Amino acid dipepetide frequency for Streptococcus phage Javan85

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.077AlaAla: 4.077 ± 1.454
0.378AlaCys: 0.378 ± 0.173
4.455AlaAsp: 4.455 ± 0.466
6.418AlaGlu: 6.418 ± 0.897
2.265AlaPhe: 2.265 ± 0.54
5.663AlaGly: 5.663 ± 1.062
1.359AlaHis: 1.359 ± 0.322
7.022AlaIle: 7.022 ± 0.954
6.342AlaLys: 6.342 ± 0.636
7.022AlaLeu: 7.022 ± 1.019
2.869AlaMet: 2.869 ± 0.977
4.002AlaAsn: 4.002 ± 0.477
2.567AlaPro: 2.567 ± 0.451
2.869AlaGln: 2.869 ± 0.664
2.869AlaArg: 2.869 ± 0.494
4.983AlaSer: 4.983 ± 0.97
5.134AlaThr: 5.134 ± 0.747
6.116AlaVal: 6.116 ± 1.096
0.982AlaTrp: 0.982 ± 0.339
2.265AlaTyr: 2.265 ± 0.448
0.0AlaXaa: 0.0 ± 0.0
Cys
0.378CysAla: 0.378 ± 0.143
0.076CysCys: 0.076 ± 0.076
0.529CysAsp: 0.529 ± 0.202
0.378CysGlu: 0.378 ± 0.184
0.302CysPhe: 0.302 ± 0.141
0.604CysGly: 0.604 ± 0.229
0.076CysHis: 0.076 ± 0.072
0.151CysIle: 0.151 ± 0.123
0.151CysLys: 0.151 ± 0.098
0.302CysLeu: 0.302 ± 0.137
0.227CysMet: 0.227 ± 0.14
0.302CysAsn: 0.302 ± 0.141
0.453CysPro: 0.453 ± 0.208
0.227CysGln: 0.227 ± 0.12
0.302CysArg: 0.302 ± 0.132
0.529CysSer: 0.529 ± 0.164
0.302CysThr: 0.302 ± 0.158
0.151CysVal: 0.151 ± 0.095
0.076CysTrp: 0.076 ± 0.077
0.227CysTyr: 0.227 ± 0.174
0.0CysXaa: 0.0 ± 0.0
Asp
3.7AspAla: 3.7 ± 0.685
0.453AspCys: 0.453 ± 0.209
3.171AspAsp: 3.171 ± 0.422
4.153AspGlu: 4.153 ± 0.691
3.473AspPhe: 3.473 ± 0.603
4.606AspGly: 4.606 ± 0.659
0.227AspHis: 0.227 ± 0.129
4.832AspIle: 4.832 ± 0.608
5.512AspLys: 5.512 ± 0.821
4.757AspLeu: 4.757 ± 0.646
1.661AspMet: 1.661 ± 0.375
3.02AspAsn: 3.02 ± 0.444
1.737AspPro: 1.737 ± 0.384
1.359AspGln: 1.359 ± 0.391
2.794AspArg: 2.794 ± 0.437
3.7AspSer: 3.7 ± 0.523
4.757AspThr: 4.757 ± 0.624
2.718AspVal: 2.718 ± 0.508
1.208AspTrp: 1.208 ± 0.372
3.02AspTyr: 3.02 ± 0.637
0.0AspXaa: 0.0 ± 0.0
Glu
5.361GluAla: 5.361 ± 0.728
0.831GluCys: 0.831 ± 0.275
2.718GluAsp: 2.718 ± 0.525
5.663GluGlu: 5.663 ± 0.948
2.416GluPhe: 2.416 ± 0.382
3.02GluGly: 3.02 ± 0.551
1.359GluHis: 1.359 ± 0.409
6.04GluIle: 6.04 ± 0.855
5.889GluLys: 5.889 ± 1.125
8.985GluLeu: 8.985 ± 1.51
2.114GluMet: 2.114 ± 0.46
3.624GluAsn: 3.624 ± 0.516
1.435GluPro: 1.435 ± 0.347
3.7GluGln: 3.7 ± 0.475
3.926GluArg: 3.926 ± 0.584
2.945GluSer: 2.945 ± 0.46
2.643GluThr: 2.643 ± 0.456
4.757GluVal: 4.757 ± 0.789
0.68GluTrp: 0.68 ± 0.169
3.473GluTyr: 3.473 ± 0.499
0.0GluXaa: 0.0 ± 0.0
Phe
2.643PheAla: 2.643 ± 0.518
0.151PheCys: 0.151 ± 0.103
3.851PheAsp: 3.851 ± 0.589
2.718PheGlu: 2.718 ± 0.395
1.057PhePhe: 1.057 ± 0.372
3.096PheGly: 3.096 ± 0.393
0.906PheHis: 0.906 ± 0.272
2.114PheIle: 2.114 ± 0.427
3.7PheLys: 3.7 ± 0.488
2.794PheLeu: 2.794 ± 0.51
1.208PheMet: 1.208 ± 0.287
1.812PheAsn: 1.812 ± 0.323
1.208PhePro: 1.208 ± 0.272
0.68PheGln: 0.68 ± 0.149
1.812PheArg: 1.812 ± 0.378
2.492PheSer: 2.492 ± 0.577
2.19PheThr: 2.19 ± 0.429
2.19PheVal: 2.19 ± 0.476
0.453PheTrp: 0.453 ± 0.209
0.831PheTyr: 0.831 ± 0.238
0.0PheXaa: 0.0 ± 0.0
Gly
4.606GlyAla: 4.606 ± 0.772
0.529GlyCys: 0.529 ± 0.178
3.549GlyAsp: 3.549 ± 0.578
3.171GlyGlu: 3.171 ± 0.478
2.794GlyPhe: 2.794 ± 0.49
3.247GlyGly: 3.247 ± 0.6
0.68GlyHis: 0.68 ± 0.219
5.285GlyIle: 5.285 ± 1.002
5.361GlyLys: 5.361 ± 0.783
4.757GlyLeu: 4.757 ± 0.631
2.039GlyMet: 2.039 ± 0.327
3.171GlyAsn: 3.171 ± 0.539
0.982GlyPro: 0.982 ± 0.272
3.624GlyGln: 3.624 ± 0.606
2.341GlyArg: 2.341 ± 0.335
4.606GlySer: 4.606 ± 0.986
4.077GlyThr: 4.077 ± 0.674
5.965GlyVal: 5.965 ± 1.198
0.982GlyTrp: 0.982 ± 0.284
2.643GlyTyr: 2.643 ± 0.451
0.0GlyXaa: 0.0 ± 0.0
His
1.359HisAla: 1.359 ± 0.327
0.151HisCys: 0.151 ± 0.103
0.982HisAsp: 0.982 ± 0.321
0.755HisGlu: 0.755 ± 0.246
0.68HisPhe: 0.68 ± 0.212
1.057HisGly: 1.057 ± 0.358
0.68HisHis: 0.68 ± 0.242
0.906HisIle: 0.906 ± 0.314
0.982HisLys: 0.982 ± 0.38
0.982HisLeu: 0.982 ± 0.324
0.302HisMet: 0.302 ± 0.145
0.68HisAsn: 0.68 ± 0.208
0.453HisPro: 0.453 ± 0.19
0.604HisGln: 0.604 ± 0.203
0.982HisArg: 0.982 ± 0.268
1.359HisSer: 1.359 ± 0.221
0.755HisThr: 0.755 ± 0.231
0.982HisVal: 0.982 ± 0.309
0.453HisTrp: 0.453 ± 0.141
0.831HisTyr: 0.831 ± 0.231
0.0HisXaa: 0.0 ± 0.0
Ile
5.738IleAla: 5.738 ± 0.746
0.453IleCys: 0.453 ± 0.224
6.342IleAsp: 6.342 ± 0.805
5.814IleGlu: 5.814 ± 0.686
1.963IlePhe: 1.963 ± 0.324
5.134IleGly: 5.134 ± 0.865
1.359IleHis: 1.359 ± 0.385
4.153IleIle: 4.153 ± 0.481
4.757IleLys: 4.757 ± 0.682
4.153IleLeu: 4.153 ± 0.474
0.831IleMet: 0.831 ± 0.247
3.398IleAsn: 3.398 ± 0.575
2.643IlePro: 2.643 ± 0.715
2.341IleGln: 2.341 ± 0.38
3.398IleArg: 3.398 ± 0.522
4.832IleSer: 4.832 ± 0.507
4.304IleThr: 4.304 ± 0.776
4.832IleVal: 4.832 ± 0.822
0.604IleTrp: 0.604 ± 0.169
2.794IleTyr: 2.794 ± 0.592
0.0IleXaa: 0.0 ± 0.0
Lys
5.965LysAla: 5.965 ± 0.737
0.302LysCys: 0.302 ± 0.139
4.077LysAsp: 4.077 ± 0.705
6.494LysGlu: 6.494 ± 1.021
2.718LysPhe: 2.718 ± 0.36
3.624LysGly: 3.624 ± 0.576
1.51LysHis: 1.51 ± 0.382
4.606LysIle: 4.606 ± 0.666
5.965LysLys: 5.965 ± 0.979
5.814LysLeu: 5.814 ± 0.647
2.416LysMet: 2.416 ± 0.422
3.851LysAsn: 3.851 ± 0.626
2.341LysPro: 2.341 ± 0.478
4.077LysGln: 4.077 ± 0.748
4.53LysArg: 4.53 ± 0.742
4.002LysSer: 4.002 ± 0.384
4.455LysThr: 4.455 ± 0.609
4.681LysVal: 4.681 ± 0.671
1.057LysTrp: 1.057 ± 0.261
2.265LysTyr: 2.265 ± 0.428
0.0LysXaa: 0.0 ± 0.0
Leu
6.871LeuAla: 6.871 ± 0.688
0.302LeuCys: 0.302 ± 0.18
5.361LeuAsp: 5.361 ± 0.69
6.947LeuGlu: 6.947 ± 0.854
2.492LeuPhe: 2.492 ± 0.381
5.21LeuGly: 5.21 ± 0.606
1.133LeuHis: 1.133 ± 0.299
4.757LeuIle: 4.757 ± 0.72
6.267LeuLys: 6.267 ± 0.678
6.267LeuLeu: 6.267 ± 0.936
1.812LeuMet: 1.812 ± 0.299
4.681LeuAsn: 4.681 ± 0.547
2.492LeuPro: 2.492 ± 0.418
3.7LeuGln: 3.7 ± 0.67
4.153LeuArg: 4.153 ± 0.771
5.587LeuSer: 5.587 ± 0.56
4.606LeuThr: 4.606 ± 0.589
5.889LeuVal: 5.889 ± 0.677
0.227LeuTrp: 0.227 ± 0.125
2.341LeuTyr: 2.341 ± 0.493
0.0LeuXaa: 0.0 ± 0.0
Met
3.02MetAla: 3.02 ± 0.636
0.0MetCys: 0.0 ± 0.0
1.359MetAsp: 1.359 ± 0.356
1.359MetGlu: 1.359 ± 0.304
1.208MetPhe: 1.208 ± 0.286
1.51MetGly: 1.51 ± 0.322
0.227MetHis: 0.227 ± 0.167
1.51MetIle: 1.51 ± 0.299
2.19MetLys: 2.19 ± 0.497
2.718MetLeu: 2.718 ± 0.478
0.906MetMet: 0.906 ± 0.32
1.359MetAsn: 1.359 ± 0.321
0.755MetPro: 0.755 ± 0.241
1.284MetGln: 1.284 ± 0.288
1.51MetArg: 1.51 ± 0.285
1.435MetSer: 1.435 ± 0.361
2.341MetThr: 2.341 ± 0.381
1.359MetVal: 1.359 ± 0.502
0.302MetTrp: 0.302 ± 0.18
0.906MetTyr: 0.906 ± 0.283
0.0MetXaa: 0.0 ± 0.0
Asn
3.398AsnAla: 3.398 ± 0.507
0.227AsnCys: 0.227 ± 0.131
3.322AsnAsp: 3.322 ± 0.569
2.945AsnGlu: 2.945 ± 0.723
1.737AsnPhe: 1.737 ± 0.29
4.304AsnGly: 4.304 ± 0.76
1.359AsnHis: 1.359 ± 0.328
3.7AsnIle: 3.7 ± 0.534
3.775AsnLys: 3.775 ± 0.564
3.624AsnLeu: 3.624 ± 0.521
1.435AsnMet: 1.435 ± 0.322
2.265AsnAsn: 2.265 ± 0.442
2.492AsnPro: 2.492 ± 0.349
1.661AsnGln: 1.661 ± 0.451
1.812AsnArg: 1.812 ± 0.341
2.794AsnSer: 2.794 ± 0.504
2.039AsnThr: 2.039 ± 0.335
3.02AsnVal: 3.02 ± 0.377
0.755AsnTrp: 0.755 ± 0.208
2.341AsnTyr: 2.341 ± 0.431
0.0AsnXaa: 0.0 ± 0.0
Pro
2.341ProAla: 2.341 ± 0.399
0.0ProCys: 0.0 ± 0.0
2.492ProAsp: 2.492 ± 0.408
2.492ProGlu: 2.492 ± 0.418
1.963ProPhe: 1.963 ± 0.551
1.359ProGly: 1.359 ± 0.326
0.529ProHis: 0.529 ± 0.241
1.51ProIle: 1.51 ± 0.331
1.661ProLys: 1.661 ± 0.34
2.114ProLeu: 2.114 ± 0.312
0.755ProMet: 0.755 ± 0.207
1.963ProAsn: 1.963 ± 0.32
1.284ProPro: 1.284 ± 0.289
1.133ProGln: 1.133 ± 0.449
1.133ProArg: 1.133 ± 0.293
2.341ProSer: 2.341 ± 0.43
2.341ProThr: 2.341 ± 0.505
2.039ProVal: 2.039 ± 0.386
0.378ProTrp: 0.378 ± 0.146
0.831ProTyr: 0.831 ± 0.275
0.0ProXaa: 0.0 ± 0.0
Gln
3.926GlnAla: 3.926 ± 0.902
0.151GlnCys: 0.151 ± 0.098
1.208GlnAsp: 1.208 ± 0.303
3.02GlnGlu: 3.02 ± 0.654
1.812GlnPhe: 1.812 ± 0.343
2.945GlnGly: 2.945 ± 0.723
0.227GlnHis: 0.227 ± 0.117
3.322GlnIle: 3.322 ± 0.426
2.869GlnLys: 2.869 ± 0.474
3.096GlnLeu: 3.096 ± 0.477
1.51GlnMet: 1.51 ± 0.352
1.737GlnAsn: 1.737 ± 0.273
1.586GlnPro: 1.586 ± 0.5
2.794GlnGln: 2.794 ± 0.941
1.812GlnArg: 1.812 ± 0.493
2.794GlnSer: 2.794 ± 0.418
2.718GlnThr: 2.718 ± 0.604
2.869GlnVal: 2.869 ± 0.53
0.378GlnTrp: 0.378 ± 0.148
1.888GlnTyr: 1.888 ± 0.399
0.0GlnXaa: 0.0 ± 0.0
Arg
4.153ArgAla: 4.153 ± 0.473
0.529ArgCys: 0.529 ± 0.201
2.039ArgAsp: 2.039 ± 0.315
3.851ArgGlu: 3.851 ± 0.457
1.586ArgPhe: 1.586 ± 0.29
2.718ArgGly: 2.718 ± 0.315
0.831ArgHis: 0.831 ± 0.246
2.492ArgIle: 2.492 ± 0.468
3.549ArgLys: 3.549 ± 0.716
4.757ArgLeu: 4.757 ± 0.631
1.133ArgMet: 1.133 ± 0.27
1.812ArgAsn: 1.812 ± 0.343
0.831ArgPro: 0.831 ± 0.254
2.341ArgGln: 2.341 ± 0.481
2.265ArgArg: 2.265 ± 0.504
2.039ArgSer: 2.039 ± 0.366
2.114ArgThr: 2.114 ± 0.401
2.869ArgVal: 2.869 ± 0.468
0.529ArgTrp: 0.529 ± 0.2
2.416ArgTyr: 2.416 ± 0.403
0.0ArgXaa: 0.0 ± 0.0
Ser
6.871SerAla: 6.871 ± 1.821
0.227SerCys: 0.227 ± 0.116
4.53SerAsp: 4.53 ± 0.656
3.624SerGlu: 3.624 ± 0.578
2.794SerPhe: 2.794 ± 0.713
5.361SerGly: 5.361 ± 0.967
0.453SerHis: 0.453 ± 0.161
3.624SerIle: 3.624 ± 0.756
4.002SerLys: 4.002 ± 0.651
4.077SerLeu: 4.077 ± 0.472
2.19SerMet: 2.19 ± 0.537
2.492SerAsn: 2.492 ± 0.537
2.341SerPro: 2.341 ± 0.419
2.492SerGln: 2.492 ± 0.509
2.265SerArg: 2.265 ± 0.477
4.153SerSer: 4.153 ± 0.947
4.002SerThr: 4.002 ± 0.569
4.077SerVal: 4.077 ± 0.701
1.208SerTrp: 1.208 ± 0.314
2.718SerTyr: 2.718 ± 0.511
0.0SerXaa: 0.0 ± 0.0
Thr
6.116ThrAla: 6.116 ± 1.376
0.076ThrCys: 0.076 ± 0.081
3.096ThrAsp: 3.096 ± 0.471
3.624ThrGlu: 3.624 ± 0.568
2.718ThrPhe: 2.718 ± 0.65
4.153ThrGly: 4.153 ± 0.496
1.133ThrHis: 1.133 ± 0.319
5.738ThrIle: 5.738 ± 0.851
4.228ThrLys: 4.228 ± 0.803
5.361ThrLeu: 5.361 ± 0.533
1.057ThrMet: 1.057 ± 0.283
2.643ThrAsn: 2.643 ± 0.327
2.039ThrPro: 2.039 ± 0.376
2.567ThrGln: 2.567 ± 0.571
1.661ThrArg: 1.661 ± 0.359
3.851ThrSer: 3.851 ± 0.617
4.228ThrThr: 4.228 ± 0.654
4.757ThrVal: 4.757 ± 0.784
0.68ThrTrp: 0.68 ± 0.276
2.492ThrTyr: 2.492 ± 0.417
0.0ThrXaa: 0.0 ± 0.0
Val
5.512ValAla: 5.512 ± 0.826
0.227ValCys: 0.227 ± 0.14
4.53ValAsp: 4.53 ± 0.544
4.832ValGlu: 4.832 ± 0.567
2.039ValPhe: 2.039 ± 0.314
3.775ValGly: 3.775 ± 0.937
0.982ValHis: 0.982 ± 0.308
4.379ValIle: 4.379 ± 0.576
4.757ValLys: 4.757 ± 0.519
5.361ValLeu: 5.361 ± 0.619
1.586ValMet: 1.586 ± 0.317
3.171ValAsn: 3.171 ± 0.438
1.435ValPro: 1.435 ± 0.264
2.718ValGln: 2.718 ± 0.648
2.492ValArg: 2.492 ± 0.453
5.965ValSer: 5.965 ± 0.762
6.418ValThr: 6.418 ± 0.784
5.21ValVal: 5.21 ± 0.61
0.453ValTrp: 0.453 ± 0.184
1.888ValTyr: 1.888 ± 0.462
0.0ValXaa: 0.0 ± 0.0
Trp
0.755TrpAla: 0.755 ± 0.273
0.227TrpCys: 0.227 ± 0.124
0.831TrpAsp: 0.831 ± 0.234
0.982TrpGlu: 0.982 ± 0.289
0.378TrpPhe: 0.378 ± 0.149
0.529TrpGly: 0.529 ± 0.181
0.227TrpHis: 0.227 ± 0.124
1.057TrpIle: 1.057 ± 0.369
0.831TrpLys: 0.831 ± 0.216
0.982TrpLeu: 0.982 ± 0.236
0.151TrpMet: 0.151 ± 0.103
0.831TrpAsn: 0.831 ± 0.323
0.076TrpPro: 0.076 ± 0.076
0.453TrpGln: 0.453 ± 0.185
0.529TrpArg: 0.529 ± 0.173
1.208TrpSer: 1.208 ± 0.366
0.604TrpThr: 0.604 ± 0.193
0.982TrpVal: 0.982 ± 0.256
0.151TrpTrp: 0.151 ± 0.153
0.302TrpTyr: 0.302 ± 0.138
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.869TyrAla: 2.869 ± 0.497
0.453TyrCys: 0.453 ± 0.178
2.416TyrAsp: 2.416 ± 0.589
2.341TyrGlu: 2.341 ± 0.539
1.51TyrPhe: 1.51 ± 0.373
2.492TyrGly: 2.492 ± 0.536
0.68TyrHis: 0.68 ± 0.192
2.643TyrIle: 2.643 ± 0.653
1.963TyrLys: 1.963 ± 0.455
3.247TyrLeu: 3.247 ± 0.478
0.982TyrMet: 0.982 ± 0.225
2.19TyrAsn: 2.19 ± 0.451
1.51TyrPro: 1.51 ± 0.302
2.039TyrGln: 2.039 ± 0.46
2.265TyrArg: 2.265 ± 0.397
1.888TyrSer: 1.888 ± 0.324
2.19TyrThr: 2.19 ± 0.403
2.265TyrVal: 2.265 ± 0.4
0.529TyrTrp: 0.529 ± 0.198
1.812TyrTyr: 1.812 ± 0.407
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 58 proteins (13245 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski