941IleLys: 1.941 ± 0.019
4.471IleLeu: 4.471 ± 0.033
0.826IleMet: 0.826 ± 0.012
1.584IleAsn: 1.584 ± 0.015
3.388IlePro: 3.388 ± 0.025
1.852IleGln: 1.852 ± 0.02
2.906IleArg: 2.906 ± 0.024
3.656IleSer: 3.656 ± 0.027
2.63IleThr: 2.63 ± 0.022
3.121IleVal: 3.121 ± 0.024
0.699IleTrp: 0.699 ± 0.01
1.253IleTyr: 1.253 ± 0.015
0.0IleXaa: 0.0 ± 0.0
Lys
4.336LysAla: 4.336 ± 0.037
0.465LysCys: 0.465 ± 0.009
2.764LysAsp: 2.764 ± 0.027
3.595LysGlu: 3.595 ± 0.032
1.385LysPhe: 1.385 ± 0.015
3.116LysGly: 3.116 ± 0.027
1.075LysHis: 1.075 ± 0.014
1.998LysIle: 1.998 ± 0.02
3.369LysLys: 3.369 ± 0.039
3.965LysLeu: 3.965 ± 0.031
0.875LysMet: 0.875 ± 0.012
1.533LysAsn: 1.533 ± 0.018
2.952LysPro: 2.952 ± 0.022
1.676LysGln: 1.676 ± 0.02
3.721LysArg: 3.721 ± 0.029
3.383LysSer: 3.383 ± 0.024
2.652LysThr: 2.652 ± 0.022
2.861LysVal: 2.861 ± 0.025
0.67LysTrp: 0.67 ± 0.01
1.212LysTyr: 1.212 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
7.693LeuAla: 7.693 ± 0.043
1.144LeuCys: 1.144 ± 0.015
5.275LeuAsp: 5.275 ± 0.035
5.979LeuGlu: 5.979 ± 0.047
3.381LeuPhe: 3.381 ± 0.027
5.474LeuGly: 5.474 ± 0.029
2.373LeuHis: 2.373 ± 0.021
3.619LeuIle: 3.619 ± 0.031
4.491LeuLys: 4.491 ± 0.035
8.32LeuLeu: 8.32 ± 0.054
1.626LeuMet: 1.626 ± 0.019
3.171LeuAsn: 3.171 ± 0.022
6.278LeuPro: 6.278 ± 0.041
3.67LeuGln: 3.67 ± 0.028
5.922LeuArg: 5.922 ± 0.036
7.7LeuSer: 7.7 ± 0.041
5.081LeuThr: 5.081 ± 0.03
5.675LeuVal: 5.675 ± 0.032
1.227LeuTrp: 1.227 ± 0.017
2.321LeuTyr: 2.321 ± 0.021
0.0LeuXaa: 0.0 ± 0.0
Met
1.794MetAla: 1.794 ± 0.018
0.199MetCys: 0.199 ± 0.006
1.214MetAsp: 1.214 ± 0.014
1.225MetGlu: 1.225 ± 0.015
0.699MetPhe: 0.699 ± 0.01
1.263MetGly: 1.263 ± 0.019
0.438MetHis: 0.438 ± 0.008
0.827MetIle: 0.827 ± 0.012
0.965MetLys: 0.965 ± 0.012
1.607MetLeu: 1.607 ± 0.017
0.465MetMet: 0.465 ± 0.009
0.698MetAsn: 0.698 ± 0.011
1.122MetPro: 1.122 ± 0.015
0.727MetGln: 0.727 ± 0.013
1.136MetArg: 1.136 ± 0.013
1.816MetSer: 1.816 ± 0.019
1.18MetThr: 1.18 ± 0.015
1.177MetVal: 1.177 ± 0.014
0.238MetTrp: 0.238 ± 0.006
0.479MetTyr: 0.479 ± 0.008
0.0MetXaa: 0.0 ± 0.0
Asn
3.088AsnAla: 3.088 ± 0.026
0.392AsnCys: 0.392 ± 0.007
1.921AsnAsp: 1.921 ± 0.02
1.897AsnGlu: 1.897 ± 0.02
1.233AsnPhe: 1.233 ± 0.015
2.757AsnGly: 2.757 ± 0.027
0.895AsnHis: 0.895 ± 0.014
1.751AsnIle: 1.751 ± 0.019
1.378AsnLys: 1.378 ± 0.019
3.329AsnLeu: 3.329 ± 0.024
0.67AsnMet: 0.67 ± 0.011
1.378AsnAsn: 1.378 ± 0.02
2.76AsnPro: 2.76 ± 0.019
1.248AsnGln: 1.248 ± 0.016
1.964AsnArg: 1.964 ± 0.017
2.664AsnSer: 2.664 ± 0.024
2.02AsnThr: 2.02 ± 0.02
2.372AsnVal: 2.372 ± 0.021
0.514AsnTrp: 0.514 ± 0.009
0.935AsnTyr: 0.935 ± 0.013
0.0AsnXaa: 0.0 ± 0.0
Pro
5.567ProAla: 5.567 ± 0.044
0.551ProCys: 0.551 ± 0.012
3.313ProAsp: 3.313 ± 0.025
3.87ProGlu: 3.87 ± 0.03
2.324ProPhe: 2.324 ± 0.023
4.211ProGly: 4.211 ± 0.031
1.628ProHis: 1.628 ± 0.023
2.815ProIle: 2.815 ± 0.019
2.87ProLys: 2.87 ± 0.027
5.428ProLeu: 5.428 ± 0.037
1.073ProMet: 1.073 ± 0.014
2.513ProAsn: 2.513 ± 0.023
7.621ProPro: 7.621 ± 0.088
2.621ProGln: 2.621 ± 0.031
3.841ProArg: 3.841 ± 0.033
7.719ProSer: 7.719 ± 0.059
4.836ProThr: 4.836 ± 0.038
4.073ProVal: 4.073 ± 0.031
0.752ProTrp: 0.752 ± 0.012
1.6ProTyr: 1.6 ± 0.017
0.0ProXaa: 0.0 ± 0.0
Gln
3.147GlnAla: 3.147 ± 0.026
0.476GlnCys: 0.476 ± 0.009
1.865GlnAsp: 1.865 ± 0.021
2.26GlnGlu: 2.26 ± 0.022
1.261GlnPhe: 1.261 ± 0.015
2.267GlnGly: 2.267 ± 0.024
1.092GlnHis: 1.092 ± 0.016
1.643GlnIle: 1.643 ± 0.014
1.668GlnLys: 1.668 ± 0.018
3.398GlnLeu: 3.398 ± 0.027
0.748GlnMet: 0.748 ± 0.011
1.26GlnAsn: 1.26 ± 0.018
2.787GlnPro: 2.787 ± 0.035
2.323GlnGln: 2.323 ± 0.045
2.644GlnArg: 2.644 ± 0.024
2.949GlnSer: 2.949 ± 0.022
2.14GlnThr: 2.14 ± 0.02
2.178GlnVal: 2.178 ± 0.021
0.542GlnTrp: 0.542 ± 0.008
1.02GlnTyr: 1.02 ± 0.013
0.0GlnXaa: 0.0 ± 0.0
Arg
4.757ArgAla: 4.757 ± 0.032
0.78ArgCys: 0.78 ± 0.011
3.38ArgAsp: 3.38 ± 0.031
4.154ArgGlu: 4.154 ± 0.042
2.312ArgPhe: 2.312 ± 0.022
3.749ArgGly: 3.749 ± 0.031
1.628ArgHis: 1.628 ± 0.017
3.017ArgIle: 3.017 ± 0.021
3.557ArgLys: 3.557 ± 0.027
5.833ArgLeu: 5.833 ± 0.031
1.325ArgMet: 1.325 ± 0.014
2.282ArgAsn: 2.282 ± 0.021
3.915ArgPro: 3.915 ± 0.033
2.46ArgGln: 2.46 ± 0.023
5.557ArgArg: 5.557 ± 0.042
5.258ArgSer: 5.258 ± 0.042
3.606ArgThr: 3.606 ± 0.028
3.718ArgVal: 3.718 ± 0.024
0.987ArgTrp: 0.987 ± 0.014
1.746ArgTyr: 1.746 ± 0.017
0.0ArgXaa: 0.0 ± 0.0
Ser
6.592SerAla: 6.592 ± 0.042
0.832SerCys: 0.832 ± 0.012
4.366SerAsp: 4.366 ± 0.034
4.14SerGlu: 4.14 ± 0.032
3.104SerPhe: 3.104 ± 0.023
5.647SerGly: 5.647 ± 0.038
2.046SerHis: 2.046 ± 0.022
3.943SerIle: 3.943 ± 0.026
3.857SerLys: 3.857 ± 0.027
7.819SerLeu: 7.819 ± 0.046
1.636SerMet: 1.636 ± 0.017
3.151SerAsn: 3.151 ± 0.024
6.562SerPro: 6.562 ± 0.059
3.208SerGln: 3.208 ± 0.025
5.478SerArg: 5.478 ± 0.038
10.707SerSer: 10.707 ± 0.087
6.517SerThr: 6.517 ± 0.052
4.848SerVal: 4.848 ± 0.036
1.041SerTrp: 1.041 ± 0.014
1.957SerTyr: 1.957 ± 0.018
0.0SerXaa: 0.0 ± 0.0
Thr
4.971ThrAla: 4.971 ± 0.032
0.724ThrCys: 0.724 ± 0.013
2.622ThrAsp: 2.622 ± 0.022
2.834ThrGlu: 2.834 ± 0.024
2.368ThrPhe: 2.368 ± 0.019
3.899ThrGly: 3.899 ± 0.027
1.397ThrHis: 1.397 ± 0.016
2.996ThrIle: 2.996 ± 0.024
2.485ThrLys: 2.485 ± 0.022
5.66ThrLeu: 5.66 ± 0.037
1.116ThrMet: 1.116 ± 0.013
2.071ThrAsn: 2.071 ± 0.018
5.064ThrPro: 5.064 ± 0.044
1.986ThrGln: 1.986 ± 0.02
3.575ThrArg: 3.575 ± 0.027
5.948ThrSer: 5.948 ± 0.042
4.581ThrThr: 4.581 ± 0.039
3.791ThrVal: 3.791 ± 0.027
0.772ThrTrp: 0.772 ± 0.011
1.489ThrTyr: 1.489 ± 0.018
0.0ThrXaa: 0.0 ± 0.0
Val
5.03ValAla: 5.03 ± 0.031
0.781ValCys: 0.781 ± 0.013
3.872ValAsp: 3.872 ± 0.031
4.13ValGlu: 4.13 ± 0.027
2.401ValPhe: 2.401 ± 0.022
3.903ValGly: 3.903 ± 0.028
1.565ValHis: 1.565 ± 0.016
2.869ValIle: 2.869 ± 0.023
3.044ValLys: 3.044 ± 0.025
5.753ValLeu: 5.753 ± 0.035
1.17ValMet: 1.17 ± 0.014
2.244ValAsn: 2.244 ± 0.023
4.16ValPro: 4.16 ± 0.031
2.411ValGln: 2.411 ± 0.019
3.471ValArg: 3.471 ± 0.026
4.653ValSer: 4.653 ± 0.03
3.524ValThr: 3.524 ± 0.025
4.646ValVal: 4.646 ± 0.032
0.914ValTrp: 0.914 ± 0.014
1.782ValTyr: 1.782 ± 0.018
0.0ValXaa: 0.0 ± 0.0
Trp
1.006TrpAla: 1.006 ± 0.013
0.189TrpCys: 0.189 ± 0.005
0.907TrpAsp: 0.907 ± 0.014
0.897TrpGlu: 0.897 ± 0.011
0.577TrpPhe: 0.577 ± 0.01
0.863TrpGly: 0.863 ± 0.013
0.332TrpHis: 0.332 ± 0.008
0.734TrpIle: 0.734 ± 0.011
0.886TrpLys: 0.886 ± 0.013
1.252TrpLeu: 1.252 ± 0.015
0.329TrpMet: 0.329 ± 0.008
0.625TrpAsn: 0.625 ± 0.011
0.584TrpPro: 0.584 ± 0.01
0.448TrpGln: 0.448 ± 0.009
1.013TrpArg: 1.013 ± 0.013
1.054TrpSer: 1.054 ± 0.012
0.906TrpThr: 0.906 ± 0.013
0.875TrpVal: 0.875 ± 0.013
0.295TrpTrp: 0.295 ± 0.007
0.426TrpTyr: 0.426 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.001TyrAla: 2.001 ± 0.017
0.375TyrCys: 0.375 ± 0.009
1.667TyrAsp: 1.667 ± 0.018
1.475TyrGlu: 1.475 ± 0.016
1.075TyrPhe: 1.075 ± 0.014
1.902TyrGly: 1.902 ± 0.025
0.761TyrHis: 0.761 ± 0.012
1.307TyrIle: 1.307 ± 0.015
1.009TyrLys: 1.009 ± 0.016
2.519TyrLeu: 2.519 ± 0.022
0.501TyrMet: 0.501 ± 0.008
1.015TyrAsn: 1.015 ± 0.013
1.64TyrPro: 1.64 ± 0.018
1.0TyrGln: 1.0 ± 0.014
1.713TyrArg: 1.713 ± 0.017
2.019TyrSer: 2.019 ± 0.022
1.574TyrThr: 1.574 ± 0.017
1.541TyrVal: 1.541 ± 0.017
0.386TyrTrp: 0.386 ± 0.008
0.874TyrTyr: 0.874 ± 0.013
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13335 proteins (6160588 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski