Amino acid dipepetide frequency for Oceanobacillus picturae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.492AlaAla: 5.492 ± 0.099
0.547AlaCys: 0.547 ± 0.022
3.505AlaAsp: 3.505 ± 0.053
4.8AlaGlu: 4.8 ± 0.079
3.379AlaPhe: 3.379 ± 0.061
5.336AlaGly: 5.336 ± 0.075
1.253AlaHis: 1.253 ± 0.038
6.116AlaIle: 6.116 ± 0.089
4.542AlaLys: 4.542 ± 0.072
7.059AlaLeu: 7.059 ± 0.093
2.175AlaMet: 2.175 ± 0.051
2.841AlaAsn: 2.841 ± 0.055
2.071AlaPro: 2.071 ± 0.049
2.107AlaGln: 2.107 ± 0.046
2.501AlaArg: 2.501 ± 0.058
4.216AlaSer: 4.216 ± 0.06
3.884AlaThr: 3.884 ± 0.065
5.419AlaVal: 5.419 ± 0.076
0.632AlaTrp: 0.632 ± 0.028
2.5AlaTyr: 2.5 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.352CysAla: 0.352 ± 0.021
0.083CysCys: 0.083 ± 0.01
0.347CysAsp: 0.347 ± 0.024
0.38CysGlu: 0.38 ± 0.019
0.268CysPhe: 0.268 ± 0.016
0.561CysGly: 0.561 ± 0.027
0.158CysHis: 0.158 ± 0.013
0.45CysIle: 0.45 ± 0.022
0.312CysLys: 0.312 ± 0.019
0.549CysLeu: 0.549 ± 0.025
0.163CysMet: 0.163 ± 0.013
0.255CysAsn: 0.255 ± 0.018
0.282CysPro: 0.282 ± 0.017
0.194CysGln: 0.194 ± 0.014
0.212CysArg: 0.212 ± 0.013
0.44CysSer: 0.44 ± 0.022
0.354CysThr: 0.354 ± 0.019
0.368CysVal: 0.368 ± 0.02
0.057CysTrp: 0.057 ± 0.009
0.237CysTyr: 0.237 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.41AspAla: 3.41 ± 0.062
0.293AspCys: 0.293 ± 0.018
2.568AspAsp: 2.568 ± 0.053
4.459AspGlu: 4.459 ± 0.07
2.436AspPhe: 2.436 ± 0.049
3.412AspGly: 3.412 ± 0.067
1.147AspHis: 1.147 ± 0.04
4.254AspIle: 4.254 ± 0.067
3.494AspLys: 3.494 ± 0.065
5.028AspLeu: 5.028 ± 0.068
1.53AspMet: 1.53 ± 0.035
2.289AspAsn: 2.289 ± 0.048
2.124AspPro: 2.124 ± 0.051
2.061AspGln: 2.061 ± 0.049
2.233AspArg: 2.233 ± 0.043
2.795AspSer: 2.795 ± 0.054
2.749AspThr: 2.749 ± 0.054
3.854AspVal: 3.854 ± 0.064
0.638AspTrp: 0.638 ± 0.026
2.337AspTyr: 2.337 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
5.928GluAla: 5.928 ± 0.091
0.297GluCys: 0.297 ± 0.017
4.376GluAsp: 4.376 ± 0.083
8.165GluGlu: 8.165 ± 0.124
2.445GluPhe: 2.445 ± 0.052
4.573GluGly: 4.573 ± 0.073
1.503GluHis: 1.503 ± 0.039
5.576GluIle: 5.576 ± 0.076
6.809GluLys: 6.809 ± 0.087
7.153GluLeu: 7.153 ± 0.093
2.378GluMet: 2.378 ± 0.048
3.911GluAsn: 3.911 ± 0.068
1.96GluPro: 1.96 ± 0.045
3.64GluGln: 3.64 ± 0.073
3.498GluArg: 3.498 ± 0.07
3.788GluSer: 3.788 ± 0.062
4.215GluThr: 4.215 ± 0.06
5.376GluVal: 5.376 ± 0.074
0.838GluTrp: 0.838 ± 0.025
2.236GluTyr: 2.236 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
2.943PheAla: 2.943 ± 0.052
0.286PheCys: 0.286 ± 0.017
2.296PheAsp: 2.296 ± 0.051
2.7PheGlu: 2.7 ± 0.051
2.276PhePhe: 2.276 ± 0.061
3.212PheGly: 3.212 ± 0.064
1.03PheHis: 1.03 ± 0.034
3.976PheIle: 3.976 ± 0.082
2.274PheLys: 2.274 ± 0.051
4.597PheLeu: 4.597 ± 0.085
1.142PheMet: 1.142 ± 0.036
1.852PheAsn: 1.852 ± 0.043
1.651PhePro: 1.651 ± 0.042
1.724PheGln: 1.724 ± 0.04
1.471PheArg: 1.471 ± 0.037
3.289PheSer: 3.289 ± 0.068
2.661PheThr: 2.661 ± 0.052
3.131PheVal: 3.131 ± 0.064
0.514PheTrp: 0.514 ± 0.022
1.724PheTyr: 1.724 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
4.86GlyAla: 4.86 ± 0.088
0.499GlyCys: 0.499 ± 0.022
3.353GlyAsp: 3.353 ± 0.061
4.807GlyGlu: 4.807 ± 0.066
3.358GlyPhe: 3.358 ± 0.06
4.699GlyGly: 4.699 ± 0.085
1.311GlyHis: 1.311 ± 0.04
5.919GlyIle: 5.919 ± 0.084
5.073GlyLys: 5.073 ± 0.066
6.516GlyLeu: 6.516 ± 0.09
2.224GlyMet: 2.224 ± 0.048
2.842GlyAsn: 2.842 ± 0.064
1.751GlyPro: 1.751 ± 0.047
2.004GlyGln: 2.004 ± 0.04
2.433GlyArg: 2.433 ± 0.06
4.045GlySer: 4.045 ± 0.064
3.99GlyThr: 3.99 ± 0.066
4.978GlyVal: 4.978 ± 0.074
0.815GlyTrp: 0.815 ± 0.027
2.822GlyTyr: 2.822 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
1.438HisAla: 1.438 ± 0.037
0.168HisCys: 0.168 ± 0.011
1.076HisAsp: 1.076 ± 0.035
1.3HisGlu: 1.3 ± 0.036
1.082HisPhe: 1.082 ± 0.035
1.4HisGly: 1.4 ± 0.035
0.638HisHis: 0.638 ± 0.029
1.509HisIle: 1.509 ± 0.043
1.003HisLys: 1.003 ± 0.027
2.074HisLeu: 2.074 ± 0.043
0.54HisMet: 0.54 ± 0.027
0.858HisAsn: 0.858 ± 0.028
1.059HisPro: 1.059 ± 0.034
0.811HisGln: 0.811 ± 0.028
0.853HisArg: 0.853 ± 0.031
1.102HisSer: 1.102 ± 0.031
1.078HisThr: 1.078 ± 0.032
1.444HisVal: 1.444 ± 0.034
0.219HisTrp: 0.219 ± 0.014
0.891HisTyr: 0.891 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.194IleAla: 6.194 ± 0.095
0.577IleCys: 0.577 ± 0.026
4.104IleAsp: 4.104 ± 0.061
5.382IleGlu: 5.382 ± 0.078
3.253IlePhe: 3.253 ± 0.075
6.085IleGly: 6.085 ± 0.094
1.59IleHis: 1.59 ± 0.044
6.011IleIle: 6.011 ± 0.102
4.503IleLys: 4.503 ± 0.072
7.304IleLeu: 7.304 ± 0.116
1.916IleMet: 1.916 ± 0.043
3.193IleAsn: 3.193 ± 0.056
3.345IlePro: 3.345 ± 0.066
2.863IleGln: 2.863 ± 0.054
2.942IleArg: 2.942 ± 0.06
5.039IleSer: 5.039 ± 0.076
4.571IleThr: 4.571 ± 0.073
5.499IleVal: 5.499 ± 0.086
0.664IleTrp: 0.664 ± 0.027
2.445IleTyr: 2.445 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
4.673LysAla: 4.673 ± 0.078
0.26LysCys: 0.26 ± 0.018
3.86LysAsp: 3.86 ± 0.063
7.183LysGlu: 7.183 ± 0.106
1.739LysPhe: 1.739 ± 0.046
4.298LysGly: 4.298 ± 0.066
1.411LysHis: 1.411 ± 0.035
4.074LysIle: 4.074 ± 0.065
5.632LysLys: 5.632 ± 0.094
5.875LysLeu: 5.875 ± 0.076
2.125LysMet: 2.125 ± 0.048
3.049LysAsn: 3.049 ± 0.057
2.131LysPro: 2.131 ± 0.044
3.593LysGln: 3.593 ± 0.064
3.307LysArg: 3.307 ± 0.058
3.343LysSer: 3.343 ± 0.055
3.445LysThr: 3.445 ± 0.059
4.322LysVal: 4.322 ± 0.064
0.75LysTrp: 0.75 ± 0.028
1.965LysTyr: 1.965 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
7.16LeuAla: 7.16 ± 0.097
0.577LeuCys: 0.577 ± 0.025
5.067LeuAsp: 5.067 ± 0.066
6.927LeuGlu: 6.927 ± 0.091
5.076LeuPhe: 5.076 ± 0.089
6.44LeuGly: 6.44 ± 0.091
2.014LeuHis: 2.014 ± 0.052
7.218LeuIle: 7.218 ± 0.1
6.175LeuLys: 6.175 ± 0.084
10.499LeuLeu: 10.499 ± 0.129
2.465LeuMet: 2.465 ± 0.051
4.156LeuAsn: 4.156 ± 0.059
3.906LeuPro: 3.906 ± 0.061
3.689LeuGln: 3.689 ± 0.069
3.583LeuArg: 3.583 ± 0.066
6.64LeuSer: 6.64 ± 0.091
5.614LeuThr: 5.614 ± 0.077
6.372LeuVal: 6.372 ± 0.086
0.755LeuTrp: 0.755 ± 0.032
3.133LeuTyr: 3.133 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.024MetAla: 2.024 ± 0.046
0.118MetCys: 0.118 ± 0.011
1.687MetAsp: 1.687 ± 0.037
2.369MetGlu: 2.369 ± 0.05
1.06MetPhe: 1.06 ± 0.035
1.843MetGly: 1.843 ± 0.042
0.487MetHis: 0.487 ± 0.025
1.933MetIle: 1.933 ± 0.045
2.392MetLys: 2.392 ± 0.048
2.766MetLeu: 2.766 ± 0.058
0.848MetMet: 0.848 ± 0.029
1.519MetAsn: 1.519 ± 0.039
0.975MetPro: 0.975 ± 0.032
1.101MetGln: 1.101 ± 0.036
1.172MetArg: 1.172 ± 0.033
1.623MetSer: 1.623 ± 0.047
1.602MetThr: 1.602 ± 0.036
1.891MetVal: 1.891 ± 0.044
0.196MetTrp: 0.196 ± 0.013
0.751MetTyr: 0.751 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.833AsnAla: 2.833 ± 0.056
0.262AsnCys: 0.262 ± 0.016
2.227AsnAsp: 2.227 ± 0.054
3.698AsnGlu: 3.698 ± 0.061
1.655AsnPhe: 1.655 ± 0.04
3.256AsnGly: 3.256 ± 0.061
0.97AsnHis: 0.97 ± 0.031
3.291AsnIle: 3.291 ± 0.058
3.094AsnLys: 3.094 ± 0.059
3.799AsnLeu: 3.799 ± 0.064
1.227AsnMet: 1.227 ± 0.036
2.085AsnAsn: 2.085 ± 0.048
1.972AsnPro: 1.972 ± 0.049
2.021AsnGln: 2.021 ± 0.047
1.944AsnArg: 1.944 ± 0.04
2.287AsnSer: 2.287 ± 0.052
2.307AsnThr: 2.307 ± 0.046
3.078AsnVal: 3.078 ± 0.057
0.545AsnTrp: 0.545 ± 0.023
1.672AsnTyr: 1.672 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
2.33ProAla: 2.33 ± 0.051
0.174ProCys: 0.174 ± 0.016
2.044ProAsp: 2.044 ± 0.05
3.112ProGlu: 3.112 ± 0.063
1.878ProPhe: 1.878 ± 0.043
2.285ProGly: 2.285 ± 0.055
0.796ProHis: 0.796 ± 0.031
2.805ProIle: 2.805 ± 0.055
2.013ProLys: 2.013 ± 0.045
3.394ProLeu: 3.394 ± 0.051
0.825ProMet: 0.825 ± 0.031
1.585ProAsn: 1.585 ± 0.043
0.95ProPro: 0.95 ± 0.032
1.099ProGln: 1.099 ± 0.037
1.01ProArg: 1.01 ± 0.034
2.218ProSer: 2.218 ± 0.046
2.018ProThr: 2.018 ± 0.045
2.887ProVal: 2.887 ± 0.057
0.375ProTrp: 0.375 ± 0.019
1.376ProTyr: 1.376 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.857GlnAla: 2.857 ± 0.052
0.174GlnCys: 0.174 ± 0.013
2.045GlnAsp: 2.045 ± 0.049
3.281GlnGlu: 3.281 ± 0.07
1.603GlnPhe: 1.603 ± 0.044
2.221GlnGly: 2.221 ± 0.048
0.85GlnHis: 0.85 ± 0.027
2.502GlnIle: 2.502 ± 0.049
2.444GlnLys: 2.444 ± 0.058
4.251GlnLeu: 4.251 ± 0.067
1.167GlnMet: 1.167 ± 0.035
1.587GlnAsn: 1.587 ± 0.038
1.25GlnPro: 1.25 ± 0.035
1.997GlnGln: 1.997 ± 0.059
1.546GlnArg: 1.546 ± 0.039
2.197GlnSer: 2.197 ± 0.057
2.158GlnThr: 2.158 ± 0.051
2.504GlnVal: 2.504 ± 0.05
0.396GlnTrp: 0.396 ± 0.018
1.236GlnTyr: 1.236 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.322ArgAla: 2.322 ± 0.044
0.235ArgCys: 0.235 ± 0.016
2.119ArgAsp: 2.119 ± 0.05
3.165ArgGlu: 3.165 ± 0.055
1.872ArgPhe: 1.872 ± 0.042
2.222ArgGly: 2.222 ± 0.052
0.778ArgHis: 0.778 ± 0.027
3.027ArgIle: 3.027 ± 0.057
3.111ArgLys: 3.111 ± 0.062
3.785ArgLeu: 3.785 ± 0.074
1.239ArgMet: 1.239 ± 0.035
1.958ArgAsn: 1.958 ± 0.047
1.18ArgPro: 1.18 ± 0.034
1.522ArgGln: 1.522 ± 0.036
1.726ArgArg: 1.726 ± 0.051
2.216ArgSer: 2.216 ± 0.05
2.015ArgThr: 2.015 ± 0.045
2.581ArgVal: 2.581 ± 0.051
0.395ArgTrp: 0.395 ± 0.021
1.496ArgTyr: 1.496 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
3.613SerAla: 3.613 ± 0.058
0.342SerCys: 0.342 ± 0.019
3.001SerAsp: 3.001 ± 0.065
4.243SerGlu: 4.243 ± 0.067
3.212SerPhe: 3.212 ± 0.05
4.402SerGly: 4.402 ± 0.063
1.143SerHis: 1.143 ± 0.03
5.146SerIle: 5.146 ± 0.072
3.642SerLys: 3.642 ± 0.064
6.081SerLeu: 6.081 ± 0.085
1.747SerMet: 1.747 ± 0.042
2.625SerAsn: 2.625 ± 0.053
2.084SerPro: 2.084 ± 0.039
1.928SerGln: 1.928 ± 0.042
2.15SerArg: 2.15 ± 0.046
4.009SerSer: 4.009 ± 0.076
3.311SerThr: 3.311 ± 0.047
4.097SerVal: 4.097 ± 0.067
0.649SerTrp: 0.649 ± 0.028
2.429SerTyr: 2.429 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.139ThrAla: 4.139 ± 0.069
0.32ThrCys: 0.32 ± 0.018
3.04ThrAsp: 3.04 ± 0.054
4.122ThrGlu: 4.122 ± 0.074
2.633ThrPhe: 2.633 ± 0.054
4.284ThrGly: 4.284 ± 0.086
1.063ThrHis: 1.063 ± 0.032
4.668ThrIle: 4.668 ± 0.071
3.385ThrLys: 3.385 ± 0.058
5.177ThrLeu: 5.177 ± 0.067
1.431ThrMet: 1.431 ± 0.036
2.45ThrAsn: 2.45 ± 0.049
2.302ThrPro: 2.302 ± 0.047
1.581ThrGln: 1.581 ± 0.039
1.812ThrArg: 1.812 ± 0.042
3.476ThrSer: 3.476 ± 0.064
3.2ThrThr: 3.2 ± 0.059
4.097ThrVal: 4.097 ± 0.06
0.543ThrTrp: 0.543 ± 0.024
2.066ThrTyr: 2.066 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
4.991ValAla: 4.991 ± 0.079
0.513ValCys: 0.513 ± 0.021
3.89ValAsp: 3.89 ± 0.056
5.257ValGlu: 5.257 ± 0.075
3.169ValPhe: 3.169 ± 0.063
4.591ValGly: 4.591 ± 0.077
1.326ValHis: 1.326 ± 0.039
5.604ValIle: 5.604 ± 0.086
4.381ValLys: 4.381 ± 0.068
6.975ValLeu: 6.975 ± 0.083
1.981ValMet: 1.981 ± 0.048
3.069ValAsn: 3.069 ± 0.055
2.549ValPro: 2.549 ± 0.05
2.4ValGln: 2.4 ± 0.056
2.625ValArg: 2.625 ± 0.053
4.549ValSer: 4.549 ± 0.07
4.135ValThr: 4.135 ± 0.066
5.047ValVal: 5.047 ± 0.088
0.644ValTrp: 0.644 ± 0.03
2.298ValTyr: 2.298 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.621TrpAla: 0.621 ± 0.024
0.065TrpCys: 0.065 ± 0.008
0.558TrpAsp: 0.558 ± 0.024
0.755TrpGlu: 0.755 ± 0.028
0.517TrpPhe: 0.517 ± 0.026
0.683TrpGly: 0.683 ± 0.031
0.206TrpHis: 0.206 ± 0.015
0.822TrpIle: 0.822 ± 0.028
0.701TrpLys: 0.701 ± 0.023
1.133TrpLeu: 1.133 ± 0.039
0.32TrpMet: 0.32 ± 0.018
0.538TrpAsn: 0.538 ± 0.02
0.251TrpPro: 0.251 ± 0.019
0.359TrpGln: 0.359 ± 0.018
0.384TrpArg: 0.384 ± 0.017
0.563TrpSer: 0.563 ± 0.024
0.489TrpThr: 0.489 ± 0.022
0.733TrpVal: 0.733 ± 0.027
0.15TrpTrp: 0.15 ± 0.012
0.345TrpTyr: 0.345 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.196TyrAla: 2.196 ± 0.053
0.232TyrCys: 0.232 ± 0.014
1.949TyrAsp: 1.949 ± 0.049
2.562TyrGlu: 2.562 ± 0.057
1.84TyrPhe: 1.84 ± 0.039
2.496TyrGly: 2.496 ± 0.048
0.87TyrHis: 0.87 ± 0.029
2.579TyrIle: 2.579 ± 0.05
2.055TyrLys: 2.055 ± 0.057
3.447TyrLeu: 3.447 ± 0.063
0.916TyrMet: 0.916 ± 0.028
1.561TyrAsn: 1.561 ± 0.037
1.379TyrPro: 1.379 ± 0.037
1.569TyrGln: 1.569 ± 0.039
1.564TyrArg: 1.564 ± 0.039
2.02TyrSer: 2.02 ± 0.042
1.992TyrThr: 1.992 ± 0.048
2.316TyrVal: 2.316 ± 0.052
0.415TyrTrp: 0.415 ± 0.02
1.479TyrTyr: 1.479 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3656 proteins (1034527 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski