Amino acid dipepetide frequency for Paracoccus aeridis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.203AlaAla: 20.203 ± 0.183	1.027AlaCys: 1.027 ± 0.029	7.969AlaAsp: 7.969 ± 0.074	8.428AlaGlu: 8.428 ± 0.08	3.938AlaPhe: 3.938 ± 0.049	11.95AlaGly: 11.95 ± 0.107	2.479AlaHis: 2.479 ± 0.041	5.706AlaIle: 5.706 ± 0.061	3.002AlaLys: 3.002 ± 0.048	13.564AlaLeu: 13.564 ± 0.114	3.503AlaMet: 3.503 ± 0.046	2.771AlaAsn: 2.771 ± 0.046	6.64AlaPro: 6.64 ± 0.088	4.559AlaGln: 4.559 ± 0.056	10.235AlaArg: 10.235 ± 0.101	6.12AlaSer: 6.12 ± 0.063	6.897AlaThr: 6.897 ± 0.059	9.797AlaVal: 9.797 ± 0.095	1.705AlaTrp: 1.705 ± 0.033	2.324AlaTyr: 2.324 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.948CysAla: 0.948 ± 0.027	0.09CysCys: 0.09 ± 0.007	0.5CysAsp: 0.5 ± 0.02	0.408CysGlu: 0.408 ± 0.017	0.254CysPhe: 0.254 ± 0.013	0.806CysGly: 0.806 ± 0.023	0.2CysHis: 0.2 ± 0.012	0.306CysIle: 0.306 ± 0.015	0.119CysLys: 0.119 ± 0.008	0.628CysLeu: 0.628 ± 0.017	0.148CysMet: 0.148 ± 0.01	0.176CysAsn: 0.176 ± 0.01	0.439CysPro: 0.439 ± 0.017	0.177CysGln: 0.177 ± 0.01	0.517CysArg: 0.517 ± 0.018	0.383CysSer: 0.383 ± 0.016	0.397CysThr: 0.397 ± 0.017	0.551CysVal: 0.551 ± 0.016	0.108CysTrp: 0.108 ± 0.008	0.155CysTyr: 0.155 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.365AspAla: 8.365 ± 0.072	0.429AspCys: 0.429 ± 0.015	3.854AspAsp: 3.854 ± 0.066	4.051AspGlu: 4.051 ± 0.059	2.245AspPhe: 2.245 ± 0.039	5.511AspGly: 5.511 ± 0.082	1.319AspHis: 1.319 ± 0.032	2.779AspIle: 2.779 ± 0.047	1.512AspLys: 1.512 ± 0.033	6.245AspLeu: 6.245 ± 0.074	1.375AspMet: 1.375 ± 0.03	1.475AspAsn: 1.475 ± 0.031	4.126AspPro: 4.126 ± 0.057	1.656AspGln: 1.656 ± 0.033	4.732AspArg: 4.732 ± 0.063	2.482AspSer: 2.482 ± 0.041	3.033AspThr: 3.033 ± 0.042	4.605AspVal: 4.605 ± 0.053	1.046AspTrp: 1.046 ± 0.029	1.446AspTyr: 1.446 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.399GluAla: 7.399 ± 0.078	0.32GluCys: 0.32 ± 0.015	3.04GluAsp: 3.04 ± 0.045	3.147GluGlu: 3.147 ± 0.053	1.814GluPhe: 1.814 ± 0.036	4.695GluGly: 4.695 ± 0.051	1.244GluHis: 1.244 ± 0.033	3.178GluIle: 3.178 ± 0.041	1.795GluLys: 1.795 ± 0.044	5.792GluLeu: 5.792 ± 0.066	1.448GluMet: 1.448 ± 0.028	1.469GluAsn: 1.469 ± 0.027	2.903GluPro: 2.903 ± 0.053	2.115GluGln: 2.115 ± 0.042	4.704GluArg: 4.704 ± 0.057	2.493GluSer: 2.493 ± 0.045	3.156GluThr: 3.156 ± 0.047	4.586GluVal: 4.586 ± 0.056	0.755GluTrp: 0.755 ± 0.022	1.072GluTyr: 1.072 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.317PheAla: 4.317 ± 0.052	0.312PheCys: 0.312 ± 0.013	2.591PheAsp: 2.591 ± 0.042	1.795PheGlu: 1.795 ± 0.033	1.188PhePhe: 1.188 ± 0.029	3.414PheGly: 3.414 ± 0.053	0.709PheHis: 0.709 ± 0.025	1.495PheIle: 1.495 ± 0.032	0.677PheLys: 0.677 ± 0.022	2.93PheLeu: 2.93 ± 0.049	0.701PheMet: 0.701 ± 0.019	0.911PheAsn: 0.911 ± 0.023	1.467PhePro: 1.467 ± 0.027	0.871PheGln: 0.871 ± 0.025	2.093PheArg: 2.093 ± 0.035	1.898PheSer: 1.898 ± 0.035	1.988PheThr: 1.988 ± 0.035	2.626PheVal: 2.626 ± 0.044	0.523PheTrp: 0.523 ± 0.019	0.809PheTyr: 0.809 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.551GlyAla: 10.551 ± 0.11	0.718GlyCys: 0.718 ± 0.021	4.988GlyAsp: 4.988 ± 0.066	5.118GlyGlu: 5.118 ± 0.062	3.375GlyPhe: 3.375 ± 0.054	7.575GlyGly: 7.575 ± 0.106	1.86GlyHis: 1.86 ± 0.034	4.468GlyIle: 4.468 ± 0.059	2.632GlyLys: 2.632 ± 0.047	8.643GlyLeu: 8.643 ± 0.08	2.46GlyMet: 2.46 ± 0.041	2.136GlyAsn: 2.136 ± 0.045	3.933GlyPro: 3.933 ± 0.061	2.948GlyGln: 2.948 ± 0.04	6.645GlyArg: 6.645 ± 0.079	4.606GlySer: 4.606 ± 0.055	5.155GlyThr: 5.155 ± 0.053	7.005GlyVal: 7.005 ± 0.077	1.566GlyTrp: 1.566 ± 0.033	2.093GlyTyr: 2.093 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.437HisAla: 2.437 ± 0.041	0.179HisCys: 0.179 ± 0.01	1.432HisAsp: 1.432 ± 0.03	1.072HisGlu: 1.072 ± 0.026	0.675HisPhe: 0.675 ± 0.022	1.992HisGly: 1.992 ± 0.037	0.55HisHis: 0.55 ± 0.021	0.853HisIle: 0.853 ± 0.022	0.406HisLys: 0.406 ± 0.015	2.028HisLeu: 2.028 ± 0.041	0.481HisMet: 0.481 ± 0.015	0.448HisAsn: 0.448 ± 0.016	1.445HisPro: 1.445 ± 0.031	0.519HisGln: 0.519 ± 0.017	1.45HisArg: 1.45 ± 0.031	0.945HisSer: 0.945 ± 0.023	0.932HisThr: 0.932 ± 0.025	1.608HisVal: 1.608 ± 0.03	0.312HisTrp: 0.312 ± 0.014	0.493HisTyr: 0.493 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.902IleAla: 6.902 ± 0.068	0.403IleCys: 0.403 ± 0.015	3.63IleAsp: 3.63 ± 0.048	3.097IleGlu: 3.097 ± 0.045	1.438IlePhe: 1.438 ± 0.031	4.456IleGly: 4.456 ± 0.059	0.869IleHis: 0.869 ± 0.024	2.001IleIle: 2.001 ± 0.044	1.016IleLys: 1.016 ± 0.025	4.036IleLeu: 4.036 ± 0.058	0.971IleMet: 0.971 ± 0.029	1.227IleAsn: 1.227 ± 0.03	2.286IlePro: 2.286 ± 0.039	1.061IleGln: 1.061 ± 0.025	3.083IleArg: 3.083 ± 0.041	2.479IleSer: 2.479 ± 0.038	2.742IleThr: 2.742 ± 0.046	4.044IleVal: 4.044 ± 0.05	0.548IleTrp: 0.548 ± 0.021	0.991IleTyr: 0.991 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.092LysAla: 3.092 ± 0.056	0.127LysCys: 0.127 ± 0.009	1.412LysAsp: 1.412 ± 0.031	1.246LysGlu: 1.246 ± 0.032	0.686LysPhe: 0.686 ± 0.021	2.109LysGly: 2.109 ± 0.045	0.49LysHis: 0.49 ± 0.02	1.17LysIle: 1.17 ± 0.029	0.958LysLys: 0.958 ± 0.031	2.487LysLeu: 2.487 ± 0.043	0.621LysMet: 0.621 ± 0.022	0.71LysAsn: 0.71 ± 0.023	1.463LysPro: 1.463 ± 0.034	0.82LysGln: 0.82 ± 0.023	1.887LysArg: 1.887 ± 0.038	1.347LysSer: 1.347 ± 0.029	1.445LysThr: 1.445 ± 0.033	2.027LysVal: 2.027 ± 0.04	0.311LysTrp: 0.311 ± 0.014	0.522LysTyr: 0.522 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.806LeuAla: 13.806 ± 0.109	0.729LeuCys: 0.729 ± 0.021	6.402LeuAsp: 6.402 ± 0.077	4.591LeuGlu: 4.591 ± 0.052	2.994LeuPhe: 2.994 ± 0.052	8.409LeuGly: 8.409 ± 0.08	1.863LeuHis: 1.863 ± 0.03	4.784LeuIle: 4.784 ± 0.066	2.425LeuLys: 2.425 ± 0.042	8.616LeuLeu: 8.616 ± 0.088	2.244LeuMet: 2.244 ± 0.035	2.424LeuAsn: 2.424 ± 0.044	5.687LeuPro: 5.687 ± 0.061	2.505LeuGln: 2.505 ± 0.041	7.393LeuArg: 7.393 ± 0.08	6.087LeuSer: 6.087 ± 0.071	5.957LeuThr: 5.957 ± 0.061	7.66LeuVal: 7.66 ± 0.079	1.199LeuTrp: 1.199 ± 0.031	1.72LeuTyr: 1.72 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.213MetAla: 3.213 ± 0.042	0.142MetCys: 0.142 ± 0.01	1.328MetAsp: 1.328 ± 0.029	1.112MetGlu: 1.112 ± 0.026	0.721MetPhe: 0.721 ± 0.023	1.979MetGly: 1.979 ± 0.041	0.412MetHis: 0.412 ± 0.016	1.317MetIle: 1.317 ± 0.031	0.759MetLys: 0.759 ± 0.021	2.382MetLeu: 2.382 ± 0.04	0.632MetMet: 0.632 ± 0.019	0.757MetAsn: 0.757 ± 0.022	1.407MetPro: 1.407 ± 0.031	0.776MetGln: 0.776 ± 0.024	1.81MetArg: 1.81 ± 0.036	1.484MetSer: 1.484 ± 0.03	1.852MetThr: 1.852 ± 0.035	1.76MetVal: 1.76 ± 0.035	0.248MetTrp: 0.248 ± 0.012	0.349MetTyr: 0.349 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.991AsnAla: 2.991 ± 0.044	0.185AsnCys: 0.185 ± 0.012	1.405AsnAsp: 1.405 ± 0.036	1.212AsnGlu: 1.212 ± 0.031	0.816AsnPhe: 0.816 ± 0.023	2.156AsnGly: 2.156 ± 0.037	0.517AsnHis: 0.517 ± 0.016	1.151AsnIle: 1.151 ± 0.026	0.591AsnLys: 0.591 ± 0.022	2.441AsnLeu: 2.441 ± 0.035	0.571AsnMet: 0.571 ± 0.019	0.667AsnAsn: 0.667 ± 0.022	1.913AsnPro: 1.913 ± 0.037	0.706AsnGln: 0.706 ± 0.02	1.716AsnArg: 1.716 ± 0.033	1.199AsnSer: 1.199 ± 0.027	1.254AsnThr: 1.254 ± 0.03	1.929AsnVal: 1.929 ± 0.035	0.407AsnTrp: 0.407 ± 0.018	0.652AsnTyr: 0.652 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.598ProAla: 7.598 ± 0.083	0.322ProCys: 0.322 ± 0.015	4.073ProAsp: 4.073 ± 0.053	3.917ProGlu: 3.917 ± 0.045	1.843ProPhe: 1.843 ± 0.03	5.38ProGly: 5.38 ± 0.061	1.128ProHis: 1.128 ± 0.028	1.989ProIle: 1.989 ± 0.034	1.256ProLys: 1.256 ± 0.027	4.679ProLeu: 4.679 ± 0.06	1.152ProMet: 1.152 ± 0.026	1.238ProAsn: 1.238 ± 0.026	2.609ProPro: 2.609 ± 0.047	1.806ProGln: 1.806 ± 0.037	3.501ProArg: 3.501 ± 0.055	2.663ProSer: 2.663 ± 0.041	2.769ProThr: 2.769 ± 0.046	4.791ProVal: 4.791 ± 0.05	0.738ProTrp: 0.738 ± 0.02	1.041ProTyr: 1.041 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	4.256GlnAla: 4.256 ± 0.058	0.165GlnCys: 0.165 ± 0.011	1.522GlnAsp: 1.522 ± 0.032	1.406GlnGlu: 1.406 ± 0.03	0.952GlnPhe: 0.952 ± 0.025	2.564GlnGly: 2.564 ± 0.039	0.575GlnHis: 0.575 ± 0.018	1.621GlnIle: 1.621 ± 0.033	0.78GlnLys: 0.78 ± 0.025	3.131GlnLeu: 3.131 ± 0.049	0.913GlnMet: 0.913 ± 0.021	0.743GlnAsn: 0.743 ± 0.021	1.815GlnPro: 1.815 ± 0.032	1.168GlnGln: 1.168 ± 0.033	2.401GlnArg: 2.401 ± 0.04	1.513GlnSer: 1.513 ± 0.033	1.518GlnThr: 1.518 ± 0.031	2.563GlnVal: 2.563 ± 0.042	0.448GlnTrp: 0.448 ± 0.016	0.534GlnTyr: 0.534 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.359ArgAla: 9.359 ± 0.099	0.455ArgCys: 0.455 ± 0.017	4.689ArgAsp: 4.689 ± 0.059	4.373ArgGlu: 4.373 ± 0.055	2.623ArgPhe: 2.623 ± 0.039	5.546ArgGly: 5.546 ± 0.059	1.697ArgHis: 1.697 ± 0.037	3.921ArgIle: 3.921 ± 0.048	1.906ArgLys: 1.906 ± 0.034	7.607ArgLeu: 7.607 ± 0.081	2.091ArgMet: 2.091 ± 0.039	1.756ArgAsn: 1.756 ± 0.028	3.848ArgPro: 3.848 ± 0.053	2.449ArgGln: 2.449 ± 0.044	6.231ArgArg: 6.231 ± 0.071	3.512ArgSer: 3.512 ± 0.043	3.649ArgThr: 3.649 ± 0.05	5.521ArgVal: 5.521 ± 0.063	1.084ArgTrp: 1.084 ± 0.026	1.546ArgTyr: 1.546 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.163SerAla: 6.163 ± 0.069	0.369SerCys: 0.369 ± 0.016	2.991SerAsp: 2.991 ± 0.049	2.6SerGlu: 2.6 ± 0.038	1.939SerPhe: 1.939 ± 0.034	5.348SerGly: 5.348 ± 0.06	1.085SerHis: 1.085 ± 0.026	2.341SerIle: 2.341 ± 0.037	1.198SerLys: 1.198 ± 0.028	4.914SerLeu: 4.914 ± 0.054	1.254SerMet: 1.254 ± 0.029	1.239SerAsn: 1.239 ± 0.027	2.796SerPro: 2.796 ± 0.041	1.549SerGln: 1.549 ± 0.03	3.656SerArg: 3.656 ± 0.048	2.787SerSer: 2.787 ± 0.048	2.934SerThr: 2.934 ± 0.043	3.961SerVal: 3.961 ± 0.053	0.764SerTrp: 0.764 ± 0.021	1.156SerTyr: 1.156 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	6.766ThrAla: 6.766 ± 0.073	0.427ThrCys: 0.427 ± 0.016	3.3ThrAsp: 3.3 ± 0.037	2.92ThrGlu: 2.92 ± 0.045	1.835ThrPhe: 1.835 ± 0.036	5.555ThrGly: 5.555 ± 0.051	1.126ThrHis: 1.126 ± 0.029	2.628ThrIle: 2.628 ± 0.047	1.197ThrLys: 1.197 ± 0.028	5.818ThrLeu: 5.818 ± 0.061	1.216ThrMet: 1.216 ± 0.026	1.294ThrAsn: 1.294 ± 0.027	3.651ThrPro: 3.651 ± 0.048	1.585ThrGln: 1.585 ± 0.037	3.808ThrArg: 3.808 ± 0.047	2.88ThrSer: 2.88 ± 0.045	3.355ThrThr: 3.355 ± 0.054	4.769ThrVal: 4.769 ± 0.062	0.744ThrTrp: 0.744 ± 0.023	1.208ThrTyr: 1.208 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.605ValAla: 10.605 ± 0.106	0.608ValCys: 0.608 ± 0.02	4.949ValAsp: 4.949 ± 0.056	4.865ValGlu: 4.865 ± 0.057	2.661ValPhe: 2.661 ± 0.042	6.084ValGly: 6.084 ± 0.073	1.402ValHis: 1.402 ± 0.03	4.073ValIle: 4.073 ± 0.052	1.874ValLys: 1.874 ± 0.044	7.748ValLeu: 7.748 ± 0.077	1.923ValMet: 1.923 ± 0.032	2.038ValAsn: 2.038 ± 0.034	4.22ValPro: 4.22 ± 0.05	2.107ValGln: 2.107 ± 0.037	5.25ValArg: 5.25 ± 0.051	4.294ValSer: 4.294 ± 0.057	5.147ValThr: 5.147 ± 0.058	6.891ValVal: 6.891 ± 0.079	1.041ValTrp: 1.041 ± 0.029	1.467ValTyr: 1.467 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.466TrpAla: 1.466 ± 0.029	0.12TrpCys: 0.12 ± 0.009	0.778TrpAsp: 0.778 ± 0.023	0.636TrpGlu: 0.636 ± 0.019	0.542TrpPhe: 0.542 ± 0.021	1.002TrpGly: 1.002 ± 0.028	0.3TrpHis: 0.3 ± 0.013	0.718TrpIle: 0.718 ± 0.024	0.378TrpLys: 0.378 ± 0.016	1.711TrpLeu: 1.711 ± 0.038	0.368TrpMet: 0.368 ± 0.016	0.421TrpAsn: 0.421 ± 0.016	0.743TrpPro: 0.743 ± 0.024	0.589TrpGln: 0.589 ± 0.022	1.189TrpArg: 1.189 ± 0.026	0.762TrpSer: 0.762 ± 0.024	0.822TrpThr: 0.822 ± 0.027	1.049TrpVal: 1.049 ± 0.027	0.278TrpTrp: 0.278 ± 0.013	0.266TrpTyr: 0.266 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.38TyrAla: 2.38 ± 0.035	0.183TyrCys: 0.183 ± 0.01	1.436TyrAsp: 1.436 ± 0.029	1.129TyrGlu: 1.129 ± 0.027	0.775TyrPhe: 0.775 ± 0.022	1.945TyrGly: 1.945 ± 0.041	0.431TyrHis: 0.431 ± 0.017	0.78TyrIle: 0.78 ± 0.023	0.449TyrLys: 0.449 ± 0.017	2.093TyrLeu: 2.093 ± 0.036	0.367TyrMet: 0.367 ± 0.014	0.581TyrAsn: 0.581 ± 0.02	1.099TyrPro: 1.099 ± 0.028	0.623TyrGln: 0.623 ± 0.021	1.563TyrArg: 1.563 ± 0.032	1.11TyrSer: 1.11 ± 0.026	1.081TyrThr: 1.081 ± 0.026	1.507TyrVal: 1.507 ± 0.029	0.31TyrTrp: 0.31 ± 0.014	0.499TyrTyr: 0.499 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5156 proteins (1652495 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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