Amino acid dipepetide frequency for Shigella phage vB_SdyM_006

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.629AlaAla: 2.629 ± 0.272
0.432AlaCys: 0.432 ± 0.101
2.571AlaAsp: 2.571 ± 0.248
3.591AlaGlu: 3.591 ± 0.277
2.1AlaPhe: 2.1 ± 0.221
2.963AlaGly: 2.963 ± 0.328
0.883AlaHis: 0.883 ± 0.129
4.101AlaIle: 4.101 ± 0.28
4.219AlaLys: 4.219 ± 0.262
5.318AlaLeu: 5.318 ± 0.348
1.334AlaMet: 1.334 ± 0.178
2.414AlaAsn: 2.414 ± 0.24
1.393AlaPro: 1.393 ± 0.166
1.727AlaGln: 1.727 ± 0.185
1.707AlaArg: 1.707 ± 0.184
4.003AlaSer: 4.003 ± 0.331
2.374AlaThr: 2.374 ± 0.254
2.806AlaVal: 2.806 ± 0.291
0.746AlaTrp: 0.746 ± 0.131
2.1AlaTyr: 2.1 ± 0.239
0.0AlaXaa: 0.0 ± 0.0
Cys
0.549CysAla: 0.549 ± 0.111
0.275CysCys: 0.275 ± 0.072
0.805CysAsp: 0.805 ± 0.134
1.119CysGlu: 1.119 ± 0.158
0.549CysPhe: 0.549 ± 0.106
0.687CysGly: 0.687 ± 0.119
0.196CysHis: 0.196 ± 0.057
1.001CysIle: 1.001 ± 0.136
0.942CysLys: 0.942 ± 0.147
0.765CysLeu: 0.765 ± 0.12
0.373CysMet: 0.373 ± 0.102
0.687CysAsn: 0.687 ± 0.127
0.53CysPro: 0.53 ± 0.105
0.294CysGln: 0.294 ± 0.066
0.608CysArg: 0.608 ± 0.104
1.001CysSer: 1.001 ± 0.143
0.53CysThr: 0.53 ± 0.107
0.706CysVal: 0.706 ± 0.11
0.059CysTrp: 0.059 ± 0.035
0.569CysTyr: 0.569 ± 0.126
0.0CysXaa: 0.0 ± 0.0
Asp
2.806AspAla: 2.806 ± 0.234
0.785AspCys: 0.785 ± 0.145
4.003AspAsp: 4.003 ± 0.31
3.944AspGlu: 3.944 ± 0.284
3.571AspPhe: 3.571 ± 0.251
3.768AspGly: 3.768 ± 0.318
1.001AspHis: 1.001 ± 0.15
6.122AspIle: 6.122 ± 0.35
5.534AspLys: 5.534 ± 0.274
5.514AspLeu: 5.514 ± 0.356
1.589AspMet: 1.589 ± 0.184
3.63AspAsn: 3.63 ± 0.247
2.237AspPro: 2.237 ± 0.218
1.805AspGln: 1.805 ± 0.16
1.982AspArg: 1.982 ± 0.202
4.709AspSer: 4.709 ± 0.324
3.532AspThr: 3.532 ± 0.341
3.846AspVal: 3.846 ± 0.263
1.393AspTrp: 1.393 ± 0.173
3.414AspTyr: 3.414 ± 0.285
0.0AspXaa: 0.0 ± 0.0
Glu
4.121GluAla: 4.121 ± 0.331
0.903GluCys: 0.903 ± 0.117
4.749GluAsp: 4.749 ± 0.343
5.828GluGlu: 5.828 ± 0.382
3.493GluPhe: 3.493 ± 0.263
3.571GluGly: 3.571 ± 0.313
1.393GluHis: 1.393 ± 0.179
5.553GluIle: 5.553 ± 0.302
5.534GluLys: 5.534 ± 0.325
7.849GluLeu: 7.849 ± 0.41
1.903GluMet: 1.903 ± 0.191
3.964GluAsn: 3.964 ± 0.254
1.589GluPro: 1.589 ± 0.193
2.59GluGln: 2.59 ± 0.234
2.551GluArg: 2.551 ± 0.214
4.827GluSer: 4.827 ± 0.307
4.16GluThr: 4.16 ± 0.262
4.553GluVal: 4.553 ± 0.331
0.844GluTrp: 0.844 ± 0.142
3.866GluTyr: 3.866 ± 0.34
0.0GluXaa: 0.0 ± 0.0
Phe
1.864PheAla: 1.864 ± 0.216
0.451PheCys: 0.451 ± 0.099
3.748PheAsp: 3.748 ± 0.221
3.552PheGlu: 3.552 ± 0.269
1.55PhePhe: 1.55 ± 0.204
2.492PheGly: 2.492 ± 0.24
0.628PheHis: 0.628 ± 0.095
3.454PheIle: 3.454 ± 0.288
5.161PheLys: 5.161 ± 0.323
2.885PheLeu: 2.885 ± 0.243
1.354PheMet: 1.354 ± 0.171
3.238PheAsn: 3.238 ± 0.255
1.334PhePro: 1.334 ± 0.199
0.844PheGln: 0.844 ± 0.112
1.393PheArg: 1.393 ± 0.187
3.257PheSer: 3.257 ± 0.273
2.571PheThr: 2.571 ± 0.21
2.629PheVal: 2.629 ± 0.197
0.687PheTrp: 0.687 ± 0.132
1.982PheTyr: 1.982 ± 0.184
0.0PheXaa: 0.0 ± 0.0
Gly
2.669GlyAla: 2.669 ± 0.278
0.608GlyCys: 0.608 ± 0.111
3.689GlyAsp: 3.689 ± 0.329
3.512GlyGlu: 3.512 ± 0.236
2.885GlyPhe: 2.885 ± 0.241
2.708GlyGly: 2.708 ± 0.267
1.02GlyHis: 1.02 ± 0.141
4.749GlyIle: 4.749 ± 0.316
4.631GlyLys: 4.631 ± 0.319
5.141GlyLeu: 5.141 ± 0.297
1.315GlyMet: 1.315 ± 0.182
2.767GlyAsn: 2.767 ± 0.253
1.805GlyPro: 1.805 ± 0.193
2.002GlyGln: 2.002 ± 0.195
2.06GlyArg: 2.06 ± 0.215
3.826GlySer: 3.826 ± 0.276
3.709GlyThr: 3.709 ± 0.292
3.356GlyVal: 3.356 ± 0.26
0.785GlyTrp: 0.785 ± 0.113
3.218GlyTyr: 3.218 ± 0.264
0.0GlyXaa: 0.0 ± 0.0
His
0.687HisAla: 0.687 ± 0.117
0.294HisCys: 0.294 ± 0.077
1.02HisAsp: 1.02 ± 0.165
0.942HisGlu: 0.942 ± 0.135
0.844HisPhe: 0.844 ± 0.136
1.02HisGly: 1.02 ± 0.148
0.392HisHis: 0.392 ± 0.081
1.609HisIle: 1.609 ± 0.184
1.55HisLys: 1.55 ± 0.164
1.668HisLeu: 1.668 ± 0.198
0.392HisMet: 0.392 ± 0.082
1.06HisAsn: 1.06 ± 0.157
0.805HisPro: 0.805 ± 0.132
0.451HisGln: 0.451 ± 0.107
0.628HisArg: 0.628 ± 0.134
1.158HisSer: 1.158 ± 0.131
0.785HisThr: 0.785 ± 0.117
1.06HisVal: 1.06 ± 0.133
0.157HisTrp: 0.157 ± 0.053
0.844HisTyr: 0.844 ± 0.13
0.0HisXaa: 0.0 ± 0.0
Ile
3.826IleAla: 3.826 ± 0.334
1.099IleCys: 1.099 ± 0.149
5.632IleAsp: 5.632 ± 0.327
6.495IleGlu: 6.495 ± 0.389
2.963IlePhe: 2.963 ± 0.262
4.494IleGly: 4.494 ± 0.328
1.354IleHis: 1.354 ± 0.189
5.887IleIle: 5.887 ± 0.362
7.849IleLys: 7.849 ± 0.466
5.887IleLeu: 5.887 ± 0.378
1.884IleMet: 1.884 ± 0.173
5.749IleAsn: 5.749 ± 0.319
3.022IlePro: 3.022 ± 0.28
2.237IleGln: 2.237 ± 0.204
2.904IleArg: 2.904 ± 0.269
5.71IleSer: 5.71 ± 0.363
4.317IleThr: 4.317 ± 0.293
4.14IleVal: 4.14 ± 0.269
0.765IleTrp: 0.765 ± 0.128
3.454IleTyr: 3.454 ± 0.274
0.0IleXaa: 0.0 ± 0.0
Lys
4.768LysAla: 4.768 ± 0.333
1.138LysCys: 1.138 ± 0.164
6.063LysAsp: 6.063 ± 0.392
7.496LysGlu: 7.496 ± 0.393
3.787LysPhe: 3.787 ± 0.269
4.709LysGly: 4.709 ± 0.306
1.825LysHis: 1.825 ± 0.184
6.731LysIle: 6.731 ± 0.315
5.377LysLys: 5.377 ± 0.275
7.535LysLeu: 7.535 ± 0.393
2.217LysMet: 2.217 ± 0.199
5.18LysAsn: 5.18 ± 0.315
2.629LysPro: 2.629 ± 0.229
2.806LysGln: 2.806 ± 0.225
2.904LysArg: 2.904 ± 0.263
5.416LysSer: 5.416 ± 0.321
6.181LysThr: 6.181 ± 0.382
4.592LysVal: 4.592 ± 0.29
1.119LysTrp: 1.119 ± 0.126
4.513LysTyr: 4.513 ± 0.295
0.0LysXaa: 0.0 ± 0.0
Leu
4.69LeuAla: 4.69 ± 0.344
1.02LeuCys: 1.02 ± 0.129
5.612LeuAsp: 5.612 ± 0.362
6.731LeuGlu: 6.731 ± 0.376
3.512LeuPhe: 3.512 ± 0.271
4.827LeuGly: 4.827 ± 0.266
1.295LeuHis: 1.295 ± 0.168
5.573LeuIle: 5.573 ± 0.319
8.222LeuLys: 8.222 ± 0.388
6.044LeuLeu: 6.044 ± 0.376
2.198LeuMet: 2.198 ± 0.207
5.632LeuAsn: 5.632 ± 0.326
3.218LeuPro: 3.218 ± 0.257
2.433LeuGln: 2.433 ± 0.213
2.806LeuArg: 2.806 ± 0.197
6.377LeuSer: 6.377 ± 0.364
4.415LeuThr: 4.415 ± 0.295
4.827LeuVal: 4.827 ± 0.295
0.844LeuTrp: 0.844 ± 0.139
3.728LeuTyr: 3.728 ± 0.255
0.0LeuXaa: 0.0 ± 0.0
Met
1.295MetAla: 1.295 ± 0.146
0.294MetCys: 0.294 ± 0.082
1.491MetAsp: 1.491 ± 0.144
1.236MetGlu: 1.236 ± 0.156
1.275MetPhe: 1.275 ± 0.126
1.001MetGly: 1.001 ± 0.16
0.432MetHis: 0.432 ± 0.083
2.1MetIle: 2.1 ± 0.211
2.06MetLys: 2.06 ± 0.19
1.589MetLeu: 1.589 ± 0.201
0.334MetMet: 0.334 ± 0.078
1.766MetAsn: 1.766 ± 0.183
0.785MetPro: 0.785 ± 0.101
0.942MetGln: 0.942 ± 0.161
0.432MetArg: 0.432 ± 0.093
1.943MetSer: 1.943 ± 0.191
1.805MetThr: 1.805 ± 0.165
1.452MetVal: 1.452 ± 0.166
0.275MetTrp: 0.275 ± 0.065
1.217MetTyr: 1.217 ± 0.151
0.0MetXaa: 0.0 ± 0.0
Asn
2.963AsnAla: 2.963 ± 0.251
0.569AsnCys: 0.569 ± 0.108
3.473AsnAsp: 3.473 ± 0.23
3.454AsnGlu: 3.454 ± 0.253
2.355AsnPhe: 2.355 ± 0.225
3.846AsnGly: 3.846 ± 0.306
1.04AsnHis: 1.04 ± 0.142
4.808AsnIle: 4.808 ± 0.289
5.337AsnLys: 5.337 ± 0.349
5.102AsnLeu: 5.102 ± 0.301
1.531AsnMet: 1.531 ± 0.164
4.454AsnAsn: 4.454 ± 0.383
3.081AsnPro: 3.081 ± 0.224
1.943AsnGln: 1.943 ± 0.226
2.257AsnArg: 2.257 ± 0.241
3.866AsnSer: 3.866 ± 0.277
3.277AsnThr: 3.277 ± 0.238
3.807AsnVal: 3.807 ± 0.314
0.667AsnTrp: 0.667 ± 0.112
2.512AsnTyr: 2.512 ± 0.215
0.0AsnXaa: 0.0 ± 0.0
Pro
1.236ProAla: 1.236 ± 0.179
0.491ProCys: 0.491 ± 0.114
2.315ProAsp: 2.315 ± 0.223
3.473ProGlu: 3.473 ± 0.293
1.668ProPhe: 1.668 ± 0.19
2.159ProGly: 2.159 ± 0.216
0.687ProHis: 0.687 ± 0.114
2.59ProIle: 2.59 ± 0.229
3.159ProLys: 3.159 ± 0.322
2.276ProLeu: 2.276 ± 0.191
0.608ProMet: 0.608 ± 0.112
1.766ProAsn: 1.766 ± 0.187
0.785ProPro: 0.785 ± 0.167
1.06ProGln: 1.06 ± 0.157
1.158ProArg: 1.158 ± 0.162
2.119ProSer: 2.119 ± 0.196
1.786ProThr: 1.786 ± 0.155
2.355ProVal: 2.355 ± 0.219
0.412ProTrp: 0.412 ± 0.082
1.393ProTyr: 1.393 ± 0.163
0.0ProXaa: 0.0 ± 0.0
Gln
1.746GlnAla: 1.746 ± 0.178
0.353GlnCys: 0.353 ± 0.081
1.688GlnAsp: 1.688 ± 0.175
2.786GlnGlu: 2.786 ± 0.282
1.511GlnPhe: 1.511 ± 0.177
2.1GlnGly: 2.1 ± 0.187
0.491GlnHis: 0.491 ± 0.099
2.61GlnIle: 2.61 ± 0.206
2.394GlnLys: 2.394 ± 0.226
2.826GlnLeu: 2.826 ± 0.241
0.628GlnMet: 0.628 ± 0.106
1.55GlnAsn: 1.55 ± 0.181
0.765GlnPro: 0.765 ± 0.138
1.177GlnGln: 1.177 ± 0.144
1.315GlnArg: 1.315 ± 0.15
1.845GlnSer: 1.845 ± 0.184
1.589GlnThr: 1.589 ± 0.204
2.276GlnVal: 2.276 ± 0.24
0.491GlnTrp: 0.491 ± 0.096
1.688GlnTyr: 1.688 ± 0.178
0.0GlnXaa: 0.0 ± 0.0
Arg
1.903ArgAla: 1.903 ± 0.215
0.373ArgCys: 0.373 ± 0.072
1.962ArgAsp: 1.962 ± 0.176
2.531ArgGlu: 2.531 ± 0.23
1.688ArgPhe: 1.688 ± 0.245
1.982ArgGly: 1.982 ± 0.212
0.765ArgHis: 0.765 ± 0.11
2.806ArgIle: 2.806 ± 0.281
2.708ArgLys: 2.708 ± 0.262
3.395ArgLeu: 3.395 ± 0.312
0.746ArgMet: 0.746 ± 0.129
2.021ArgAsn: 2.021 ± 0.199
1.02ArgPro: 1.02 ± 0.133
1.197ArgGln: 1.197 ± 0.155
1.629ArgArg: 1.629 ± 0.185
2.139ArgSer: 2.139 ± 0.211
2.021ArgThr: 2.021 ± 0.207
2.531ArgVal: 2.531 ± 0.242
0.432ArgTrp: 0.432 ± 0.089
1.589ArgTyr: 1.589 ± 0.17
0.0ArgXaa: 0.0 ± 0.0
Ser
3.081SerAla: 3.081 ± 0.25
1.138SerCys: 1.138 ± 0.176
4.651SerAsp: 4.651 ± 0.364
4.454SerGlu: 4.454 ± 0.301
2.904SerPhe: 2.904 ± 0.229
4.435SerGly: 4.435 ± 0.312
1.177SerHis: 1.177 ± 0.138
6.26SerIle: 6.26 ± 0.352
6.888SerLys: 6.888 ± 0.382
6.103SerLeu: 6.103 ± 0.34
1.609SerMet: 1.609 ± 0.19
3.826SerAsn: 3.826 ± 0.289
1.845SerPro: 1.845 ± 0.207
2.276SerGln: 2.276 ± 0.189
2.374SerArg: 2.374 ± 0.216
4.925SerSer: 4.925 ± 0.329
3.65SerThr: 3.65 ± 0.275
4.199SerVal: 4.199 ± 0.316
0.746SerTrp: 0.746 ± 0.131
2.826SerTyr: 2.826 ± 0.252
0.0SerXaa: 0.0 ± 0.0
Thr
2.629ThrAla: 2.629 ± 0.207
0.608ThrCys: 0.608 ± 0.102
3.297ThrAsp: 3.297 ± 0.226
4.415ThrGlu: 4.415 ± 0.301
2.688ThrPhe: 2.688 ± 0.224
3.316ThrGly: 3.316 ± 0.252
0.962ThrHis: 0.962 ± 0.137
4.533ThrIle: 4.533 ± 0.281
4.415ThrLys: 4.415 ± 0.286
4.749ThrLeu: 4.749 ± 0.33
1.06ThrMet: 1.06 ± 0.133
3.12ThrAsn: 3.12 ± 0.222
2.61ThrPro: 2.61 ± 0.235
2.139ThrGln: 2.139 ± 0.159
2.374ThrArg: 2.374 ± 0.228
3.807ThrSer: 3.807 ± 0.27
2.374ThrThr: 2.374 ± 0.23
3.336ThrVal: 3.336 ± 0.305
0.824ThrTrp: 0.824 ± 0.137
2.394ThrTyr: 2.394 ± 0.212
0.0ThrXaa: 0.0 ± 0.0
Val
2.728ValAla: 2.728 ± 0.259
0.687ValCys: 0.687 ± 0.123
4.062ValAsp: 4.062 ± 0.267
4.297ValGlu: 4.297 ± 0.283
2.904ValPhe: 2.904 ± 0.225
2.963ValGly: 2.963 ± 0.25
0.726ValHis: 0.726 ± 0.114
4.808ValIle: 4.808 ± 0.323
5.828ValLys: 5.828 ± 0.372
5.122ValLeu: 5.122 ± 0.314
1.158ValMet: 1.158 ± 0.142
3.63ValAsn: 3.63 ± 0.265
2.002ValPro: 2.002 ± 0.192
2.139ValGln: 2.139 ± 0.219
2.041ValArg: 2.041 ± 0.2
4.356ValSer: 4.356 ± 0.271
2.826ValThr: 2.826 ± 0.238
3.768ValVal: 3.768 ± 0.291
0.746ValTrp: 0.746 ± 0.122
3.257ValTyr: 3.257 ± 0.276
0.0ValXaa: 0.0 ± 0.0
Trp
0.824TrpAla: 0.824 ± 0.126
0.196TrpCys: 0.196 ± 0.067
1.04TrpAsp: 1.04 ± 0.146
0.805TrpGlu: 0.805 ± 0.122
0.392TrpPhe: 0.392 ± 0.079
0.589TrpGly: 0.589 ± 0.107
0.235TrpHis: 0.235 ± 0.077
0.942TrpIle: 0.942 ± 0.138
1.04TrpLys: 1.04 ± 0.144
0.844TrpLeu: 0.844 ± 0.123
0.412TrpMet: 0.412 ± 0.083
0.765TrpAsn: 0.765 ± 0.122
0.392TrpPro: 0.392 ± 0.095
0.392TrpGln: 0.392 ± 0.076
0.334TrpArg: 0.334 ± 0.087
0.824TrpSer: 0.824 ± 0.134
0.746TrpThr: 0.746 ± 0.123
1.04TrpVal: 1.04 ± 0.155
0.098TrpTrp: 0.098 ± 0.043
0.667TrpTyr: 0.667 ± 0.12
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.394TyrAla: 2.394 ± 0.221
0.53TyrCys: 0.53 ± 0.095
3.316TyrAsp: 3.316 ± 0.227
3.179TyrGlu: 3.179 ± 0.24
2.433TyrPhe: 2.433 ± 0.191
2.826TyrGly: 2.826 ± 0.226
0.863TyrHis: 0.863 ± 0.143
3.454TyrIle: 3.454 ± 0.251
4.14TyrLys: 4.14 ± 0.268
3.395TyrLeu: 3.395 ± 0.26
1.06TyrMet: 1.06 ± 0.131
3.12TyrAsn: 3.12 ± 0.285
1.648TyrPro: 1.648 ± 0.164
1.374TyrGln: 1.374 ± 0.171
1.982TyrArg: 1.982 ± 0.187
3.257TyrSer: 3.257 ± 0.271
3.002TyrThr: 3.002 ± 0.261
2.767TyrVal: 2.767 ± 0.202
0.491TyrTrp: 0.491 ± 0.091
2.06TyrTyr: 2.06 ± 0.247
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 252 proteins (50962 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski