human papillomavirus 150

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Betapapillomavirus; Betapapillomavirus 5

Average proteome isoelectric point is 6.18

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|D3VNF1|D3VNF1_9PAPI Replication protein E1 OS=human papillomavirus 150 OX=743811 GN=E1 PE=3 SV=1
MM1 pKa = 7.43IGKK4 pKa = 8.97EE5 pKa = 3.79VTIPDD10 pKa = 4.17IEE12 pKa = 5.64LEE14 pKa = 4.19LQDD17 pKa = 4.42LVQPIDD23 pKa = 3.48LHH25 pKa = 7.72CDD27 pKa = 3.07EE28 pKa = 4.87VLSPEE33 pKa = 3.93EE34 pKa = 4.19SEE36 pKa = 4.38NLSEE40 pKa = 4.18SSQAEE45 pKa = 4.21VEE47 pKa = 4.15PEE49 pKa = 3.96RR50 pKa = 11.84ILFKK54 pKa = 10.62IVAPCGGCEE63 pKa = 4.27ARR65 pKa = 11.84LKK67 pKa = 10.78LHH69 pKa = 6.49IASSRR74 pKa = 11.84LGIRR78 pKa = 11.84CLEE81 pKa = 3.95NLLLSEE87 pKa = 4.5ICLLCPACRR96 pKa = 11.84HH97 pKa = 5.29GRR99 pKa = 11.84QQ100 pKa = 3.13

Molecular weight: 11.11 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|D3VNF3|D3VNF3_9PAPI Putative E4 product OS=human papillomavirus 150 OX=743811 GN=E4 PE=4 SV=1
MM1 pKa = 7.45EE2 pKa = 5.85ALNQRR7 pKa = 11.84FTVLQDD13 pKa = 3.35QLMDD17 pKa = 3.31IYY19 pKa = 11.21EE20 pKa = 4.53RR21 pKa = 11.84GSDD24 pKa = 3.43TLEE27 pKa = 3.75EE28 pKa = 4.33QIKK31 pKa = 9.81HH32 pKa = 3.94WTLLKK37 pKa = 10.36QEE39 pKa = 4.21QIILNYY45 pKa = 9.64ARR47 pKa = 11.84RR48 pKa = 11.84RR49 pKa = 11.84GIMRR53 pKa = 11.84LGYY56 pKa = 10.54HH57 pKa = 6.58PVPSLAISEE66 pKa = 4.72SKK68 pKa = 11.03AKK70 pKa = 10.45DD71 pKa = 3.77AIAMALHH78 pKa = 6.67LEE80 pKa = 3.99NLKK83 pKa = 10.56RR84 pKa = 11.84SPYY87 pKa = 9.98KK88 pKa = 10.45DD89 pKa = 3.83EE90 pKa = 4.22PWTLINTSLEE100 pKa = 4.31TFRR103 pKa = 11.84TAPANCFKK111 pKa = 10.85KK112 pKa = 10.49GPQNVEE118 pKa = 4.18VIFDD122 pKa = 4.36ADD124 pKa = 3.67PEE126 pKa = 4.44NIMLYY131 pKa = 8.1TAWKK135 pKa = 9.13FIYY138 pKa = 10.8YY139 pKa = 10.17EE140 pKa = 4.47DD141 pKa = 6.2ADD143 pKa = 4.28GQWQKK148 pKa = 9.81TEE150 pKa = 3.73GHH152 pKa = 6.49IDD154 pKa = 3.4YY155 pKa = 10.86SGLYY159 pKa = 9.58FLEE162 pKa = 4.52GTIKK166 pKa = 10.19HH167 pKa = 6.03YY168 pKa = 10.64YY169 pKa = 9.94VEE171 pKa = 4.34FAVDD175 pKa = 3.26ARR177 pKa = 11.84RR178 pKa = 11.84FGSGSEE184 pKa = 3.77WEE186 pKa = 4.07VRR188 pKa = 11.84FNGEE192 pKa = 3.88TLFAPVTSSSPSSLEE207 pKa = 3.71EE208 pKa = 3.68SRR210 pKa = 11.84EE211 pKa = 4.02RR212 pKa = 11.84PEE214 pKa = 4.08SQSPDD219 pKa = 3.46VPEE222 pKa = 4.15TTTDD226 pKa = 3.47AGTLLQRR233 pKa = 11.84EE234 pKa = 4.27TRR236 pKa = 11.84PTEE239 pKa = 3.51RR240 pKa = 11.84AEE242 pKa = 3.73PRR244 pKa = 11.84KK245 pKa = 9.5GRR247 pKa = 11.84RR248 pKa = 11.84YY249 pKa = 8.72EE250 pKa = 4.06RR251 pKa = 11.84KK252 pKa = 9.12EE253 pKa = 3.77SSPTSTSVRR262 pKa = 11.84GRR264 pKa = 11.84QRR266 pKa = 11.84VSGAPARR273 pKa = 11.84KK274 pKa = 9.17KK275 pKa = 10.3DD276 pKa = 3.25IRR278 pKa = 11.84RR279 pKa = 11.84SRR281 pKa = 11.84SRR283 pKa = 11.84SSGRR287 pKa = 11.84FEE289 pKa = 3.99TDD291 pKa = 2.29QATARR296 pKa = 11.84GRR298 pKa = 11.84GQRR301 pKa = 11.84QARR304 pKa = 11.84LRR306 pKa = 11.84TRR308 pKa = 11.84SRR310 pKa = 11.84SRR312 pKa = 11.84RR313 pKa = 11.84RR314 pKa = 11.84SSSRR318 pKa = 11.84SRR320 pKa = 11.84SRR322 pKa = 11.84GRR324 pKa = 11.84DD325 pKa = 2.82RR326 pKa = 11.84KK327 pKa = 8.9QSKK330 pKa = 9.55RR331 pKa = 11.84GRR333 pKa = 11.84GGRR336 pKa = 11.84GYY338 pKa = 10.29FARR341 pKa = 11.84SRR343 pKa = 11.84SRR345 pKa = 11.84SAEE348 pKa = 3.9SRR350 pKa = 11.84SADD353 pKa = 3.09QFGILPPQVGTGVQSVGRR371 pKa = 11.84KK372 pKa = 8.2HH373 pKa = 5.94SSRR376 pKa = 11.84VEE378 pKa = 3.79RR379 pKa = 11.84LLAEE383 pKa = 4.47AVDD386 pKa = 3.9PPVILFRR393 pKa = 11.84GPPNTLKK400 pKa = 10.6CYY402 pKa = 10.23RR403 pKa = 11.84YY404 pKa = 9.67RR405 pKa = 11.84EE406 pKa = 4.07KK407 pKa = 11.0EE408 pKa = 4.03RR409 pKa = 11.84LKK411 pKa = 10.94GSYY414 pKa = 10.49DD415 pKa = 3.36RR416 pKa = 11.84FSTTWSWVGSEE427 pKa = 3.91GNARR431 pKa = 11.84LGRR434 pKa = 11.84ARR436 pKa = 11.84MLVSFLSEE444 pKa = 3.83NQRR447 pKa = 11.84DD448 pKa = 3.76QFIDD452 pKa = 3.39KK453 pKa = 9.61MRR455 pKa = 11.84LPKK458 pKa = 10.77DD459 pKa = 3.52VDD461 pKa = 3.03WSFGNFASII470 pKa = 4.42

Molecular weight: 54.13 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2553

100

605

364.7

41.09

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.445 ± 0.3

2.193 ± 0.854

5.601 ± 0.382

7.521 ± 0.81

3.995 ± 0.459

6.933 ± 0.861

2.154 ± 0.332

4.896 ± 0.731

4.896 ± 0.675

9.127 ± 0.943

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.449 ± 0.384

4.348 ± 0.94

6.032 ± 1.063

4.23 ± 0.244

7.09 ± 1.536

8.108 ± 0.589

5.719 ± 0.876

5.797 ± 0.656

1.293 ± 0.366

3.173 ± 0.277
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski