Amino acid dipepetide frequency for Thiomicrorhabdus sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.404AlaAla: 7.404 ± 0.139
0.783AlaCys: 0.783 ± 0.04
5.214AlaAsp: 5.214 ± 0.106
6.437AlaGlu: 6.437 ± 0.108
3.394AlaPhe: 3.394 ± 0.073
5.729AlaGly: 5.729 ± 0.105
1.626AlaHis: 1.626 ± 0.046
5.961AlaIle: 5.961 ± 0.1
5.529AlaLys: 5.529 ± 0.106
9.944AlaLeu: 9.944 ± 0.144
2.834AlaMet: 2.834 ± 0.076
3.817AlaAsn: 3.817 ± 0.08
2.649AlaPro: 2.649 ± 0.07
4.824AlaGln: 4.824 ± 0.097
3.355AlaArg: 3.355 ± 0.066
4.962AlaSer: 4.962 ± 0.089
3.901AlaThr: 3.901 ± 0.095
5.918AlaVal: 5.918 ± 0.091
1.032AlaTrp: 1.032 ± 0.039
2.502AlaTyr: 2.502 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.699CysAla: 0.699 ± 0.039
0.118CysCys: 0.118 ± 0.014
0.521CysAsp: 0.521 ± 0.027
0.547CysGlu: 0.547 ± 0.028
0.345CysPhe: 0.345 ± 0.023
0.747CysGly: 0.747 ± 0.034
0.317CysHis: 0.317 ± 0.024
0.486CysIle: 0.486 ± 0.031
0.373CysLys: 0.373 ± 0.022
0.891CysLeu: 0.891 ± 0.04
0.176CysMet: 0.176 ± 0.016
0.278CysAsn: 0.278 ± 0.022
0.442CysPro: 0.442 ± 0.026
0.481CysGln: 0.481 ± 0.027
0.417CysArg: 0.417 ± 0.024
0.538CysSer: 0.538 ± 0.032
0.329CysThr: 0.329 ± 0.019
0.492CysVal: 0.492 ± 0.028
0.075CysTrp: 0.075 ± 0.01
0.291CysTyr: 0.291 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.6AspAla: 4.6 ± 0.089
0.514AspCys: 0.514 ± 0.029
3.178AspAsp: 3.178 ± 0.079
4.196AspGlu: 4.196 ± 0.09
2.731AspPhe: 2.731 ± 0.063
3.646AspGly: 3.646 ± 0.089
1.068AspHis: 1.068 ± 0.035
4.296AspIle: 4.296 ± 0.076
3.542AspLys: 3.542 ± 0.071
5.659AspLeu: 5.659 ± 0.097
1.537AspMet: 1.537 ± 0.055
2.8AspAsn: 2.8 ± 0.07
1.852AspPro: 1.852 ± 0.056
2.158AspGln: 2.158 ± 0.054
2.249AspArg: 2.249 ± 0.06
3.528AspSer: 3.528 ± 0.078
2.466AspThr: 2.466 ± 0.066
3.66AspVal: 3.66 ± 0.087
0.912AspTrp: 0.912 ± 0.038
2.35AspTyr: 2.35 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
5.411GluAla: 5.411 ± 0.093
0.419GluCys: 0.419 ± 0.022
3.06GluAsp: 3.06 ± 0.067
3.785GluGlu: 3.785 ± 0.087
2.646GluPhe: 2.646 ± 0.07
3.269GluGly: 3.269 ± 0.081
1.542GluHis: 1.542 ± 0.053
4.213GluIle: 4.213 ± 0.082
4.059GluLys: 4.059 ± 0.09
6.972GluLeu: 6.972 ± 0.122
1.942GluMet: 1.942 ± 0.052
3.116GluAsn: 3.116 ± 0.064
2.197GluPro: 2.197 ± 0.058
4.591GluGln: 4.591 ± 0.085
3.082GluArg: 3.082 ± 0.076
3.755GluSer: 3.755 ± 0.076
3.318GluThr: 3.318 ± 0.072
4.65GluVal: 4.65 ± 0.097
0.691GluTrp: 0.691 ± 0.027
1.682GluTyr: 1.682 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.796PheAla: 3.796 ± 0.08
0.447PheCys: 0.447 ± 0.026
2.876PheAsp: 2.876 ± 0.068
2.64PheGlu: 2.64 ± 0.069
1.807PhePhe: 1.807 ± 0.066
2.927PheGly: 2.927 ± 0.078
0.771PheHis: 0.771 ± 0.03
3.003PheIle: 3.003 ± 0.081
2.296PheLys: 2.296 ± 0.061
3.525PheLeu: 3.525 ± 0.08
1.109PheMet: 1.109 ± 0.044
2.045PheAsn: 2.045 ± 0.06
1.237PhePro: 1.237 ± 0.048
1.491PheGln: 1.491 ± 0.044
1.337PheArg: 1.337 ± 0.045
3.125PheSer: 3.125 ± 0.071
1.892PheThr: 1.892 ± 0.057
2.593PheVal: 2.593 ± 0.068
0.565PheTrp: 0.565 ± 0.027
1.501PheTyr: 1.501 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
4.957GlyAla: 4.957 ± 0.114
0.783GlyCys: 0.783 ± 0.037
3.593GlyAsp: 3.593 ± 0.077
4.122GlyGlu: 4.122 ± 0.081
3.292GlyPhe: 3.292 ± 0.068
4.391GlyGly: 4.391 ± 0.098
1.647GlyHis: 1.647 ± 0.052
4.394GlyIle: 4.394 ± 0.086
3.794GlyLys: 3.794 ± 0.09
6.988GlyLeu: 6.988 ± 0.104
2.032GlyMet: 2.032 ± 0.06
2.386GlyAsn: 2.386 ± 0.065
1.54GlyPro: 1.54 ± 0.047
2.859GlyGln: 2.859 ± 0.067
2.973GlyArg: 2.973 ± 0.074
3.711GlySer: 3.711 ± 0.085
3.101GlyThr: 3.101 ± 0.095
4.757GlyVal: 4.757 ± 0.089
0.869GlyTrp: 0.869 ± 0.036
2.459GlyTyr: 2.459 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.725HisAla: 1.725 ± 0.055
0.288HisCys: 0.288 ± 0.024
1.105HisAsp: 1.105 ± 0.04
1.128HisGlu: 1.128 ± 0.04
1.037HisPhe: 1.037 ± 0.042
1.563HisGly: 1.563 ± 0.053
0.708HisHis: 0.708 ± 0.033
1.518HisIle: 1.518 ± 0.052
1.194HisLys: 1.194 ± 0.044
2.321HisLeu: 2.321 ± 0.067
0.527HisMet: 0.527 ± 0.029
1.042HisAsn: 1.042 ± 0.043
1.144HisPro: 1.144 ± 0.037
1.354HisGln: 1.354 ± 0.046
0.965HisArg: 0.965 ± 0.038
1.453HisSer: 1.453 ± 0.049
0.987HisThr: 0.987 ± 0.038
1.03HisVal: 1.03 ± 0.043
0.363HisTrp: 0.363 ± 0.022
0.883HisTyr: 0.883 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.466IleAla: 6.466 ± 0.11
0.563IleCys: 0.563 ± 0.03
5.036IleAsp: 5.036 ± 0.086
5.539IleGlu: 5.539 ± 0.096
2.119IlePhe: 2.119 ± 0.063
4.806IleGly: 4.806 ± 0.098
1.34IleHis: 1.34 ± 0.047
3.916IleIle: 3.916 ± 0.089
3.83IleLys: 3.83 ± 0.081
5.368IleLeu: 5.368 ± 0.102
1.472IleMet: 1.472 ± 0.058
3.314IleAsn: 3.314 ± 0.074
2.463IlePro: 2.463 ± 0.071
2.565IleGln: 2.565 ± 0.063
2.768IleArg: 2.768 ± 0.068
4.42IleSer: 4.42 ± 0.088
3.329IleThr: 3.329 ± 0.091
4.122IleVal: 4.122 ± 0.091
0.683IleTrp: 0.683 ± 0.036
1.755IleTyr: 1.755 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
5.475LysAla: 5.475 ± 0.109
0.272LysCys: 0.272 ± 0.022
2.941LysAsp: 2.941 ± 0.071
3.155LysGlu: 3.155 ± 0.073
1.594LysPhe: 1.594 ± 0.048
3.144LysGly: 3.144 ± 0.069
1.321LysHis: 1.321 ± 0.039
3.433LysIle: 3.433 ± 0.079
3.275LysLys: 3.275 ± 0.077
5.48LysLeu: 5.48 ± 0.095
1.634LysMet: 1.634 ± 0.049
2.439LysAsn: 2.439 ± 0.059
2.65LysPro: 2.65 ± 0.069
3.816LysGln: 3.816 ± 0.087
2.878LysArg: 2.878 ± 0.082
3.335LysSer: 3.335 ± 0.072
3.345LysThr: 3.345 ± 0.076
3.921LysVal: 3.921 ± 0.077
0.552LysTrp: 0.552 ± 0.03
1.338LysTyr: 1.338 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
9.744LeuAla: 9.744 ± 0.126
0.813LeuCys: 0.813 ± 0.034
5.991LeuAsp: 5.991 ± 0.104
6.149LeuGlu: 6.149 ± 0.104
4.291LeuPhe: 4.291 ± 0.099
6.42LeuGly: 6.42 ± 0.114
2.122LeuHis: 2.122 ± 0.06
6.814LeuIle: 6.814 ± 0.116
6.129LeuLys: 6.129 ± 0.092
10.644LeuLeu: 10.644 ± 0.182
2.97LeuMet: 2.97 ± 0.073
5.06LeuAsn: 5.06 ± 0.09
4.439LeuPro: 4.439 ± 0.084
5.447LeuGln: 5.447 ± 0.123
4.044LeuArg: 4.044 ± 0.092
7.404LeuSer: 7.404 ± 0.115
5.273LeuThr: 5.273 ± 0.088
6.729LeuVal: 6.729 ± 0.112
1.125LeuTrp: 1.125 ± 0.047
2.777LeuTyr: 2.777 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.819MetAla: 2.819 ± 0.065
0.154MetCys: 0.154 ± 0.017
1.586MetAsp: 1.586 ± 0.051
1.386MetGlu: 1.386 ± 0.056
0.852MetPhe: 0.852 ± 0.036
1.85MetGly: 1.85 ± 0.055
0.64MetHis: 0.64 ± 0.029
1.637MetIle: 1.637 ± 0.053
1.42MetLys: 1.42 ± 0.04
2.678MetLeu: 2.678 ± 0.06
0.803MetMet: 0.803 ± 0.038
1.255MetAsn: 1.255 ± 0.046
1.393MetPro: 1.393 ± 0.045
1.788MetGln: 1.788 ± 0.052
1.219MetArg: 1.219 ± 0.042
2.03MetSer: 2.03 ± 0.059
1.639MetThr: 1.639 ± 0.048
1.911MetVal: 1.911 ± 0.058
0.197MetTrp: 0.197 ± 0.017
0.46MetTyr: 0.46 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.832AsnAla: 3.832 ± 0.086
0.386AsnCys: 0.386 ± 0.024
2.457AsnAsp: 2.457 ± 0.057
2.698AsnGlu: 2.698 ± 0.068
1.545AsnPhe: 1.545 ± 0.051
2.991AsnGly: 2.991 ± 0.08
1.083AsnHis: 1.083 ± 0.038
2.921AsnIle: 2.921 ± 0.068
2.383AsnLys: 2.383 ± 0.06
4.467AsnLeu: 4.467 ± 0.081
1.056AsnMet: 1.056 ± 0.037
2.148AsnAsn: 2.148 ± 0.071
2.304AsnPro: 2.304 ± 0.066
2.665AsnGln: 2.665 ± 0.072
2.291AsnArg: 2.291 ± 0.061
2.767AsnSer: 2.767 ± 0.07
2.151AsnThr: 2.151 ± 0.052
2.518AsnVal: 2.518 ± 0.07
0.63AsnTrp: 0.63 ± 0.031
1.308AsnTyr: 1.308 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
2.968ProAla: 2.968 ± 0.072
0.299ProCys: 0.299 ± 0.023
2.23ProAsp: 2.23 ± 0.059
3.083ProGlu: 3.083 ± 0.074
1.655ProPhe: 1.655 ± 0.05
2.355ProGly: 2.355 ± 0.07
0.788ProHis: 0.788 ± 0.033
2.516ProIle: 2.516 ± 0.061
1.998ProLys: 1.998 ± 0.05
3.826ProLeu: 3.826 ± 0.069
1.055ProMet: 1.055 ± 0.043
1.709ProAsn: 1.709 ± 0.059
1.121ProPro: 1.121 ± 0.044
1.929ProGln: 1.929 ± 0.056
1.223ProArg: 1.223 ± 0.043
2.142ProSer: 2.142 ± 0.067
1.827ProThr: 1.827 ± 0.054
3.177ProVal: 3.177 ± 0.069
0.486ProTrp: 0.486 ± 0.029
1.219ProTyr: 1.219 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
5.912GlnAla: 5.912 ± 0.111
0.378GlnCys: 0.378 ± 0.024
2.129GlnAsp: 2.129 ± 0.062
2.404GlnGlu: 2.404 ± 0.063
1.987GlnPhe: 1.987 ± 0.058
3.158GlnGly: 3.158 ± 0.069
1.273GlnHis: 1.273 ± 0.046
3.305GlnIle: 3.305 ± 0.076
2.914GlnLys: 2.914 ± 0.071
5.895GlnLeu: 5.895 ± 0.117
1.355GlnMet: 1.355 ± 0.045
2.367GlnAsn: 2.367 ± 0.066
2.046GlnPro: 2.046 ± 0.058
4.485GlnGln: 4.485 ± 0.117
2.636GlnArg: 2.636 ± 0.059
3.46GlnSer: 3.46 ± 0.086
2.879GlnThr: 2.879 ± 0.073
3.739GlnVal: 3.739 ± 0.093
0.675GlnTrp: 0.675 ± 0.03
1.38GlnTyr: 1.38 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.21ArgAla: 3.21 ± 0.075
0.363ArgCys: 0.363 ± 0.022
2.242ArgAsp: 2.242 ± 0.057
2.685ArgGlu: 2.685 ± 0.074
2.318ArgPhe: 2.318 ± 0.062
2.363ArgGly: 2.363 ± 0.068
1.093ArgHis: 1.093 ± 0.043
2.983ArgIle: 2.983 ± 0.068
2.281ArgLys: 2.281 ± 0.063
5.019ArgLeu: 5.019 ± 0.092
1.246ArgMet: 1.246 ± 0.042
1.916ArgAsn: 1.916 ± 0.059
1.498ArgPro: 1.498 ± 0.046
2.436ArgGln: 2.436 ± 0.066
2.01ArgArg: 2.01 ± 0.072
2.328ArgSer: 2.328 ± 0.057
1.758ArgThr: 1.758 ± 0.056
2.912ArgVal: 2.912 ± 0.065
0.593ArgTrp: 0.593 ± 0.032
1.639ArgTyr: 1.639 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
5.525SerAla: 5.525 ± 0.104
0.573SerCys: 0.573 ± 0.027
3.545SerAsp: 3.545 ± 0.075
4.099SerGlu: 4.099 ± 0.076
2.775SerPhe: 2.775 ± 0.072
4.778SerGly: 4.778 ± 0.087
1.442SerHis: 1.442 ± 0.05
4.069SerIle: 4.069 ± 0.082
3.083SerLys: 3.083 ± 0.07
6.852SerLeu: 6.852 ± 0.117
1.725SerMet: 1.725 ± 0.046
2.59SerAsn: 2.59 ± 0.07
2.148SerPro: 2.148 ± 0.06
3.197SerGln: 3.197 ± 0.071
2.642SerArg: 2.642 ± 0.068
3.964SerSer: 3.964 ± 0.098
2.855SerThr: 2.855 ± 0.063
4.262SerVal: 4.262 ± 0.096
0.801SerTrp: 0.801 ± 0.036
1.869SerTyr: 1.869 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.301ThrAla: 4.301 ± 0.098
0.367ThrCys: 0.367 ± 0.024
2.967ThrAsp: 2.967 ± 0.062
3.239ThrGlu: 3.239 ± 0.077
1.823ThrPhe: 1.823 ± 0.062
3.606ThrGly: 3.606 ± 0.073
1.134ThrHis: 1.134 ± 0.044
3.124ThrIle: 3.124 ± 0.1
2.111ThrLys: 2.111 ± 0.058
5.703ThrLeu: 5.703 ± 0.098
1.206ThrMet: 1.206 ± 0.042
1.855ThrAsn: 1.855 ± 0.062
2.39ThrPro: 2.39 ± 0.059
2.328ThrGln: 2.328 ± 0.065
1.94ThrArg: 1.94 ± 0.06
2.702ThrSer: 2.702 ± 0.064
2.583ThrThr: 2.583 ± 0.07
3.511ThrVal: 3.511 ± 0.092
0.478ThrTrp: 0.478 ± 0.027
1.351ThrTyr: 1.351 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
5.862ValAla: 5.862 ± 0.096
0.636ValCys: 0.636 ± 0.031
4.085ValAsp: 4.085 ± 0.076
4.869ValGlu: 4.869 ± 0.088
2.87ValPhe: 2.87 ± 0.073
4.246ValGly: 4.246 ± 0.087
1.289ValHis: 1.289 ± 0.049
4.76ValIle: 4.76 ± 0.1
3.862ValLys: 3.862 ± 0.084
6.935ValLeu: 6.935 ± 0.107
2.04ValMet: 2.04 ± 0.057
2.937ValAsn: 2.937 ± 0.068
2.339ValPro: 2.339 ± 0.061
2.476ValGln: 2.476 ± 0.061
2.609ValArg: 2.609 ± 0.068
4.558ValSer: 4.558 ± 0.082
3.421ValThr: 3.421 ± 0.086
5.076ValVal: 5.076 ± 0.114
0.722ValTrp: 0.722 ± 0.027
1.836ValTyr: 1.836 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.717TrpAla: 0.717 ± 0.03
0.125TrpCys: 0.125 ± 0.015
0.515TrpAsp: 0.515 ± 0.026
0.426TrpGlu: 0.426 ± 0.029
0.613TrpPhe: 0.613 ± 0.031
0.647TrpGly: 0.647 ± 0.031
0.38TrpHis: 0.38 ± 0.022
0.74TrpIle: 0.74 ± 0.031
0.465TrpLys: 0.465 ± 0.03
1.904TrpLeu: 1.904 ± 0.056
0.341TrpMet: 0.341 ± 0.022
0.416TrpAsn: 0.416 ± 0.028
0.469TrpPro: 0.469 ± 0.029
1.258TrpGln: 1.258 ± 0.044
0.61TrpArg: 0.61 ± 0.029
0.636TrpSer: 0.636 ± 0.029
0.443TrpThr: 0.443 ± 0.025
0.824TrpVal: 0.824 ± 0.036
0.186TrpTrp: 0.186 ± 0.017
0.321TrpTyr: 0.321 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.396TyrAla: 2.396 ± 0.064
0.282TyrCys: 0.282 ± 0.02
1.669TyrAsp: 1.669 ± 0.054
1.814TyrGlu: 1.814 ± 0.056
1.288TyrPhe: 1.288 ± 0.044
2.01TyrGly: 2.01 ± 0.051
0.75TyrHis: 0.75 ± 0.031
1.787TyrIle: 1.787 ± 0.053
1.46TyrLys: 1.46 ± 0.049
3.316TyrLeu: 3.316 ± 0.068
0.655TyrMet: 0.655 ± 0.029
1.112TyrAsn: 1.112 ± 0.042
1.289TyrPro: 1.289 ± 0.046
2.23TyrGln: 2.23 ± 0.075
1.645TyrArg: 1.645 ± 0.055
1.975TyrSer: 1.975 ± 0.058
1.217TyrThr: 1.217 ± 0.046
1.626TyrVal: 1.626 ± 0.057
0.399TyrTrp: 0.399 ± 0.022
0.974TyrTyr: 0.974 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2078 proteins (695024 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski