Amino acid dipepetide frequency for Streptomyces paludis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.141AlaAla: 22.141 ± 0.157	0.978AlaCys: 0.978 ± 0.022	8.278AlaAsp: 8.278 ± 0.064	8.783AlaGlu: 8.783 ± 0.087	3.413AlaPhe: 3.413 ± 0.042	14.188AlaGly: 14.188 ± 0.089	2.858AlaHis: 2.858 ± 0.039	3.501AlaIle: 3.501 ± 0.047	2.884AlaLys: 2.884 ± 0.054	14.923AlaLeu: 14.923 ± 0.116	2.436AlaMet: 2.436 ± 0.028	1.978AlaAsn: 1.978 ± 0.034	7.663AlaPro: 7.663 ± 0.083	3.446AlaGln: 3.446 ± 0.04	10.57AlaArg: 10.57 ± 0.08	5.981AlaSer: 5.981 ± 0.05	7.354AlaThr: 7.354 ± 0.068	12.549AlaVal: 12.549 ± 0.097	1.803AlaTrp: 1.803 ± 0.026	2.789AlaTyr: 2.789 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.093CysAla: 1.093 ± 0.025	0.095CysCys: 0.095 ± 0.007	0.445CysAsp: 0.445 ± 0.015	0.363CysGlu: 0.363 ± 0.013	0.219CysPhe: 0.219 ± 0.011	0.936CysGly: 0.936 ± 0.022	0.178CysHis: 0.178 ± 0.009	0.135CysIle: 0.135 ± 0.007	0.102CysLys: 0.102 ± 0.008	0.685CysLeu: 0.685 ± 0.02	0.107CysMet: 0.107 ± 0.008	0.124CysAsn: 0.124 ± 0.007	0.46CysPro: 0.46 ± 0.016	0.157CysGln: 0.157 ± 0.008	0.574CysArg: 0.574 ± 0.017	0.405CysSer: 0.405 ± 0.011	0.446CysThr: 0.446 ± 0.015	0.644CysVal: 0.644 ± 0.015	0.115CysTrp: 0.115 ± 0.007	0.152CysTyr: 0.152 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.696AspAla: 7.696 ± 0.069	0.38AspCys: 0.38 ± 0.015	3.417AspAsp: 3.417 ± 0.048	3.62AspGlu: 3.62 ± 0.046	1.618AspPhe: 1.618 ± 0.026	6.544AspGly: 6.544 ± 0.068	1.357AspHis: 1.357 ± 0.029	1.99AspIle: 1.99 ± 0.031	1.12AspLys: 1.12 ± 0.026	5.796AspLeu: 5.796 ± 0.057	0.766AspMet: 0.766 ± 0.019	0.934AspAsn: 0.934 ± 0.024	4.477AspPro: 4.477 ± 0.054	1.451AspGln: 1.451 ± 0.029	5.099AspArg: 5.099 ± 0.052	2.684AspSer: 2.684 ± 0.038	3.429AspThr: 3.429 ± 0.046	4.16AspVal: 4.16 ± 0.046	0.977AspTrp: 0.977 ± 0.022	1.069AspTyr: 1.069 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.131GluAla: 7.131 ± 0.064	0.351GluCys: 0.351 ± 0.012	2.573GluAsp: 2.573 ± 0.034	3.318GluGlu: 3.318 ± 0.045	1.406GluPhe: 1.406 ± 0.026	4.084GluGly: 4.084 ± 0.044	1.396GluHis: 1.396 ± 0.026	2.292GluIle: 2.292 ± 0.033	1.413GluLys: 1.413 ± 0.027	6.665GluLeu: 6.665 ± 0.068	0.862GluMet: 0.862 ± 0.021	1.036GluAsn: 1.036 ± 0.022	3.431GluPro: 3.431 ± 0.05	1.967GluGln: 1.967 ± 0.029	5.538GluArg: 5.538 ± 0.055	2.776GluSer: 2.776 ± 0.034	3.044GluThr: 3.044 ± 0.038	4.267GluVal: 4.267 ± 0.047	0.742GluTrp: 0.742 ± 0.016	1.1GluTyr: 1.1 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.593PheAla: 3.593 ± 0.044	0.261PheCys: 0.261 ± 0.01	1.94PheAsp: 1.94 ± 0.031	1.349PheGlu: 1.349 ± 0.028	0.888PhePhe: 0.888 ± 0.022	2.99PheGly: 2.99 ± 0.042	0.584PheHis: 0.584 ± 0.013	0.741PheIle: 0.741 ± 0.02	0.498PheLys: 0.498 ± 0.016	2.581PheLeu: 2.581 ± 0.036	0.39PheMet: 0.39 ± 0.014	0.573PheAsn: 0.573 ± 0.016	1.402PhePro: 1.402 ± 0.027	0.677PheGln: 0.677 ± 0.017	1.815PheArg: 1.815 ± 0.028	1.488PheSer: 1.488 ± 0.027	2.071PheThr: 2.071 ± 0.035	2.122PheVal: 2.122 ± 0.036	0.414PheTrp: 0.414 ± 0.012	0.57PheTyr: 0.57 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.949GlyAla: 11.949 ± 0.088	0.821GlyCys: 0.821 ± 0.018	5.169GlyAsp: 5.169 ± 0.055	5.109GlyGlu: 5.109 ± 0.048	2.873GlyPhe: 2.873 ± 0.038	9.531GlyGly: 9.531 ± 0.102	2.304GlyHis: 2.304 ± 0.034	3.515GlyIle: 3.515 ± 0.047	2.366GlyLys: 2.366 ± 0.039	9.46GlyLeu: 9.46 ± 0.066	1.928GlyMet: 1.928 ± 0.031	1.776GlyAsn: 1.776 ± 0.033	5.591GlyPro: 5.591 ± 0.055	2.613GlyGln: 2.613 ± 0.036	8.118GlyArg: 8.118 ± 0.062	5.594GlySer: 5.594 ± 0.06	6.932GlyThr: 6.932 ± 0.069	7.646GlyVal: 7.646 ± 0.081	1.676GlyTrp: 1.676 ± 0.028	2.27GlyTyr: 2.27 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.558HisAla: 2.558 ± 0.039	0.2HisCys: 0.2 ± 0.011	1.273HisAsp: 1.273 ± 0.024	1.157HisGlu: 1.157 ± 0.025	0.634HisPhe: 0.634 ± 0.017	2.261HisGly: 2.261 ± 0.032	0.674HisHis: 0.674 ± 0.02	0.696HisIle: 0.696 ± 0.018	0.312HisLys: 0.312 ± 0.013	2.302HisLeu: 2.302 ± 0.037	0.308HisMet: 0.308 ± 0.012	0.37HisAsn: 0.37 ± 0.013	1.789HisPro: 1.789 ± 0.034	0.625HisGln: 0.625 ± 0.017	2.131HisArg: 2.131 ± 0.035	1.029HisSer: 1.029 ± 0.022	1.46HisThr: 1.46 ± 0.028	1.511HisVal: 1.511 ± 0.027	0.34HisTrp: 0.34 ± 0.013	0.465HisTyr: 0.465 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.878IleAla: 4.878 ± 0.049	0.287IleCys: 0.287 ± 0.011	2.266IleAsp: 2.266 ± 0.036	1.975IleGlu: 1.975 ± 0.033	0.706IlePhe: 0.706 ± 0.019	3.662IleGly: 3.662 ± 0.051	0.647IleHis: 0.647 ± 0.018	0.931IleIle: 0.931 ± 0.024	0.753IleLys: 0.753 ± 0.017	2.4IleLeu: 2.4 ± 0.035	0.448IleMet: 0.448 ± 0.014	0.706IleAsn: 0.706 ± 0.02	1.805IlePro: 1.805 ± 0.03	0.714IleGln: 0.714 ± 0.019	2.271IleArg: 2.271 ± 0.033	1.767IleSer: 1.767 ± 0.027	2.3IleThr: 2.3 ± 0.035	2.725IleVal: 2.725 ± 0.041	0.379IleTrp: 0.379 ± 0.015	0.522IleTyr: 0.522 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.793LysAla: 2.793 ± 0.046	0.111LysCys: 0.111 ± 0.007	1.306LysAsp: 1.306 ± 0.028	1.172LysGlu: 1.172 ± 0.027	0.469LysPhe: 0.469 ± 0.014	1.793LysGly: 1.793 ± 0.037	0.406LysHis: 0.406 ± 0.014	0.882LysIle: 0.882 ± 0.02	0.906LysLys: 0.906 ± 0.028	1.963LysLeu: 1.963 ± 0.036	0.375LysMet: 0.375 ± 0.014	0.596LysAsn: 0.596 ± 0.021	1.301LysPro: 1.301 ± 0.027	0.641LysGln: 0.641 ± 0.021	1.423LysArg: 1.423 ± 0.027	1.194LysSer: 1.194 ± 0.026	1.294LysThr: 1.294 ± 0.03	1.806LysVal: 1.806 ± 0.036	0.251LysTrp: 0.251 ± 0.011	0.453LysTyr: 0.453 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.27LeuAla: 15.27 ± 0.109	0.803LeuCys: 0.803 ± 0.02	6.653LeuAsp: 6.653 ± 0.06	4.386LeuGlu: 4.386 ± 0.055	2.578LeuPhe: 2.578 ± 0.037	9.241LeuGly: 9.241 ± 0.074	2.15LeuHis: 2.15 ± 0.03	3.416LeuIle: 3.416 ± 0.047	1.98LeuLys: 1.98 ± 0.035	11.405LeuLeu: 11.405 ± 0.096	1.62LeuMet: 1.62 ± 0.031	1.695LeuAsn: 1.695 ± 0.031	6.59LeuPro: 6.59 ± 0.055	1.978LeuGln: 1.978 ± 0.033	8.731LeuArg: 8.731 ± 0.084	5.459LeuSer: 5.459 ± 0.057	7.148LeuThr: 7.148 ± 0.057	8.455LeuVal: 8.455 ± 0.068	1.259LeuTrp: 1.259 ± 0.024	1.873LeuTyr: 1.873 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.252MetAla: 2.252 ± 0.028	0.12MetCys: 0.12 ± 0.007	0.856MetAsp: 0.856 ± 0.019	0.737MetGlu: 0.737 ± 0.018	0.414MetPhe: 0.414 ± 0.013	1.28MetGly: 1.28 ± 0.025	0.306MetHis: 0.306 ± 0.011	0.659MetIle: 0.659 ± 0.017	0.411MetLys: 0.411 ± 0.014	1.597MetLeu: 1.597 ± 0.03	0.293MetMet: 0.293 ± 0.01	0.419MetAsn: 0.419 ± 0.014	1.04MetPro: 1.04 ± 0.023	0.36MetGln: 0.36 ± 0.013	1.376MetArg: 1.376 ± 0.025	1.288MetSer: 1.288 ± 0.026	1.527MetThr: 1.527 ± 0.026	1.268MetVal: 1.268 ± 0.025	0.2MetTrp: 0.2 ± 0.01	0.327MetTyr: 0.327 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.274AsnAla: 2.274 ± 0.038	0.156AsnCys: 0.156 ± 0.009	0.955AsnAsp: 0.955 ± 0.018	0.819AsnGlu: 0.819 ± 0.017	0.513AsnPhe: 0.513 ± 0.015	2.005AsnGly: 2.005 ± 0.041	0.367AsnHis: 0.367 ± 0.014	0.681AsnIle: 0.681 ± 0.02	0.43AsnLys: 0.43 ± 0.014	1.598AsnLeu: 1.598 ± 0.031	0.288AsnMet: 0.288 ± 0.012	0.435AsnAsn: 0.435 ± 0.02	1.29AsnPro: 1.29 ± 0.026	0.514AsnGln: 0.514 ± 0.015	1.235AsnArg: 1.235 ± 0.022	1.01AsnSer: 1.01 ± 0.025	1.213AsnThr: 1.213 ± 0.024	1.36AsnVal: 1.36 ± 0.027	0.291AsnTrp: 0.291 ± 0.013	0.426AsnTyr: 0.426 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	9.496ProAla: 9.496 ± 0.087	0.314ProCys: 0.314 ± 0.014	4.383ProAsp: 4.383 ± 0.042	4.33ProGlu: 4.33 ± 0.054	1.519ProPhe: 1.519 ± 0.027	7.021ProGly: 7.021 ± 0.067	1.36ProHis: 1.36 ± 0.025	1.211ProIle: 1.211 ± 0.024	1.139ProLys: 1.139 ± 0.025	5.48ProLeu: 5.48 ± 0.047	0.949ProMet: 0.949 ± 0.023	0.905ProAsn: 0.905 ± 0.021	3.705ProPro: 3.705 ± 0.063	1.556ProGln: 1.556 ± 0.033	4.086ProArg: 4.086 ± 0.046	3.247ProSer: 3.247 ± 0.048	3.176ProThr: 3.176 ± 0.041	5.776ProVal: 5.776 ± 0.054	0.881ProTrp: 0.881 ± 0.021	1.48ProTyr: 1.48 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.256GlnAla: 3.256 ± 0.039	0.145GlnCys: 0.145 ± 0.008	1.27GlnAsp: 1.27 ± 0.026	1.317GlnGlu: 1.317 ± 0.027	0.662GlnPhe: 0.662 ± 0.017	2.12GlnGly: 2.12 ± 0.035	0.611GlnHis: 0.611 ± 0.016	1.066GlnIle: 1.066 ± 0.025	0.555GlnLys: 0.555 ± 0.016	2.947GlnLeu: 2.947 ± 0.04	0.418GlnMet: 0.418 ± 0.013	0.525GlnAsn: 0.525 ± 0.017	1.576GlnPro: 1.576 ± 0.034	1.197GlnGln: 1.197 ± 0.035	2.336GlnArg: 2.336 ± 0.036	1.234GlnSer: 1.234 ± 0.023	1.285GlnThr: 1.285 ± 0.025	2.077GlnVal: 2.077 ± 0.032	0.437GlnTrp: 0.437 ± 0.014	0.593GlnTyr: 0.593 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.386ArgAla: 10.386 ± 0.089	0.579ArgCys: 0.579 ± 0.017	4.379ArgAsp: 4.379 ± 0.051	4.697ArgGlu: 4.697 ± 0.051	2.297ArgPhe: 2.297 ± 0.033	6.111ArgGly: 6.111 ± 0.064	2.057ArgHis: 2.057 ± 0.029	3.312ArgIle: 3.312 ± 0.041	1.557ArgLys: 1.557 ± 0.028	8.88ArgLeu: 8.88 ± 0.08	1.663ArgMet: 1.663 ± 0.03	1.341ArgAsn: 1.341 ± 0.026	5.069ArgPro: 5.069 ± 0.061	2.211ArgGln: 2.211 ± 0.031	7.723ArgArg: 7.723 ± 0.076	4.02ArgSer: 4.02 ± 0.046	5.856ArgThr: 5.856 ± 0.054	5.88ArgVal: 5.88 ± 0.062	1.365ArgTrp: 1.365 ± 0.026	1.843ArgTyr: 1.843 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	7.101SerAla: 7.101 ± 0.072	0.397SerCys: 0.397 ± 0.014	2.7SerAsp: 2.7 ± 0.038	2.378SerGlu: 2.378 ± 0.035	1.602SerPhe: 1.602 ± 0.028	6.39SerGly: 6.39 ± 0.065	0.985SerHis: 0.985 ± 0.021	1.413SerIle: 1.413 ± 0.03	0.999SerLys: 0.999 ± 0.025	4.94SerLeu: 4.94 ± 0.064	1.027SerMet: 1.027 ± 0.022	0.887SerAsn: 0.887 ± 0.021	3.218SerPro: 3.218 ± 0.038	1.171SerGln: 1.171 ± 0.024	3.702SerArg: 3.702 ± 0.046	2.93SerSer: 2.93 ± 0.045	3.161SerThr: 3.161 ± 0.043	4.477SerVal: 4.477 ± 0.047	0.906SerTrp: 0.906 ± 0.019	1.264SerTyr: 1.264 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.659ThrAla: 9.659 ± 0.077	0.388ThrCys: 0.388 ± 0.013	3.838ThrAsp: 3.838 ± 0.043	3.419ThrGlu: 3.419 ± 0.038	1.631ThrPhe: 1.631 ± 0.026	7.342ThrGly: 7.342 ± 0.069	1.261ThrHis: 1.261 ± 0.022	1.713ThrIle: 1.713 ± 0.03	1.225ThrLys: 1.225 ± 0.03	5.931ThrLeu: 5.931 ± 0.059	0.907ThrMet: 0.907 ± 0.018	1.044ThrAsn: 1.044 ± 0.024	4.309ThrPro: 4.309 ± 0.055	1.285ThrGln: 1.285 ± 0.025	3.91ThrArg: 3.91 ± 0.041	3.215ThrSer: 3.215 ± 0.043	4.127ThrThr: 4.127 ± 0.071	6.39ThrVal: 6.39 ± 0.058	0.839ThrTrp: 0.839 ± 0.022	1.406ThrTyr: 1.406 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	10.622ValAla: 10.622 ± 0.078	0.733ValCys: 0.733 ± 0.02	4.612ValAsp: 4.612 ± 0.052	4.521ValGlu: 4.521 ± 0.056	2.429ValPhe: 2.429 ± 0.042	6.299ValGly: 6.299 ± 0.057	1.841ValHis: 1.841 ± 0.031	2.931ValIle: 2.931 ± 0.038	1.738ValLys: 1.738 ± 0.033	9.322ValLeu: 9.322 ± 0.082	1.412ValMet: 1.412 ± 0.025	1.666ValAsn: 1.666 ± 0.029	5.45ValPro: 5.45 ± 0.055	1.906ValGln: 1.906 ± 0.03	7.369ValArg: 7.369 ± 0.072	4.438ValSer: 4.438 ± 0.052	5.717ValThr: 5.717 ± 0.055	7.65ValVal: 7.65 ± 0.08	1.111ValTrp: 1.111 ± 0.023	1.526ValTyr: 1.526 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.596TrpAla: 1.596 ± 0.028	0.148TrpCys: 0.148 ± 0.008	0.793TrpAsp: 0.793 ± 0.021	0.681TrpGlu: 0.681 ± 0.016	0.459TrpPhe: 0.459 ± 0.013	1.036TrpGly: 1.036 ± 0.027	0.365TrpHis: 0.365 ± 0.012	0.547TrpIle: 0.547 ± 0.016	0.359TrpLys: 0.359 ± 0.012	1.688TrpLeu: 1.688 ± 0.032	0.283TrpMet: 0.283 ± 0.01	0.406TrpAsn: 0.406 ± 0.015	0.777TrpPro: 0.777 ± 0.018	0.587TrpGln: 0.587 ± 0.016	1.333TrpArg: 1.333 ± 0.027	0.946TrpSer: 0.946 ± 0.021	1.049TrpThr: 1.049 ± 0.023	0.917TrpVal: 0.917 ± 0.02	0.337TrpTrp: 0.337 ± 0.013	0.36TrpTyr: 0.36 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.769TyrAla: 2.769 ± 0.037	0.168TyrCys: 0.168 ± 0.008	1.478TyrAsp: 1.478 ± 0.034	1.263TyrGlu: 1.263 ± 0.024	0.619TyrPhe: 0.619 ± 0.018	2.408TyrGly: 2.408 ± 0.034	0.388TyrHis: 0.388 ± 0.012	0.511TyrIle: 0.511 ± 0.016	0.385TyrLys: 0.385 ± 0.016	2.126TyrLeu: 2.126 ± 0.033	0.247TyrMet: 0.247 ± 0.01	0.441TyrAsn: 0.441 ± 0.015	1.072TyrPro: 1.072 ± 0.022	0.57TyrGln: 0.57 ± 0.017	1.887TyrArg: 1.887 ± 0.031	0.945TyrSer: 0.945 ± 0.022	1.251TyrThr: 1.251 ± 0.027	1.613TyrVal: 1.613 ± 0.026	0.349TyrTrp: 0.349 ± 0.013	0.426TyrTyr: 0.426 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6807 proteins (2381321 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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